WO2001023570A3 - Methodes et compositions relatives a de nouvelles sous-unites beta1a du canal sodique - Google Patents

Methodes et compositions relatives a de nouvelles sous-unites beta1a du canal sodique Download PDF

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Publication number
WO2001023570A3
WO2001023570A3 PCT/US2000/027034 US0027034W WO0123570A3 WO 2001023570 A3 WO2001023570 A3 WO 2001023570A3 US 0027034 W US0027034 W US 0027034W WO 0123570 A3 WO0123570 A3 WO 0123570A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
subunits
subunit
sodium channel
compositions relating
Prior art date
Application number
PCT/US2000/027034
Other languages
English (en)
Other versions
WO2001023570A2 (fr
Inventor
Andrea Michael D
Kathryn E Rogers
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Priority to AU77435/00A priority Critical patent/AU7743500A/en
Publication of WO2001023570A2 publication Critical patent/WO2001023570A2/fr
Publication of WO2001023570A3 publication Critical patent/WO2001023570A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne une nouvelle sous-unité de canaux sodiques potentiel-dépendants. Cette sous-unité est un variant d'épissage de la sous-unité bêta des canaux sodiques codant une nouvelle protéine. L'invention concerne également des méthodes et des compositions utilisant ces acides nucléiques et protéines de ladite sous-unité. Elle concerne en outre des méthodes de traitement de la douleur neuropathique.
PCT/US2000/027034 1999-09-30 2000-09-29 Methodes et compositions relatives a de nouvelles sous-unites beta1a du canal sodique WO2001023570A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU77435/00A AU7743500A (en) 1999-09-30 2000-09-29 Methods and compositions relating to novel sodium channel $(b)1a subunits

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15683799P 1999-09-30 1999-09-30
US60/156,837 1999-09-30

Publications (2)

Publication Number Publication Date
WO2001023570A2 WO2001023570A2 (fr) 2001-04-05
WO2001023570A3 true WO2001023570A3 (fr) 2001-10-25

Family

ID=22561303

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2000/027034 WO2001023570A2 (fr) 1999-09-30 2000-09-29 Methodes et compositions relatives a de nouvelles sous-unites beta1a du canal sodique
PCT/US2000/027119 WO2001023571A1 (fr) 1999-09-30 2000-09-29 PROCEDES ET COMPOSITIONS RELATIFS AUX SOUS-UNITES β1A DE CANAUX SODIQUES

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2000/027119 WO2001023571A1 (fr) 1999-09-30 2000-09-29 PROCEDES ET COMPOSITIONS RELATIFS AUX SOUS-UNITES β1A DE CANAUX SODIQUES

Country Status (5)

Country Link
EP (1) EP1216300A1 (fr)
JP (1) JP2003510079A (fr)
AU (2) AU7746100A (fr)
CA (1) CA2381771A1 (fr)
WO (2) WO2001023570A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE368740T1 (de) * 2000-06-07 2007-08-15 Ortho Mcneil Pharm Inc Die menschliche beta-1a-untereinheit des potential-abhängigen natriumkanals und deren verwendungen
US6897319B2 (en) 2001-12-27 2005-05-24 Ortho-Mcneil Pharmaceutical, Inc. Useful aroyl pyrrole heteroaryl methanones and methanols
EP1336847B1 (fr) * 2002-02-14 2007-12-12 Biofrontera Pharmaceuticals AG Inhibiteurs de la Cathepsine Y pour le développement de médicaments pour le traitement de la douleur

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063367A1 (fr) * 1999-04-15 2000-10-26 Warner-Lambert Company Nouvelle famille de proteines sous-unite $g(b) du canal sodique potentio-dependant, acides nucleiques codant pour elles et leur utilisation a des fins therapeutiques et diagnostiques
WO2000069912A1 (fr) * 1999-05-14 2000-11-23 Millennium Pharmaceuticals, Inc. Gene codant pour une sous-unite de proteine beta-3 de canal sodique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063367A1 (fr) * 1999-04-15 2000-10-26 Warner-Lambert Company Nouvelle famille de proteines sous-unite $g(b) du canal sodique potentio-dependant, acides nucleiques codant pour elles et leur utilisation a des fins therapeutiques et diagnostiques
WO2000069912A1 (fr) * 1999-05-14 2000-11-23 Millennium Pharmaceuticals, Inc. Gene codant pour une sous-unite de proteine beta-3 de canal sodique

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BELCHER S M ET AL: "Cloning of the cDNA encoding the sodium channel beta1 subunit from rabbit", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 170, no. 2, 8 May 1996 (1996-05-08), pages 285 - 286, XP004042842, ISSN: 0378-1119 *
ISOM L L ET AL: "PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE BETA-1 SUBUNIT OF THE RAT BRAIN SODIUM CHANNEL", SCIENCE (WASHINGTON D C), vol. 256, no. 5058, 1992, pages 839 - 842, XP002159778, ISSN: 0036-8075 *
KAZEN-GILLESPIE KRISTIN A ET AL: "Cloning, localization, and functional expression of sodium channel beta1A subunits.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 2, 14 January 2000 (2000-01-14), pages 1079 - 1088, XP002159777, ISSN: 0021-9258 *
MAKITA NAOMASA ET AL: "Voltage-gated Na+ channel beta-1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene", JOURNAL OF BIOLOGICAL CHEMISTRY,THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,,US, vol. 269, no. 10, 1994, pages 7571 - 7578, XP002145888, ISSN: 0021-9258 *
MARBAN E ET AL: "STRUCTURE AND FUNCTION OF VOLTAGE-GATED SODIUM CHANNELS", JOURNAL OF PHYSIOLOGY,XX,XX, vol. 508, no. 3, 1 May 1998 (1998-05-01), pages 647 - 657, XP000938782, ISSN: 0022-3751 *
SUTKOWSKI E M ET AL: "BETA-1 SUBUNITS OF SODIUM CHANNELS STUDIES WITH SUBUNIT-SPECIFIC ANTIBODIES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 21, 1990, pages 12393 - 12399, XP002159776, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
JP2003510079A (ja) 2003-03-18
CA2381771A1 (fr) 2001-04-05
WO2001023570A2 (fr) 2001-04-05
AU7743500A (en) 2001-04-30
WO2001023571A1 (fr) 2001-04-05
EP1216300A1 (fr) 2002-06-26
AU7746100A (en) 2001-04-30

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