WO2001023369A3 - Process for preparing benzoic acids - Google Patents

Process for preparing benzoic acids Download PDF

Info

Publication number
WO2001023369A3
WO2001023369A3 PCT/US2000/021974 US0021974W WO0123369A3 WO 2001023369 A3 WO2001023369 A3 WO 2001023369A3 US 0021974 W US0021974 W US 0021974W WO 0123369 A3 WO0123369 A3 WO 0123369A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzoic acids
preparing benzoic
formula
preparing
piperidin
Prior art date
Application number
PCT/US2000/021974
Other languages
French (fr)
Other versions
WO2001023369A2 (en
Inventor
Wayne Douglas Luke
Original Assignee
Lilly Co Eli
Wayne Douglas Luke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Wayne Douglas Luke filed Critical Lilly Co Eli
Priority to EP00966691A priority Critical patent/EP1220847A2/en
Priority to JP2001526522A priority patent/JP2003510313A/en
Priority to AU76998/00A priority patent/AU7699800A/en
Publication of WO2001023369A2 publication Critical patent/WO2001023369A2/en
Publication of WO2001023369A3 publication Critical patent/WO2001023369A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

An improved process for the preparation of 4[(2-piperidin-1-yl)ethoxy]benzoic acid derivatives, comprising reacting a haloalkyl amine of formula (III) with a compound of formula (IV) in the presence of a hydrated inorganic base in an appropriate solvent.
PCT/US2000/021974 1999-09-27 2000-09-18 Process for preparing benzoic acids WO2001023369A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00966691A EP1220847A2 (en) 1999-09-27 2000-09-18 Process for preparing benzoic acids
JP2001526522A JP2003510313A (en) 1999-09-27 2000-09-18 Method for producing benzoic acid
AU76998/00A AU7699800A (en) 1999-09-27 2000-09-18 Process for preparing benzoic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15620599P 1999-09-27 1999-09-27
US60/156,205 1999-09-27

Publications (2)

Publication Number Publication Date
WO2001023369A2 WO2001023369A2 (en) 2001-04-05
WO2001023369A3 true WO2001023369A3 (en) 2001-11-22

Family

ID=22558560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/021974 WO2001023369A2 (en) 1999-09-27 2000-09-18 Process for preparing benzoic acids

Country Status (4)

Country Link
EP (1) EP1220847A2 (en)
JP (1) JP2003510313A (en)
AU (1) AU7699800A (en)
WO (1) WO2001023369A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1826205A1 (en) 2002-09-30 2007-08-29 A/S GEA Farmaceutisk Fabrik Novel raloxifene succinic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699672A1 (en) * 1994-08-31 1996-03-06 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699672A1 (en) * 1994-08-31 1996-03-06 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Also Published As

Publication number Publication date
AU7699800A (en) 2001-04-30
EP1220847A2 (en) 2002-07-10
JP2003510313A (en) 2003-03-18
WO2001023369A2 (en) 2001-04-05

Similar Documents

Publication Publication Date Title
WO2002100860A3 (en) Heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as anti-bacterial agents
CA2433288A1 (en) Process for making amlodipine maleate
WO1998046589A3 (en) Indazole amide compounds as serotoninergic agents
CA2389379A1 (en) Method for the preparation of 5-carboxyphthalide
AU6077798A (en) A condensed piperidine compound
ES2159488A1 (en) Method for preparing pyrimidone derivatives with antifungal activity
CA2362217A1 (en) Process for preparing phenylpyrazole pesticidal intermediates
CA2427831A1 (en) Cyclization process step in the making of quinolones and naphthyridines
WO2001023346A3 (en) Process for phenylacetic acid derivatives
WO2001023369A3 (en) Process for preparing benzoic acids
ZA200201781B (en) Process for production of naphthyridine-3-carboxylic acid derivatives.
NZ513551A (en) Novel process for preparing alendronic acid
CA2419764A1 (en) Process for preparing a substituted imidazopyridine compound
CA2199645A1 (en) Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof
CA2366600A1 (en) A process for the preparation of 1,4,7,10-tetraazacyclododecane
HUP0000982A3 (en) Process for the preparation of 1,1-dioxo-penicillanic acid derivatives
CA2339826A1 (en) Process for the production of n-protected azetidine-2-carboxylic acids (azeohs)
NO20004918D0 (en) Process for the preparation of benzothiophenecarboxylic acid amide derivatives
CA2390934A1 (en) Process for producing benzylamine compound
AU7005800A (en) Method for preparing a carboxylic acid
WO2003040116A8 (en) A process for the preparation of cephalosporins side chains
EP1186588A4 (en) 6-hydroxy-2-naphthylcarbinol and process for the preparation thereof
WO2001012597A3 (en) Method for preparing quinoline-5,8-diones
WO2002076382A3 (en) Preparation of polyaryl carboxylic acids
AU2002212060A1 (en) A new process for preparing a quinolone-carboxylic acid

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10088002

Country of ref document: US

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 526522

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000966691

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000966691

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000966691

Country of ref document: EP