WO2001022978A3 - Autologous marrow stem cell (msc) transplantation for myocardial regeneration - Google Patents

Autologous marrow stem cell (msc) transplantation for myocardial regeneration Download PDF

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Publication number
WO2001022978A3
WO2001022978A3 PCT/CA2000/001114 CA0001114W WO0122978A3 WO 2001022978 A3 WO2001022978 A3 WO 2001022978A3 CA 0001114 W CA0001114 W CA 0001114W WO 0122978 A3 WO0122978 A3 WO 0122978A3
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WO
WIPO (PCT)
Prior art keywords
mscs
patient
further comprise
implanted
msc
Prior art date
Application number
PCT/CA2000/001114
Other languages
French (fr)
Other versions
WO2001022978A2 (en
Inventor
Ray C J Chiu
Dominique Shum-Tim
Jacques Galipeau
Original Assignee
Univ Mcgill
Ray C J Chiu
Shum Tim Dominique
Jacques Galipeau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mcgill, Ray C J Chiu, Shum Tim Dominique, Jacques Galipeau filed Critical Univ Mcgill
Priority to AU75004/00A priority Critical patent/AU7500400A/en
Priority to EP00963823A priority patent/EP1221956A2/en
Publication of WO2001022978A2 publication Critical patent/WO2001022978A2/en
Publication of WO2001022978A3 publication Critical patent/WO2001022978A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention relates to a method of improving cardiac function in a patient with heart failure without eliciting an immune response and without sacrificing the patient's skeletal muscle; which comprises the step of transplanting autologous bone marrow stroma cells (MSCs) into said patient's myocardium to grow new muscle fibers. The method may further comprise the step of using cell labeling technique to confirm survival and differentiation of implanted MSCs, and to identify said MSCs phenotype by both morphology and molecular markers. The method may further comprise examining the effects of the micro-environment of implanted MSCs on their differentiation and phenotype expression. The method may further comprise examining functional contribution of MSCs implanted into an ischemic segment of the myocardium.
PCT/CA2000/001114 1999-09-30 2000-09-28 Autologous marrow stem cell (msc) transplantation for myocardial regeneration WO2001022978A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU75004/00A AU7500400A (en) 1999-09-30 2000-09-28 Autologous marrow stem cell (msc) transplantation for myocardial regeneration
EP00963823A EP1221956A2 (en) 1999-09-30 2000-09-28 Autologous marrow stem cell (msc) transplantation for myocardial regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15670099P 1999-09-30 1999-09-30
US60/156,700 1999-09-30

Publications (2)

Publication Number Publication Date
WO2001022978A2 WO2001022978A2 (en) 2001-04-05
WO2001022978A3 true WO2001022978A3 (en) 2001-08-16

Family

ID=22560676

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001114 WO2001022978A2 (en) 1999-09-30 2000-09-28 Autologous marrow stem cell (msc) transplantation for myocardial regeneration

Country Status (3)

Country Link
EP (1) EP1221956A2 (en)
AU (1) AU7500400A (en)
WO (1) WO2001022978A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002008389A2 (en) * 2000-07-26 2002-01-31 Scimed Life Systems, Inc. Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
JP2004535199A (en) 2001-07-12 2004-11-25 ジェロン コーポレイション Cardiomyocyte lineage cells produced from human pluripotent stem cells
US7682825B2 (en) * 2002-02-06 2010-03-23 Sanbio, Inc. Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
US7452718B2 (en) 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
EP1855700B1 (en) 2005-03-07 2013-10-30 SanBio, Inc. Use of neuronal precursor cells for treatment of central nervous system lesions
US8889122B2 (en) 2005-05-09 2014-11-18 Mytogen, Inc. Cellular cardiomyoplasty as supportive therapy in patients with heart disease
KR101529317B1 (en) 2005-06-22 2015-06-16 아스테리아스 바이오세라퓨틱스, 인크. Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
WO2007021210A1 (en) * 2005-08-15 2007-02-22 Krasnozhenyuk Alexei Dmitrievi Method for treating diseases caused by vascular diseases
KR20110005682A (en) 2008-01-30 2011-01-18 제론 코포레이션 Synthetic surfaces for culturing stem cell derived cardiomyocytes
US20110195054A1 (en) * 2009-10-06 2011-08-11 Michael Cohen Preparation And Use Of Stromal Cells For Treatment Of Cardiac Diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
WO1999003973A1 (en) * 1997-07-14 1999-01-28 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
WO1999003973A1 (en) * 1997-07-14 1999-01-28 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRUDER S P ET AL: "MESENCHYMAL STEM CELLS IN BONE DEVELOPMENT, BONE REPAIR, AND SKELETAL REGENERATION THERAPY", JOURNAL OF CELL BIOLOGY,US,ROCKEFELLER UNIVERSITY PRESS, NEW YORK, US, vol. 56, no. 3, 1994, pages 283 - 294, XP000865959, ISSN: 0021-9525 *
FERRARI G ET AL: "Muscle regeneration by bone marrow -derived myogenic progenitors [see comments] [published erratum appears in Science 1998 Aug 14;281(5379):923]", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 279, 6 March 1998 (1998-03-06), pages 1528 - 1530, XP002098163, ISSN: 0036-8075 *
KESSLER P D ET AL: "MYOBLAST CELL GRAFTING INTO HEART MUSCLE: CELLULAR BIOLOGY AND POTENTIAL APPLICATIONS", ANNUAL REVIEW OF PHYSIOLOGY,US,ANNUAL REVIEWS, INC., PALO ALTO, CA, vol. 61, 1999, pages 219 - 242, XP000865708, ISSN: 0066-4278 *
MAKINO S. ET AL: "Cardiomyocytes can be generated from marrow stromal cells in vitro", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 103, no. 5, March 1999 (1999-03-01), pages 697 - 705, XP000990317 *
PROCKPO D. ET AL: "Marrow stromal cells for nonhematopoietic tissues", SCIENCE, vol. 276, 1997, pages 71 - 74, XP002162972 *
TOMITA S ET AL: "AUTOTRANSPLANTED MESENCHYMAL STEM CELLS IMPROVE FUNCTION AFTER A MYOCARDIAL INFARCATION", CIRCULATION,US,AMERICAN HEART ASSOCIATION, DALLAS, TX, vol. 98, no. SUPPL. 17, 1998, pages ABS1036, XP000870314, ISSN: 0009-7322 *

Also Published As

Publication number Publication date
AU7500400A (en) 2001-04-30
EP1221956A2 (en) 2002-07-17
WO2001022978A2 (en) 2001-04-05

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