WO2001021805B1 - Antigenes de chlamydia, fragments d'adn correspondants, et utilisations desdits fragments - Google Patents
Antigenes de chlamydia, fragments d'adn correspondants, et utilisations desdits fragmentsInfo
- Publication number
- WO2001021805B1 WO2001021805B1 PCT/CA2000/001089 CA0001089W WO0121805B1 WO 2001021805 B1 WO2001021805 B1 WO 2001021805B1 CA 0001089 W CA0001089 W CA 0001089W WO 0121805 B1 WO0121805 B1 WO 0121805B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptide
- nucleic acid
- seq
- vaccine
- acid sequence
- Prior art date
Links
- 241000606161 Chlamydia Species 0.000 title claims abstract 6
- 239000012634 fragment Substances 0.000 title claims 19
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 49
- 108020004707 nucleic acids Proteins 0.000 claims abstract 33
- 102000039446 nucleic acids Human genes 0.000 claims abstract 33
- 239000002773 nucleotide Substances 0.000 claims abstract 8
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 8
- 230000000694 effects Effects 0.000 claims abstract 5
- 101710202659 Type II secretion system protein E Proteins 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 241001647372 Chlamydia pneumoniae Species 0.000 claims abstract 2
- 230000003053 immunization Effects 0.000 claims abstract 2
- 229920001184 polypeptide Polymers 0.000 claims 89
- 108090000765 processed proteins & peptides Proteins 0.000 claims 89
- 102000004196 processed proteins & peptides Human genes 0.000 claims 89
- 229960005486 vaccine Drugs 0.000 claims 24
- 108020001507 fusion proteins Proteins 0.000 claims 17
- 102000037865 fusion proteins Human genes 0.000 claims 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 230000002163 immunogen Effects 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 8
- 230000028993 immune response Effects 0.000 claims 7
- 230000005847 immunogenicity Effects 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 208000007190 Chlamydia Infections Diseases 0.000 claims 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 230000000692 anti-sense effect Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000013613 expression plasmid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002853 nucleic acid probe Substances 0.000 claims 1
- -1 DNA Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Abstract
L'invention concerne une méthode permettant d'utiliser une séquence d'acide nucléique comprenant un ADN, et d'immuniser un hôte, notamment un humain, contre des maladies associées à une infection provoquée par une souche de Chlamydia, en particulier C. pneumoniae. Ledit procédé utilise un vecteur qui contient une séquence nucléotidique codant pour une protéine E de chemin de sécrétion général de la souche de Chlamydia pneumoniae, et un promoteur permettant d'exprimer le gène de ladite protéine E chez l'hôte. Il est possible d'effectuer des modifications dans le cadre de cette invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU73986/00A AU7398600A (en) | 1999-09-17 | 2000-09-15 | Chlamydia antigens and corresponding dna fragments and uses thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15459599P | 1999-09-17 | 1999-09-17 | |
| US60/154,595 | 1999-09-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001021805A1 WO2001021805A1 (fr) | 2001-03-29 |
| WO2001021805B1 true WO2001021805B1 (fr) | 2001-08-02 |
Family
ID=22551960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CA2000/001089 WO2001021805A1 (fr) | 1999-09-17 | 2000-09-15 | Antigenes de chlamydia, fragments d'adn correspondants, et utilisations desdits fragments |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU7398600A (fr) |
| WO (1) | WO2001021805A1 (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010032336A (ko) * | 1997-11-21 | 2001-04-16 | 브랑디 빠스깔 | 클라미디아 뉴모니아 게놈 서열과 폴리펩티드, 이의 단편및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도 |
-
2000
- 2000-09-15 AU AU73986/00A patent/AU7398600A/en not_active Abandoned
- 2000-09-15 WO PCT/CA2000/001089 patent/WO2001021805A1/fr active Application Filing
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