WO2001020337A8 - Genetic testing for periodontitis based on cathepsin c - Google Patents

Genetic testing for periodontitis based on cathepsin c

Info

Publication number
WO2001020337A8
WO2001020337A8 PCT/GB2000/003512 GB0003512W WO0120337A8 WO 2001020337 A8 WO2001020337 A8 WO 2001020337A8 GB 0003512 W GB0003512 W GB 0003512W WO 0120337 A8 WO0120337 A8 WO 0120337A8
Authority
WO
WIPO (PCT)
Prior art keywords
cathepsin
periodontitis
genetic testing
periodontitis based
assaying
Prior art date
Application number
PCT/GB2000/003512
Other languages
French (fr)
Other versions
WO2001020337A1 (en
Inventor
Nalin Thakker
Michael Dixon
Jacqueline James
Original Assignee
Univ Manchester
Nalin Thakker
Michael Dixon
Jacqueline James
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Manchester, Nalin Thakker, Michael Dixon, Jacqueline James filed Critical Univ Manchester
Priority to AU73004/00A priority Critical patent/AU7300400A/en
Publication of WO2001020337A1 publication Critical patent/WO2001020337A1/en
Publication of WO2001020337A8 publication Critical patent/WO2001020337A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/488—Aspartic endopeptidases (3.4.23), e.g. pepsin, chymosin, renin, cathepsin E

Abstract

The present invention relates to a method for diagnosing or detecting a predisposition to periodontitis comprising assaying a bodily sample in vitro directly or indirectly for a reduced level of cathepsin, by assaying at either a protein or genetic level. Also provided is a method of treatment of periodontitis and kits for performing the assay.
PCT/GB2000/003512 1999-09-14 2000-09-13 GENETIC TESTING FOR PERIODONTITIS BASED ON CATHEPSIN c WO2001020337A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73004/00A AU7300400A (en) 1999-09-14 2000-09-13 Genetic testing

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9921544.4A GB9921544D0 (en) 1999-09-14 1999-09-14 Genetic testing
GB9921544.4 1999-09-14

Publications (2)

Publication Number Publication Date
WO2001020337A1 WO2001020337A1 (en) 2001-03-22
WO2001020337A8 true WO2001020337A8 (en) 2001-06-07

Family

ID=10860777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003512 WO2001020337A1 (en) 1999-09-14 2000-09-13 GENETIC TESTING FOR PERIODONTITIS BASED ON CATHEPSIN c

Country Status (3)

Country Link
AU (1) AU7300400A (en)
GB (1) GB9921544D0 (en)
WO (1) WO2001020337A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017009214A1 (en) * 2015-07-10 2017-01-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Early and non invasive method for assessing a subject's risk of having a papillon-lefevre syndrome

Also Published As

Publication number Publication date
GB9921544D0 (en) 1999-11-17
AU7300400A (en) 2001-04-17
WO2001020337A1 (en) 2001-03-22

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