WO2001019817A3 - 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission - Google Patents
3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission Download PDFInfo
- Publication number
- WO2001019817A3 WO2001019817A3 PCT/US2000/025444 US0025444W WO0119817A3 WO 2001019817 A3 WO2001019817 A3 WO 2001019817A3 US 0025444 W US0025444 W US 0025444W WO 0119817 A3 WO0119817 A3 WO 0119817A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrrolidinyloxy
- ether compounds
- compounds useful
- synaptic transmission
- controlling chemical
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002381252A CA2381252A1 (en) | 1999-09-14 | 2000-09-14 | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
EP00965070A EP1212319A2 (en) | 1999-09-14 | 2000-09-14 | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
MXPA02002115A MXPA02002115A (en) | 1999-09-14 | 2000-09-14 | 3-pyrrolidinyloxy-3 -pyridyl ether compounds useful for controlling chemical synaptic transmission. |
JP2001523394A JP2003529547A (en) | 1999-09-14 | 2000-09-14 | 3-Pyrrolidinyloxy-3'-pyridyl ether compounds effective for controlling chemical synaptic transmission |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39514699A | 1999-09-14 | 1999-09-14 | |
US09/395,146 | 1999-09-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001019817A2 WO2001019817A2 (en) | 2001-03-22 |
WO2001019817A3 true WO2001019817A3 (en) | 2002-01-17 |
Family
ID=23561895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/025444 WO2001019817A2 (en) | 1999-09-14 | 2000-09-14 | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1212319A2 (en) |
JP (1) | JP2003529547A (en) |
CA (1) | CA2381252A1 (en) |
MX (1) | MXPA02002115A (en) |
WO (1) | WO2001019817A2 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562847B1 (en) | 1998-08-25 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
DE10135043A1 (en) * | 2001-07-11 | 2003-01-30 | Bayer Cropscience Gmbh | Substituted 3-heteroaryl (amino or oxy) pyrrolidin-2-ones, process for their preparation and use as herbicides or as plant growth regulators |
AU2002353147A1 (en) * | 2001-12-13 | 2003-06-30 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
US7148236B2 (en) | 2002-01-17 | 2006-12-12 | Merck & Co., Inc. | Modulators of acetylcholine receptors |
EP1546116A1 (en) | 2002-08-08 | 2005-06-29 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
US7659305B2 (en) | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
US7098331B2 (en) | 2003-03-05 | 2006-08-29 | Targacept, Inc. | Arylvinylazacycloalkane compounds and methods of preparation and use thereof |
EP1670794A2 (en) * | 2003-09-30 | 2006-06-21 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
AU2005212438A1 (en) | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
ATE471320T1 (en) | 2004-02-27 | 2010-07-15 | Lilly Co Eli | 4-AMINOPIPERIDINE DERIVATIVES AS INHIBITORS OF MONOAMINE ABSORPTION |
US7301022B2 (en) | 2005-02-15 | 2007-11-27 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
KR100939347B1 (en) | 2005-07-20 | 2010-01-29 | (주)카이로드 | Synthetic Method of optically pure S-3-hydroxypyrrolidine |
CN102112469B (en) * | 2008-05-23 | 2014-09-10 | 乔治敦大学 | Silent desensitizers of neuronal nAChR and methods of use thereof |
WO2010045212A2 (en) * | 2008-10-14 | 2010-04-22 | Psychogenics, Incstatuts | Nicotinic acetylcholine receptor ligands and the uses thereof |
AR075988A1 (en) | 2009-04-09 | 2011-05-11 | Lilly Co Eli | PIRIDYLOXI COMPOUND - PIRROLIDINE INHIBITOR OF RECOVERY OF SEROTONINE AND NOREPINEFRINE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CHRONIC PAIN |
JP2013512922A (en) | 2009-12-07 | 2013-04-18 | ターガセプト,インコーポレイテッド | 3,6-diazabicyclo [3.1.1] heptane as a neuronal nicotinic acetylcholine receptor ligand |
EP2544690A4 (en) * | 2010-03-11 | 2013-07-10 | Targacept Inc | Arylvinylazacycloalkane compounds for constipation |
ES2903528T3 (en) * | 2016-10-10 | 2022-04-04 | Dong A Socio Holdings Co Ltd | Heteroaryl compounds and their use as MER inhibitors |
EP4382529A1 (en) | 2022-12-07 | 2024-06-12 | Bayer Consumer Care AG | A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0107930A2 (en) * | 1982-09-30 | 1984-05-09 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine |
US4643995A (en) * | 1983-12-28 | 1987-02-17 | Degussa Aktiengesellschaft | Analgesic pyridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4667031A (en) * | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
WO1994008992A1 (en) * | 1992-10-09 | 1994-04-28 | Abbott Laboratories | Heterocyclic ether compounds that enhance cognitive function |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
WO1999024422A1 (en) * | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
WO2000010997A1 (en) * | 1998-08-25 | 2000-03-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
-
2000
- 2000-09-14 MX MXPA02002115A patent/MXPA02002115A/en unknown
- 2000-09-14 WO PCT/US2000/025444 patent/WO2001019817A2/en not_active Application Discontinuation
- 2000-09-14 JP JP2001523394A patent/JP2003529547A/en not_active Withdrawn
- 2000-09-14 EP EP00965070A patent/EP1212319A2/en not_active Withdrawn
- 2000-09-14 CA CA002381252A patent/CA2381252A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0107930A2 (en) * | 1982-09-30 | 1984-05-09 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine |
US4643995A (en) * | 1983-12-28 | 1987-02-17 | Degussa Aktiengesellschaft | Analgesic pyridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
US4667031A (en) * | 1985-10-15 | 1987-05-19 | Ethyl Corporation | Process for preparing oxazepinones |
WO1994008992A1 (en) * | 1992-10-09 | 1994-04-28 | Abbott Laboratories | Heterocyclic ether compounds that enhance cognitive function |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
WO1999024422A1 (en) * | 1997-11-05 | 1999-05-20 | Neurosearch A/S | Azaring-ether derivatives and their use as nicotinic ach receptor modulators |
WO2000010997A1 (en) * | 1998-08-25 | 2000-03-02 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application |
Also Published As
Publication number | Publication date |
---|---|
CA2381252A1 (en) | 2001-03-22 |
EP1212319A2 (en) | 2002-06-12 |
MXPA02002115A (en) | 2002-10-31 |
JP2003529547A (en) | 2003-10-07 |
WO2001019817A2 (en) | 2001-03-22 |
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