WO2001019817A3 - 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission - Google Patents

3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission Download PDF

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Publication number
WO2001019817A3
WO2001019817A3 PCT/US2000/025444 US0025444W WO0119817A3 WO 2001019817 A3 WO2001019817 A3 WO 2001019817A3 US 0025444 W US0025444 W US 0025444W WO 0119817 A3 WO0119817 A3 WO 0119817A3
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WO
WIPO (PCT)
Prior art keywords
pyrrolidinyloxy
ether compounds
compounds useful
synaptic transmission
controlling chemical
Prior art date
Application number
PCT/US2000/025444
Other languages
French (fr)
Other versions
WO2001019817A2 (en
Inventor
Nan-Horng Lin
Yihong Li
Irene Drizin
John F Kincaid
Anwer Basha
Liming Dong
Ahmed A Hakeem
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to JP2001523394A priority Critical patent/JP2003529547A/en
Priority to CA002381252A priority patent/CA2381252A1/en
Priority to EP00965070A priority patent/EP1212319A2/en
Priority to MXPA02002115A priority patent/MXPA02002115A/en
Publication of WO2001019817A2 publication Critical patent/WO2001019817A2/en
Publication of WO2001019817A3 publication Critical patent/WO2001019817A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

A series of 3-pyrrolidinyloxy-3'-pyridyl ether compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical compositions including these compounds. Preferred compounds are 3-pyrrolidinylmethoxy-3'-(5'-and/or 6'-substituted) pyridyl ethers.
PCT/US2000/025444 1999-09-14 2000-09-14 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission WO2001019817A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001523394A JP2003529547A (en) 1999-09-14 2000-09-14 3-Pyrrolidinyloxy-3'-pyridyl ether compounds effective for controlling chemical synaptic transmission
CA002381252A CA2381252A1 (en) 1999-09-14 2000-09-14 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
EP00965070A EP1212319A2 (en) 1999-09-14 2000-09-14 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
MXPA02002115A MXPA02002115A (en) 1999-09-14 2000-09-14 3-pyrrolidinyloxy-3 -pyridyl ether compounds useful for controlling chemical synaptic transmission.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39514699A 1999-09-14 1999-09-14
US09/395,146 1999-09-14

Publications (2)

Publication Number Publication Date
WO2001019817A2 WO2001019817A2 (en) 2001-03-22
WO2001019817A3 true WO2001019817A3 (en) 2002-01-17

Family

ID=23561895

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/025444 WO2001019817A2 (en) 1999-09-14 2000-09-14 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission

Country Status (5)

Country Link
EP (1) EP1212319A2 (en)
JP (1) JP2003529547A (en)
CA (1) CA2381252A1 (en)
MX (1) MXPA02002115A (en)
WO (1) WO2001019817A2 (en)

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DK1107965T3 (en) 1998-08-25 2004-11-29 Ortho Mcneil Pharm Inc Pyridyl ethers and thioethers as nicotine acetylcholine receptor ligands and their therapeutic use
DE10135043A1 (en) * 2001-07-11 2003-01-30 Bayer Cropscience Gmbh Substituted 3-heteroaryl (amino or oxy) pyrrolidin-2-ones, process for their preparation and use as herbicides or as plant growth regulators
EP1463505A2 (en) * 2001-12-13 2004-10-06 Abbott Laboratories 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
US7148236B2 (en) 2002-01-17 2006-12-12 Merck & Co., Inc. Modulators of acetylcholine receptors
EP1717220A3 (en) 2002-08-08 2007-08-22 Amgen, Inc Vanilloid receptor ligands and their use in treatments
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
US7098331B2 (en) 2003-03-05 2006-08-29 Targacept, Inc. Arylvinylazacycloalkane compounds and methods of preparation and use thereof
US7390907B2 (en) * 2003-09-30 2008-06-24 Amgen Inc. Vanilloid receptor ligands and their use in treatments
CA2556239A1 (en) 2004-02-11 2005-08-25 Amgen Inc. Vanilloid receptor ligands and their use in treatments
MY139645A (en) 2004-02-11 2009-10-30 Amgen Inc Vanilloid receptor ligands and their use in treatments
ATE471320T1 (en) 2004-02-27 2010-07-15 Lilly Co Eli 4-AMINOPIPERIDINE DERIVATIVES AS INHIBITORS OF MONOAMINE ABSORPTION
US7301022B2 (en) 2005-02-15 2007-11-27 Amgen Inc. Vanilloid receptor ligands and their use in treatments
KR100939347B1 (en) 2005-07-20 2010-01-29 (주)카이로드 Synthetic Method of optically pure S-3-hydroxypyrrolidine
US8729103B2 (en) 2008-05-23 2014-05-20 Georgetown University Silent desensitizers of neuronal nAChR and methods of use thereof
KR20110091501A (en) * 2008-10-14 2011-08-11 싸이코제닉스 아이엔씨. Nicotinic acetylcholine receptor ligands and the uses thereof
AR075988A1 (en) 2009-04-09 2011-05-11 Lilly Co Eli PIRIDYLOXI COMPOUND - PIRROLIDINE INHIBITOR OF RECOVERY OF SEROTONINE AND NOREPINEFRINE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF CHRONIC PAIN
CA2782409A1 (en) 2009-12-07 2011-06-16 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetylcholine receptor ligands
US20130237550A1 (en) * 2010-03-11 2013-09-12 Targacept, Inc. Arylvinylazacycloalkane compounds for constipation
EP3523292B1 (en) * 2016-10-10 2021-12-15 Dong-A Socio Holdings Co., Ltd. Heteroaryl compounds and their use as mer inhibitors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107930A2 (en) * 1982-09-30 1984-05-09 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine
US4643995A (en) * 1983-12-28 1987-02-17 Degussa Aktiengesellschaft Analgesic pyridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4667031A (en) * 1985-10-15 1987-05-19 Ethyl Corporation Process for preparing oxazepinones
WO1994008992A1 (en) * 1992-10-09 1994-04-28 Abbott Laboratories Heterocyclic ether compounds that enhance cognitive function
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
WO1999024422A1 (en) * 1997-11-05 1999-05-20 Neurosearch A/S Azaring-ether derivatives and their use as nicotinic ach receptor modulators
WO2000010997A1 (en) * 1998-08-25 2000-03-02 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107930A2 (en) * 1982-09-30 1984-05-09 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine
US4643995A (en) * 1983-12-28 1987-02-17 Degussa Aktiengesellschaft Analgesic pyridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
US4667031A (en) * 1985-10-15 1987-05-19 Ethyl Corporation Process for preparing oxazepinones
WO1994008992A1 (en) * 1992-10-09 1994-04-28 Abbott Laboratories Heterocyclic ether compounds that enhance cognitive function
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
WO1999024422A1 (en) * 1997-11-05 1999-05-20 Neurosearch A/S Azaring-ether derivatives and their use as nicotinic ach receptor modulators
WO2000010997A1 (en) * 1998-08-25 2000-03-02 Ortho-Mcneil Pharmaceutical, Inc. Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application

Also Published As

Publication number Publication date
CA2381252A1 (en) 2001-03-22
MXPA02002115A (en) 2002-10-31
WO2001019817A2 (en) 2001-03-22
EP1212319A2 (en) 2002-06-12
JP2003529547A (en) 2003-10-07

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