WO2001019791A3 - 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments - Google Patents

3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments Download PDF

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Publication number
WO2001019791A3
WO2001019791A3 PCT/EP2000/008860 EP0008860W WO0119791A3 WO 2001019791 A3 WO2001019791 A3 WO 2001019791A3 EP 0008860 W EP0008860 W EP 0008860W WO 0119791 A3 WO0119791 A3 WO 0119791A3
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WO
WIPO (PCT)
Prior art keywords
derivatives
optionally substituted
substituted
vinylpyrrole
medicaments
Prior art date
Application number
PCT/EP2000/008860
Other languages
German (de)
French (fr)
Other versions
WO2001019791A2 (en
Inventor
Barbara Beck
Alexander Doemling
Original Assignee
Morphochem Ag
Barbara Beck
Alexander Doemling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphochem Ag, Barbara Beck, Alexander Doemling filed Critical Morphochem Ag
Priority to AU75178/00A priority Critical patent/AU7517800A/en
Publication of WO2001019791A2 publication Critical patent/WO2001019791A2/en
Publication of WO2001019791A3 publication Critical patent/WO2001019791A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The invention relates to 3-vinylpryrrole derivatives of general formula (I), wherein M represents a substituted peptide, a substituted hydantoin or thiohydantoin, tetrazole, lactam or lactone group, Y and Z independently represent a hydrogen atom, a halogen atom, a pseudohalogen, an optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aralkenyl, aralkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, cycloaralkyl, cycloaralkenyl, cycloaralkinyl, aryl, alkoxy or aralkoxy group or a heterocyclic ring, and X is an optionally substituted and/or an optionally anellated or heteroanellated 3-pyrrole ring, and X and Y or X and Z or N and Z form part of a cycle. The invention further relates to pharmaceutical compounds that contain at least one of the above-mentioned compounds in combination with conventional excipients and/or adjuvants.
PCT/EP2000/008860 1999-09-10 2000-09-11 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments WO2001019791A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU75178/00A AU7517800A (en) 1999-09-10 2000-09-11 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19943508A DE19943508A1 (en) 1999-09-10 1999-09-10 3-vinylpyrene derivatives, process for their preparation and their use as medicines
DE19943508.1 1999-09-10

Publications (2)

Publication Number Publication Date
WO2001019791A2 WO2001019791A2 (en) 2001-03-22
WO2001019791A3 true WO2001019791A3 (en) 2002-02-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/008860 WO2001019791A2 (en) 1999-09-10 2000-09-11 3-vinylpyrrole derivatives, method for the production thereof and their use as medicaments

Country Status (3)

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AU (1) AU7517800A (en)
DE (1) DE19943508A1 (en)
WO (1) WO2001019791A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003045982A1 (en) * 2001-11-29 2003-06-05 The Kitasato Institute Antibiotics fki-9739 and process for producing the same
EP1829862A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor compounds
CN112028833B (en) * 2020-09-25 2022-07-05 西南大学 Para-aminosalicylic acid azole derivative and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017705A1 (en) * 1979-02-07 1980-10-29 Troponwerke GmbH & Co. KG Phenylalanyl-tryptophan derivatives, pharmaceutical compositions containing them, their preparation and use
JPH01149766A (en) * 1987-12-04 1989-06-12 Otsuka Pharmaceut Co Ltd Indole derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017705A1 (en) * 1979-02-07 1980-10-29 Troponwerke GmbH & Co. KG Phenylalanyl-tryptophan derivatives, pharmaceutical compositions containing them, their preparation and use
JPH01149766A (en) * 1987-12-04 1989-06-12 Otsuka Pharmaceut Co Ltd Indole derivative

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AZUMI K ET AL: "INHIBITORY EFFECT OF HALOCYAMINE, AN ANTIMICROBIAL SUBSTANCE FROM ASCIDIAN HEMOCYTES, ON THE GROWTH OF FISH VIRUSES AND MARINE BACTERIA", EXPERIENTIA,CH,BIRKHAUSER VERLAG. BASEL, vol. 46, no. 10, 15 October 1990 (1990-10-15), pages 1066 - 1068, XP000161420, ISSN: 0014-4754 *
BECK B ET AL: "One-pot synthesis and biological evaluation of aspergillamides and analogues", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,OXFORD,GB, vol. 10, no. 15, 7 August 2000 (2000-08-07), pages 1701 - 1705, XP004213227, ISSN: 0960-894X *
CHEMICAL ABSTRACTS, vol. 128, no. 24, 15 June 1998, Columbus, Ohio, US; abstract no. 292580, WITTER, LUDWIG ET AL: "A new inhibitor of synovial phospholipase A2 from fermentations of Penicillium sp. 62-92" XP002169681 *
KAGAMIZONO T ET AL: "Terpeptin, A Novel Mammalian Cell Cycle Inhibitor, Produced by Aspergillus terreus 95F-1", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 38, no. 7, 17 February 1997 (1997-02-17), pages 1223 - 1226, XP004034240, ISSN: 0040-4039 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 408 (C - 634) 8 September 1989 (1989-09-08) *
TOSKE S G ET AL: "Aspergillamides A and B: Modified Cytotoxic Tripeptides Produced by a Marine Fungus of the Genus Aspergillus", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 54, no. 44, 29 October 1998 (1998-10-29), pages 13459 - 13466, XP004139351, ISSN: 0040-4020 *
Z. NATURFORSCH., C: BIOSCI. (1998), 53(1/2), 60-64 *

Also Published As

Publication number Publication date
DE19943508A1 (en) 2001-03-15
WO2001019791A2 (en) 2001-03-22
AU7517800A (en) 2001-04-17

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