WO2001019238A1 - Method for measuring dye concentrations in subjects - Google Patents
Method for measuring dye concentrations in subjects Download PDFInfo
- Publication number
- WO2001019238A1 WO2001019238A1 PCT/US2000/024851 US0024851W WO0119238A1 WO 2001019238 A1 WO2001019238 A1 WO 2001019238A1 US 0024851 W US0024851 W US 0024851W WO 0119238 A1 WO0119238 A1 WO 0119238A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light
- living organism
- blood
- absorbing material
- concentration
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- 239000008280 blood Substances 0.000 claims abstract description 56
- 210000004369 blood Anatomy 0.000 claims abstract description 56
- 230000003287 optical effect Effects 0.000 claims abstract description 37
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 15
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 15
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
- 239000001301 oxygen Substances 0.000 claims abstract description 10
- 238000005259 measurement Methods 0.000 claims description 13
- 239000011358 absorbing material Substances 0.000 claims description 11
- 230000000541 pulsatile effect Effects 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 abstract description 9
- 230000000747 cardiac effect Effects 0.000 abstract description 9
- 238000002347 injection Methods 0.000 abstract description 8
- 239000007924 injection Substances 0.000 abstract description 8
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 15
- 229960004657 indocyanine green Drugs 0.000 description 15
- 210000004556 brain Anatomy 0.000 description 14
- 239000000523 sample Substances 0.000 description 14
- 210000004165 myocardium Anatomy 0.000 description 12
- 230000002490 cerebral effect Effects 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- 230000004087 circulation Effects 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 210000005013 brain tissue Anatomy 0.000 description 5
- 239000000835 fiber Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 108010064719 Oxyhemoglobins Proteins 0.000 description 4
- 230000003727 cerebral blood flow Effects 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 230000008033 biological extinction Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 102000003712 Complement factor B Human genes 0.000 description 2
- 108090000056 Complement factor B Proteins 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 210000005245 right atrium Anatomy 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000002302 brachial artery Anatomy 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 108010036302 hemoglobin AS Proteins 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000002496 oximetry Methods 0.000 description 1
- 238000002106 pulse oximetry Methods 0.000 description 1
- 210000002321 radial artery Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000002366 time-of-flight method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/0275—Measuring blood flow using tracers, e.g. dye dilution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physiology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/394,913 | 1999-09-13 | ||
| US09/394,913 US6339714B1 (en) | 1999-09-13 | 1999-09-13 | Apparatus and method for measuring concentrations of a dye in a living organism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001019238A1 true WO2001019238A1 (en) | 2001-03-22 |
Family
ID=23560914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2000/024851 WO2001019238A1 (en) | 1999-09-13 | 2000-09-11 | Method for measuring dye concentrations in subjects |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US6339714B1 (US06339714-20020115-M00006.png) |
| WO (1) | WO2001019238A1 (US06339714-20020115-M00006.png) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318504B2 (en) | 2008-05-15 | 2012-11-27 | Norgine Bv | MRP2 efflux pathway prognostic method |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6577884B1 (en) * | 2000-06-19 | 2003-06-10 | The General Hospital Corporation | Detection of stroke events using diffuse optical tomagraphy |
| US6757554B2 (en) * | 2001-05-22 | 2004-06-29 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution |
| DE10315574A1 (de) * | 2003-04-05 | 2004-10-28 | ETH Zürich | Vorrichtung zur Bestimmung des Blutflusses in einem Organ |
| US7754197B2 (en) * | 2003-10-16 | 2010-07-13 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using coordinated polydentate compounds |
| EP1981401A4 (en) * | 2006-01-20 | 2010-07-21 | Alfred E Mann Inst Biomed Eng | MEASURING CARDIAC FLOW AND BLOOD VOLUME BY NON-INVASIVE DETERMINATION OF INDICATOR DILUTION |
| WO2008060833A2 (en) | 2006-10-24 | 2008-05-22 | The Research Foundation Of State University Of New York | Composition, method, system, and kit for optical electrophysiology |
| JP2021508526A (ja) * | 2017-12-27 | 2021-03-11 | オレゴン ヘルス アンド サイエンス ユニバーシティ | 血液量測定のためのデバイス及び方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5178141A (en) * | 1989-05-24 | 1993-01-12 | Sumitomo Electric Industries, Ltd. | Liver function testing apparatus |
| US5766125A (en) * | 1994-04-28 | 1998-06-16 | Nihon Kohden Corporation | Apparatus for determining the concentration of light-absorbing materials in blood |
| US5999841A (en) * | 1993-12-17 | 1999-12-07 | Nihon Kohden Corporation | Apparatus for measuring circulating blood volume |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1095114A (en) | 1963-12-09 | 1967-12-13 | Atlas Werke Ag | Apparatus for the measurement of dye dilution in blood |
| US4281645A (en) | 1977-06-28 | 1981-08-04 | Duke University, Inc. | Method and apparatus for monitoring metabolism in body organs |
| EP0059032A1 (en) | 1981-02-03 | 1982-09-01 | Virgil B. Elings | Measurement of dye concentration in the bloodstream |
| JPH0657216B2 (ja) | 1988-09-14 | 1994-08-03 | 住友電気工業株式会社 | 肝機能検査装置 |
| US4972331A (en) | 1989-02-06 | 1990-11-20 | Nim, Inc. | Phase modulated spectrophotometry |
| EP0502270B1 (en) | 1991-03-07 | 1997-01-02 | Hamamatsu Photonics K.K. | Tissue oxygen measuring system |
| ATE145805T1 (de) | 1991-03-25 | 1996-12-15 | Hoeft Andreas | Vorrichtung und verfahren zur ermittlung des herzzeitvolumens |
| US5687726A (en) | 1991-09-13 | 1997-11-18 | Hoeft; Andreas | Process for determining the volume of blood in circulation |
| DE4325529C2 (de) | 1993-07-29 | 1996-11-28 | Pulsion Verwaltungs Gmbh & Co | Vorrichtung zum Bestimmen der Konzentration von Stoffen im Blut |
| US5458128A (en) | 1994-06-17 | 1995-10-17 | Polanyi; Michael | Method and apparatus for noninvasively measuring concentration of a dye in arterial blood |
| EP0794729B1 (de) | 1994-12-01 | 2001-04-11 | Hoeft, Andreas, Prof. Dr. med. | Vorrichtung zur ermittlung der hirndurchblutung und des intracraniellen blutvolumens |
| US5706808A (en) | 1995-01-31 | 1998-01-13 | Kleinerman; Marcos Y. | Fiber optic system for measuring cardiac output |
| GB9517366D0 (en) | 1995-08-24 | 1995-10-25 | Johnson & Johnson Medical | Method of quantatively determining one or more characteristics of a substance |
| DE19635038A1 (de) | 1996-08-29 | 1998-03-12 | Pulsion Verwaltungs Gmbh & Co | Verfahren zur nicht invasiven Bestimmung des zerebralen Blutflusses mittels Nah-Infrarot-Spektroskopie |
-
1999
- 1999-09-13 US US09/394,913 patent/US6339714B1/en not_active Expired - Fee Related
-
2000
- 2000-09-11 WO PCT/US2000/024851 patent/WO2001019238A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5178141A (en) * | 1989-05-24 | 1993-01-12 | Sumitomo Electric Industries, Ltd. | Liver function testing apparatus |
| US5999841A (en) * | 1993-12-17 | 1999-12-07 | Nihon Kohden Corporation | Apparatus for measuring circulating blood volume |
| US5766125A (en) * | 1994-04-28 | 1998-06-16 | Nihon Kohden Corporation | Apparatus for determining the concentration of light-absorbing materials in blood |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8318504B2 (en) | 2008-05-15 | 2012-11-27 | Norgine Bv | MRP2 efflux pathway prognostic method |
| US8513023B2 (en) | 2008-05-15 | 2013-08-20 | Norgine Bv | Prognostic method |
Also Published As
| Publication number | Publication date |
|---|---|
| US6339714B1 (en) | 2002-01-15 |
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