WO2001018057A3 - Serine protease inhibitors (spn43a) from drosophila - Google Patents

Serine protease inhibitors (spn43a) from drosophila Download PDF

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Publication number
WO2001018057A3
WO2001018057A3 PCT/GB2000/003448 GB0003448W WO0118057A3 WO 2001018057 A3 WO2001018057 A3 WO 2001018057A3 GB 0003448 W GB0003448 W GB 0003448W WO 0118057 A3 WO0118057 A3 WO 0118057A3
Authority
WO
WIPO (PCT)
Prior art keywords
drosophila
genes
spn43a
protease inhibitors
serine protease
Prior art date
Application number
PCT/GB2000/003448
Other languages
French (fr)
Other versions
WO2001018057A2 (en
Inventor
David Christopher Gubb
Jean-Marc Reichhart
Original Assignee
Univ Cambridge Tech
David Christopher Gubb
Reichhart Jean Marc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cambridge Tech, David Christopher Gubb, Reichhart Jean Marc filed Critical Univ Cambridge Tech
Priority to AU70249/00A priority Critical patent/AU7024900A/en
Publication of WO2001018057A2 publication Critical patent/WO2001018057A2/en
Publication of WO2001018057A3 publication Critical patent/WO2001018057A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Tree related Drosophila genes, coding for the serine protease inhibitors (serpins) Spn43a and Spn43Ac, have been characterised, and their nucleic acid and encoded amino acid sequences are provided herein. Developmental expression profiles and in situ hybridisation patterns for the encoded proteins have been obtained. Transgenic experiments on mutant forms of the genes have demonstrated a link between mutations in one of the genes and the occurrence of a characteristic mutant phenotype of Drosophila flies. Materials, methods and uses based on this discovery are also described.
PCT/GB2000/003448 1999-09-07 2000-09-07 Serine protease inhibitors (spn43a) from drosophila WO2001018057A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70249/00A AU7024900A (en) 1999-09-07 2000-09-07 Materials and methods relating to the identification and mutation of a drosophila gene, and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9921133.6 1999-09-07
GBGB9921133.6A GB9921133D0 (en) 1999-09-07 1999-09-07 Materials and methods relating to the identification and mutation of a drosophila gene, and uses thereof

Publications (2)

Publication Number Publication Date
WO2001018057A2 WO2001018057A2 (en) 2001-03-15
WO2001018057A3 true WO2001018057A3 (en) 2001-11-15

Family

ID=10860509

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003448 WO2001018057A2 (en) 1999-09-07 2000-09-07 Serine protease inhibitors (spn43a) from drosophila

Country Status (3)

Country Link
AU (1) AU7024900A (en)
GB (1) GB9921133D0 (en)
WO (1) WO2001018057A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8450079B2 (en) 2003-10-31 2013-05-28 Immunetics, Inc. Method for detecting bacteria
US7598054B2 (en) 2003-10-31 2009-10-06 Immunetics, Inc. Rapid peptidoglycan-based assay for detection of bacterial contamination of platelets
WO2014090948A1 (en) * 2012-12-13 2014-06-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Serpin spn4a and biologically active derivatives thereof for use in the treatment of cancer

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CELNIKER S.E. ET AL.: "Sequencing of Drosophila chromosome 2R, region 43A1-43A2; Drosophila melanogaster, chromosome 2R, region 43A1-43A2, P1 clones DS02730 and DS07472, complete sequence", EMBL DATABASE ENTRY AC006469, ACCESSION NO. AC006469, 1 February 1999 (1999-02-01), XP002165860 *
COLEMAN S. ET AL.: "A Drosophila male accessory gland protein that is a member of the serpin superfamily of protease inhibitors is transferred to females during mating", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 25, 1995, pages 203 - 207, XP000997774 *
GREEN C. ET AL.: "The necrotic Gene in Drosophila Corresponds to One of a Cluster of Three Serpin Transcripts Mapping at 43A1.2", GENETICS, vol. 156, November 2000 (2000-11-01), pages 1117 - 1127, XP002165862 *
HARVEY D. ET AL.: "BDGP/HHMI Drosophila EST Project; LP08647.5prime LP Drosophila melanogaster larval-early pupal pOT2 Drosophila melanogaster cDNA clone LP08647 5prime, mRNA sequence", EMBL DATABASE ENTRY AI295111, 2 December 1998 (1998-12-02), XP002165861 *
IMLER J.-L. ET AL.: "Signaling mechanisms in the antimircobial host defense of Drosophila", CURRENT OPINION IN MICROBIOLOGY, vol. 3, February 2000 (2000-02-01), pages 16 - 22, XP000998531 *
KANOST M.R.: "Serine proteinase inhibitors in arthropod immunity", DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, vol. 23, no. 4-5, July 1999 (1999-07-01), pages 291 - 301, XP000926268 *
LAVASHINA E.A. ET AL.: "Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila", SCIENCE, vol. 285, 17 September 1999 (1999-09-17), pages 1917 - 1919, XP002165863 *
OKUYAMA E. ET AL.: "Molecular analysis of the intergenic region of the duplicated Amy genes of Drosophila melanogaster and Drosophila teiissieri", JOURNAL OF MOLECULAR EVOLUTION, vol. 45, 1997, pages 32 - 42, XP000997773 *
REICHHART J M, ET AL.: "SERINE PROTEASE/SERPIN BALANCE REGULATES EXPRESSION OF THE ANTIFUNGAL PEPTIDE GENE DROSOMYCIN IN DROSOPHILA", ANNUAL MEETING OF THE AMERICAN SOCIETY OF HUMAN GENETICS., XX, XX, 1 January 1998 (1998-01-01), XX, pages A128, XP000998276 *
WOLFNER M.F. ET AL.: "New genes for male accessory gland proteins in Drosophila melanogaster", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 27, no. 10, October 1997 (1997-10-01), pages 825 - 834, XP000926270 *

Also Published As

Publication number Publication date
AU7024900A (en) 2001-04-10
WO2001018057A2 (en) 2001-03-15
GB9921133D0 (en) 1999-11-10

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