WO2001018044A3 - Modulation par semaphorines de l'efflux cellulaire - Google Patents

Modulation par semaphorines de l'efflux cellulaire Download PDF

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Publication number
WO2001018044A3
WO2001018044A3 PCT/US2000/024560 US0024560W WO0118044A3 WO 2001018044 A3 WO2001018044 A3 WO 2001018044A3 US 0024560 W US0024560 W US 0024560W WO 0118044 A3 WO0118044 A3 WO 0118044A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulation
semaphorin
cellular efflux
semaphorins
compositions
Prior art date
Application number
PCT/US2000/024560
Other languages
English (en)
Other versions
WO2001018044A2 (fr
Inventor
Melanie K Spriggs
Original Assignee
Immunex Corp
Melanie K Spriggs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corp, Melanie K Spriggs filed Critical Immunex Corp
Priority to EP00961634A priority Critical patent/EP1210368A2/fr
Priority to AU73556/00A priority patent/AU770157B2/en
Priority to CA002384104A priority patent/CA2384104A1/fr
Publication of WO2001018044A2 publication Critical patent/WO2001018044A2/fr
Publication of WO2001018044A3 publication Critical patent/WO2001018044A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des compositions et des procédés comprenant l'utilisation de sémaphorines, de récepteurs à sémaphorines, et de polynucléotides codant pour des sémaphorines et des récepteurs à sémaphorines, pour la modulation de pompes à efflux cellulaire. Cette invention concerne également des compositions et des procédés permettant de contrôler des phénotypes à résistance médicamenteuse multiple par contrôle de l'efflux cellulaire.
PCT/US2000/024560 1999-09-08 2000-09-07 Modulation par semaphorines de l'efflux cellulaire WO2001018044A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00961634A EP1210368A2 (fr) 1999-09-08 2000-09-07 Modulation par semaphorines de l'efflux cellulaire
AU73556/00A AU770157B2 (en) 1999-09-08 2000-09-07 Use of semaphorin for modulation of cellular efflux
CA002384104A CA2384104A1 (fr) 1999-09-08 2000-09-07 Modulation par semaphorines de l'efflux cellulaire

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US15291499P 1999-09-08 1999-09-08
US60/152,914 1999-09-08
US15625799P 1999-09-27 1999-09-27
US60/156,257 1999-09-27
US17390699P 1999-12-29 1999-12-29
US60/173,906 1999-12-29

Publications (2)

Publication Number Publication Date
WO2001018044A2 WO2001018044A2 (fr) 2001-03-15
WO2001018044A3 true WO2001018044A3 (fr) 2001-10-25

Family

ID=27387351

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024560 WO2001018044A2 (fr) 1999-09-08 2000-09-07 Modulation par semaphorines de l'efflux cellulaire

Country Status (4)

Country Link
EP (1) EP1210368A2 (fr)
AU (1) AU770157B2 (fr)
CA (1) CA2384104A1 (fr)
WO (1) WO2001018044A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010217A2 (fr) 2000-08-02 2002-02-07 The Johns Hopkins University Profils d'expression de cellules endotheliales
EP1429801A1 (fr) * 2001-09-26 2004-06-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Neuropiline comme nouvelle cible therapeutique pour la modulation de reponses immunitaires

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007706A1 (fr) * 1993-09-13 1995-03-23 The Regents Of The University Of California Famille du gene de la semaphorine
WO1999021997A1 (fr) * 1997-10-28 1999-05-06 Immunex Corporation Adn et polypeptides recepteurs des proteines de semaphorine a codage viral
WO1999045114A2 (fr) * 1998-03-03 1999-09-10 Zymogenetics, Inc. Semaphorine humaine zsmf-7

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270831B (it) * 1993-09-17 1997-05-13 Romano Deghenghi Composizioni farmaceutiche orali effervescenti contenenti estrone

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007706A1 (fr) * 1993-09-13 1995-03-23 The Regents Of The University Of California Famille du gene de la semaphorine
US5935865A (en) * 1993-09-13 1999-08-10 The Regents Of The University Of California Semaphorin gene family
WO1999021997A1 (fr) * 1997-10-28 1999-05-06 Immunex Corporation Adn et polypeptides recepteurs des proteines de semaphorine a codage viral
WO1999045114A2 (fr) * 1998-03-03 1999-09-10 Zymogenetics, Inc. Semaphorine humaine zsmf-7

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALTAN ET AL: "Defective acidification in human breast tumor cells and implications for chemotherapy", JOURNAL OF EXPERIMENTAL MEDICINE,JP,TOKYO, vol. 187, no. 10, 18 May 1998 (1998-05-18), pages 1583 - 1598, XP002118974, ISSN: 0022-1007 *
J. H. WEISBURG ET AL: "Intracellular pH and Multidrug Resistance Regulate Complement-mediated Cytotoxicity of Nucleated Human Cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 16, 16 April 1999 (1999-04-16), pages 10877 - 10888, XP002164647 *
M SCHINDLER ET AL: "Defective pH Regulation of Acidic Compartments in Human Breast Cancer Cells (MCF-7) Is Normalized in Adriamycin-Resistant Cells (MCF-7adr)", BIOCHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, PA, vol. 35, no. 9, 5 March 1996 (1996-03-05), pages 2811 - 2817, XP002118976, ISSN: 0006-2960 *
TESSHI YAMADA ET AL: "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE USA, vol. 94, December 1997 (1997-12-01), pages 14713 - 14718, XP002164646 *

Also Published As

Publication number Publication date
WO2001018044A2 (fr) 2001-03-15
CA2384104A1 (fr) 2001-03-15
AU770157B2 (en) 2004-02-12
AU7355600A (en) 2001-04-10
EP1210368A2 (fr) 2002-06-05

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