WO2001018037A3 - A p53-induced protein with a death domain that can promote apoptosis - Google Patents

A p53-induced protein with a death domain that can promote apoptosis Download PDF

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Publication number
WO2001018037A3
WO2001018037A3 PCT/CA2000/001021 CA0001021W WO0118037A3 WO 2001018037 A3 WO2001018037 A3 WO 2001018037A3 CA 0001021 W CA0001021 W CA 0001021W WO 0118037 A3 WO0118037 A3 WO 0118037A3
Authority
WO
WIPO (PCT)
Prior art keywords
death domain
induced protein
promote apoptosis
nucleic acid
acid molecules
Prior art date
Application number
PCT/CA2000/001021
Other languages
French (fr)
Other versions
WO2001018037A2 (en
Inventor
Samuel Benchimol
Yunping Lin
Original Assignee
Univ Health Network
Samuel Benchimol
Yunping Lin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Health Network, Samuel Benchimol, Yunping Lin filed Critical Univ Health Network
Priority to AU69749/00A priority Critical patent/AU6974900A/en
Publication of WO2001018037A2 publication Critical patent/WO2001018037A2/en
Publication of WO2001018037A3 publication Critical patent/WO2001018037A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to nucleic acid molecules encoding a p53 induced protein with a death domain that can promote apoptosis; the proteins encoded by the nucleic acid molecules; and, uses of the proteins and nucleic acid molecules, especially in the treatment of cancer and dysplasia, autoimmune disease neurodegenerative disorders, or stroke.
PCT/CA2000/001021 1999-09-07 2000-09-07 A p53-induced protein with a death domain that can promote apoptosis WO2001018037A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69749/00A AU6974900A (en) 1999-09-07 2000-09-07 A p53-induced protein with a death domain that can promote apoptosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15235999P 1999-09-07 1999-09-07
US60/152,359 1999-09-07
US21108600P 2000-06-13 2000-06-13
US60/211,086 2000-06-13

Publications (2)

Publication Number Publication Date
WO2001018037A2 WO2001018037A2 (en) 2001-03-15
WO2001018037A3 true WO2001018037A3 (en) 2001-11-08

Family

ID=26849492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001021 WO2001018037A2 (en) 1999-09-07 2000-09-07 A p53-induced protein with a death domain that can promote apoptosis

Country Status (2)

Country Link
AU (1) AU6974900A (en)
WO (1) WO2001018037A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005074521A2 (en) 2004-01-30 2005-08-18 The Trustees Of Columbia University In The City Of New York C-TERMINAL p53 PALINDROMIC PEPTIDE THAT INDUCES APOPTOSIS OF CELLS WITH ABERRANT p53 AND USES THEREOF
WO2005075677A2 (en) * 2004-02-03 2005-08-18 Apoxis S.A. Identification of compounds susceptible to induce pidd in cells lacking p53 and their use in combination with genotoxins for the treatment of cancer
JP2010507387A (en) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド Novel siRNA and method of using the same
RU2487716C2 (en) 2007-10-03 2013-07-20 Кварк Фармасьютикалс, Инк. New structures of small interfering rna (sirna)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051742A2 (en) * 1998-04-07 1999-10-14 Genetics Institute, Inc. Dadd, death activator death domain protein
WO2000056752A2 (en) * 1999-03-24 2000-09-28 Human Genome Sciences, Inc. Apoptosis related genes
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051742A2 (en) * 1998-04-07 1999-10-14 Genetics Institute, Inc. Dadd, death activator death domain protein
WO2000056752A2 (en) * 1999-03-24 2000-09-28 Human Genome Sciences, Inc. Apoptosis related genes
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 21 November 1996 (1996-11-21), XP002171652 *
DATABASE EMBL 23 August 1999 (1999-08-23), XP002171653 *
DATABASE EMBL 3 August 1999 (1999-08-03), XP002171654 *
HOFMANN K.: "The modular nature of apoptotic signaling proteins", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 55, July 1999 (1999-07-01), pages 1113 - 1128, XP002171651 *
LEVY-STRUMPF N. ET AL.: "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions", ONCOGENE, vol. 17, no. 25, 24 December 1998 (1998-12-24), pages 3331 - 3340, XP000881581, ISSN: 0950-9232 *
LIN Y. ET AL.: "Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis", NATURE GENETICS, vol. 26, no. 1, 1 September 2000 (2000-09-01), pages 122 - 125, XP001010254 *
TELLIEZ J.-B. ET AL.: "LRDD, a novel leucine rich repeat and death domain containing protein", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1478, no. 2, 23 May 2000 (2000-05-23), pages 280 - 288, XP001010260 *

Also Published As

Publication number Publication date
AU6974900A (en) 2001-04-10
WO2001018037A2 (en) 2001-03-15

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