WO2001016357A3 - Novel target for antiparasitic agents and inhibitors thereof - Google Patents

Novel target for antiparasitic agents and inhibitors thereof Download PDF

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Publication number
WO2001016357A3
WO2001016357A3 PCT/EP2000/008410 EP0008410W WO0116357A3 WO 2001016357 A3 WO2001016357 A3 WO 2001016357A3 EP 0008410 W EP0008410 W EP 0008410W WO 0116357 A3 WO0116357 A3 WO 0116357A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
screening assay
suppressors
enzyme
phosphatases
Prior art date
Application number
PCT/EP2000/008410
Other languages
French (fr)
Other versions
WO2001016357A2 (en
Inventor
Johan Thevelein
Dijck Patrick Van
Original Assignee
Leuven K U Res & Dev
Johan Thevelein
Dijck Patrick Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99202805A external-priority patent/EP1081232A1/en
Application filed by Leuven K U Res & Dev, Johan Thevelein, Dijck Patrick Van filed Critical Leuven K U Res & Dev
Priority to EP00964054A priority Critical patent/EP1206568A2/en
Priority to AU75118/00A priority patent/AU7511800A/en
Publication of WO2001016357A2 publication Critical patent/WO2001016357A2/en
Publication of WO2001016357A3 publication Critical patent/WO2001016357A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Abstract

The use of an enzyme found in fungi, bacteria, insects, nematodes, worms, mites, protozoa etc. as a target in a screening assay is described by means of which agents capable of inhibiting the function of that enzyme may be identified. The screening assay may include complete cell or purified-enzyme assays. In particular, the present invention relates to a screening assay for inhibitors or suppressors of sugar alcohol phosphatases or sugar phosphatases, and more in particular inhibitors or suppressors of trehalose-6-phosphate phosphatase, as well as preparations, in particular, pharmaceutical preparations, which include inhibitors or suppressors obtained from the screening assay. Inhibitors are described as well as applications in biocides and antifungal pharmaceuticals.
PCT/EP2000/008410 1999-08-30 2000-08-29 Novel target for antiparasitic agents and inhibitors thereof WO2001016357A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00964054A EP1206568A2 (en) 1999-08-30 2000-08-29 Target for antiparasitic agents and inhibitors thereof
AU75118/00A AU7511800A (en) 1999-08-30 2000-08-29 Novel target for antiparasitic agents and inhibitors thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99202805.0 1999-08-30
EP99202805A EP1081232A1 (en) 1999-08-30 1999-08-30 Novel target for antifungals
EP00870145 2000-06-27
EP00870145.0 2000-06-27

Publications (2)

Publication Number Publication Date
WO2001016357A2 WO2001016357A2 (en) 2001-03-08
WO2001016357A3 true WO2001016357A3 (en) 2001-11-29

Family

ID=26074264

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/008410 WO2001016357A2 (en) 1999-08-30 2000-08-29 Novel target for antiparasitic agents and inhibitors thereof

Country Status (3)

Country Link
EP (1) EP1206568A2 (en)
AU (1) AU7511800A (en)
WO (1) WO2001016357A2 (en)

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FR2819507B1 (en) * 2001-01-17 2007-09-28 Inst Rech Developpement Ird SUBSTITUTED QUINOLINES FOR THE TREATMENT OF PROTOZOAN AND RETROVIRUS CO-INFECTIONS
JP2002338538A (en) * 2001-05-21 2002-11-27 Takeda Schering-Plough Animal Health Kk New sulfonamide derivative and antiparasitic agent containing the same and used for fishes
AU2002342447A1 (en) * 2001-09-21 2003-04-01 K.U.Leuven Research And Development Methods and yeast strains for screening antifungal agents
US7119072B2 (en) 2002-01-30 2006-10-10 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis C virus
FR2835253B1 (en) * 2002-01-31 2008-02-01 Pape Patrice Le COMPOUNDS, ESPECIALLY FROM UREA DERIVATIVES OR ESTERS OF HALOACETAMIDOBENZOIC ACID AND THEIR USE FOR THE TREATMENT OF PARASITIC DISEASES
US6642204B2 (en) 2002-02-01 2003-11-04 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor tri-peptides
US7091184B2 (en) 2002-02-01 2006-08-15 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor tri-peptides
CA2501685A1 (en) * 2002-10-08 2004-04-22 Massachusetts Institute Of Technology Compounds for modulation of cholesterol transport
US20050075279A1 (en) 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
PT1654261E (en) 2003-05-21 2008-01-18 Boehringer Ingelheim Int Hepatitis c inhibitor compounds
JP2005065692A (en) * 2003-08-07 2005-03-17 Nippon Kayaku Co Ltd Method for simply detecting endoplasmic reticulum stress and its use
DE602004031645D1 (en) 2003-09-22 2011-04-14 Boehringer Ingelheim Pharma MACROCYCLIC PEPTIDES WITH EFFECT AGAINST HEPATITIS C VIRUS
CA2549851C (en) 2004-01-21 2012-09-11 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis c virus
UY29016A1 (en) 2004-07-20 2006-02-24 Boehringer Ingelheim Int ANALOGS OF INHIBITING DIPEPTIDES OF HEPATITIS C
EP1771454B1 (en) 2004-07-20 2011-06-15 Boehringer Ingelheim International GmbH Hepatitis c inhibitor peptide analogs
WO2007015632A1 (en) * 2005-08-04 2007-02-08 Cgk Co., Ltd. Atm and atr inhibitor
WO2007019180A2 (en) * 2005-08-04 2007-02-15 Science & Technology Corporation @ Unm Compounds for binding to eralpha/beta and gpr30, methods of treating disease states and conditions mediated through these receptors and identification thereof
CA2638770A1 (en) 2006-02-28 2007-09-07 Suntory Limited Gene encoding trehalose-6-phosphate phosphatase and use thereof
EP1991215A1 (en) * 2006-03-09 2008-11-19 Cenix Bioscience GmbH Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases
EP1832283A1 (en) * 2006-03-09 2007-09-12 Cenix Bioscience GmbH Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases
KR100787131B1 (en) 2006-07-04 2007-12-21 한국생명공학연구원 Compounds that inhibit hif-1 activity the method for preparation thereof and the pharmaceutical composition containing them as an effective component
EP2046122A4 (en) * 2006-07-24 2009-12-23 Univ Maryland Heme oxygenase inhibitors and methods of therapeutic use
EP1886685A1 (en) 2006-08-11 2008-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
KR100786336B1 (en) * 2007-10-30 2007-12-14 한국생명공학연구원 Compounds that inhibit hif-1 activity, the method for preparation thereof and the pharmaceutical composition containing them as an effective component
WO2010010027A1 (en) * 2008-07-23 2010-01-28 Vib Vzw Antifungal compounds
KR101145206B1 (en) * 2008-11-10 2012-05-25 건국대학교 산학협력단 THE USE OF 4-CYCLOHEXYL- IMINOMETHYL-BENZENE-1,3-DIOL AS INHIBITOR OF beta-KETOACYL ACYL CARRIER PROTEIN SYNTHASE III (KAS III)
WO2012107589A1 (en) 2011-02-11 2012-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of hcv infections

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Patent Citations (4)

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WO1997031107A2 (en) * 1996-02-20 1997-08-28 Coles John G Human serum lectin - induced apoptosis and method for detecting apoptosis
US5759795A (en) * 1996-03-08 1998-06-02 Schering Corporation Assay for determining inhibitors of ATPase
WO1999029894A1 (en) * 1997-12-05 1999-06-17 Pharmacia & Upjohn Company Fluorescence-based high throughput screening assays for protein kinases and phosphatases

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HOHMANN S ET AL: "EVIDENCE FOR TREHALOSE-6-PHOSPHATE-DEPENDENT AND -INDEPENDENT MECHANISMS IN THE CONTROL OF SUGAR INFLUX INTO YEAST GLYCOLYSIS", MOLECULAR MICROBIOLOGY,GB,OXFORD, vol. 20, no. 5, pages 981-991, XP000615219 *
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Also Published As

Publication number Publication date
WO2001016357A2 (en) 2001-03-08
EP1206568A2 (en) 2002-05-22
AU7511800A (en) 2001-03-26

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