WO2001012658A3 - Human icos ligand and application thereof - Google Patents

Human icos ligand and application thereof Download PDF

Info

Publication number
WO2001012658A3
WO2001012658A3 PCT/GB2000/003079 GB0003079W WO0112658A3 WO 2001012658 A3 WO2001012658 A3 WO 2001012658A3 GB 0003079 W GB0003079 W GB 0003079W WO 0112658 A3 WO0112658 A3 WO 0112658A3
Authority
WO
WIPO (PCT)
Prior art keywords
application
icos
human icos
icos ligand
protein
Prior art date
Application number
PCT/GB2000/003079
Other languages
French (fr)
Other versions
WO2001012658A2 (en
Inventor
Simon Davis
Original Assignee
Isis Innovations Ltd
Simon Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovations Ltd, Simon Davis filed Critical Isis Innovations Ltd
Priority to AU64584/00A priority Critical patent/AU6458400A/en
Publication of WO2001012658A2 publication Critical patent/WO2001012658A2/en
Publication of WO2001012658A3 publication Critical patent/WO2001012658A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human protein termed herein B7-3 encoded by the B7-3 gene has been cloned and characterised and can be made recombinantly and used. B7-3 protein is a ligand for inducible co-stimulator protein (ICOS). A soluble form of B7-3, for example comprising the extracellular domain shown to bind ICOS, is further provided, as are assay methods for obtaining agents for modulation of the interaction between B7-3 and ICOS.
PCT/GB2000/003079 1999-08-11 2000-08-10 Human icos ligand and application thereof WO2001012658A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64584/00A AU6458400A (en) 1999-08-11 2000-08-10 Nucleic acid, polypeptides, assays, therapeutic methods and means

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14840299P 1999-08-11 1999-08-11
US60/148,402 1999-08-11

Publications (2)

Publication Number Publication Date
WO2001012658A2 WO2001012658A2 (en) 2001-02-22
WO2001012658A3 true WO2001012658A3 (en) 2001-08-30

Family

ID=22525622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003079 WO2001012658A2 (en) 1999-08-11 2000-08-10 Human icos ligand and application thereof

Country Status (2)

Country Link
AU (1) AU6458400A (en)
WO (1) WO2001012658A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7708993B2 (en) 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
US8624010B1 (en) 1999-02-03 2014-01-07 Steven K. Yoshinaga Nucleic acids encoding B7RP1

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3521382B2 (en) 1997-02-27 2004-04-19 日本たばこ産業株式会社 Cell surface molecules that mediate cell-cell adhesion and signal transduction
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
US7435796B1 (en) 1999-02-03 2008-10-14 Amgen Inc. Antibodies which bind B7RP1
DK2332978T3 (en) 1999-02-03 2014-06-23 Amgen Inc Novel polypeptides involved in an immune response
JP4210454B2 (en) * 2001-03-27 2009-01-21 日本たばこ産業株式会社 Inflammatory bowel disease treatment
JP3871503B2 (en) 1999-08-30 2007-01-24 日本たばこ産業株式会社 Immune disease treatment
JP3597140B2 (en) 2000-05-18 2004-12-02 日本たばこ産業株式会社 Human monoclonal antibody against costimulatory molecule AILIM and pharmaceutical use thereof
JP4212278B2 (en) 2001-03-01 2009-01-21 日本たばこ産業株式会社 Graft rejection inhibitor
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
JOP20140087B1 (en) 2013-03-13 2021-08-17 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
WO2024061930A1 (en) * 2022-09-22 2024-03-28 Institut National de la Santé et de la Recherche Médicale New method to treat and diagnose peripheral t-cell lymphoma (ptcl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003408A1 (en) * 1993-07-26 1995-02-02 Dana-Farber Cancer Institute B7-2: ctl a4/cd 28 counter receptor
WO1999015553A2 (en) * 1997-09-23 1999-04-01 Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des Robert-Koch-Instituts Costimulating t-cell polypeptide, monoclonal antibodies, their preparation and use
WO2000046240A2 (en) * 1999-02-03 2000-08-10 Amgen Inc. Polypeptides involved in immune response

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003408A1 (en) * 1993-07-26 1995-02-02 Dana-Farber Cancer Institute B7-2: ctl a4/cd 28 counter receptor
WO1999015553A2 (en) * 1997-09-23 1999-04-01 Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des Robert-Koch-Instituts Costimulating t-cell polypeptide, monoclonal antibodies, their preparation and use
WO2000046240A2 (en) * 1999-02-03 2000-08-10 Amgen Inc. Polypeptides involved in immune response

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ANGELISOVÁ P. ET AL.: "Association of the putative B-lymphocyte surface molecule B7.3 with a protein kinase activity", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 228, 1996, pages 489 - 493, XP002156737 *
BRODIE D. ET AL.: "LICOS, a primordial costimulatory ligand?", CURRENT BIOLOGY, vol. 10, no. 6, 10 March 2000 (2000-03-10), pages 333 - 336, XP000971730 *
DATABASE EMBL 15 July 1998 (1998-07-15), "Homo sapiens mRNA for KIA0653 protein, partial cds.", XP002156738 *
DATABASE EMBL 23 April 1995 (1995-04-23), XP002156739 *
HENRY J. ET AL.: "Cloning, structural analysis, and mapping of the B30 and B7 multigenic families to the major histocompatibility complex (MHC) and other chromosomal regions", IMMUNOGENETICS, vol. 46, 1997, pages 383 - 395, XP000971256 *
HUTLOFF A. ET AL.: "ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28", NATURE, vol. 397, 21 January 1999 (1999-01-21), pages 263 - 266, XP002156736 *
ISHIKAWA K. ET AL.: "Prediction of the coding sequence of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 5, 1998, pages 169 - 176, XP002089186 *
LING V. ET AL.: "Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor", THE JOURNAL OF IMMUNOLOGY, vol. 164, no. 4, 15 February 2000 (2000-02-15), pages 1653 - 1657, XP002156735 *
WANG S. ET AL.: "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS", BLOOD, vol. 96, no. 8, 15 October 2000 (2000-10-15), pages 2808 - 2813, XP002156742 *
YOSHINAGA S.K. ET AL.: "Characterization of a new human B7-related protein: B7RP-1 is the ligand to the new co-stimulatory protein ICOS", INTERNATIONAL IMMUNOLOGY, vol. 12, no. 10, October 2000 (2000-10-01), pages 1439 - 1447, XP000971269 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7708993B2 (en) 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
US8309083B2 (en) 1999-02-03 2012-11-13 Amgen, Inc. Polypeptides involved in immune response
US8624010B1 (en) 1999-02-03 2014-01-07 Steven K. Yoshinaga Nucleic acids encoding B7RP1

Also Published As

Publication number Publication date
AU6458400A (en) 2001-03-13
WO2001012658A2 (en) 2001-02-22

Similar Documents

Publication Publication Date Title
WO2001012658A3 (en) Human icos ligand and application thereof
LUC00074I2 (en) Method for controlling the activity of immunologically functional molecule
ZA200100901B (en) Catalytic composition for dimersing, co-dimerising and oligomerising olefins.
WO1998046257A8 (en) Compositions comprising conjugates of stable, active, human ob protein with antibody fc chain and methods
WO2001016114A3 (en) Heterocyclic compounds and methods for modulating cxcr3 function
WO2001034646A3 (en) Recombinant gelatins
WO2001014424A3 (en) Human ctla-4 antibodies and their uses
WO1999014330A8 (en) DcR3 POLYPEPTIDE, A TNFR HOMOLOG
WO2000018921A3 (en) Synthetic peptides having fgf receptor affinity
AU5624699A (en) Use of 5ht-6 antagonists
WO2003010284A3 (en) Antisense modulation of c-reactive protein expression
WO2003052072A3 (en) Antisense modulation of estrogen receptor alpha expression
BG103016A (en) Polypeptides capable of forming antigen-binding structures of specificity to rhesus d antigens, their encoding dna and method for their prparation and application
AU3814799A (en) Chiral phosphorated ligands useful in catalysts
EP1189918A4 (en) Antisense modulation of integrin beta 3 expression
EP1131107A4 (en) Antisense modulation of inhibitor-kappa b kinase-alpha expression
EP1131332A4 (en) Antisense modulation of inhibitor-kappa b kinase-beta expression
EP1212456A4 (en) Antisense modulation of shp-2 expression
WO2001029175A3 (en) Antisense modulation of fra-1 expression
WO2003028636A3 (en) Antisense modulation of il-1 receptor-associated kinase-4 expression
EP1144690A4 (en) Antisense modulation of cellular inhibitor of apoptosis-2 expression
AU6941000A (en) Polypeptides that bind hiv gp120 and related nucleic acids, antibodies, compositions, and methods of use
EP0995430A3 (en) Use of diacylolycerols for enhancing the barrier function of the skin
WO2003020759A3 (en) A caspase- 8 binding protein, its preparation and use
ES2171136A1 (en) Enzyme with proteolytic activity

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP