WO2001010427A3 - Use of anti-muscarinic agents for treating skin disorders - Google Patents

Use of anti-muscarinic agents for treating skin disorders Download PDF

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Publication number
WO2001010427A3
WO2001010427A3 PCT/GB2000/003032 GB0003032W WO0110427A3 WO 2001010427 A3 WO2001010427 A3 WO 2001010427A3 GB 0003032 W GB0003032 W GB 0003032W WO 0110427 A3 WO0110427 A3 WO 0110427A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin disorders
treating skin
muscarinic agents
muscarinic
agents
Prior art date
Application number
PCT/GB2000/003032
Other languages
French (fr)
Other versions
WO2001010427A2 (en
Inventor
Paula Collier
David Thomas Manallack
Robin Mark Bannister
Original Assignee
Arakis Ltd
Paula Collier
David Thomas Manallack
Robin Mark Bannister
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arakis Ltd, Paula Collier, David Thomas Manallack, Robin Mark Bannister filed Critical Arakis Ltd
Priority to JP2001514947A priority Critical patent/JP2003506405A/en
Priority to CA002378445A priority patent/CA2378445A1/en
Priority to IL14789100A priority patent/IL147891A0/en
Priority to AU63064/00A priority patent/AU6306400A/en
Priority to EP00949799A priority patent/EP1202723A2/en
Publication of WO2001010427A2 publication Critical patent/WO2001010427A2/en
Publication of WO2001010427A3 publication Critical patent/WO2001010427A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A compound having anti-muscarinic activity, a dipole moment greater than 4D and anti-proliferation activity of at least 50% at 10 νM, e.g. glycopyrrolate, is useful for the treatment of skin conditions such as psoriasis.
PCT/GB2000/003032 1999-08-09 2000-08-07 Use of anti-muscarinic agents for treating skin disorders WO2001010427A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2001514947A JP2003506405A (en) 1999-08-09 2000-08-07 Topical use of antimuscarinics
CA002378445A CA2378445A1 (en) 1999-08-09 2000-08-07 Use of anti-muscarinic agents for treating skin disorders
IL14789100A IL147891A0 (en) 1999-08-09 2000-08-07 Topical use of anti-muscarnic agents
AU63064/00A AU6306400A (en) 1999-08-09 2000-08-07 Topical use of anti-muscarinic agents
EP00949799A EP1202723A2 (en) 1999-08-09 2000-08-07 Use of anti-muscarinic agents for treating skin disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9918760.1A GB9918760D0 (en) 1999-08-09 1999-08-09 Topical treatment
GB9918760.1 1999-08-09

Publications (2)

Publication Number Publication Date
WO2001010427A2 WO2001010427A2 (en) 2001-02-15
WO2001010427A3 true WO2001010427A3 (en) 2001-09-20

Family

ID=10858850

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/003032 WO2001010427A2 (en) 1999-08-09 2000-08-07 Use of anti-muscarinic agents for treating skin disorders

Country Status (8)

Country Link
EP (1) EP1202723A2 (en)
JP (1) JP2003506405A (en)
AU (1) AU6306400A (en)
CA (1) CA2378445A1 (en)
GB (1) GB9918760D0 (en)
IL (1) IL147891A0 (en)
WO (1) WO2001010427A2 (en)
ZA (1) ZA200200795B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302458A4 (en) * 2000-07-11 2005-10-19 Banyu Pharma Co Ltd Ester derivatives
DE10111843A1 (en) 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Compounds for the treatment of inflammatory diseases
DE102004016179A1 (en) * 2004-03-30 2005-10-20 Boehringer Ingelheim Pharma Compounds for the treatment of proliferative processes
WO2006054312A1 (en) * 2004-11-16 2006-05-26 Munisekhar Medasani Ammonium compounds for treating psoriasis and eczema
CA2632780C (en) * 2005-12-21 2013-11-12 Meda Pharma Gmbh & Co. Kg Combination of r,r-glycopyrrolate, rolipram, and budesonide for the treatment of inflammatory diseases
GB0611240D0 (en) * 2006-06-07 2006-07-19 Daniolabs Ltd The treatment of increased sebum production
WO2009068876A1 (en) * 2007-11-30 2009-06-04 Summit Corporation Plc Compositions for the treatment of skin disorders
WO2009150408A2 (en) * 2008-06-13 2009-12-17 Summit Corporation Plc Topical antimuscarinic formulations
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
KR20150119468A (en) 2013-02-28 2015-10-23 더미라, 인코포레이티드 Glycopyrrolate salts
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN107531655B (en) 2015-04-28 2021-03-12 荷兰联合利华有限公司 N-aralkylcarbonyl-piperazine and N-aralkylcarbonyl-homopiperazine compounds and personal care compositions containing the same
MX368097B (en) 2015-04-28 2019-09-19 Unilever Nv N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same.
CN112730821B (en) * 2019-10-14 2024-04-09 泰州医药城国科化物生物医药科技有限公司 Method for analyzing long-acting property of receptor antagonist
CN110898227A (en) * 2019-11-04 2020-03-24 上海交通大学医学院附属瑞金医院卢湾分院 Combined medicine for treating psoriasis and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000119A2 (en) * 1996-07-02 1998-01-08 Boehringer Ingelheim Pharma Kg Applications of active substances affecting the functions of non neuronal acetylcholine
WO1999059577A1 (en) * 1998-05-21 1999-11-25 El Khoury George F Topical application of muscarinic analgesic drugs such as neostigmine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000119A2 (en) * 1996-07-02 1998-01-08 Boehringer Ingelheim Pharma Kg Applications of active substances affecting the functions of non neuronal acetylcholine
DE19626373A1 (en) * 1996-07-02 1998-01-08 Boehringer Ingelheim Kg Novel use of active ingredients that affect the function of non-neuronal acetylcholine
WO1999059577A1 (en) * 1998-05-21 1999-11-25 El Khoury George F Topical application of muscarinic analgesic drugs such as neostigmine

Also Published As

Publication number Publication date
CA2378445A1 (en) 2001-02-15
GB9918760D0 (en) 1999-10-13
JP2003506405A (en) 2003-02-18
WO2001010427A2 (en) 2001-02-15
EP1202723A2 (en) 2002-05-08
IL147891A0 (en) 2002-08-14
AU6306400A (en) 2001-03-05
ZA200200795B (en) 2003-03-26

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