WO2001010387A3 - Antiviral therapy use of P-glycoprotein modulators - Google Patents

Antiviral therapy use of P-glycoprotein modulators Download PDF

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Publication number
WO2001010387A3
WO2001010387A3 PCT/US2000/040588 US0040588W WO0110387A3 WO 2001010387 A3 WO2001010387 A3 WO 2001010387A3 US 0040588 W US0040588 W US 0040588W WO 0110387 A3 WO0110387 A3 WO 0110387A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease inhibitor
antiviral therapy
methanodibenzosuberane
therapy use
glycoprotein modulators
Prior art date
Application number
PCT/US2000/040588
Other languages
French (fr)
Other versions
WO2001010387A2 (en
Inventor
Alastair J J Wood
Richard B Kim
Grant R Wilkinson
Original Assignee
Univ Vanderbilt
Wood Alastair J
Richard B Kim
Grant R Wilkinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt, Wood Alastair J, Richard B Kim, Grant R Wilkinson filed Critical Univ Vanderbilt
Priority to JP2001514912A priority Critical patent/JP2003523944A/en
Priority to CA002378984A priority patent/CA2378984A1/en
Priority to EP00967364A priority patent/EP1202737A4/en
Priority to AU77574/00A priority patent/AU7757400A/en
Publication of WO2001010387A2 publication Critical patent/WO2001010387A2/en
Publication of WO2001010387A3 publication Critical patent/WO2001010387A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a pharmaceutical composition comprising a 10, 11 methanodibenzosuberane and use thereof for the treatment of HIV infection. Co-administration of the 10, 11 methanodibenzosuberane with an HIV protease inhibitor increases the concentration of the protease inhibitor in certain tissues, including the brain and testes, without substantially increasing plasma levels of the protease inhibitor. Accordingly, additional antiviral therapy can be achieved without use of increased drug dosages, thereby reducing the potential for occurrence of undesirable side effects deriving from drug toxicity.
PCT/US2000/040588 1999-08-09 2000-08-07 Antiviral therapy use of p-glycoprotein modulators WO2001010387A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001514912A JP2003523944A (en) 1999-08-09 2000-08-07 Antiviral therapy using P-glycoprotein modifiers
CA002378984A CA2378984A1 (en) 1999-08-09 2000-08-07 Antiviral therapy use of p-glycoprotein modulators
EP00967364A EP1202737A4 (en) 1999-08-09 2000-08-07 Antiviral therapy use of p-glycoprotein modulators
AU77574/00A AU7757400A (en) 1999-08-09 2000-08-07 Antiviral therapy use of p-glycoprotein modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37026699A 1999-08-09 1999-08-09
US09/370,266 1999-08-09

Publications (2)

Publication Number Publication Date
WO2001010387A2 WO2001010387A2 (en) 2001-02-15
WO2001010387A3 true WO2001010387A3 (en) 2001-08-23

Family

ID=23458912

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/040588 WO2001010387A2 (en) 1999-08-09 2000-08-07 Antiviral therapy use of p-glycoprotein modulators

Country Status (5)

Country Link
EP (1) EP1202737A4 (en)
JP (1) JP2003523944A (en)
AU (1) AU7757400A (en)
CA (1) CA2378984A1 (en)
WO (1) WO2001010387A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6398199B1 (en) 1999-09-03 2002-06-04 Barber Manufacturing Company, Inc. Coil spring assembly
DE60124080T2 (en) 2000-03-23 2007-03-01 Elan Pharmaceuticals, Inc., San Francisco COMPOUNDS AND METHOD FOR THE TREATMENT OF ALZHEIMER'S DISEASE
DE60226729D1 (en) 2001-06-01 2008-07-03 Elan Pharm Inc HYDROXYALKYLAMINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND THEIR USE FOR THE TREATMENT OF ALZHEIMER'S DISEASE OR SIMILAR ILLNESSES
JP2004532894A (en) 2001-06-13 2004-10-28 イーラン　ファーマスーティカルズ、インコーポレイテッド Amine diol for treating Alzheimer's disease
US7067542B2 (en) 2001-07-10 2006-06-27 Pharmacia & Upjohn Company Diaminediols for the treatment of Alzheimer's disease
CA2453451A1 (en) 2001-07-10 2003-01-23 Elan Pharmaceuticals, Inc. Aminediols for the treatment of alzheimer's disease
BR0213139A (en) 2001-10-04 2004-08-10 Elan Pharm Inc Compound, method of treating or preventing disease and preparing a compound, use of a compound and pharmaceutical composition
EA200400648A1 (en) 2001-11-08 2005-04-28 Элан Фармасьютикалз, Инк. N, N'-SUBSTITUTED DERIVATIVES 1,3-DIAMINO-2-HYDROXYPROPANE
US7312360B2 (en) 2001-12-06 2007-12-25 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamines
US7262208B2 (en) 2002-04-30 2007-08-28 Elan Pharmaceuticals, Inc. Hydroxypropyl amides for the treatment of Alzheimer's disease
WO2004094384A2 (en) 2003-04-21 2004-11-04 Elan Pharmaceuticals, Inc. (hetero) arylamide 2-hydroxy-3-diaminoalkanes for use in the treatment of alzheimer’s disease
CA2558034A1 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
US7618978B2 (en) 2004-04-22 2009-11-17 Eli Lilly And Company Amides as BACE inhibitors
CA2573138A1 (en) 2004-07-09 2006-01-26 Elan Pharmaceuticals Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
JP2011231127A (en) * 2011-08-01 2011-11-17 Sekisui Medical Co Ltd Preparation for improving oral absorption and pharmaceutical composition utilizing the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
US5939456A (en) * 1996-07-26 1999-08-17 Perrine; Susan P. Pulsed administration of compositions for the treatment of blood disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643909A (en) * 1993-04-19 1997-07-01 Syntex (U.S.A.) Inc. 10,11-Methanodibenzosuberane derivatives
US5939456A (en) * 1996-07-26 1999-08-17 Perrine; Susan P. Pulsed administration of compositions for the treatment of blood disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1202737A4 *

Also Published As

Publication number Publication date
CA2378984A1 (en) 2001-02-15
EP1202737A2 (en) 2002-05-08
AU7757400A (en) 2001-03-05
EP1202737A4 (en) 2005-03-02
WO2001010387A2 (en) 2001-02-15
JP2003523944A (en) 2003-08-12

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