WO2001009611A3 - An vivo identification of specific binding molecules for cancer detection - Google Patents
An vivo identification of specific binding molecules for cancer detection Download PDFInfo
- Publication number
- WO2001009611A3 WO2001009611A3 PCT/US2000/020273 US0020273W WO0109611A3 WO 2001009611 A3 WO2001009611 A3 WO 2001009611A3 US 0020273 W US0020273 W US 0020273W WO 0109611 A3 WO0109611 A3 WO 0109611A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- subject
- specific
- specific binding
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Methods of identifying a subject-specific, tissue-specific binding molecule in a human subject are provided. The method involves injecting a library of molecules into a human and identifying molecules which bind to a specific tissue. The binding molecule can be used to direct drugs to the specific tissue of the human to treat various diseases such as cancer. The method can also be used to direct an immunomodulatory molecule to a tissue to stimulate the production of a local immune response at the tissue. The methods are particularly advantageous in developing individualized therapies. The methods can also be used to detect cancer cells in a subject after treatment for cancer and preferably from a subject who has undergone surgery.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU66086/00A AU6608600A (en) | 1999-07-29 | 2000-07-26 | In vivo methods for the identification of target specific binding molecules in a human and their use in cancer detection |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36422899A | 1999-07-29 | 1999-07-29 | |
US09/364,228 | 1999-07-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001009611A2 WO2001009611A2 (en) | 2001-02-08 |
WO2001009611A3 true WO2001009611A3 (en) | 2001-11-22 |
Family
ID=23433598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/020273 WO2001009611A2 (en) | 1999-07-29 | 2000-07-26 | An vivo identification of specific binding molecules for cancer detection |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6608600A (en) |
WO (1) | WO2001009611A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7049140B1 (en) | 1999-04-29 | 2006-05-23 | Vanderbilt University | X-ray guided drug delivery |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
US7306925B2 (en) | 2001-11-09 | 2007-12-11 | Vanderbilt University | Phage antibodies to radiation-inducible neoantigens |
DE60232688D1 (en) | 2001-11-20 | 2009-07-30 | Univ Duke | BOUNDARY-BIOMATERIALS |
DE10224338A1 (en) * | 2002-05-29 | 2003-12-24 | Gerald-F Gerlach | Means and methods for the enrichment and detection of microorganisms |
WO2013019730A1 (en) | 2011-07-29 | 2013-02-07 | The Washington University | Antibodies to tip-1 and grp78 |
US10449261B2 (en) | 2014-07-24 | 2019-10-22 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
US11352436B2 (en) | 2017-02-10 | 2022-06-07 | Washington University | Antibodies to TIP1 and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007214A1 (en) * | 1978-07-07 | 1980-01-23 | Samuel Dr. Bogoch | Product for detecting the presence of cancerous or malignant tumor cells |
WO1998010795A2 (en) * | 1996-09-10 | 1998-03-19 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
-
2000
- 2000-07-26 AU AU66086/00A patent/AU6608600A/en not_active Abandoned
- 2000-07-26 WO PCT/US2000/020273 patent/WO2001009611A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007214A1 (en) * | 1978-07-07 | 1980-01-23 | Samuel Dr. Bogoch | Product for detecting the presence of cancerous or malignant tumor cells |
WO1998010795A2 (en) * | 1996-09-10 | 1998-03-19 | The Burnham Institute | Tumor homing molecules, conjugates derived therefrom, and methods of using same |
Non-Patent Citations (3)
Title |
---|
ARAP W ET AL: "CANCER TREATMENT BY TARGETED DRUG DELIVERY TO TUMOR VASCULATURE IN A MOUSE MODEL", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 279, 16 January 1998 (1998-01-16), pages 377 - 380, XP000857470, ISSN: 0036-8075 * |
BARRY MICHAEL A ET AL: "Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries.", NATURE MEDICINE, vol. 2, no. 3, 1996, pages 299 - 305, XP002156129, ISSN: 1078-8956 * |
PASQUALINI R & RUOSLAHTI E: "Organ targeting in vivo using display peptide libraries", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 380, no. 6572, 28 March 1996 (1996-03-28), pages 364 - 366, XP002128874, ISSN: 0028-0836 * |
Also Published As
Publication number | Publication date |
---|---|
AU6608600A (en) | 2001-02-19 |
WO2001009611A2 (en) | 2001-02-08 |
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