WO2001009129A3 - 1h-pirido[3, 4-b]indol-1-one derivatives - Google Patents

1h-pirido[3, 4-b]indol-1-one derivatives Download PDF

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Publication number
WO2001009129A3
WO2001009129A3 PCT/EP2000/007279 EP0007279W WO0109129A3 WO 2001009129 A3 WO2001009129 A3 WO 2001009129A3 EP 0007279 W EP0007279 W EP 0007279W WO 0109129 A3 WO0109129 A3 WO 0109129A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
hydrogen
groups
aralkyl
cycloalkyl
Prior art date
Application number
PCT/EP2000/007279
Other languages
French (fr)
Other versions
WO2001009129A2 (en
Inventor
Ernesto Menta
Nicoletta Pescalli
Silvano Spinelli
Original Assignee
Novuspharma Spa
Ernesto Menta
Nicoletta Pescalli
Silvano Spinelli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma Spa, Ernesto Menta, Nicoletta Pescalli, Silvano Spinelli filed Critical Novuspharma Spa
Priority to AU68315/00A priority Critical patent/AU6831500A/en
Publication of WO2001009129A2 publication Critical patent/WO2001009129A2/en
Publication of WO2001009129A3 publication Critical patent/WO2001009129A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Compounds of formula (I) wherein: R is hydrogen; C1-C6 alkyl optionally substituted with one or more primary, secondary or tertiary amino groups, hydroxy or carboxy groups; C5-C6 cycloalkyl; aralkyl; heteroalkyl; aryl; heteroaryl; R1 is hydrogen; C1-C6 alkyl optionally substituted with one or more primary, secondary or tertiary amino groups, hydroxy or carboxy groups; C5-C6 cycloalkyl; aralkyl; heteroalkyl; R2 is hydrogen; C1-C6 alkyl optionally substituted with one or more primary, secondary or tertiary amino groups, hydroxy or carboxy groups; C5-C6 cycloalkyl; aralkyl; aryl; heteroaryl; heteroarylalkyl; C1-C6 acyl; X is one or more groups independently selected from hydrogen, C1-C6 alkyl, hydroxy, C1-C4 alkoxy, C1-C3 haloalkoxy, amino, C1-C3 alkylamino, C1-C3- acylamino, C1-C3 alkylsulfonylamino, halogen, nitro, cyano, carboxy, C1-C3 alkoxycarbonyl, sulfonyl, C1-C3- alkylsulfonyl, aminosulfonyl, C1-C3-alkylaminosulfonyl, trifluoromethyl with antitumor activity.
PCT/EP2000/007279 1999-08-03 2000-07-28 1h-pirido[3, 4-b]indol-1-one derivatives WO2001009129A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU68315/00A AU6831500A (en) 1999-08-03 2000-07-28 1h-pirido[3, 4-b]indol-1-one derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001740A IT1313592B1 (en) 1999-08-03 1999-08-03 DERIVATIVES OF 1H-PYRID 3,4-B INDOL-1-ONE.
ITMI99A001740 1999-08-03

Publications (2)

Publication Number Publication Date
WO2001009129A2 WO2001009129A2 (en) 2001-02-08
WO2001009129A3 true WO2001009129A3 (en) 2001-04-26

Family

ID=11383490

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/007279 WO2001009129A2 (en) 1999-08-03 2000-07-28 1h-pirido[3, 4-b]indol-1-one derivatives

Country Status (3)

Country Link
AU (1) AU6831500A (en)
IT (1) IT1313592B1 (en)
WO (1) WO2001009129A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823975B1 (en) 2001-04-27 2003-05-30 Sanofi Synthelabo NEW USE OF PYRIDOINDOLONE
US7456193B2 (en) 2002-10-23 2008-11-25 Sanofi-Aventis Pyridoindolone derivatives substituted in the 3-position by a heterocyclic group, their preparation and their application in therapeutics
FR2846329B1 (en) * 2002-10-23 2004-12-03 Sanofi Synthelabo PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN -3 BY A PHENYL, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2869316B1 (en) 2004-04-21 2006-06-02 Sanofi Synthelabo PYRIDOINDOLONE DERIVATIVES SUBSTITUTED IN -6, THEIR PREPARATION AND THEIR THERAPEUTIC USE.
FR2892416B1 (en) 2005-10-20 2008-06-27 Sanofi Aventis Sa 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
WO2010042867A2 (en) * 2008-10-09 2010-04-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
CN102127074A (en) * 2010-12-17 2011-07-20 中国药科大学 6-sulfamyl substituted-beta-carboline-1-ketone cell cycle protein dependent kinase 2 inhibitor and application thereof
WO2012157744A1 (en) * 2011-05-19 2012-11-22 国立大学法人 富山大学 1-THIOXO-1,2,3,4-TETRAHYDRO-β-CARBOLINE DERIVATIVE AND ANTI-CANCER AGENT COMPRISING SAME
FR3034095A1 (en) * 2015-03-26 2016-09-30 Agronomique Inst Nat Rech PREVENTING AND / OR TREATING PARASITOSES INDUCED BY PARASITES BELONGING TO THE PHYLUM OF APICOMPLEXES

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897391A (en) * 1988-06-17 1990-01-30 Schering Corporation Tricyclic anti-allergy, antiinflammatory and anti-hyperproliferative compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897391A (en) * 1988-06-17 1990-01-30 Schering Corporation Tricyclic anti-allergy, antiinflammatory and anti-hyperproliferative compounds

Also Published As

Publication number Publication date
ITMI991740A0 (en) 1999-08-03
WO2001009129A2 (en) 2001-02-08
IT1313592B1 (en) 2002-09-09
ITMI991740A1 (en) 2001-02-03
AU6831500A (en) 2001-02-19

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