WO2001007439A3 - Process for the production of epothiolone b and derivatives as well as intermediate products for this process - Google Patents

Process for the production of epothiolone b and derivatives as well as intermediate products for this process Download PDF

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Publication number
WO2001007439A3
WO2001007439A3 PCT/US2000/020064 US0020064W WO0107439A3 WO 2001007439 A3 WO2001007439 A3 WO 2001007439A3 US 0020064 W US0020064 W US 0020064W WO 0107439 A3 WO0107439 A3 WO 0107439A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
epothiolone
derivatives
well
intermediate products
Prior art date
Application number
PCT/US2000/020064
Other languages
French (fr)
Other versions
WO2001007439A2 (en
Inventor
Johann Mulzer
Harry Martin
Original Assignee
Schering Ag
Johann Mulzer
Harry Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Johann Mulzer, Harry Martin filed Critical Schering Ag
Priority to EP00948907A priority Critical patent/EP1226142A2/en
Priority to JP2001512523A priority patent/JP2003505459A/en
Priority to AU62336/00A priority patent/AU6233600A/en
Publication of WO2001007439A2 publication Critical patent/WO2001007439A2/en
Publication of WO2001007439A3 publication Critical patent/WO2001007439A3/en
Priority to NO20020308A priority patent/NO20020308L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention is directed to a process for the production of epothilone compounds, the improvement comprising preparing said compounds by cyclization of a compound produced from an intermediate of formula (II) wherein PG is a protecting group.
PCT/US2000/020064 1999-07-22 2000-07-24 Process for the production of epothiolone b and derivatives as well as intermediate products for this process WO2001007439A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00948907A EP1226142A2 (en) 1999-07-22 2000-07-24 Process for the production of epothiolone b and derivatives as well as intermediate products for this process
JP2001512523A JP2003505459A (en) 1999-07-22 2000-07-24 Process for the production of epothilone B and derivatives and intermediate products for this process
AU62336/00A AU6233600A (en) 1999-07-22 2000-07-24 Process for the production of epothiolone b and derivatives as well as intermediate products for this process
NO20020308A NO20020308L (en) 1999-07-22 2002-01-21 Process for the preparation of epothilone B and its derivatives and intermediates for the process

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14500599P 1999-07-22 1999-07-22
US60/145,005 1999-07-22

Publications (2)

Publication Number Publication Date
WO2001007439A2 WO2001007439A2 (en) 2001-02-01
WO2001007439A3 true WO2001007439A3 (en) 2001-05-03

Family

ID=22511165

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/020064 WO2001007439A2 (en) 1999-07-22 2000-07-24 Process for the production of epothiolone b and derivatives as well as intermediate products for this process

Country Status (5)

Country Link
EP (1) EP1226142A2 (en)
JP (1) JP2003505459A (en)
AU (1) AU6233600A (en)
NO (1) NO20020308L (en)
WO (1) WO2001007439A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41990E1 (en) 1996-12-03 2010-12-07 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1483251T3 (en) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilone derivatives
GB0221312D0 (en) * 2002-09-13 2002-10-23 Novartis Ag Organic compounds
ATE502039T1 (en) * 2007-07-04 2011-04-15 Sanofi Aventis MACROLACTONE DERIVATIVES
EP3566719A1 (en) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019086A1 (en) * 1995-11-17 1997-05-29 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Epothilone derivatives, preparation and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019086A1 (en) * 1995-11-17 1997-05-29 GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) Epothilone derivatives, preparation and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARTIN H.J. ET AL.: "How stable are epoxides? A novel synthesis of epothilone B", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION., vol. 39, no. 3, 4 February 2000 (2000-02-04), VERLAG CHEMIE. WEINHEIM., DE, pages 581 - 583, XP002156413, ISSN: 0570-0833 *
NICOLAU K.C. ET AL: "Total syntheses of epothilones A and B via a macro- lactonization-based strategy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 119, no. 34, 27 August 1997 (1997-08-27), AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, pages 7974 - 7991, XP002156412, ISSN: 0002-7863 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41990E1 (en) 1996-12-03 2010-12-07 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof

Also Published As

Publication number Publication date
WO2001007439A2 (en) 2001-02-01
JP2003505459A (en) 2003-02-12
AU6233600A (en) 2001-02-13
EP1226142A2 (en) 2002-07-31
NO20020308D0 (en) 2002-01-21
NO20020308L (en) 2002-03-21

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