WO2001005974A3 - The il-1l1 gene and polypeptide products - Google Patents

The il-1l1 gene and polypeptide products Download PDF

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Publication number
WO2001005974A3
WO2001005974A3 PCT/US2000/019508 US0019508W WO0105974A3 WO 2001005974 A3 WO2001005974 A3 WO 2001005974A3 US 0019508 W US0019508 W US 0019508W WO 0105974 A3 WO0105974 A3 WO 0105974A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
polypeptide products
polypeptide
1beta
interleukin
Prior art date
Application number
PCT/US2000/019508
Other languages
French (fr)
Other versions
WO2001005974A2 (en
WO2001005974A9 (en
Inventor
Martin Nicklin
Jenny Barton
Original Assignee
Interleukin Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interleukin Genetics Inc filed Critical Interleukin Genetics Inc
Priority to CA002378954A priority Critical patent/CA2378954A1/en
Priority to JP2001511187A priority patent/JP2003523943A/en
Priority to EP00948733A priority patent/EP1200593A2/en
Priority to AU62194/00A priority patent/AU6219400A/en
Priority to IL14753400A priority patent/IL147534A0/en
Publication of WO2001005974A2 publication Critical patent/WO2001005974A2/en
Publication of WO2001005974A3 publication Critical patent/WO2001005974A3/en
Publication of WO2001005974A9 publication Critical patent/WO2001005974A9/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)

Abstract

The present invention relates to the discovery of novel genes encoded by the interleukin-1 locus. The IL-1L1 gene is located in the interval between the IL-1Beta and IL-1 receptor antagonist encoding genes and encodes a polypeptide which is homologous to both IL-1 agonist and IL-1 antagonist proteins. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.
PCT/US2000/019508 1999-07-16 2000-07-17 The il-1l1 gene and polypeptide products WO2001005974A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002378954A CA2378954A1 (en) 1999-07-16 2000-07-17 The il-1l1 gene and polypeptide products
JP2001511187A JP2003523943A (en) 1999-07-16 2000-07-17 IL-1L1 gene and polypeptide products
EP00948733A EP1200593A2 (en) 1999-07-16 2000-07-17 The il-1l1 gene and polypeptide products
AU62194/00A AU6219400A (en) 1999-07-16 2000-07-17 The il-1l1 gene and polypeptide products
IL14753400A IL147534A0 (en) 1999-07-16 2000-07-17 The il-il1 gene and polypeptide products

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14429899P 1999-07-16 1999-07-16
US60/144,298 1999-07-16

Publications (3)

Publication Number Publication Date
WO2001005974A2 WO2001005974A2 (en) 2001-01-25
WO2001005974A3 true WO2001005974A3 (en) 2001-05-10
WO2001005974A9 WO2001005974A9 (en) 2001-06-28

Family

ID=22507973

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019508 WO2001005974A2 (en) 1999-07-16 2000-07-17 The il-1l1 gene and polypeptide products

Country Status (6)

Country Link
EP (1) EP1200593A2 (en)
JP (1) JP2003523943A (en)
AU (1) AU6219400A (en)
CA (1) CA2378954A1 (en)
IL (1) IL147534A0 (en)
WO (1) WO2001005974A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2317918A1 (en) 1998-01-09 1999-07-15 Immunex Corporation Il-1 delta dna and polypeptides
EP1407005A4 (en) * 2001-06-11 2006-05-31 Interleukin Genetics Inc Integrative assays for monitoring molecular assembly events
EP2500438A3 (en) * 2002-09-25 2012-11-28 Genentech, Inc. Novel compositions and methods for the treatment of psoriasis
US20100031378A1 (en) 2008-08-04 2010-02-04 Edwards Joel A Novel gene disruptions, compositions and methods relating thereto
WO2005085866A1 (en) * 2004-02-27 2005-09-15 Novartis Ag Screening assay for modulators of interaction between interleukin-12 and/or -23 with their receptors
CA2662549C (en) * 2006-09-08 2014-10-28 Amgen Inc. Il-1 family variants
EP3554343A1 (en) * 2016-12-14 2019-10-23 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an il-1 inhibitor
CN107362351B (en) * 2017-09-04 2020-11-10 上海市儿童医院 Application of IL-36R antagonist in preparation of analgesic drugs

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998047921A1 (en) * 1997-04-21 1998-10-29 Schering Corporation Mammalian cytokines; related reagents and methods
WO1999035268A1 (en) * 1998-01-09 1999-07-15 Immunex Corporation IL-1 delta DNA AND POLYPEPTIDES
WO1999051744A2 (en) * 1998-04-03 1999-10-14 Hyseq, Inc. A interleukin-1 receptor antagonist and uses thereof
WO2000008045A2 (en) * 1998-08-07 2000-02-17 Millennium Pharmaceuticals, Inc. Novel molecules of the tango-93-related protein family and uses thereof
WO2000020595A1 (en) * 1998-10-08 2000-04-13 Zymogenetics, Inc. Interleukin-1 homolog
WO2000039297A2 (en) * 1998-12-23 2000-07-06 Genentech, Inc. Il-1 related polypeptides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998047921A1 (en) * 1997-04-21 1998-10-29 Schering Corporation Mammalian cytokines; related reagents and methods
WO1999035268A1 (en) * 1998-01-09 1999-07-15 Immunex Corporation IL-1 delta DNA AND POLYPEPTIDES
WO1999051744A2 (en) * 1998-04-03 1999-10-14 Hyseq, Inc. A interleukin-1 receptor antagonist and uses thereof
WO2000008045A2 (en) * 1998-08-07 2000-02-17 Millennium Pharmaceuticals, Inc. Novel molecules of the tango-93-related protein family and uses thereof
WO2000020595A1 (en) * 1998-10-08 2000-04-13 Zymogenetics, Inc. Interleukin-1 homolog
WO2000039297A2 (en) * 1998-12-23 2000-07-06 Genentech, Inc. Il-1 related polypeptides

Also Published As

Publication number Publication date
AU6219400A (en) 2001-02-05
WO2001005974A2 (en) 2001-01-25
JP2003523943A (en) 2003-08-12
EP1200593A2 (en) 2002-05-02
IL147534A0 (en) 2002-08-14
CA2378954A1 (en) 2001-01-25
WO2001005974A9 (en) 2001-06-28

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