WO2001000803A3 - Proteine associee a l'apolipoproteine a-iv (aa4rp): sequences polypeptidiques, polynucleotidiques et marqueurs bialleliques de ces dernieres - Google Patents

Proteine associee a l'apolipoproteine a-iv (aa4rp): sequences polypeptidiques, polynucleotidiques et marqueurs bialleliques de ces dernieres Download PDF

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Publication number
WO2001000803A3
WO2001000803A3 PCT/IB2000/001011 IB0001011W WO0100803A3 WO 2001000803 A3 WO2001000803 A3 WO 2001000803A3 IB 0001011 W IB0001011 W IB 0001011W WO 0100803 A3 WO0100803 A3 WO 0100803A3
Authority
WO
WIPO (PCT)
Prior art keywords
aa4rp
related disorder
gene
biallelic markers
provides
Prior art date
Application number
PCT/IB2000/001011
Other languages
English (en)
Other versions
WO2001000803A2 (fr
Inventor
Frances Yen
Blake Denison
Barbara Bour
Bernard Bihain
Lydie Bougueleret
Aymeric Duclert
Milne Edwards Jean-Bapti Dumas
Catherine Clusel
Original Assignee
Genset Sa
Frances Yen
Blake Denison
Barbara Bour
Bernard Bihain
Lydie Bougueleret
Aymeric Duclert
Dumas Milne Edwards Jean Bapti
Catherine Clusel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB1999/002058 external-priority patent/WO2000037491A2/fr
Application filed by Genset Sa, Frances Yen, Blake Denison, Barbara Bour, Bernard Bihain, Lydie Bougueleret, Aymeric Duclert, Dumas Milne Edwards Jean Bapti, Catherine Clusel filed Critical Genset Sa
Priority to AU58383/00A priority Critical patent/AU5838300A/en
Priority to US09/751,877 priority patent/US20040204349A9/en
Priority to US09/750,580 priority patent/US6455280B1/en
Publication of WO2001000803A2 publication Critical patent/WO2001000803A2/fr
Publication of WO2001000803A3 publication Critical patent/WO2001000803A3/fr
Priority to US10/121,034 priority patent/US7122644B2/en
Priority to US11/412,373 priority patent/US20060189793A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne la séquence génomique de l'AA4RP, des ADNc de l'AA4RP et des polypeptides de l'AA4RP. L'invention concerne également des polynucléotides contenant des marqueurs bialléliques dérivés du gène de l'AA4RP et de régions génomiques voisines du gène. L'invention concerne en outre des polynucléotides et des méthodes permettant de génotyper un échantillon renfermant un acide nucléique pour au moins un des marqueurs bialléliques de l'invention. L'invention concerne par ailleurs des méthodes de détection d'une corrélation statistique entre un allèle du marqueur biallélique et un phénotype et/ou entre un haplotype du marqueur biallélique et un phénotype. L'invention concerne de plus des méthodes diagnostiques permettant de déterminer si un individu coure le risque de développer un trouble du métabolisme lipidique et/ou un trouble hépatique, ou si un individu est atteint d'un trouble du métabolisme lipidique et/ou d'un trouble hépatique induit par un polymorphisme dans le gène de l'AA4RP.
PCT/IB2000/001011 1998-12-22 2000-06-21 Proteine associee a l'apolipoproteine a-iv (aa4rp): sequences polypeptidiques, polynucleotidiques et marqueurs bialleliques de ces dernieres WO2001000803A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU58383/00A AU5838300A (en) 1999-06-25 2000-06-21 Apolipoprotein a-iv-related protein: polypeptide, polynucleotide sequences and biallelic markers thereof
US09/751,877 US20040204349A9 (en) 1998-12-22 2000-12-28 Methods and compositions for inhibiting neoplastic cells growth
US09/750,580 US6455280B1 (en) 1998-12-22 2000-12-28 Methods and compositions for inhibiting neoplastic cell growth
US10/121,034 US7122644B2 (en) 1998-12-22 2002-04-10 Methods and compositions for inhibiting neoplastic cell growth
US11/412,373 US20060189793A1 (en) 1998-12-22 2006-04-27 Methods and compositions for inhibiting neoplastic cell growth

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US14103299P 1999-06-25 1999-06-25
US60/141,032 1999-06-25
IBPCT/IB99/02058 1999-12-20
PCT/IB1999/002058 WO2000037491A2 (fr) 1998-12-22 1999-12-20 Adn complementaires codant pour des proteines secretees avec des peptides signaux
US46909999A 1999-12-21 1999-12-21
US09/469,099 1999-12-21

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/IB1999/002058 Continuation-In-Part WO2000037491A2 (fr) 1998-12-22 1999-12-20 Adn complementaires codant pour des proteines secretees avec des peptides signaux
US46909999A Continuation-In-Part 1998-12-22 1999-12-21

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US59936200A Continuation-In-Part 1998-12-22 2000-06-21
US09/750,580 Continuation-In-Part US6455280B1 (en) 1998-12-22 2000-12-28 Methods and compositions for inhibiting neoplastic cell growth
US09/751,877 Continuation-In-Part US20040204349A9 (en) 1998-12-22 2000-12-28 Methods and compositions for inhibiting neoplastic cells growth

Publications (2)

Publication Number Publication Date
WO2001000803A2 WO2001000803A2 (fr) 2001-01-04
WO2001000803A3 true WO2001000803A3 (fr) 2001-12-27

Family

ID=26838728

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/IB2000/001010 WO2001000661A2 (fr) 1999-06-25 2000-06-21 Proteine 1 associee a un transporteur de carnitine (ccrp-1)
PCT/IB2000/000951 WO2001000806A2 (fr) 1997-11-13 2000-06-21 Proteines codant des adn complementaires avec des peptides-signal
PCT/IB2000/001011 WO2001000803A2 (fr) 1998-12-22 2000-06-21 Proteine associee a l'apolipoproteine a-iv (aa4rp): sequences polypeptidiques, polynucleotidiques et marqueurs bialleliques de ces dernieres

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/IB2000/001010 WO2001000661A2 (fr) 1999-06-25 2000-06-21 Proteine 1 associee a un transporteur de carnitine (ccrp-1)
PCT/IB2000/000951 WO2001000806A2 (fr) 1997-11-13 2000-06-21 Proteines codant des adn complementaires avec des peptides-signal

Country Status (4)

Country Link
EP (1) EP1200576A2 (fr)
AU (2) AU5559400A (fr)
CA (1) CA2368098A1 (fr)
WO (3) WO2001000661A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1244784A2 (fr) * 2000-01-06 2002-10-02 Genentech, Inc. Methodes et compositions permettant d'inhiber la croissance cellulaire neoplasique
CA2397896A1 (fr) * 2000-01-19 2001-07-26 University Of Virginia Patent Foundation Proteines du type lisozyme, specifiques du sperme
US7125550B2 (en) 2000-01-19 2006-10-24 University Of Virginia Patent Foundation Human sperm specific lysozyme-like proteins
WO2001060859A1 (fr) * 2000-02-21 2001-08-23 Kureha Chemical Industry Co., Ltd. Nouvelles proteines et nouveaux genes codant ces proteines
US7094566B2 (en) 2000-03-16 2006-08-22 Amgen Inc., IL-17 receptor like molecules and uses thereof
WO2003002737A1 (fr) * 2001-06-27 2003-01-09 Riken Nouvelle proteine inhibitrice de la topoisomerase humaine 2$g(a) et utilisation associee
WO2003018807A1 (fr) * 2001-08-24 2003-03-06 Hisamitsu Pharmaceutical Co., Inc. Acides nucleiques presentant une difference d'expression dans l'hepatoblastome et dans le foie normal
US7238475B2 (en) 2001-08-27 2007-07-03 The Regents Of The University Of California Apolipoprotein gene involved in lipid metabolism
FR2829581A1 (fr) * 2001-09-07 2003-03-14 Genfit S A Methodes de criblage de molecules utiles pour la prevention ou le traitement du syndrome metabolique, des maladies cardiovasculaires et de l'atherosclerose
FR2843395A1 (fr) * 2002-08-12 2004-02-13 Genfit S A Composition et methodes pour le dosage de l'aa4rp
EP1423708B1 (fr) * 2001-09-07 2006-11-29 Genfit Compositions et methodes pour le dosage de l'aa4rp
US20060089297A1 (en) * 2003-01-16 2006-04-27 Herr John C Sperm specific lysozyme-like proteins
AU2011213901B2 (en) * 2003-09-26 2012-07-05 BioNTech SE Identification of tumour-associated cell surface antigens for diagnosis and therapy
DE10344799A1 (de) 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
DK2275556T3 (da) 2004-01-17 2013-07-08 Korea Res Inst Of Bioscience Hurtig fremgangsmåde til screening af translationsfusionspartnere til fremstilling af rekombinante proteiner og translationsfusionpartnere screenet derfra
US7892733B1 (en) 2004-04-22 2011-02-22 Amgen Inc. Response element regions
KR20070009269A (ko) 2005-07-15 2007-01-18 한국생명공학연구원 재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자
KR101498668B1 (ko) 2008-12-04 2015-03-06 한국생명공학연구원 고분비성 단백질의 스크리닝 및 재조합 단백질의 생산을 위한 융합 파트너로서 그의 용도
WO2012060666A2 (fr) 2010-11-04 2012-05-10 한국생명공학연구원 Procédé de production à grande échelle de facteur de croissance épidermique humain à partir de levures
US8854361B1 (en) 2013-03-13 2014-10-07 Cambridgesoft Corporation Visually augmenting a graphical rendering of a chemical structure representation or biological sequence representation with multi-dimensional information

Citations (1)

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WO1993015198A1 (fr) * 1992-01-27 1993-08-05 Rhone-Poulenc Rorer S.A. Polypeptides derives de l'apolipoproteine aiv humaine, leur preparation et leur utilisation

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AU6241698A (en) * 1997-01-21 1998-08-07 Human Genome Sciences, Inc. Tace-like and matrilysin-like polypeptides
AU6956798A (en) * 1997-04-10 1998-10-30 Genetics Institute Inc. Secreted expressed sequence tags (sests)
DE19816395A1 (de) * 1998-04-03 1999-10-07 Metagen Gesellschaft Fuer Genomforschung Mbh Menschliche Nukleinsäuresequenzen aus Ovar-Normalgewebe
WO2000037491A2 (fr) * 1998-12-22 2000-06-29 Genset Adn complementaires codant pour des proteines secretees avec des peptides signaux

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1993015198A1 (fr) * 1992-01-27 1993-08-05 Rhone-Poulenc Rorer S.A. Polypeptides derives de l'apolipoproteine aiv humaine, leur preparation et leur utilisation

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NORMAN R A ET AL: "Empirically determined power calculations for single locus allelic association studies.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 67, no. 4 Supplement 2, October 2000 (2000-10-01), 50th Annual Meeting of the American Society of Human Genetics;Philadelphia, Pennsylvania, USA; October 03-07, 2000, pages 320, XP000979348, ISSN: 0002-9297 *
OSADA J. ET AL.: "Apolipoprotein A-IV Precursor (APO-A IV)", EMBL DATABASE, 15 December 1998 (1998-12-15), HEIDELBERG, DE, XP002162305 *

Also Published As

Publication number Publication date
AU5559400A (en) 2001-01-31
WO2001000661A2 (fr) 2001-01-04
WO2001000806A3 (fr) 2002-01-10
CA2368098A1 (fr) 2001-01-04
EP1200576A2 (fr) 2002-05-02
WO2001000661A3 (fr) 2002-01-10
WO2001000803A2 (fr) 2001-01-04
WO2001000806A2 (fr) 2001-01-04
AU5838200A (en) 2001-01-31

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