WO2001000789A3 - Cyanobacterial strain of the genus nostoc and bioactive molecules obtained therefrom - Google Patents

Cyanobacterial strain of the genus nostoc and bioactive molecules obtained therefrom Download PDF

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Publication number
WO2001000789A3
WO2001000789A3 PCT/EP2000/006066 EP0006066W WO0100789A3 WO 2001000789 A3 WO2001000789 A3 WO 2001000789A3 EP 0006066 W EP0006066 W EP 0006066W WO 0100789 A3 WO0100789 A3 WO 0100789A3
Authority
WO
WIPO (PCT)
Prior art keywords
nostoc
extracts
kona97
growth
obtained therefrom
Prior art date
Application number
PCT/EP2000/006066
Other languages
French (fr)
Other versions
WO2001000789A2 (en
Inventor
Raffaella Piccardi
Andrea Frosini
Alba Ena
Maria Cristina Margheri
Innocenti Alessandro Degli
Luca Calamai
Mario Roberto Tredici
Original Assignee
Univ Firenze
Consiglio Nazionale Ricerche
Sogesca S R L
Raffaella Piccardi
Andrea Frosini
Alba Ena
Maria Cristina Margheri
Innocenti Alessandro Degli
Luca Calamai
Mario Roberto Tredici
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Firenze, Consiglio Nazionale Ricerche, Sogesca S R L, Raffaella Piccardi, Andrea Frosini, Alba Ena, Maria Cristina Margheri, Innocenti Alessandro Degli, Luca Calamai, Mario Roberto Tredici filed Critical Univ Firenze
Priority to AU64302/00A priority Critical patent/AU6430200A/en
Publication of WO2001000789A2 publication Critical patent/WO2001000789A2/en
Publication of WO2001000789A3 publication Critical patent/WO2001000789A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Abstract

A new cyanobacterial strain of the genus Nostoc, suitable for exploitation in agriculture, pharmaceutics and cosmetics. A molecule having molecular weight of 356 present in cultures, biomasses and extracts of Nostoc KONA97, has shown marked antifungal and antitumor properties. Particularly, lipophilic extracts of KONA97 completely inhibit the growth of Colletotrichum trifolii, Penicillium expansum and Rhizoctonia solani, while lower levels of inhibition have been found against Candida albicans, Phoma sp. and Fusarium roseum. The lipophilic extracts have shown marked toxicity against Artemia salina and Brachionus sp., also inhibiting the growth of HCT8 tumour cell lines.
PCT/EP2000/006066 1999-06-29 2000-06-29 Cyanobacterial strain of the genus nostoc and bioactive molecules obtained therefrom WO2001000789A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64302/00A AU6430200A (en) 1999-06-29 2000-06-29 Cyanobacterial strain of the genus nostoc, cultures, biomasses, extracts, bioactive molecules obtained therefrom and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPI99A000038 1999-06-29
IT1999PI000038A IT1307320B1 (en) 1999-06-29 1999-06-29 CYANOBACTERIAL STOCK OF THE NOSTOC GENUS, AS WELL AS CULTURES, BIOMASSES, EXTRACTS, BIOACTIVE MOLOCULES DERIVED FROM SUCH STOCK AND THEIR USE IN

Publications (2)

Publication Number Publication Date
WO2001000789A2 WO2001000789A2 (en) 2001-01-04
WO2001000789A3 true WO2001000789A3 (en) 2001-05-25

Family

ID=11394410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/006066 WO2001000789A2 (en) 1999-06-29 2000-06-29 Cyanobacterial strain of the genus nostoc and bioactive molecules obtained therefrom

Country Status (3)

Country Link
AU (1) AU6430200A (en)
IT (1) IT1307320B1 (en)
WO (1) WO2001000789A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ305944B6 (en) * 2015-03-27 2016-05-11 Mikrobiologický Ústav Av Čr V.V.I. Isolated blue-green alga strain Nostoc sp. and isolated blue-green alga strain Nodularia, blue-green alga metabolite, process for preparing the blue-green alga metabolite and use of the blue-green alga metabolite as medicament
US20220298098A1 (en) * 2019-08-30 2022-09-22 Ciimar - Centro Interdisciplinar De Investigaçäo Marinha E Ambiental Halogenated compounds, process and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2220657A (en) * 1988-07-15 1990-01-17 Merck & Co Inc Antifungal fermentation product
JPH06116159A (en) * 1992-09-07 1994-04-26 Max Fuakutaa Kk Extract of nostoc commune
WO1995017093A1 (en) * 1993-12-21 1995-06-29 University Of Hawaii New cryptophycins
JPH07242689A (en) * 1994-03-04 1995-09-19 Kibun Foods Inc Antifungal activator derived from blue-green alga and its production

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2220657A (en) * 1988-07-15 1990-01-17 Merck & Co Inc Antifungal fermentation product
JPH06116159A (en) * 1992-09-07 1994-04-26 Max Fuakutaa Kk Extract of nostoc commune
WO1995017093A1 (en) * 1993-12-21 1995-06-29 University Of Hawaii New cryptophycins
JPH07242689A (en) * 1994-03-04 1995-09-19 Kibun Foods Inc Antifungal activator derived from blue-green alga and its production

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DE CANO M M S ET AL: "INHIBITION OF CANDIDA-ALBICANS AND STAPHYLOCOCCUS-AUREUS BY PHENOLIC COMPOUNDS FROM THE TERRESTRIAL CYANOBACTERIUM NOSTOC-MUSCORUM", JOURNAL OF APPLIED PHYCOLOGY, vol. 2, no. 1, 1990, pages 79 - 82, XP000990274, ISSN: 0921-8971 *
GOLAKOTI T ET AL: "STRUCTURE DETERMINATION, CONFORMATIONAL ANALYSIS, CHEMICAL STABILITY STUDIES, AND ANTITUMOR EVALUATION OF THE CRYPTOPHYCINS. ISOLATION OF 18 NEW ANALOGS FROM NOSTOC SP. STRAIN GSV 224", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 117, no. 49, 13 December 1995 (1995-12-13), pages 12030 - 12049, XP002066326, ISSN: 0002-7863 *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 400 (C - 1230) 26 July 1994 (1994-07-26) *
PICCARDI RAFFAELLA ET AL: "Bioactivity in free-living and symbiotic cyanobacteria of the genus Nostoc.", JOURNAL OF APPLIED PHYCOLOGY, vol. 12, no. 3-5, October 2000 (2000-10-01), pages 543 - 547, XP000990256, ISSN: 0921-8971 *

Also Published As

Publication number Publication date
IT1307320B1 (en) 2001-10-30
AU6430200A (en) 2001-01-31
WO2001000789A2 (en) 2001-01-04
ITPI990038A1 (en) 2000-12-29

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