WO2000077812A8 - Light-induced electron capture at a surface - Google Patents

Light-induced electron capture at a surface

Info

Publication number
WO2000077812A8
WO2000077812A8 PCT/US2000/040173 US0040173W WO0077812A8 WO 2000077812 A8 WO2000077812 A8 WO 2000077812A8 US 0040173 W US0040173 W US 0040173W WO 0077812 A8 WO0077812 A8 WO 0077812A8
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
electron
light
electron capture
induced electron
Prior art date
Application number
PCT/US2000/040173
Other languages
French (fr)
Other versions
WO2000077812A3 (en
WO2000077812A2 (en
Inventor
Poguang Wang
Xin Zhang
Roger W Giese
Original Assignee
Univ Northeastern
Poguang Wang
Xin Zhang
Roger W Giese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Northeastern, Poguang Wang, Xin Zhang, Roger W Giese filed Critical Univ Northeastern
Publication of WO2000077812A2 publication Critical patent/WO2000077812A2/en
Publication of WO2000077812A3 publication Critical patent/WO2000077812A3/en
Publication of WO2000077812A8 publication Critical patent/WO2000077812A8/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method for increasing the performance and usefulness of laser induced electron capture mass spectrometry (LI-EC-MS). Light (photons) from a light source (laser), is used to activate an electron of a surface, preferably a metal surface, where the light energy is below the work function of the surface. The electron is transferred to an analyte on the surface, forming an anionic product from the analyte. The anionic product can simultaneously undergo desorption for detection in a mass spectrometer. Alternatively, the analyte (first substance) can receive an electron from an intermediate compound having a low ionization potential which is deposited with the analyte. This gives a sharper or more intense sig nal from an analyte than prior forms of LI-EC-MS, but utilizes ordinary MS equipment. Further, the procedure even enables detection of species, such as nucleic acids labeled with polyfluoro-containing groups, that previously were beyond the reach of LI-EC-MS techniques.
PCT/US2000/040173 1999-06-10 2000-06-08 Light-induced electron capture at a surface WO2000077812A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13846699P 1999-06-10 1999-06-10
US60/138,466 1999-06-10
US13917099P 1999-06-15 1999-06-15
US60/139,170 1999-06-15

Publications (3)

Publication Number Publication Date
WO2000077812A2 WO2000077812A2 (en) 2000-12-21
WO2000077812A3 WO2000077812A3 (en) 2002-01-24
WO2000077812A8 true WO2000077812A8 (en) 2002-06-20

Family

ID=26836219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/040173 WO2000077812A2 (en) 1999-06-10 2000-06-08 Light-induced electron capture at a surface

Country Status (1)

Country Link
WO (1) WO2000077812A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401558A4 (en) 2001-05-25 2007-12-12 Waters Investments Ltd Desalting plate for maldi mass spectrometry
GB0120131D0 (en) 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
DE102008035773A1 (en) * 2008-07-31 2010-02-04 Eads Deutschland Gmbh Method and device for ionization and provided therewith gas detection device

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2236184B (en) * 1989-09-12 1993-07-28 Finnigan Mat Ltd Method of preparing samples for laser spectrometry analysis
US5648201A (en) * 1991-04-25 1997-07-15 The United Sates Of America As Represented By The Secretary Of The Navy Efficient chemistry for selective modification and metallization of substrates
US5370855A (en) * 1991-11-25 1994-12-06 Gruen; Dieter M. Conversion of fullerenes to diamond
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
ATE242485T1 (en) * 1993-05-28 2003-06-15 Baylor College Medicine METHOD AND MASS SPECTROMETER FOR THE DESORPTION AND IONIZATION OF ANALYTES

Also Published As

Publication number Publication date
WO2000077812A3 (en) 2002-01-24
WO2000077812A2 (en) 2000-12-21

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