WO2000077040A3 - Human intracellular signaling molecules - Google Patents

Human intracellular signaling molecules Download PDF

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Publication number
WO2000077040A3
WO2000077040A3 PCT/US2000/016636 US0016636W WO0077040A3 WO 2000077040 A3 WO2000077040 A3 WO 2000077040A3 US 0016636 W US0016636 W US 0016636W WO 0077040 A3 WO0077040 A3 WO 0077040A3
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WO
WIPO (PCT)
Prior art keywords
intracellular signaling
signaling molecules
human intracellular
intra
provides
Prior art date
Application number
PCT/US2000/016636
Other languages
French (fr)
Other versions
WO2000077040A9 (en
WO2000077040A2 (en
Inventor
Henry Yue
Y Tom Tang
Jennifer L Hillman
Preeti Lal
Olga Bandman
Mariah R Baughn
Yalda Azimzai
Junming Yang
Roopa Reddy
Dyung Aina M Lu
Original Assignee
Incyte Genomics Inc
Henry Yue
Y Tom Tang
Jennifer L Hillman
Preeti Lal
Olga Bandman
Mariah R Baughn
Yalda Azimzai
Junming Yang
Roopa Reddy
Dyung Aina M Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Henry Yue, Y Tom Tang, Jennifer L Hillman, Preeti Lal, Olga Bandman, Mariah R Baughn, Yalda Azimzai, Junming Yang, Roopa Reddy, Dyung Aina M Lu filed Critical Incyte Genomics Inc
Priority to CA002374909A priority Critical patent/CA2374909A1/en
Priority to EP00941487A priority patent/EP1203081A2/en
Priority to JP2001503896A priority patent/JP2003530071A/en
Priority to AU56191/00A priority patent/AU5619100A/en
Publication of WO2000077040A2 publication Critical patent/WO2000077040A2/en
Publication of WO2000077040A3 publication Critical patent/WO2000077040A3/en
Publication of WO2000077040A9 publication Critical patent/WO2000077040A9/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides human intracellular signaling molecules (INTRA) and polynucleotides which identify and encode INTRA. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of INTRA.
PCT/US2000/016636 1999-06-16 2000-06-16 Human intracellular signaling molecules WO2000077040A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002374909A CA2374909A1 (en) 1999-06-16 2000-06-16 Human intracellular signaling molecules
EP00941487A EP1203081A2 (en) 1999-06-16 2000-06-16 Human intracellular signaling molecules
JP2001503896A JP2003530071A (en) 1999-06-16 2000-06-16 Intracellular signaling molecule
AU56191/00A AU5619100A (en) 1999-06-16 2000-06-16 Intracellular signaling molecules

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13956699P 1999-06-16 1999-06-16
US60/139,566 1999-06-16
US14964099P 1999-08-17 1999-08-17
US60/149,640 1999-08-17
US16441799P 1999-11-09 1999-11-09
US60/164,417 1999-11-09

Publications (3)

Publication Number Publication Date
WO2000077040A2 WO2000077040A2 (en) 2000-12-21
WO2000077040A3 true WO2000077040A3 (en) 2001-04-26
WO2000077040A9 WO2000077040A9 (en) 2002-08-01

Family

ID=27385364

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016636 WO2000077040A2 (en) 1999-06-16 2000-06-16 Human intracellular signaling molecules

Country Status (5)

Country Link
EP (1) EP1203081A2 (en)
JP (1) JP2003530071A (en)
AU (1) AU5619100A (en)
CA (1) CA2374909A1 (en)
WO (1) WO2000077040A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3593482B2 (en) * 1999-11-24 2004-11-24 独立行政法人 科学技術振興機構 Human nucleoprotein having WW domain and cDNA encoding the same
WO2001042294A2 (en) * 1999-12-13 2001-06-14 Arbor Vita Corporation Clasp-4 transmembrane protein
CA2404496A1 (en) * 2000-03-30 2001-10-04 Merck Patent Gesellschaft Mit Beschraenkter Haftung Calcium binding regulatory subunit
WO2003014298A2 (en) * 2001-08-03 2003-02-20 Origene Technologies, Inc. Full-length prostate selective polynucleotides and polypeptides
DE10222845A1 (en) * 2002-05-23 2003-12-04 Dresden Arzneimittel Cloning, expression and characterization of the overall sequence of phosphodiesterase 8B
WO2004042077A2 (en) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 8b (pde8b)
EP1572104A4 (en) * 2002-11-14 2007-01-17 Kirk Sperber Induction of apoptosis by hiv-1 infected monocytic cells
WO2007064647A2 (en) 2005-12-01 2007-06-07 New York Blood Center, Inc. Peptide inhibitors of abl kinases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602019A (en) * 1991-04-19 1997-02-11 The Board Of Regents Of The University Of Washington DNA encoding mammalian phosphodiesterases
WO1997015587A1 (en) * 1995-10-27 1997-05-01 Duke University Abl-interactor protein
WO1997044347A1 (en) * 1996-05-21 1997-11-27 Smithkline Beecham Corporation Human cis protein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602019A (en) * 1991-04-19 1997-02-11 The Board Of Regents Of The University Of Washington DNA encoding mammalian phosphodiesterases
WO1997015587A1 (en) * 1995-10-27 1997-05-01 Duke University Abl-interactor protein
WO1997044347A1 (en) * 1996-05-21 1997-11-27 Smithkline Beecham Corporation Human cis protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EMBL database, Heidelberg, FRG Emest_Hum3 accession number AI083494 18 August 1998 NCI-CGAP: "ox75a07.x1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:1662132 3' similar to TR:Q13802 Q13802 ARGBPIB PROTEIN, mRNA sequence" *

Also Published As

Publication number Publication date
WO2000077040A9 (en) 2002-08-01
CA2374909A1 (en) 2000-12-21
WO2000077040A2 (en) 2000-12-21
JP2003530071A (en) 2003-10-14
AU5619100A (en) 2001-01-02
EP1203081A2 (en) 2002-05-08

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