WO2000077040A2 - Molecules de signalisation intracellulaires - Google Patents

Molecules de signalisation intracellulaires Download PDF

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Publication number
WO2000077040A2
WO2000077040A2 PCT/US2000/016636 US0016636W WO0077040A2 WO 2000077040 A2 WO2000077040 A2 WO 2000077040A2 US 0016636 W US0016636 W US 0016636W WO 0077040 A2 WO0077040 A2 WO 0077040A2
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WO
WIPO (PCT)
Prior art keywords
seq
polypeptide
polynucleotide
entra
sequences
Prior art date
Application number
PCT/US2000/016636
Other languages
English (en)
Other versions
WO2000077040A9 (fr
WO2000077040A3 (fr
Inventor
Henry Yue
Y. Tom Tang
Jennifer L. Hillman
Preeti Lal
Olga Bandman
Mariah R. Baughn
Yalda Azimzai
Junming Yang
Roopa Reddy
Dyung Aina M. Lu
Original Assignee
Incyte Genomics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics, Inc. filed Critical Incyte Genomics, Inc.
Priority to JP2001503896A priority Critical patent/JP2003530071A/ja
Priority to CA002374909A priority patent/CA2374909A1/fr
Priority to AU56191/00A priority patent/AU5619100A/en
Priority to EP00941487A priority patent/EP1203081A2/fr
Publication of WO2000077040A2 publication Critical patent/WO2000077040A2/fr
Publication of WO2000077040A3 publication Critical patent/WO2000077040A3/fr
Publication of WO2000077040A9 publication Critical patent/WO2000077040A9/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des molécules de signalisation intracellulaires humaines (INTRA) et des polynucléotides qui identifient et codent ces INTRA. L'invention concerne également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes ainsi que des antagonistes. Enfin, l'invention propose des procédés de diagnostic, de traitement ou de prévention des troubles liés à l'expression des INTRA.
PCT/US2000/016636 1999-06-16 2000-06-16 Molecules de signalisation intracellulaires WO2000077040A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001503896A JP2003530071A (ja) 1999-06-16 2000-06-16 細胞内シグナル伝達分子
CA002374909A CA2374909A1 (fr) 1999-06-16 2000-06-16 Molecules de signalisation intracellulaires
AU56191/00A AU5619100A (en) 1999-06-16 2000-06-16 Intracellular signaling molecules
EP00941487A EP1203081A2 (fr) 1999-06-16 2000-06-16 Molecules de signalisation intracellulaires

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13956699P 1999-06-16 1999-06-16
US60/139,566 1999-06-16
US14964099P 1999-08-17 1999-08-17
US60/149,640 1999-08-17
US16441799P 1999-11-09 1999-11-09
US60/164,417 1999-11-09

Publications (3)

Publication Number Publication Date
WO2000077040A2 true WO2000077040A2 (fr) 2000-12-21
WO2000077040A3 WO2000077040A3 (fr) 2001-04-26
WO2000077040A9 WO2000077040A9 (fr) 2002-08-01

Family

ID=27385364

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016636 WO2000077040A2 (fr) 1999-06-16 2000-06-16 Molecules de signalisation intracellulaires

Country Status (5)

Country Link
EP (1) EP1203081A2 (fr)
JP (1) JP2003530071A (fr)
AU (1) AU5619100A (fr)
CA (1) CA2374909A1 (fr)
WO (1) WO2000077040A2 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042294A2 (fr) * 1999-12-13 2001-06-14 Arbor Vita Corporation Proteine transmembranaire clasp-4
WO2001072772A2 (fr) * 2000-03-30 2001-10-04 Merck Patent Gmbh Nouvelle sous-unité de régulation de la fixation du calcium
EP1148125A1 (fr) * 1999-11-24 2001-10-24 Japan Science and Technology Corporation Nucleoproteine humaine possedant un domaine www et polynucleotide codant cette nucleoproteine
WO2003014298A2 (fr) * 2001-08-03 2003-02-20 Origene Technologies, Inc. Polynucleotides et polypeptides selectifs pour la prostate et presentant une longueur totale de chaine
WO2003100047A1 (fr) * 2002-05-23 2003-12-04 Elbion Ag Clonage, expression et caracterisation de la sequence complete d'une phosphodiesterase 8b
WO2004042077A3 (fr) * 2002-11-08 2005-01-13 Bayer Healthcare Ag Diagnostics et traitements de maladies associees a la phosphodiesterase 8b humaine (pde8b)
EP1572104A2 (fr) * 2002-11-14 2005-09-14 Kirk Sperber Induction de l'apoptose par des cellules monocytiques infectees par le vih-1
US8148320B2 (en) 2005-12-01 2012-04-03 New York Blood Center, Inc. Peptide inhibitors of ABL kinases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602019A (en) * 1991-04-19 1997-02-11 The Board Of Regents Of The University Of Washington DNA encoding mammalian phosphodiesterases
WO1997015587A1 (fr) * 1995-10-27 1997-05-01 Duke University Proteine interagissant avec abl
WO1997044347A1 (fr) * 1996-05-21 1997-11-27 Smithkline Beecham Corporation Proteine cis humaine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602019A (en) * 1991-04-19 1997-02-11 The Board Of Regents Of The University Of Washington DNA encoding mammalian phosphodiesterases
WO1997015587A1 (fr) * 1995-10-27 1997-05-01 Duke University Proteine interagissant avec abl
WO1997044347A1 (fr) * 1996-05-21 1997-11-27 Smithkline Beecham Corporation Proteine cis humaine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EMBL database, Heidelberg, FRG Emest_Hum3 accession number AI083494 18 August 1998 NCI-CGAP: "ox75a07.x1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:1662132 3' similar to TR:Q13802 Q13802 ARGBPIB PROTEIN, mRNA sequence" XP002149761 *
See also references of EP1203081A2 *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1148125A1 (fr) * 1999-11-24 2001-10-24 Japan Science and Technology Corporation Nucleoproteine humaine possedant un domaine www et polynucleotide codant cette nucleoproteine
EP1148125A4 (fr) * 1999-11-24 2002-06-12 Japan Science & Tech Corp Nucleoproteine humaine possedant un domaine www et polynucleotide codant cette nucleoproteine
WO2001042294A2 (fr) * 1999-12-13 2001-06-14 Arbor Vita Corporation Proteine transmembranaire clasp-4
WO2001042294A3 (fr) * 1999-12-13 2002-01-03 Arbor Vita Corp Proteine transmembranaire clasp-4
WO2001072772A2 (fr) * 2000-03-30 2001-10-04 Merck Patent Gmbh Nouvelle sous-unité de régulation de la fixation du calcium
WO2001072772A3 (fr) * 2000-03-30 2001-12-13 Merck Patent Gmbh Nouvelle sous-unité de régulation de la fixation du calcium
WO2003014298A2 (fr) * 2001-08-03 2003-02-20 Origene Technologies, Inc. Polynucleotides et polypeptides selectifs pour la prostate et presentant une longueur totale de chaine
WO2003014298A3 (fr) * 2001-08-03 2004-12-02 Origene Technologies Inc Polynucleotides et polypeptides selectifs pour la prostate et presentant une longueur totale de chaine
WO2003100047A1 (fr) * 2002-05-23 2003-12-04 Elbion Ag Clonage, expression et caracterisation de la sequence complete d'une phosphodiesterase 8b
WO2004042077A3 (fr) * 2002-11-08 2005-01-13 Bayer Healthcare Ag Diagnostics et traitements de maladies associees a la phosphodiesterase 8b humaine (pde8b)
EP1572104A2 (fr) * 2002-11-14 2005-09-14 Kirk Sperber Induction de l'apoptose par des cellules monocytiques infectees par le vih-1
EP1572104A4 (fr) * 2002-11-14 2007-01-17 Kirk Sperber Induction de l'apoptose par des cellules monocytiques infectees par le vih-1
US8148320B2 (en) 2005-12-01 2012-04-03 New York Blood Center, Inc. Peptide inhibitors of ABL kinases

Also Published As

Publication number Publication date
CA2374909A1 (fr) 2000-12-21
AU5619100A (en) 2001-01-02
WO2000077040A9 (fr) 2002-08-01
EP1203081A2 (fr) 2002-05-08
JP2003530071A (ja) 2003-10-14
WO2000077040A3 (fr) 2001-04-26

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