WO2000076956A3 - Enantiomers of n-desmethyl venlafaxine - Google Patents

Enantiomers of n-desmethyl venlafaxine Download PDF

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Publication number
WO2000076956A3
WO2000076956A3 PCT/US2000/016439 US0016439W WO0076956A3 WO 2000076956 A3 WO2000076956 A3 WO 2000076956A3 US 0016439 W US0016439 W US 0016439W WO 0076956 A3 WO0076956 A3 WO 0076956A3
Authority
WO
WIPO (PCT)
Prior art keywords
enantiomers
desmethyl venlafaxine
desmethyl
venlafaxine
well
Prior art date
Application number
PCT/US2000/016439
Other languages
French (fr)
Other versions
WO2000076956A2 (en
Inventor
John Patrick Yardley
Andre Alfred Asselin
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Priority to AU56136/00A priority Critical patent/AU5613600A/en
Publication of WO2000076956A2 publication Critical patent/WO2000076956A2/en
Publication of WO2000076956A3 publication Critical patent/WO2000076956A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention provides enantiomers of N-Desmethyl venlafaxine, as well as their use in pharmaceutical compositions and medically useful treatments, particularly including central nervous system uses.
PCT/US2000/016439 1999-06-15 2000-06-14 Enantiomers of n-desmethyl venlafaxine WO2000076956A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56136/00A AU5613600A (en) 1999-06-15 2000-06-14 Enantiomers of n-desmethyl venlafaxine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33320799A 1999-06-15 1999-06-15
US09/333,207 1999-06-15

Publications (2)

Publication Number Publication Date
WO2000076956A2 WO2000076956A2 (en) 2000-12-21
WO2000076956A3 true WO2000076956A3 (en) 2001-06-28

Family

ID=23301803

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016439 WO2000076956A2 (en) 1999-06-15 2000-06-14 Enantiomers of n-desmethyl venlafaxine

Country Status (2)

Country Link
AU (1) AU5613600A (en)
WO (1) WO2000076956A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
AU2003281158A1 (en) * 2002-07-12 2004-02-02 Arakis Ltd. The treatment of emesis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5788986A (en) * 1995-04-06 1998-08-04 Trustees Of Tufts College Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression using R enantiomers, S enantiomers, and racemic mixtures of selective serotonin reuptake inhibitor compounds or their active metabolites
WO2000032555A1 (en) * 1998-12-01 2000-06-08 Sepracor Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
WO2000032556A1 (en) * 1998-12-01 2000-06-08 Sepracor Inc. Derivatives of (-)-venlafaxine and methods of preparing and using the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5788986A (en) * 1995-04-06 1998-08-04 Trustees Of Tufts College Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression using R enantiomers, S enantiomers, and racemic mixtures of selective serotonin reuptake inhibitor compounds or their active metabolites
WO2000032555A1 (en) * 1998-12-01 2000-06-08 Sepracor Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
WO2000032556A1 (en) * 1998-12-01 2000-06-08 Sepracor Inc. Derivatives of (-)-venlafaxine and methods of preparing and using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YARDLEY J P ET AL: "2-PHENYL-2-(1-HYDROXYCYCLOALKYL)ETHYLAMINE DERIVATIVES: SYNTHESIS AND ANTIDEPRESSANT ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY. WASHINGTON,US, vol. 33, 1990, pages 2899 - 2905, XP000891765, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
AU5613600A (en) 2001-01-02
WO2000076956A2 (en) 2000-12-21

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