WO2000076582A1

WO2000076582A1 - Method and apparatus for ion transport activation

Info

Publication number: WO2000076582A1
Application number: PCT/PL1999/000031
Authority: WO
Inventors: Feliks Jaroszyk; Janusz BORCZYŃSKI; Janusz CHUDORLIŃSKI; Waldemar Deka; Michał GRĄDZKI; Janusz Paluszak; Aleksander SIEROŃ
Original assignee: Med Life Polska Sp. Z O.O.
Priority date: 1999-06-14
Filing date: 1999-09-15
Publication date: 2000-12-21
Also published as: RU2002118595A; PL194547B1; CA2409245C; PL333729A1; EP1299154A1; CA2409245A1; RU2232597C2

Abstract

A method of ion transport activation through cell membranes and capillary walls of living organisms consists in an influence of pulsed very low frequency electromagnetic field, generated by electric current pulses. Two types of signals are used, as well as their combinations in a form of consecutive packets, packet groups, packet group series, packet group series sets and combinations of packet group series, for a purpose to create simultaneous magnetomechanical and electrodynamic influence on ions of different elements, giving rise to ion cyclotron resonance. An apparatus for ion transport activation contains control and supervision panel (PS) connected to infrared radiation receiver (IR) remotely controlled from remote infrared radiation transmitter (P). A control and supervision panel (PS) is connected to a microprocessor control unit (MUS) containing RAM memory and non-volatile EEPROM memory. Microprocessor control unit (MUS) is connected - by voltage amplifier (W), symmetrical current source (IS) and execution circuit (UW) - to current pulse-to-magnetic signal converter (PA).

Description

Method and apparatus for ion transport activation

Background of the invention

The present invention relates to a method of ion movement activation, especially through cell membranes and capillary walls in living organisms, and apparatus for application of this method.

Known ion movement methods are based on pulsed very low frequency electromagnetic field impact on living organisms. Magnetic fields with negligible electric component are generated by electric current pulses. A method and aparatus for ion movement through cell membranes is known from EP 0407006 European Patent Application. A method disclosed is based on a simultaneous activation of different ionic species, Ca⁺⁺ and Mg⁺⁺ in particular, using magnetic cyclotron resonance frequency. An effect of uniform very low frequency magnetic fields generated by sinusoidal electric current pulses of non-zero average value is used for this purpose, when field lines are parallel to the axis on which a part of the living organism is located. Sinusoidal electric pulses produce changes of magnetic flux at the cyclotron resonance frequency, determined by the equation f_c = Bq/2πm, where f_c - is fluctuating magnetic field frequency, in Hz; q/m - is ion charge-to-mass ratio, in C/kg; B - is average flux density along the axis, in Tesla.

An apparatus for using the method according the above patent application comprises a generator of sinusoidal electric pulses which is connected to a constant and defined direct current circuit and to an amplifier, outputs of both are controlled with the switch controlling a pair of Helmholtz coils which operate as electrical pulse to magnetic signal converter.

In another embodiment shown in European patent EP 0594655, a basic current pulse consisting of a square wave superimposed onto an exponentially increasing current is used for ion transportation, then an interruption as long as at least pulse duration follows. Pulses and interruptions form a 100 to 1000 Hz wave. Pulse amplitude is modulated with a 0,5 to 35 Hz signal, modulation envelope is triangular (close to an isosceles triangle). Modulated basic pulse string of constant polarisation forms a packet 0,3 to 1 second long, then a 0,7 to 5,0 seconds interruption follows. Pulse packets are converted into alternating magnetic field signals, electrodynamically and magnetomechanically influencing ions and especially protons to cause their transport through cell membranes.

An apparatus for ion transport as described in the patent discussed consists of a control desk connected to a microprocessor control unit and then, by an amplifier, with a transmitting coil which converts current pulses into magnetic signals. A control circuit consists of microprocessor, clock generator, memory, address generator and analog-to-digital converter.

Brief summary and objects of the invention

According to the present invention, a method of ion transport activation through cell membranes and capillary walls in live organisms is based on the effects of pulsed very low frequency electromagnetic field generated by electric current pulses. Two types of signals are used, as well as their combinations into consecutive packets, packet groups, packet group series, sets of packet group series, combined sets of packet groups series. They magnetomechanically and electrodynamically influence ions of different elements, giving rise to ion cyclotron resonance in live organisms cells. As a result of magnetic field electrodynamic impact on an approximately cylindrically shaped biological system, electric field is induced. Field intensity E depends upon induction change rate dB/dt according to the equation

E =

2 ώ where r is cylinder radius. The alternating field E induces inductive ion currents of density j as defined in the equation j = δ₀ ^• E where δ₀ is electrical conductivity of the biological system. When 10 mA/m² current density is exceeded, carbohydrates metabolism changes occur and lipid cell membranes permeablity changes, facilitating ion transport through cell membranes.

An effect of iόri cyclotron resonance is associated with ion eddy current phenomenon. Both pulsation ω and linear cyclotron resonance frequency f_c = ϋ)J2π depend upon magnetic field induction B in a particular place of living organism and upon its charge q-to mass-m ratio according to the formula ω_c = 2πf_c = B ^• -3- m

Magnetomechanical effect on a biological system consists in the creation of magnetomechanical force F, causing the movement of particles and atoms with non-compensated spins. Magnetomechanical force F is a result of magnetic field induction B gradient dB/dx and can be expressed as the equation

(μ '-- \\))VV dd_B

F B μ₀ JY where:

V - is the volume of uncompensated spins μ is the relative magnetic permeability of a biological system μ₀ - is the magnetic permeability of vacuum.

Characteristics of induction B as a function of time B = f(t) for both types of signals used in the present invention are open polygon lines, increasing from zero to B_max. The characteristic of the first type of signal is an open polygon line consisting of seven sections of 3,0 to 9,4 ms total duration. Within its first section, induction increases linearly from zero to 1/3 B_max during 0,5 to 1 ,6 ms. Within its second section, which is parallel to f axis, induction has constant value of 1/3 B_max during 0,5 to 1 ,2 ms then, within its third section it increases linearly from 1/3 B_max to 2/3 B_max during 0,4 to 1 ,5 ms. Within its fourth section which is parallel to f axis, induction is kept constant on the 2/3 B_max value during 0,1 to 0,5 ms. Within its fifth section, induction increases linearly to B_max during 0,5 to 1,5 ms. Within its sixth section, which is nearly perpendicular to t axis, induction sharply decreases to zero during 0,1 ms or less, remaining at zero value within its seventh section during 0,5 to 1 ,5 ms. The characteristic of the second type of signal is shaped as an open polygon line consisting of five sections of 5.0 to 9,4 ms total duration. Within its first section, induction increases linearly to 1/2 B_max value during 0,7 to 1 ,3 ms. Within its second section, which is parallel to f axis, induction is kept constant on the 1/2 B_max value during 1 ,8 to 2,8 ms then, within its third section, it increases linearly to B_max during 0,5 to 1 ,2 ms. Within its fourth section, which is nearly perpendicular to t axis, induction sharply decreases to zero within maximum 0,1 ms, remaining at zero value within its fifth section during 1 to 2 ms. For both types of signal, induction B does not overrun the effective value of B_sk =

100 μT. Its linear increase, shown on B = f(t) characteristics in a form of sections inclined relative to t axis, causes mainly electrodynamic and magnetomechanical effect.

On the other hand, induction which is kept constant on 1/3 B_max, 2/3 B_max and 1/2 B_max levels and is shown on B = f(t) characteristics as sections parallel to axis, gives rise to ion cyclotron resonance mainly. Alternating magnetic field frequencies are ion resonance frequencies f_c of different elements. Ratios of f_c to induction B of alternating magnetic field are equal to the ratio of a particular element's ion electric charge to ion mass.

In the method according to the present invention signals of both types are combined into packets, each of which consists of consecutive particular signals string, an interruption is included between consecutive packets, duration of the interruption between consecutive first type signals is longer than duration ot the interruption between consecutive second type signals. Packets consisting of four first type signals and five second type signals are the most frequently used. The first type signal packet duration is 10 to 50 ms and interruption duration is 40 to 60 ms. The second type signal packet duration is 20 to 30 ms, interruption duration is 20 to 50 ms.

A combination of packets formed into packet groups of both signal types is also used. Each group consists of a particular type signal packet series, with an interruption between consecutive groups. The first type signal packets lasts for 250 to 400 ms, interruption duration is 40 to 60 ms.

The second type signal packets lasts for 140 to 300 ms, interruption duration is 80 to 200 ms. It is advantageous to use the first type signal packet groups containing at least five packets and the second type signal packet groups containing at least four packets. Moreover, combinations of packet groups into series and then combinations of series into sets is used. Each series consists of a particular signal packet groups sequence, the interruption appears between consecutive packet group series.

The first type signal packet group series duration is 7 to 10 s, an interruption between series lasts for 3 to 4 s.

The second type signal packet group series duration is 5 to 9 s, an interruption between series lasts for 2 to 4 s.

A series of the first type signal packet groups consists usually of twenty to twenty six groups, advantageously - of twenty four groups, when a series of the second type signal packet groups consists twenty to twenty four groups, advantageously

- of twenty two groups. Combination of series into sets is used, each set consists of a particular type signal packet group series sequences. The duration of first and second type signal packet group series lies between 90 and 240 s.

Positive and negative polarisation, usually alternating, is used for a set of packet group series of particular signal type. It is advantageous when the first type signal packet group series set consists of at least ten series and when the second type signal packet group series set consists of at least twelve series.

Signal amplitude in both type signal packet group sets is kept on a specified level not exceeding the effective value of B_sk = 100 μT, and/or is changed stepwise up in the consecutive series. Combinations of the first and the second type signal packet group series sets in a form of at least two first type signal packet groups series sets, after which at least two second type signal packet group sets follow, are the most frequently used. Different set polarisation of neigbouring sets is used.

An apparatus for ion transport activation according to the present invention consists of control and supervision panel with control pushbuttons and signal lamps, connected to a microprocessor control unit with a generator and memory, as further to an amplifier. The amplifier is connected to a converter and dummy load by a symmetrical current source and execution system. The execution system is directly connected to the microprocessor control system. A current pulse-to-electromagnetic signal converter is usually made as a magnetic applicator containing at least one electromagnetic coil generating the nonuniform magnetic field. The control and supervision panel is conected to an infrared radiation receiver, controlled by a remote controller. The microprocessor control unit contains a memory, advantageously of RAM type for direct control, and non- volatile EEPROM memory for external apparatus functions programming. RAM memory contains shapes of current signals of both types, their sequence of occurence, combinations and forms of packets, packet groups, packet group series, packet group series sets with time relations taken into consideration, and amplitude changes. The non-volatile EEPROM memory contains ready-made programs of signals combinations into packets, packet groups, packet group series and sets of packet group series with time relations and amplitude changes taken into consideration. The voltage amplifier contains two operational amplifiers. Voltage amplifier input is connected directly to the first operational amplifier non-inverting input and - by a resistor - to the second operational amplifier inverting input. The second operational amplifier, together with four resistors, forms a differential amplifier with its non-inverting imput connected to the first operational amplifier output. Parallel-connected circuits consisting of a resistor in series with a key are connected between ground and first operational amplifier inverting input to create first operational amplifier negative feedback circuit. Voltage amplifier output is the second operational amplifier output.

Voltage amplifier output voltage changes depend upon keys switched on, according to the formula:

and Uwy = 0 for n = 0, where

Uwy - is amplifier output voltage, and U_we - is amplifier input voltage.

A method according to the present invention of ion transport activation through living organisms cell membranes under the influence of nonuniform very low frequency magnetic field ensures an increase in number of transported ions of a particular element and in number of types of elements, ions of which are transported. This effect is a result of introduction of two types of magnetic signals with characteristics shaped according to the present invention, resulting in simultaneous occurence of three effect types: electrodynamic effect, magnetomechanical effect and ion cyclotron resonance effect. Possibility of combining signals into packets, packet groups, packet group series and packet group series sets, along with a possibility of duration and amplitude changes, enables quantitative and qualitative control of a wide range of ions transported by changing a share of a particular magnetic field influence type. The apparatus for application of ion transport activation method, fitted with microprocessor control unit connected to an amplifier and converter by the symmetrical current source enables the generation, amplification and transmission of two signal types with characteristics according to the present invention.

RAM memory of microprocessor control unit permits direct setting of both signals combinations of packets, packet groups, packet group series and sets of packet group series with appropriate durations and amplitude changes, all controlled from control panel. Fitting microprocessor control unit with remote controller and infrared radiation receiver as well as with additional EEPROM memory enables a choice and switching of signal combination sets already created, duration and amplitude changes taken into account,

An essential merit of such a solution is the possibility of remotely switching the apparatus on with no exposure of personnel on the long-term magnetic field influence. The binary-controlled voltage amplifier with parallel-connected resistor and key series circuits guarantees that output amplitude control depends upon program chosen. Moreover, fitting the apparatus with dummy-loaded execution circuit enables the simulation of apparatus operation.

Brief description of the drawings

Fig. 1 illustrates the characteristic of induction B changes as a function of the first type signal duration;

Fig, 2 illustrates the characteristic of induction B changes as a function of the second type signal duration;

Fig. 3 presents the characteristic of induction B changes as a function of time for a packet of four first type signals;

Fig. 4 illustrates the characteristic of induction B changes as a function of time for a packet of five second type signals; Fig. 5 illustrates the characteristic of induction B changes as a function of time for a group of five first type signal packets;

Fig. 6 presents the characteristic of induction B changes as a function of time for a group of four second type signal packets;

Fig. 7 illustrates the characteristic of induction B changes as a function of time for a series of twenty four first type signal packet groups;

Fig. 8 illustrates the characteristic of induction B changes as a function of time for a series of twenty two second type signal packet groups; Fig. 9 presents the characteristic of induction B changes as a function of time for two sets of fifteen first type signal packet group series each;

Fig. 10 illustrates the characteristic of induction B changes as a function of time for two sets of eighteen second type signal packet group series each;

Fig. 11 illustrates the characteristic of induction B changes as a function of time for two sets of ten first type signal packet group series each;

Fig. 12 illustrates the characteristic of induction B changes as a function of time for two sets of twelve first type signal packet group series each;

Fig. 13 illustrates the characteristic of induction B changes as a function of time for a combination of two sets of the first type signal packet group series with two sets of second type signal packet group series;

Fig. 14 presents the characteristic of induction B changes as a function of time for a combination of two sets of the second type signal packet group series with two sets of the first type signal packet group series;

Fig. 15 illustrates the characteristic of induction B changes as a function of time for a combination of two sets of the second type signal packet group series and two sets of the first type signal packet group series with amplitude increasing stepwise within each set; Fig. 16 illustrates the characteristic of induction B changes as a function of time for a combination of two sets of the first type signal packet group series and two sets of the second type packet group series with amplitude increasing stepwise within the first set and decreasing stepwise within the last set; Fig. 17 is the block schematic of the apparatus for ion transport activation; Fig. 18 is the schematic drawing of voltage amplifier.

Detailed description of preferred embodiments

Example 1

A method of ion transport activation consists in the application of two signal types and their combinations in a form of consecutive packets, packet groups, packet group series, packet group series sets and combinations of packet group series sets. For both signals, characteristics of induction B changes as a function of time f are shaped as two different open polygon lines.

The line for the first type signal as shown in Fig.1 is formed of seven a, b, c, d, e, f, g sections of T., = 5,33 ms total duration. Within its first section a of t, = 1 ,2 ms duration, induction increases linearly from zero to 1/3 B_max = 30 μT, then it remains constant at this value for time t₂ = 0,8 ms within section b. Within section c, induction increases to 2/3 B_max = 60 μT during t₃ = 1 ,0 ms, then it remains constant at this value for time t₄ = 0,3 ms within section d. Further on, induction B increases linearly within section e up to B_max = 90 μT during t₅ = 0,95 ms, then within section f it sharply decreases to zero during t₆ = 0,08 ms, remaining within section g at zero value during t₇ = 1 ms. The line for the second type signal as shown in Fig.2 is formed of five k, I, m, n, r sections of T₂ = 5,53 ms total duration. Within its section k of t,'= 0,9 ms duration induction increases linearly from zero to 1/2 B_max = 40 μT, then remains constant at this value for time t₂ - 2,3 ms within section I. Within section m it increases linearly to B_max = 80 μT during t₃' = 0,75 ms, then sharply decreases within section n to zero during t₄' = 0,08 ms and remains zero within section r during t₅' = 1 ,5 ms. The linear induction increase as shown within a, c, e sections of the first type signal characteristic and k, m sections of the second type signal characteristic gives rise to electrodynamic and magnetomechanical effects mainly. The constant induction within b, d sections (B = 30 μT and B = 60 μT respectively) for the first type signals and within I section (B = 40 μT) for the second type signal gives rise to ion cyclotron resonance mainly, of which frequencies f_c for ions of different elements are equal to frequencies of alternating magnetic field. The ratio of f_c frequencies to induction B of alternating magnetic field is equal to the ratio of a given element's ion electric charge q to its mass m ₌ 1 B m

Ion cyclotron resonance frequencies f_c for selected ions of living organisms body fluids as a function of alternating magnetic field induction are shown in Table 1. Table 1

Table 2 shows the ratio of electric charge q to ion mass m for elements from the Table 1.

Table 2

Combination of both signal types into packets is used. The first type signal packet as shown in Fig. 3 consists of four consecutive signals of T_p1 = 21 ,32 ms total duration. An interruption of t_p1 = 50 ms duration between packets is used. The second type signal packet as shown in Fig. 4 consists of five signals of T_p2 = 27,65 ms total duration with interruption between packets of t_p2 = 35 ms duration. In turn, packets are combined into one type signal groups. The first type signal packets group as shown in Fig. 5 contains five packets four signals each. Total packets group duration is T_g1 = 306,6 ms, the interruption between packet groups is of t_g1 = 50 ms duration. The second type signal packet group as shown in Fig. 6 contains four packets, five signals each. Total packet group duration is T_g2 = 215,6 ms with interruption between packet groups being of t_g2 = 130 ms duration.

Packet groups are combined into first type signal packet group series. The first type signal packet group series as shown in Fig. 7 consists of twenty four groups, five packets each. Total series duration is T_s1 = 8,5 s with interruption between series of t_s1 = 3,5 s duration. The second type signal packet group series as shown in Fig. 8 consists of twenty two groups, four packets each. Total series duration is T_s2 = 7,5 s with interruption between series of t_s2 of 2,5 s duration. Packet group series are further combined into sets of one signal type. Set of the first signal type packet group series as shown in Fig. 9 contains fifteen series twenty four groups each. Set duration is T_z1 = 3 minutes. Polarization of consecutive sets alternates between positive and negative. Set of the second signal type packet group series as shown in fig. 12 contains twelve series, twenty two groups each. Set duration is T_z2 = 2 minutes. Alternating positive and negative polarization is used in consecutive sets. Program I of 10 minutes duration as shown in Fig. 13 is used for living organisms. It is the combination of two sets of the first type signal packet group series, three minutes each, and of two sets of the second type signal packet group series, two minutes each. Consecutive sets change their polarisation into a reverse one.

Example 2 Series of the first and the second type signals as described in Example 1 and combined into sets are used. A set of the first type signal packet group series as shown in Fig. 11 contains ten series, twenty four groups each, total T_z1 = 2 minutes duration. Alemating positive and negative polarisation is used in consecutive sets. The set of the second type signal packet group series as shown in Fig. 10 contains eighteen series, twenty two groups each, total T_ώ = 3 minutes duration.

Alernating positive and negative polarisation is used in consecutive sets.

Program II of 10 minutes duration as shown in Fig. 14 is used for living organisms. It is the combination of two sets of the second type signal packet group series, three minutes each, and of two sets of the first type signal packet group series, two minutes each. Consecutive sets change their polarisation into a reverse one. Example

Series of the first and the second type signals as described in Example 1 and combined into sets are used. Program III of 15 minutes duration as shown in Fig. 15 is used for living organisms. It is a combination of two second type signal packet group series and two first type signal packet group series.

The second type signal sets duration is six minutes. One set contains twelve series of two minutes total duration and the next set contains twenty four series of four minutes total duration.

The first type signal sets duration is six minutes. One set contains twenty series and lasts for four minutes and the next set contains ten series and lasts for two minutes.

The amplitude of each series is changed stepwise within a cycle from minimum induction value to the set B_s value, the same cycle is repeated in all sets.

Example 4

Series of the first and the second type signals as described in Example 1 and combined into sets are used. Program IV of twelve minutes duration as shown in Fig. 16 is used for living organisms. It is a combination of two first type signal packet group series and two second signal type packet group series.

The first type signal sets duration is six minutes. One set contains ten series of two minutes total duration and the next set contains twenty series of four minutes total duration.

The second type signal sets duration is six minutes. One set contains twenty four series of four minutes total duration and the next set contains twelve series of two minutes total duration. Within the first set, series amplitude is changed stepwise from minimum induction value to 0,8 B_sk.

Within central sets, series amplitude is constant and equal to B_sk. Within the last set, series amplitude changes from 0,8 B_sk to minimum induction value.

Example 5

The apparatus for ion transport activation as shown in Fig. 17 consists of control and supervision panel PS with control pushbuttons and signal lamps, connected to a microprocessor control unit MUS with a generator as well as with RAM and EEPROM memories, and followed by amplifier W. Amplifier W is connected by symmetrical current source IS and execution system UW to the converter PA and dummy load PL. Execution system UW is connected directly to the microprocessor control unit MUS. The control and supervision panel PS is connected to the infrared radiation receiver IR, controlled with the use of remote controller P. Microprocessor control unit MUS contains RAM memory for direct control operations and an additional non-volatile EEPROM memory for equipment functions programming from the outside world. RAM memory contains shapes of current signals of two types, their sequence of occurence, combinations of signals into packets, packet groups, packet group series and packet group series sets, taking into consideration their time relations and amplitude changes. Non-volatile EEPROM memory contains ready-made programs of packet group series sets combination blocks, time relations and amplitude changes taken into consideration.

Voltage amplifier as shown in Fig. 18 contains two operational amplifiers W1 and W2. Voltage amplifier input WE is direcltly connected to the first operational amplifier W1 non-inverting input (+) and is connected by the resistor R1 to the second operational amplifier inverting input (-). Operational amplifier W2 together with four resistors R1 operates as differential amplifier with its non- inverting (+) input connected to the first operational amplifier W1 output.

Between ground and first amplifier W1 inverting (-) input, circuits consisting of keys K1, K2, K3....Kn series connected with R, R/2, R/4, ...R/²"-¹ resistors are connected in parallel as the first operational amplifier W1 negative feedback circuit. Output of the second operational amplifier W2 serves as WY output of voltage amplifier W simultaneously. Voltage amplifier W output voltage U^ is changed depending upon K1 , K2, K3....Kn keys switched on, according to the formula

U_wy = U_w,∑2-¹ for n > 1

1 and U^ = 0 for n = 0 where:

U^ is amplifier W output voltage, and

U_we is amplifier W input voltage.

The apparatus is started after program is chosen and pushbuttons on control panel PS or remote controller P are switched on. Microprocessor control unit MUS generates two pulse types and their combinations into packets, packet groups, packet group series, packet group series sets and combinations of packet group series sets, stored in RAM and EEPROM memories in a digital form. Signal amplitude is controlled by binary controlled amplifier W. Amplifier output voltage U^ is changed depending upon the status of K1 ,

K2,...Kn keys in feedback circuitry. Voltage amplifier W drives the symmecthcal current source IS, which enables non-contact polarisation switching of pulses which drive PA converter through execution circuit UW when operated in its basic state. Current pulses are converted in PA converter into signals of alternating magnetic field that effect a living organism. When the apparatus operation is simulated, execution circuit UW is switched into the second state, in which it is loaded with dummy load PL.

Claims

1. A method of ion transport activation through cell membranes and capillary walls of living organisms, consisting in the influence of very low frequency pulsed electromagnetic field generated by electric current pulses, characterized in that two signal types and their combinations in a form of consecutive packets, packet groups, packet group series, packet group series sets and combinations of packet group series sets are used for the purpose of obtaining a simultaneous magnetomechanical and electrodynamic influence on ions of different elements giving also rise to ion cyclotron resonance, characteristics of induction B as a function of time B = f(t) are open polygon line-shaped, different for both signal types and increasing from zero to B_max, where the first signal type characteristic is open polygon line consisting of seven sections (a, b, c, d, e, f, g) of total duration (T-,) between 3,0 and 9,4 milliseconds, induction increases linearly within the first section (a) from zero to 1/3 B_max and remains at this level within the second section (b) which is parallel to t axis, then within the third section (c) induction increases linearly from 1/3 B_max to 2/3 B_max and remains at the last value within the fourth section (d) which is parallel to f axis, further it increases to B_max linearly within the fifth section (e) and then it sharply decreases to zero within the sixth section (f) which is nearly perpendicular to axis, then remaining zero within the seventh section (g), moreover, the second type signal characteristic is also open polygon line consisting of five sections (k, I, m, n, r) of total duration (T₂) between 5,0 and

9,4 milliseconds, where induction increases linearly within the first section (k) from zero to 1/2 B_max and remains at this level within the second section (I) which is parallel to t axis, then within the third section (m) induction increases linearly from 1/2 B_max to B_max, and further it sharply decreases to zero within the fourth section (n) which is nearly perpendicular to r axis and remains at zero level within the fifth section (r), when effective induction values for both signal types are not higher than B_sκ = 100 μT, and where linear induction B increase shown as sections (a, c, e) and (k, m) inclined relative to f axis in both type signals characteristics gives rise to electrodynamic and electromechanical influence mainly, and constant induction B kept at 1/3 B_max, 2/3 B_max and 1/2 B_max and shown as sections (b, d) and (I) parallel to f axis gives rise to ion cyclotron resonance mainly.

2. A method according to claim 1 , characterized in that the first type signal is used in which the first section (a) duration (t.,) is between 0,5 and 1 ,6 millisecond, the second section (b) duration (t₂) is between 0,5 and 1 ,2 millisecond, the third section (c) duration (t₃) is between 0,4 and 1 ,5 millisecond, the fourth section (d) duration (t₄) is between 0,1 and 0,5 millisecond, the fifth section (e) duration (t₅) is between 0,5 and 1,5 millisecond, the sixth section (f) duration (t₆) is not longer than 0,1 millisecond and the seventh section (g) duration (t₇) is between 0,5 and 1 ,5 millisecond; the second type signal is used as well, in which the first section

(k) duration (t.,) is between 0,7 and 1 ,3 millisecond, the second section (I) duration (t₂) is between 1 ,8 and 2,8 millisecond, the third section (m) duration (t₃) is between 0,5 and 1,2 millisecond, the fourth section (n) duration (t₄) is not longer than 0,1 millisecond and the fifth section (r) duration (t₅) is between 1 and 2 milliseconds.

3. A method according to claim 2, characterized in that both signal type packets are used, each of which consists of a sequence of successive single signals of a given type and interruption is used between consecutive packets, when the first type signal packet duration (T^) lasts between 10 and 50 milliseconds and interruption duration (t^) lasts between 40 and 60 milliseconds, when the second type signal packet duration (T^) lasts for 20 to 30 milliseconds and duration (t^) of interruption between packets lasts for 20 to 50 milliseconds, moreover, duration (t^) of interruption between consecutive first type signal packets is longer than duration (i^ of interruption between second type signal packets.

4. A method according to claim 3, characterized in that the first type signal packets consisting of at least four signals each are used.

5. A method according to claim 3, characterized in that the second type signal packets consisting of at least five signals are used.

6. A method according to claim 3, characterized in that both signal type packet groups are used, each group consists of a given signal type packet series and interruption is used between consecutive groups, where duration (T_p1) of the first type signal packet group is 250 to 400 milliseconds, and interruption (t_p1) lasts for 40 to 60 milliseconds; moreover, duration (T_p2) of the second type signal packet group is 140 to 300 milliseconds and interruption (t_p1) lasts for 80 to 200 milliseconds;

7. A method according to claim 6, characterized in that the first type signal packet groups consisting of at least five packets each are used.

8. A method according to claim 6, characterized in that the second type signal packet groups consisting of at least four packets each are used.

9. A method according to claim 6, characterized in that both signal type packet group series are used, each series consists of a given signal type packet groups series and interuption is used between consecutive series, where duration (T_s1) of the first type signal packet group series is 7 to 10 seconds, and interruption period (t_s1) between series is 3 to 4 seconds; moreover, duration (T_s2) of the second type signal packet group series is 5 to 9 seconds, and interruption (t_p1) between series is 2 to 4 seconds;

10. A method according to claim 9, characterized in that the first signal type packet group series are used, each series consists of twenty to twenty six groups where twenty four groups are advantageous.

11. A method according to claim 9, characterized in that the second signal type packet group series are used, each series consists of twenty to twenty four groups where twenty two groups are advantageous.

12. A method according to claim 9, characterized in that both signal type packet group series sets are used, each set consists of a given signal type packet groups series, duration (T_z1, T^) of the first and the second type signal packet group series is between 90 and 240 seconds, as well as positive and negative polarisation is used for a given signal type packet group series set.

13. A method according to claim 12, characterized in that sets of the first signal type packet group series are used, each set consists of ten series at least, where alternating positive and negative polarisation is used for consecutive sets.

14. A method according to claim 12, characterized in that sets of the second signal type packet group series are used, each set consists of twelve series at least, where alternating positive and negative polarisation is used for consecutive sets.

15. A method according to claim 12, characterized in that amplitude of signals in both signal type packet group series sets is kept on a defined level which is not higher than B_sκ = 100 μT of effective value, and/or is changed stepwise in consecutive series.

16. A method according to claim 12, characterized in that combinations of the first and the second type signals packet group series sets are used in a form of at least two first signal type packet group series sets, after which at least two second signal type packet group series sets follow, where opposite polarisation is used for neighbouring sets.

17. An apparatus for ion transport activation containing a control and supervision panel with control pushbuttons and signal lamps, which is connected to a microprocessor control unit with a generator and memory as well as further connected by an amplifier to current pulse-to-electromagnetic signals converter, characterized in that control and supervision panel (PS) is connected to infrared radiation receiver (IR) controlled by remote controller (P), a microprocessor control unit (MUS) contains a memory of RAM type advantageously for direct control and also contains an additional non- volatile EEPROM memory for apparatus function programming from the outside world, where RAM memory contains shapes of current signals of two types, sequence of their occurence, combinations of their setting into packets, packet groups, packet group series, packet group series sets with time relations and amplitude changes taken into account, moreover, a nonvolatile EEPROM memory contains ready-made programs for setting combinations of signals into packets, packet groups, packet grup series, packet group series sets with time relations and amplitude changes taken into consideration, also a binary-controlled voltage amplifier (W) is connected to symmetrical current source (IS) and is further connected to the switching execution circuit (UW) which is driven directly from microprocessor control unit (MUS) and further connected to a converter (PA) and load (PL), the voltage amplifier (W) contains two operational amplifiers (W1 , W2) where voltage amplifier input (WE) is directly connected to the first operational amplifier (W1) noninverting (+) input and - by (R1) resistor - to the second operational amplifier (W2) inverting imput (-), the second operational amplifier (W2) together with four resistors (R1) forms a differential amplifier with its non-inverting input (+) connected to the first operational amplifier (W1) output and, moreover, between the ground and the first operational amplifier (W1) inverting input (-), branches of series connected keys (K-,, K₂, K₃,...K_n) and resistors (R, R/2, R/4, ... R/²"-¹) are connected in the first operational amplifier (W1) negative feedback circuit and voltage amplifier (W) output (WY) is the second operational amplifier (W2) output simultaneously.

18. An apparatus according to claim 17, characterized in that output voltage

(U^) of a voltage amplifier (W) is changed depending upon keys (K_{1 (} K₂, K₃,...K_n) switched on according to the formula U_wy = U_vvp.∑2"-' for n > 1

and U_yyy = 0 for n = 0, where U^ is amplifier output voltage, U_we is amplifier input voltage, and n is an integer.

19. An apparatus according to claim 17, characterized in that current pulse converter (PA) serves as the magnetic applicator.