WO2000076500A8 - Compound for use as a medicament for treatment of disorders involving bronchocontraction - Google Patents

Compound for use as a medicament for treatment of disorders involving bronchocontraction

Info

Publication number
WO2000076500A8
WO2000076500A8 PCT/SE2000/001267 SE0001267W WO0076500A8 WO 2000076500 A8 WO2000076500 A8 WO 2000076500A8 SE 0001267 W SE0001267 W SE 0001267W WO 0076500 A8 WO0076500 A8 WO 0076500A8
Authority
WO
WIPO (PCT)
Prior art keywords
medicament
compound
treatment
disorders involving
bronchocontraction
Prior art date
Application number
PCT/SE2000/001267
Other languages
English (en)
Other versions
WO2000076500A3 (fr
WO2000076500A2 (fr
Inventor
Staffan Skogvall
Original Assignee
Respiratorius Ab
Staffan Skogvall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9902252A external-priority patent/SE9902252D0/xx
Priority claimed from SE9902251A external-priority patent/SE9902251D0/xx
Priority claimed from PCT/SE2000/000819 external-priority patent/WO2000064441A2/fr
Priority to EP00944534A priority Critical patent/EP1185263A2/fr
Priority to JP2001502833A priority patent/JP2003501462A/ja
Priority to AU58619/00A priority patent/AU5861900A/en
Application filed by Respiratorius Ab, Staffan Skogvall filed Critical Respiratorius Ab
Priority to AU2001225664A priority patent/AU2001225664A1/en
Priority to AU2001225663A priority patent/AU2001225663A1/en
Priority to PCT/SE2000/002612 priority patent/WO2001095902A1/fr
Priority to PCT/SE2000/002613 priority patent/WO2001095903A1/fr
Publication of WO2000076500A2 publication Critical patent/WO2000076500A2/fr
Publication of WO2000076500A3 publication Critical patent/WO2000076500A3/fr
Publication of WO2000076500A8 publication Critical patent/WO2000076500A8/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/547—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame spiro-condensed or forming part of bridged ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un composé qui présente une activité d'agoniste du récepteur 5-HT4 et qui est destiné à être utilisé comme médicament, l'utilisation dudit composé dans la fabrication d'un médicament destiné à être utilisé dans le cadre d'un traitement thérapeutique ou prophylactique de troubles impliquant une bronchoconstriction chez l'homme ou chez l'animal, et des méthodes de traitement basées sur l'administration desdits composés. La présente invention concerne également un composé qui présente une activité d'antagoniste du récepteur 5-HT3 et qui est destiné à être utilisé comme médicament, l'utilisation dudit composé dans la fabrication d'un médicament destiné à être utilisé dans le cadre d'un traitement thérapeutique ou prophylactique de troubles impliquant une bronchoconstriction chez l'homme ou chez l'animal, et des méthodes de traitement basées sur l'administration desdits composés.
PCT/SE2000/001267 1999-06-15 2000-06-15 Compound for use as a medicament for treatment of disorders involving bronchocontraction WO2000076500A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP00944534A EP1185263A2 (fr) 1999-06-15 2000-06-15 Agonistes et antagonistes de recepteurs
JP2001502833A JP2003501462A (ja) 1999-06-15 2000-06-15 受容体アゴニストおよびアンタゴニスト
AU58619/00A AU5861900A (en) 1999-06-15 2000-06-15 Receptor agonists and antagonists
PCT/SE2000/002613 WO2001095903A1 (fr) 2000-06-15 2000-12-20 Antagonistes du recepteur 5-ht3 destines au traitement de troubles englobant la constriction des voies aeriennes
PCT/SE2000/002612 WO2001095902A1 (fr) 2000-06-15 2000-12-20 Composition contenant une association d'agonistes et d'antagonistes d'un recepteur
AU2001225664A AU2001225664A1 (en) 2000-06-15 2000-12-20 5-ht3 receptor antagonists for treatment of disorders involving airway constriction
AU2001225663A AU2001225663A1 (en) 2000-06-15 2000-12-20 A composition comprising a combination of receptor agonists and antagonists

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
SE9902252A SE9902252D0 (sv) 1999-06-15 1999-06-15 Medicinskt preparat
SE9902252-7 1999-06-15
SE9902251-9 1999-06-15
SE9902251A SE9902251D0 (sv) 1999-06-15 1999-06-15 Medicinskt preparat
US13963299P 1999-06-17 1999-06-17
US13963399P 1999-06-17 1999-06-17
US60/139,632 1999-06-17
US60/139,633 1999-06-17
PCT/SE2000/000819 WO2000064441A2 (fr) 1999-04-28 2000-04-28 Medicament
SEPCT/SE00/00819 2000-04-28

Publications (3)

Publication Number Publication Date
WO2000076500A2 WO2000076500A2 (fr) 2000-12-21
WO2000076500A3 WO2000076500A3 (fr) 2001-07-12
WO2000076500A8 true WO2000076500A8 (fr) 2001-08-16

Family

ID=56290034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2000/001267 WO2000076500A2 (fr) 1999-06-15 2000-06-15 Compound for use as a medicament for treatment of disorders involving bronchocontraction

Country Status (5)

Country Link
EP (1) EP1185263A2 (fr)
JP (1) JP2003501462A (fr)
CN (1) CN1355698A (fr)
AU (1) AU5861900A (fr)
WO (1) WO2000076500A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9918425D0 (en) * 1999-08-04 1999-10-06 Novartis Ag Organic compounds
AU2001225664A1 (en) * 2000-06-15 2001-12-24 Respiratorius Ab 5-ht3 receptor antagonists for treatment of disorders involving airway constriction
WO2002036113A1 (fr) * 2000-11-01 2002-05-10 Respiratorius Ab Composition comprenant des agonistes (5ht-4) et des antagonistes (5ht-2, 5ht-3) recepteurs de la serotonine
JP2005533101A (ja) * 2002-07-10 2005-11-04 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー アロステリック阻害剤又はマトリックス金属タンパク質分解酵素−１３の、セレコキシブでもバルデコキシブでもないシクロオキシゲナーゼ−２の選択的阻害剤との組合せ物
US6986901B2 (en) 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
ATE495171T1 (de) 2005-06-07 2011-01-15 Theravance Inc Benzimidazoloncarbonsäureamidverbindungen als agonisten des 5-ht4-rezeptors
GB0901487D0 (en) 2009-01-30 2009-03-11 Movetis N V Asthma Therapy
PL3261645T3 (pl) 2015-02-27 2021-12-06 Dechra Limited Pobudzanie apetytu, zarządzanie utratą masy ciała, i leczenie anoreksji u psów i kotów

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02502185A (ja) * 1987-11-14 1990-07-19 ビーチヤム　グループ　ピーエルシー 咳および気管支収縮の治療用５‐ｈｔ３レセプター拮抗物質
SU1701320A1 (ru) * 1988-03-29 1991-12-30 Рижский Медицинский Институт Способ купировани приступа бронхиальной астмы
FR2696176B1 (fr) * 1992-09-28 1994-11-10 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
CA2236357C (fr) * 1995-11-09 2006-10-17 Synthelabo Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h3

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EP1185263A2 (fr) 2002-03-13
WO2000076500A2 (fr) 2000-12-21
CN1355698A (zh) 2002-06-26
AU5861900A (en) 2001-01-02
JP2003501462A (ja) 2003-01-14

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