WO2000072803A3 - Souche vaccin contre streptococcus pneumoniae et ses applications - Google Patents

Souche vaccin contre streptococcus pneumoniae et ses applications Download PDF

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Publication number
WO2000072803A3
WO2000072803A3 PCT/US2000/015231 US0015231W WO0072803A3 WO 2000072803 A3 WO2000072803 A3 WO 2000072803A3 US 0015231 W US0015231 W US 0015231W WO 0072803 A3 WO0072803 A3 WO 0072803A3
Authority
WO
WIPO (PCT)
Prior art keywords
streptococcus pneumoniae
vaccine strain
pneumoniae vaccine
strains
eliciting immunity
Prior art date
Application number
PCT/US2000/015231
Other languages
English (en)
Other versions
WO2000072803A2 (fr
Inventor
Janet Yother
Ashalla Magee
Original Assignee
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Priority to AU53159/00A priority Critical patent/AU5315900A/en
Publication of WO2000072803A2 publication Critical patent/WO2000072803A2/fr
Publication of WO2000072803A3 publication Critical patent/WO2000072803A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des souches mutantes de Streptococcus pneumoniae qui produisent des niveaux réduits de polysaccharide capsulaire tout en maintenant la capacité à la colonisation. Ainsi, ces mutants offrent de nouveaux moyens potentiels pour éliciter une réponse immunitaire aux infections pneumococciques grâce à l'utilisation d'un vaccin atténué vivant susceptible d'être maintenu dans l'hôte avec un risque moindre de provoquer la maladie. En outre, les antigènes hétérologues peuvent être exprimés dans les souches et servent ainsi de vecteur pour éliciter une réponse immunitaire à d'autres agents infectieux.
PCT/US2000/015231 1999-06-01 2000-06-01 Souche vaccin contre streptococcus pneumoniae et ses applications WO2000072803A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53159/00A AU5315900A (en) 1999-06-01 2000-06-01 LTiGTstreptococcus pneumoniaeLT/iGT vaccine strain and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13692799P 1999-06-01 1999-06-01
US60/136,927 1999-06-01

Publications (2)

Publication Number Publication Date
WO2000072803A2 WO2000072803A2 (fr) 2000-12-07
WO2000072803A3 true WO2000072803A3 (fr) 2002-09-12

Family

ID=22475046

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015231 WO2000072803A2 (fr) 1999-06-01 2000-06-01 Souche vaccin contre streptococcus pneumoniae et ses applications

Country Status (2)

Country Link
AU (1) AU5315900A (fr)
WO (1) WO2000072803A2 (fr)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DILLARD ET AL.: "Characterization of the cassette containing genes for type 3 capsular polysaccharide biosynthesis in streptococcus pneumoniae", J. EXP. MED., vol. 181, 1995, pages 973 - 983, XP002930265 *
DILLARD ET AL.: "Genetic and molecular characterization of capsular polysaccharide biosynthesis in streptococcus pneumoniae type 3", MOLECULAR MICROBIOLOGY, vol. 12, no. 6, 1994, pages 959 - 972, XP002930264 *
HARDY ET AL.: "Capsule biosynthesis and basic metabolism in streptococcus pneumoniae are linked through the cellular phosphoglucomutase", JOURNAL OF BACTERIOLOGY, vol. 182, no. 7, April 2000 (2000-04-01), pages 1854 - 1863, XP002930263 *

Also Published As

Publication number Publication date
AU5315900A (en) 2000-12-18
WO2000072803A2 (fr) 2000-12-07

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WO2000072803A3 (fr) Souche vaccin contre streptococcus pneumoniae et ses applications

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