WO2000072802A3 - Water soluble multi-biotin-containing compounds - Google Patents

Water soluble multi-biotin-containing compounds Download PDF

Info

Publication number
WO2000072802A3
WO2000072802A3 PCT/US2000/015081 US0015081W WO0072802A3 WO 2000072802 A3 WO2000072802 A3 WO 2000072802A3 US 0015081 W US0015081 W US 0015081W WO 0072802 A3 WO0072802 A3 WO 0072802A3
Authority
WO
WIPO (PCT)
Prior art keywords
biotin
water soluble
containing compounds
disclosed
moieties
Prior art date
Application number
PCT/US2000/015081
Other languages
French (fr)
Other versions
WO2000072802A2 (en
WO2000072802A8 (en
Inventor
Scott D Wilbur
Pradip M Pathare
Donald K Hamlin
Ananda S Weerawarna
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Priority to AU53121/00A priority Critical patent/AU5312100A/en
Priority to EP00938025A priority patent/EP1196199A4/en
Publication of WO2000072802A2 publication Critical patent/WO2000072802A2/en
Publication of WO2000072802A8 publication Critical patent/WO2000072802A8/en
Publication of WO2000072802A3 publication Critical patent/WO2000072802A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Water soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water soluble biotin-containing compounds may additionally comprise one or more moieties that confer resistance to cleavage by biotinidase or that is cleavable in vitro or in vivo. The discrete multi-biotin-containing compounds may include a reactive moiety that provides a site for reaction with yet another moiety, such as a targeting, diagnostic or therapeutic functional moiety. Biotinylation reagents comprising water soluble linker moieties are also disclosed and may additionally comprise a biotinidase protective group. Methods for amplifying the number of sites for binding biotin-binding proteins at a selected target using multi-biotin compounds are also disclosed.
PCT/US2000/015081 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds WO2000072802A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU53121/00A AU5312100A (en) 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds
EP00938025A EP1196199A4 (en) 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32426799A 1999-06-02 1999-06-02
US09/324,267 1999-06-02

Publications (3)

Publication Number Publication Date
WO2000072802A2 WO2000072802A2 (en) 2000-12-07
WO2000072802A8 WO2000072802A8 (en) 2001-04-19
WO2000072802A3 true WO2000072802A3 (en) 2002-02-07

Family

ID=23262837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015081 WO2000072802A2 (en) 1999-06-02 2000-06-01 Water soluble multi-biotin-containing compounds

Country Status (3)

Country Link
EP (1) EP1196199A4 (en)
AU (1) AU5312100A (en)
WO (1) WO2000072802A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102822673A (en) * 2010-01-12 2012-12-12 生物梅里埃公司 Method for preparing polybiotinylated compounds

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010023288A1 (en) 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
SE0002287D0 (en) 2000-06-16 2000-06-16 Department Of Radiation Oncolo biotin
DE10151158B4 (en) * 2001-10-19 2004-07-29 Esplora GmbH c/o TU Darmstadt Institut für Biochemie Compounds for labeling cell membrane proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482698A (en) * 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
US5521319A (en) * 1993-01-27 1996-05-28 Huber; Erasmus Biotinylation reagent and method of use thereof
US5714166A (en) * 1986-08-18 1998-02-03 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
US5750357A (en) * 1994-05-18 1998-05-12 Microquest Diagnostics, Inc. Method of rapid analyte detection

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029114A1 (en) * 1996-02-08 1997-08-14 Board Of Regents Of The University Of Washington Biotin-containing compounds, biotinylation reagents and methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714166A (en) * 1986-08-18 1998-02-03 The Dow Chemical Company Bioactive and/or targeted dendrimer conjugates
US5521319A (en) * 1993-01-27 1996-05-28 Huber; Erasmus Biotinylation reagent and method of use thereof
US5482698A (en) * 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
US5750357A (en) * 1994-05-18 1998-05-12 Microquest Diagnostics, Inc. Method of rapid analyte detection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1196199A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102822673A (en) * 2010-01-12 2012-12-12 生物梅里埃公司 Method for preparing polybiotinylated compounds

Also Published As

Publication number Publication date
WO2000072802A2 (en) 2000-12-07
WO2000072802A8 (en) 2001-04-19
EP1196199A2 (en) 2002-04-17
AU5312100A (en) 2000-12-18
EP1196199A4 (en) 2002-06-19

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