WO2000072182A3 - Methods and system for amplitude normalization and selection of data peaks - Google Patents

Methods and system for amplitude normalization and selection of data peaks Download PDF

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Publication number
WO2000072182A3
WO2000072182A3 PCT/US2000/014159 US0014159W WO0072182A3 WO 2000072182 A3 WO2000072182 A3 WO 2000072182A3 US 0014159 W US0014159 W US 0014159W WO 0072182 A3 WO0072182 A3 WO 0072182A3
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WO
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Prior art keywords
data
methods
experimental
experimental data
system
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PCT/US2000/014159
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French (fr)
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WO2000072182A2 (en )
Inventor
Jayson T Durham
Dennis R Grace
Original Assignee
Digital Gene Tech Inc
Jayson T Durham
Dennis R Grace
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    • GPHYSICS
    • G06COMPUTING; CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F19/00Digital computing or data processing equipment or methods, specially adapted for specific applications
    • G06F19/10Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
    • G06F19/20Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation

Abstract

Methods and system for amplitude normalization and selection of data peaks from experimental data including polynucleotide data such as DNA, cDNA or mRNA from biotechnology experiments. The methods and systems include removing spectral overlap, spatially detrending and normalizing a multi-component data signal into experimental data from a desired experiment (e.g., biotechnology data). Standard data sizes are determined and data clutter is rejected for filtered experimental data. Data sizes are calibrated and error removed from experimental data. Data stutter is removed and the number of data values is reduced. The methods and system help automate the processing of experimental data to eliminate or reduce errors and leave processed experimental data in a format suitable for visual display, comparative analysis and other analysis. The methods and systems may help reduce or eliminate inconsistencies in processing experimental data that typically lead to unreliable or erroneous results. The methods and system of the present invention may be used to refine processing of biotechnology data with new techniques that can be used for bioinformatics and for other types of experimental data that are visual displayed (e.g., telecommunications data, electrical data for electrical devices, optical data, physical data, or other data).
PCT/US2000/014159 1999-05-25 2000-05-23 Methods and system for amplitude normalization and selection of data peaks WO2000072182A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US31869999 true 1999-05-25 1999-05-25
US09/318,699 1999-05-25

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000620505A JP2003500662A (en) 1999-05-25 2000-05-23 Method and system for normalization and data peaks choice amplitude
CA 2375180 CA2375180A1 (en) 1999-05-25 2000-05-23 Methods and system for amplitude normalization and selection of data peaks
EP20000936213 EP1190365A2 (en) 1999-05-25 2000-05-23 Methods and system for amplitude normalization and selection of data peaks

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WO2000072182A2 true WO2000072182A2 (en) 2000-11-30
WO2000072182A3 true true WO2000072182A3 (en) 2001-03-15

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PCT/US2000/014159 WO2000072182A3 (en) 1999-05-25 2000-05-23 Methods and system for amplitude normalization and selection of data peaks

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EP (1) EP1190365A2 (en)
JP (1) JP2003500662A (en)
CA (1) CA2375180A1 (en)
WO (1) WO2000072182A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7492372B2 (en) * 2006-02-21 2009-02-17 Bio-Rad Laboratories, Inc. Overlap density (OD) heatmaps and consensus data displays
GB201102385D0 (en) 2011-02-10 2011-03-30 Biocule Scotland Ltd Two-dimensional gel electrophoresis apparatus and method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000708A1 (en) * 1996-06-27 1998-01-08 Visible Genetics Inc. Method and apparatus for alignment of signals for use in dna base-calling
US5853979A (en) * 1995-06-30 1998-12-29 Visible Genetics Inc. Method and system for DNA sequence determination and mutation detection with reference to a standard
WO2000022173A1 (en) * 1998-10-15 2000-04-20 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853979A (en) * 1995-06-30 1998-12-29 Visible Genetics Inc. Method and system for DNA sequence determination and mutation detection with reference to a standard
WO1998000708A1 (en) * 1996-06-27 1998-01-08 Visible Genetics Inc. Method and apparatus for alignment of signals for use in dna base-calling
WO2000022173A1 (en) * 1998-10-15 2000-04-20 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GIDDINGS M C ET AL: "AN ADAPTIVE, OBJECT ORIENTED STRATEGY FOR BASE CALLING IN DNA SEQUENCE ANALYSIS", NUCLEIC ACIDS RESEARCH,OXFORD UNIVERSITY PRESS, SURREY,GB, vol. 21, no. 19, 1993, pages 4530 - 4540, XP000919267, ISSN: 0305-1048 *
LUCKE L ET AL: "A DIGIT-SERIAL ARCHITECTURE FOR GRAY-SCALE MORPHOLOGICAL FILTERING", IEEE TRANSACTIONS ON IMAGE PROCESSING,US,IEEE INC. NEW YORK, vol. 4, no. 3, 1 March 1995 (1995-03-01), pages 387 - 391, XP000501913, ISSN: 1057-7149 *
VERBEEK P W ET AL: "2-D ADAPTIVE SMOOTHING BY 3-D DISTANCE TRANSFORMATION", PATTERN RECOGNITION LETTERS,NL,NORTH-HOLLAND PUBL. AMSTERDAM, vol. 9, no. 1, 1989, pages 53 - 65, XP000098457, ISSN: 0167-8655 *

Also Published As

Publication number Publication date Type
EP1190365A2 (en) 2002-03-27 application
JP2003500662A (en) 2003-01-07 application
WO2000072182A2 (en) 2000-11-30 application
CA2375180A1 (en) 2000-11-30 application

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