WO2000070017A3 - Methods using of fab i and compounds modulating fab i activity - Google Patents

Methods using of fab i and compounds modulating fab i activity Download PDF

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Publication number
WO2000070017A3
WO2000070017A3 PCT/US2000/012104 US0012104W WO0070017A3 WO 2000070017 A3 WO2000070017 A3 WO 2000070017A3 US 0012104 W US0012104 W US 0012104W WO 0070017 A3 WO0070017 A3 WO 0070017A3
Authority
WO
WIPO (PCT)
Prior art keywords
fab
disclosed
methods
polypeptides
activity
Prior art date
Application number
PCT/US2000/012104
Other languages
French (fr)
Other versions
WO2000070017A2 (en
Inventor
Walter E Dewolf
Original Assignee
Smithkline Beecham Corp
Smithkline Beecham Plc
Walter E Dewolf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Smithkline Beecham Plc, Walter E Dewolf filed Critical Smithkline Beecham Corp
Priority to JP2000618423A priority Critical patent/JP2002544291A/en
Priority to EP00935862A priority patent/EP1180164A4/en
Publication of WO2000070017A2 publication Critical patent/WO2000070017A2/en
Publication of WO2000070017A3 publication Critical patent/WO2000070017A3/en
Priority to US10/888,524 priority patent/US20050112713A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Prokayrotic FAB I polypeptides and DNA (RNA) encoding such FAB I and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such FAB I for the treatment of infection, such as bacterial infections. Antagonists against such FAB I and their use as a therapeutic to treat /infections, such as staphylococcal infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of FAB I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding FAB I and for detecting the polypeptide in a host.
PCT/US2000/012104 1996-08-28 2000-05-04 Methods using of fab i and compounds modulating fab i activity WO2000070017A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000618423A JP2002544291A (en) 1999-05-14 2000-05-04 How to use FABI
EP00935862A EP1180164A4 (en) 1999-05-14 2000-05-04 Methods using of fab i and compounds modulating fab i activity
US10/888,524 US20050112713A1 (en) 1996-08-28 2004-07-09 Methods of using Fab I and compounds modulating Fab I activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13436299P 1999-05-14 1999-05-14
US60/134,362 1999-05-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/888,524 Continuation-In-Part US20050112713A1 (en) 1996-08-28 2004-07-09 Methods of using Fab I and compounds modulating Fab I activity

Publications (2)

Publication Number Publication Date
WO2000070017A2 WO2000070017A2 (en) 2000-11-23
WO2000070017A3 true WO2000070017A3 (en) 2001-02-08

Family

ID=22463029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012104 WO2000070017A2 (en) 1996-08-28 2000-05-04 Methods using of fab i and compounds modulating fab i activity

Country Status (3)

Country Link
EP (1) EP1180164A4 (en)
JP (1) JP2002544291A (en)
WO (1) WO2000070017A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6010881A (en) 1996-02-20 2000-01-04 Smithkline Beecham Corporation RibG
EP0956289A4 (en) 1996-08-16 2004-10-13 Smithkline Beecham Corp Novel prokaryotic polynucleotides, polypeptides and their uses
US6995254B1 (en) 1996-08-28 2006-02-07 Affinium Pharmaceuticals, Inc. Polynucleotide encoding the enoyl-acyl carrier protein reductase of Staphylococcus aureus, FAB I
US6951729B1 (en) 1999-10-27 2005-10-04 Affinium Pharmaceuticals, Inc. High throughput screening method for biological agents affecting fatty acid biosynthesis
US7048926B2 (en) 2000-10-06 2006-05-23 Affinium Pharmaceuticals, Inc. Methods of agonizing and antagonizing FabK
EP1648928A2 (en) 2003-07-11 2006-04-26 Affinium Pharmaceuticals, Inc. Novel purified polypeptides from staphylococcus aureus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826774A2 (en) * 1996-08-28 1998-03-04 Smithkline Beecham Corporation Staphylococcal Fab I enoyl-ACP reductase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0826774A2 (en) * 1996-08-28 1998-03-04 Smithkline Beecham Corporation Staphylococcal Fab I enoyl-ACP reductase
JPH10174590A (en) * 1996-08-28 1998-06-30 Smithkline Beecham Corp Fab i

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BERGLER H. ET AL.: "Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of escherichia coli", J. BIOL. CHEM., vol. 269, no. 8, 25 February 1994 (1994-02-25), pages 5493 - 5496, XP002933508 *
See also references of EP1180164A4 *

Also Published As

Publication number Publication date
EP1180164A4 (en) 2002-11-27
EP1180164A2 (en) 2002-02-20
JP2002544291A (en) 2002-12-24
WO2000070017A2 (en) 2000-11-23

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