WO2000068259A3 - Vaccine - Google Patents

Vaccine Download PDF

Info

Publication number
WO2000068259A3
WO2000068259A3 PCT/IB2000/000726 IB0000726W WO0068259A3 WO 2000068259 A3 WO2000068259 A3 WO 2000068259A3 IB 0000726 W IB0000726 W IB 0000726W WO 0068259 A3 WO0068259 A3 WO 0068259A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyogenes
streptococcus
group
polypeptide
seq
Prior art date
Application number
PCT/IB2000/000726
Other languages
French (fr)
Other versions
WO2000068259A2 (en
Inventor
Gunnar Lindahl
Margareth Stalhammar-Carlemalm
Thomas Areschoug
Charlotte Larsson
Original Assignee
Gunnar Lindahl
Stalhammar Carlemalm Margareth
Thomas Areschoug
Charlotte Larsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gunnar Lindahl, Stalhammar Carlemalm Margareth, Thomas Areschoug, Charlotte Larsson filed Critical Gunnar Lindahl
Priority to CA002372497A priority Critical patent/CA2372497A1/en
Priority to AU46051/00A priority patent/AU778526B2/en
Priority to US09/959,594 priority patent/US7220415B1/en
Priority to EP00927666A priority patent/EP1175437B1/en
Priority to DE60022995T priority patent/DE60022995T2/en
Priority to AT00927666T priority patent/ATE305941T1/en
Publication of WO2000068259A2 publication Critical patent/WO2000068259A2/en
Publication of WO2000068259A3 publication Critical patent/WO2000068259A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Use of a polypeptide which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to S. pyogenes, or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of generating a protective immune response to S. pyogenes, in the manufacture of medicament for use as a vaccine against S. pyogenes. A pharmaceutical composition for use in vaccinating against S. pyogenes or Group B streptococcus comprises a polypeptide which comprises: (A) the amino acid sequence of SEQ ID No 2, (B) a variant of (A) which is capable of conferring protective immunity to S. pyogenes or Group B streptococcus, or (C) a fragment of (A) or (B) of at least 6 amino acids in length which is capable of conferring protective immunity to S. pyogenes or Group B streptococcus.
PCT/IB2000/000726 1999-05-05 2000-05-05 Vaccine WO2000068259A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002372497A CA2372497A1 (en) 1999-05-05 2000-05-05 Vaccine composition comprising r28 protein of streptococcus pyogenes
AU46051/00A AU778526B2 (en) 1999-05-05 2000-05-05 Vaccine composition
US09/959,594 US7220415B1 (en) 1999-05-05 2000-05-05 Vaccine composition
EP00927666A EP1175437B1 (en) 1999-05-05 2000-05-05 Vaccine
DE60022995T DE60022995T2 (en) 1999-05-05 2000-05-05 VACCINE
AT00927666T ATE305941T1 (en) 1999-05-05 2000-05-05 VACCINE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9910375.6 1999-05-05
GBGB9910375.6A GB9910375D0 (en) 1999-05-05 1999-05-05 Vaccine composition

Publications (2)

Publication Number Publication Date
WO2000068259A2 WO2000068259A2 (en) 2000-11-16
WO2000068259A3 true WO2000068259A3 (en) 2001-07-12

Family

ID=10852842

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/000726 WO2000068259A2 (en) 1999-05-05 2000-05-05 Vaccine

Country Status (9)

Country Link
US (1) US7220415B1 (en)
EP (1) EP1175437B1 (en)
AT (1) ATE305941T1 (en)
AU (1) AU778526B2 (en)
CA (1) CA2372497A1 (en)
DE (1) DE60022995T2 (en)
ES (1) ES2250131T3 (en)
GB (1) GB9910375D0 (en)
WO (1) WO2000068259A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1490100T3 (en) * 2002-03-28 2012-03-12 Brenntag Biosector As Combined DNA / protein vaccine preparations
US20070053924A1 (en) * 2002-08-26 2007-03-08 Herve Tettelin Conserved and specific streptococcal genomes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010317A2 (en) * 1992-11-02 1994-05-11 The General Hospital Corporation Conjugate vaccine against group b streptococcus
WO1998006428A1 (en) * 1996-08-16 1998-02-19 The Uab Research Foundation Mucosal immunogens for novel vaccines
EP0866133A2 (en) * 1997-03-19 1998-09-23 Brigham And Women's Hospital, Inc. A group b streptococcus vaccine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE459503B (en) 1985-05-03 1989-07-10 Excorim Kommanditbolag HYBRID DNA MOLECULE CONTAINING DNA SEQUENCE CODING FOR PROTEIN G AND PROCEDURE FOR PRODUCING PROTEIN G
EP0398872A1 (en) 1988-02-12 1990-11-28 HighTech Receptor AB Immunoglobulin binding substance, subfragments, a process for preparing thereof, reagent kit and immunoglobulin binding organisms
EP0367890A1 (en) 1988-11-11 1990-05-16 HighTech Receptor AB Protein Arp, with immunoglobulin A binding activity, cloning and expression thereof
US6015889A (en) * 1993-03-19 2000-01-18 Gunnar Lindahl Protein rib, a cell surface protein that confers immunity to many strains of the group B streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition
SG47049A1 (en) 1993-03-19 1998-03-20 Gunnar Lindahl Protein rib a cell surface protein that confers immunity to manu strains of the group b strepto-ccus process for purification of the protein reagent kit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010317A2 (en) * 1992-11-02 1994-05-11 The General Hospital Corporation Conjugate vaccine against group b streptococcus
WO1998006428A1 (en) * 1996-08-16 1998-02-19 The Uab Research Foundation Mucosal immunogens for novel vaccines
EP0866133A2 (en) * 1997-03-19 1998-09-23 Brigham And Women's Hospital, Inc. A group b streptococcus vaccine

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J D CHAPPELL ET AL: "Demonstration of protection in mice from a lethal challenge of three M serotypes of Streptococcus pyogenes using an M-negative vaccine", VACCINE,GB,BUTTERWORTH SCIENTIFIC. GUILDFORD, vol. 11, 1993, pages 643 - 649, XP002137199, ISSN: 0264-410X *
LACHENAUER C S ET AL: "Mosaicism in the alpha-like protein genes of group B streptococci.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 17, 15 August 2000 (2000-08-15), August 15, 2000, pages 9630 - 9635, XP002152238, ISSN: 0027-8424 *
STAALHAMMAR-CARLEMALM MARGARETHA ET AL: "Cross-protection between group A and group B streptococci due to cross-reacting surface proteins.", JOURNAL OF INFECTIOUS DISEASES, vol. 182, no. 1, July 2000 (2000-07-01), pages 142 - 149, XP002156997, ISSN: 0022-1899 *
STAALHAMMAR-CARLEMALM MARGARETHA ET AL: "The R28 protein of Streptococcus pyogenes is related to several group B streptococcal surface proteins, confers protective immunity and promotes binding to human epithelial cells.", MOLECULAR MICROBIOLOGY, vol. 33, no. 1, July 1999 (1999-07-01), pages 208 - 219, XP000964694, ISSN: 0950-382X *
WÄSTFELT MARIA ET AL: "Identification of a family of streptococcal surface proteins with extremely repetitive structure.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 31, 1996, pages 18892 - 18897, XP002152237, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
ATE305941T1 (en) 2005-10-15
CA2372497A1 (en) 2000-11-16
DE60022995T2 (en) 2006-06-22
EP1175437A2 (en) 2002-01-30
US7220415B1 (en) 2007-05-22
DE60022995D1 (en) 2006-02-16
ES2250131T3 (en) 2006-04-16
AU778526B2 (en) 2004-12-09
EP1175437B1 (en) 2005-10-05
WO2000068259A2 (en) 2000-11-16
GB9910375D0 (en) 1999-06-30
AU4605100A (en) 2000-11-21

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