WO2000067740A3 - Aminoguanidine for treating glaucomatous optic neuropathy - Google Patents

Aminoguanidine for treating glaucomatous optic neuropathy Download PDF

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Publication number
WO2000067740A3
WO2000067740A3 PCT/US2000/012609 US0012609W WO0067740A3 WO 2000067740 A3 WO2000067740 A3 WO 2000067740A3 US 0012609 W US0012609 W US 0012609W WO 0067740 A3 WO0067740 A3 WO 0067740A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminoguanidine
optic neuropathy
glaucomatous optic
treating glaucomatous
treating
Prior art date
Application number
PCT/US2000/012609
Other languages
French (fr)
Other versions
WO2000067740A2 (en
WO2000067740A9 (en
Inventor
Arthur H Neufeld
Original Assignee
Univ Washington
Arthur H Neufeld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington, Arthur H Neufeld filed Critical Univ Washington
Priority to AU49956/00A priority Critical patent/AU4995600A/en
Publication of WO2000067740A2 publication Critical patent/WO2000067740A2/en
Publication of WO2000067740A3 publication Critical patent/WO2000067740A3/en
Publication of WO2000067740A9 publication Critical patent/WO2000067740A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for treating glaucomatous optic neuropathy using caminoguanidine is described.
PCT/US2000/012609 1999-05-10 2000-05-09 Aminoguanidine for treating glaucomatous optic neuropathy WO2000067740A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49956/00A AU4995600A (en) 1999-05-10 2000-05-09 Aminoguanidine for treating glaucomatous optic neuropathy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13332199P 1999-05-10 1999-05-10
US60/133,321 1999-05-10

Publications (3)

Publication Number Publication Date
WO2000067740A2 WO2000067740A2 (en) 2000-11-16
WO2000067740A3 true WO2000067740A3 (en) 2001-08-09
WO2000067740A9 WO2000067740A9 (en) 2002-02-21

Family

ID=22458034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012609 WO2000067740A2 (en) 1999-05-10 2000-05-09 Aminoguanidine for treating glaucomatous optic neuropathy

Country Status (2)

Country Link
AU (1) AU4995600A (en)
WO (1) WO2000067740A2 (en)

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
GEYER O. ET AL.: "Nitric oxide synthase inhibitors protect rat retina against ischemic injury.", FEBS LETTERS, vol. 374, 1995, pages 399 - 402, XP000982136 *
GEYER, ORNA ET AL: "Nitric oxide synthase activity in tissues of the bovine eye", GRAEFE'S ARCH. CLIN. EXP. OPHTHALMOL. (1997), 235(12), 786-793, XP000986593 *
INOUE M.: "The characteristics of diabetic optic neuropathy.", FOLIA OPHTHALMOLOGICA JAPONICA, (1999) 50/1 (6-11)., XP000986597 *
INO-UE, MASANORI ET AL: "Effect of aminoguanidine on optic nerve involvement in experimental diabetic rats", BRAIN RES. (1998), 800(2), 319-322, XP000986601 *
NEUFELD A. H. ET AL.: "Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, 1999, pages 9944 - 9948, XP000982141 *
OSBORNE N.N. ET AL: "Neuroprotection in relation to retinal ischemia and relevance to glaucoma.", SURVEY OF OPHTHALMOLOGY, (1999) 43/6 SUPPL. (S102-S128)., XP000986473 *
OSBORNE N.N. ET AL: "The potential of neuroprotection in glaucoma treatment.", CURRENT OPINION IN OPHTHALMOLOGY, (1999) 10/2 (82-92)., XP000870145 *
TANIGUCHI T ET AL: "Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits.", CURRENT EYE RESEARCH, (1998 MAR) 17 (3) 308-15., XP000986589 *

Also Published As

Publication number Publication date
WO2000067740A2 (en) 2000-11-16
AU4995600A (en) 2000-11-21
WO2000067740A9 (en) 2002-02-21

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