WO2000066108A3 - Anticonvulsant derivatives useful in treating cocaine dependency - Google Patents

Anticonvulsant derivatives useful in treating cocaine dependency Download PDF

Info

Publication number
WO2000066108A3
WO2000066108A3 PCT/US2000/011722 US0011722W WO0066108A3 WO 2000066108 A3 WO2000066108 A3 WO 2000066108A3 US 0011722 W US0011722 W US 0011722W WO 0066108 A3 WO0066108 A3 WO 0066108A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives useful
treating cocaine
cocaine dependency
alkyl
anticonvulsant derivatives
Prior art date
Application number
PCT/US2000/011722
Other languages
French (fr)
Other versions
WO2000066108A2 (en
Inventor
Richard P Shank
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Priority to JP2000614993A priority Critical patent/JP2002543123A/en
Priority to AU46853/00A priority patent/AU4685300A/en
Priority to EP00928651A priority patent/EP1175211A2/en
Priority to CA002372083A priority patent/CA2372083A1/en
Priority to MXPA01011014A priority patent/MXPA01011014A/en
Publication of WO2000066108A2 publication Critical patent/WO2000066108A2/en
Publication of WO2000066108A3 publication Critical patent/WO2000066108A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Anticonvulsant derivatives of formula (I) useful in treating cocaine dependency are disclosed. Formula (I) wherein X is Ch2 or oxygen; R1 is hydrogen or C1-C4 alkyl; and R2, R3, R4 and R5 are independently hydrogen or C1 -C3 alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of formula (II), wherein R6 and R7 are the same or different and are hydrogen, C1 -C3 alkyl or R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.
PCT/US2000/011722 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in treating cocaine dependency WO2000066108A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2000614993A JP2002543123A (en) 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in the treatment of cocaine dependence
AU46853/00A AU4685300A (en) 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in treating cocaine dependency
EP00928651A EP1175211A2 (en) 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in treating cocaine dependency
CA002372083A CA2372083A1 (en) 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in treating cocaine dependency
MXPA01011014A MXPA01011014A (en) 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in treating cocaine dependency.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13187799P 1999-04-30 1999-04-30
US60/131,877 1999-04-30

Publications (2)

Publication Number Publication Date
WO2000066108A2 WO2000066108A2 (en) 2000-11-09
WO2000066108A3 true WO2000066108A3 (en) 2001-01-11

Family

ID=22451401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/011722 WO2000066108A2 (en) 1999-04-30 2000-04-28 Anticonvulsant derivatives useful in treating cocaine dependency

Country Status (6)

Country Link
EP (1) EP1175211A2 (en)
JP (1) JP2002543123A (en)
AU (1) AU4685300A (en)
CA (1) CA2372083A1 (en)
MX (1) MXPA01011014A (en)
WO (1) WO2000066108A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890951B2 (en) 1998-08-05 2005-05-10 Brookhaven Science Associates Llc Treatment of addiction and addiction-related behavior
US6541520B1 (en) 1998-08-05 2003-04-01 Brookhaven Science Associates Treatment of addiction and addiction-related behavior
DE60019904T2 (en) 1999-02-24 2006-05-04 University Of Cincinnati, Cincinnati USE OF SULPHATE DERIVATIVES FOR THE TREATMENT OF IMPULSE CONTROL DISEASES
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
WO2000007583A2 (en) * 1998-08-05 2000-02-17 Brookhaven Science Associates Treatment of addiction and addiction-related behavior

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
WO2000007583A2 (en) * 1998-08-05 2000-02-17 Brookhaven Science Associates Treatment of addiction and addiction-related behavior

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEWEY S L ET AL: "A NOVEL STRATEGY FOR THE TREATMENT OF COCAINE ADDICTION", SYNAPSE,GB,WILEY AND SONS, CHICHESTER, vol. 30, no. 2, October 1998 (1998-10-01), pages 119 - 129, XP000856612, ISSN: 0887-4476 *
DEWEY S L ET AL: "A NW GABAERGIC STRATEGY FOR TREATING COCAINE ADDICTION", JOURNAL OF NUCLEAR MEDICINE,US,SOCIETY OF NUCLEAR MEDICINE. NEW YORK, vol. 39, no. 5, May 1998 (1998-05-01), pages 99P - 100P, XP000857227, ISSN: 0161-5505 *
K.T. BRADY ET AL.: "The Relatioship Between Substance Use Disorders, Impulse Control Disorders, and Pathological Aggression", AMERICAN JOURNAL OF ADDICTIONS, vol. 7, no. 3, 1998, pages 221 - 230, XP000951530 *
KUZIECKY R ET AL: "TOPIRAMATE INCREASE CEREBRAL GABA IN HEALTHY HUMANS", NEUROLOGY,LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA,US, no. 51, August 1998 (1998-08-01), pages 627 - 629, XP000923467, ISSN: 0028-3878 *

Also Published As

Publication number Publication date
JP2002543123A (en) 2002-12-17
WO2000066108A2 (en) 2000-11-09
CA2372083A1 (en) 2000-11-09
MXPA01011014A (en) 2003-06-30
EP1175211A2 (en) 2002-01-30
AU4685300A (en) 2000-11-17

Similar Documents

Publication Publication Date Title
CA2359541A1 (en) Anticonvulsant derivatives useful in treating cluster headaches
WO2000061139A8 (en) Anticonvulsant derivatives useful in reducing blood glucose levels
WO2000061138A8 (en) Anticonvulsant derivatives useful in treating chronic neurodegenerative disorders
WO2002003984A3 (en) Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
CA2369093A1 (en) Anticonvulsant derivatives useful in lowering lipids
CA2369091A1 (en) Anticonvulsant derivatives useful in lowering blood pressure
TW370450B (en) Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives
DE60015927D1 (en) Phenylharnstoff und phenylthioharnstoffderivate
WO2000042995A3 (en) Use of anticonvulsant derivatives for treating transformed migraine
NZ514662A (en) Amine derivatives
WO2003035620A1 (en) Bicyclic compound
WO1999009965A3 (en) Anti-inflammatory agent
PL341239A1 (en) Dihydrobenzofuranes
EP1070715A4 (en) Arylpiperidine derivatives and use thereof
WO2000066108A3 (en) Anticonvulsant derivatives useful in treating cocaine dependency
CA2267945A1 (en) Anticonvulsant derivatives useful in treating neuropathic pain
WO2000048549A3 (en) Anticonvulsant derivatives useful in treating essential tremor
NZ511881A (en) Anticonvulsant O-aklyl sulfamate derivatives useful in treating post traumatic stress disorder
TW355124B (en) Substituted pyrazolylpyrazole derivatives and their use as herbicides
CA2244417A1 (en) Optically active bisoxazoline compounds, production and use thereof
WO2000023059A3 (en) Use of anticonvulsant derivatives for treating alcohol dependency
GB9907055D0 (en) Antibacterial agents
MX9700365A (en) Use of benzaldehydes to mark hydrocarbons.
AR034088A1 (en) COMPOSITION THAT INCLUDES USEFUL ANTI-CONVULSIVING DERIVATIVES IN THE TREATMENT OF SCHIZOPHRENIA AND THE USE OF SUCH DERIVATIVE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
AR029331A1 (en) USE OF ANTI-CONVULSIVE DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT IN THE TREATMENT OF NERVOUS BULIMIA

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2372083

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2372083

ENP Entry into the national phase

Ref document number: 2000 614993

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/011014

Country of ref document: MX

Ref document number: 46853/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 515324

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2000928651

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000928651

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000928651

Country of ref document: EP