WO2000064409A1 - Tissus absorbants ameliorant la qualite de la barriere cutanee - Google Patents

Tissus absorbants ameliorant la qualite de la barriere cutanee Download PDF

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Publication number
WO2000064409A1
WO2000064409A1 PCT/US2000/011142 US0011142W WO0064409A1 WO 2000064409 A1 WO2000064409 A1 WO 2000064409A1 US 0011142 W US0011142 W US 0011142W WO 0064409 A1 WO0064409 A1 WO 0064409A1
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WO
WIPO (PCT)
Prior art keywords
oil
composition
weight percent
product
skin
Prior art date
Application number
PCT/US2000/011142
Other languages
English (en)
Inventor
Duane Gerard Krzysik
Brenda Marie Nelson
Beth Anne Lange
David Roland Otts
Original Assignee
Kimberly-Clark Worldwide, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly-Clark Worldwide, Inc. filed Critical Kimberly-Clark Worldwide, Inc.
Priority to KR1020017013438A priority Critical patent/KR20010108523A/ko
Priority to AU44914/00A priority patent/AU4491400A/en
Priority to BR0009979-1A priority patent/BR0009979A/pt
Priority to DE10084499T priority patent/DE10084499T1/de
Priority to GB0126110A priority patent/GB2367490A/en
Publication of WO2000064409A1 publication Critical patent/WO2000064409A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47K—SANITARY EQUIPMENT NOT OTHERWISE PROVIDED FOR; TOILET ACCESSORIES
    • A47K10/00—Body-drying implements; Toilet paper; Holders therefor
    • A47K10/16—Paper towels; Toilet paper; Holders therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to the inclusion of a lipid-enriched hydrophilic lotion on absorbent tissue products, such as facial tissue, bath tissue, paper towels, and the like. More particularly, the present invention relates to improving skin health via enhancement of skin barrier function by the delivery of lipids and humectants from a hydrophilic lotion from said absorbent tissue products to the skin.
  • the stratum corneum is the outer-most layer of the skin and is responsible for regulating skin water levels and functioning as a barrier against chemicals and other stressors found in the environment.
  • the complex arrangement of lipids in the intercellular space of the stratum corneum is responsible for the establishment of normal barrier function.
  • Multi-layered structures of cholesterol, ceramides, and fatty acids, as well as some other minor lipids provide the major barrier to the transport of hydrophilic substances into the or through the skin.
  • the link between the barrier function and skin health is apparent from the skin inflammation caused by lipid extraction from the skin.
  • Skin barrier can be damaged due to a number of mechanisms. Physical abrasion, for example caused by the repeated rubbing of absorbent tissue products on the skin, strips away layers of the skin and thus damages skin barrier.
  • Biological fluids such as urine, feces, nasal and vaginal secretions, may contain a variety of components that can damage skin barrier. Examples of these components include proteases, lipases, bile acids, and fatty acids. Once the skin barrier is compromised, these components, in addition to other constituents of biological fluids, can initiate or exacerbate skin inflammation.
  • Excessive hydration also has a negative impact on skin barrier.
  • the hydration level of diapered skin may reach between five to ten times that of undiapered skin. Frequent contact of diapered skin with fluids such as nasal secretion may also contribute to increased skin hydration.
  • Increased skin hydration disrupts skin lipid organization in the stratum corneum. This disruption may increase-the skin permeability irritants, thus increasing the risk of skin inflammation.
  • topically applied barrier creams, lotions and ointments are used to provide an artificial hydrophobic barrier on the skin.
  • These products typically contain mineral oils, petrolatum and silicones that are heavy, greasy to the touch and are typically used to treat, rather than prevent skin irritation. In some instances, such as individuals suffering from sore, irritated noses during a cold, these products are avoided due to their poor cosmetic value to the consumer.
  • Absorbent tissue products such as facial tissue and bath tissue have been used to absorb body fluids and leave the skin dry.
  • Absorbent tissue in addition to absorbing fluids, however, also abrade the skin during use and frequently do not leave the skin completely dry and free of the body fluid the tissue is trying to absorb. During frequent nose-blowing or perianal wiping, for example, the skin can become so abraded as to appear red and be sore to the touch.
  • tissue additive formulations can be applied to the tissue such that, in use, the additive formulation either provides lubricity causing the tissue to glide across the surface of the skin, or leaves the tissue and is deposited on the skin.
  • these additive formulations provide a skin benefit by occluding the skin.
  • these formulations provide a short-term benefit by providing an artificial barrier, even though the underlying stratum corneum is still damaged.
  • these formulations have been wax-based semi-solids or solids at room temperature. Since these formulations are lipophilic, it is sometimes difficult to incorporate hydrophilic or water soluble surfactants, cosmetic materials or other active ingredients that can provide a skin health benefit.
  • formulation chemistry that, when applied from an absorbent tissue, enhances the skin's barrier function while minimizing or eliminating the physical damage caused by the rubbing of the said absorbent tissue on the skin surface.
  • a skin barrier enhancing tissue product can be made applying, on the surface(s) of the tissue, a lipid-enriched melted hydrophilic composition comprising a hydrophilic solvent, a high molecular weight polyethylene glycol, a fatty alcohol (C 14 - C 30 or greater), a humectant, an oil-in-water emulsifying surfactant having an HLB range greater than 7, a sterol, and a natural fat or oil, and thereafter resolidifying the composition to form a distribution, preferably a uniform distribution, of solid deposits on the surface(s) of the tissue. Because the hydrophilic composition is a solid at room temperature and rapidly solidifies after deposition, it has less tendency to penetrate and migrate into the sheet.
  • the present invention is a hydrophilic composition
  • a hydrophilic composition comprising from about 10 to about 95 weight percent hydrophilic solvent, from about 5 to about 95 weight percent high molecular weight polyethylene glycol (preferably having a molecular weight of about 720 or greater), from about 1 to about 30 weight percent of a C 14 to C 30 or greater fatty alcohol, from about 0.5 to about 30 weight percent of humectant, from about 1 to about 20 weight percent emulsifying surfactant having an HLB range greater than 7, from about 0.1 to about 10 weight percent of sterol or sterol derivative, and from about 0.1 to about 30 weight percent of natural fats or oils.
  • the hydrophilic composition may have a melting point from about 30 °C. to about 100 °C.
  • the composition may also have a penetration hardness of from about 5 millimeters to 360 millimeters.
  • the invention resides in a tissue product wherein one or both of the outer surfaces of the product have solidified deposits of a composition comprising from about 10 to about 95 weight percent hydrophilic solvent, from about 5 to about 95 weight percent high molecular weight polyethylene glycol (preferably having a molecular weight of about 720 or greater), from about 1 to about 30 weight percent of a C 14 to C 30 or
  • the hydrophilic composition may have a melting point from about 30°C. to about 100°C.
  • the composition may also have a
  • the present invention is a method of making a soft tissue or towel product that enhances skin barrier comprising: (a) heating a hydrophilic composition comprising a hydrophilic solvent, high molecular weight polyethylene glycol, a
  • the hydrophilic composition may have a melting point of from about
  • One embodiment of the present invention is a tissue or towel product having two outer surfaces.
  • One or both outer surfaces of the product have solidified deposits of a composition that enhances skin barrier.
  • the composition may comprise from about 10 to about 95 weight percent hydrophilic solvent, from about 5 to about 95 weight percent high molecular weight polyethylene glycol having a molecular weight of about 720 or greater,
  • the composition may have a melting point from about 30° C to about 100 °C.
  • the composition may have a penetration hardness of from about 5 millimeters to about 360 millimeters.
  • the add-on amount of the composition may be from about 0.5 to about 30 weight percent based on the weight of said product.
  • the add-on amount of the 145 composition may also be expressed as from about 0.1 grams per meter squared (g/m 2 ) to about 30 g/m 2 of the tissue or towel product, and more preferably from about 0.5 g/m 2 to about 25 g/m 2 .
  • the hydrophilic solvent used in the composition may include water, propylene 150 glycol, a low molecular weight polyethylene glycol, glycerin, or hydrogenated starch hydrolysate.
  • the fatty alcohol used in the composition may include cetyl alcohol, stearyl alcohol, arachidyl alcohol, or behenyl alcohol.
  • the molecular weight of said high molecular weight polyethylene glycol used in the composition may include from about 720 to about 1 ,840,000 daltons, more specifically from about 1 ,400 to about 440,000 daltons. 155
  • the molecular weight of said high molecular weight polyethylene glycol used in the composition may include polyethylene glycol 1 ,400, polyethylene glycol 8,000, or polyethylene glycol 10,000.
  • the humectant used in the composition may include glycerin, sorbitol, or hydrogenated starch hydrolysate.
  • the surfactant used in the composition may include glyceryl stearate SE, glycol stearate SE, or emulsifying wax NF.
  • the sterol or 160 sterol derivative used in the composition may include soy sterol, cholesterol, or lanasterol.
  • the natural fat or oil used in the composition may include sunflower oil, borage oil, or avocado oil.
  • Another embodiment of the present invention is a method of making a tissue or 165 towel material having an outer surface comprising: (a) heating a composition that enhances skin barrier comprising a hydrophilic solvent, a high molecular weight polyethylene glycol, a fatty alcohol, a humectant, an oil-in-water emulsifying surfactant having an HLB range greater than 7, a natural fat or oil, and a sterol or sterol derivative, to a temperature above the melting point of the composition, causing the composition to 170 melt; (b) applying the melted composition to the outer surface of a liner or tissue material web; and (c) resolidifying the melted composition.
  • a composition that enhances skin barrier comprising a hydrophilic solvent, a high molecular weight polyethylene glycol, a fatty alcohol, a humectant, an oil-in-water emulsifying surfactant having an HLB range greater than 7, a natural fat or oil, and a sterol or ste
  • the composition may have a melting point of from about 30 °C to about 100 °C.
  • the resolidified composition may have a penetration hardness of from about 5 to about 175 360 millimeters.
  • the melted composition may be applied by printing.
  • Another embodiment of the present invention is a skin barrier enhancing composition comprising from about 5 to about 90 weight percent hydrophilic solvent, from about 5 to about 95 weight percent high molecular weight polyethylene glycol having a
  • the composition may have a melting point from about 30 °C. to about 100 °C.
  • the resolidified composition may have a penetration hardness of from about 5 to about 360 millimeters.
  • the hydrophilic solvent of the composition may be selected from the group consisting of: water, propylene glycol, low molecular weight polyethylene glycol, glycerin, sorbitol, hydrogenated starch hydrolysate, silicone glycol, and the like, as well as mixtures thereof.
  • the fatty alcohol of the composition may be selected from the group consisting of: cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, and the like, as well
  • the high molecular weight polyethylene glycol of the composition may be selected from the group consisting of: polyethylene glycols having a average molecular weight greater than 720 daltons.
  • the humectant of the composition may be selected from the group consisting of: 200 glycerin, propylene glycol, sorbitol, polyethylene glycol , hydrogenated starch hydrolysates, sodium PCA, potassium PCA, sodium lactate, and the like, as well as mixtures thereof.
  • the surfactant of the composition may be selected from the group consisting of: glyceryl stearate SE, glyceryl stearate, glycol stearate SE, glycol stearate, emulsifying wax NF, and the like, as well as mixtures thereof.
  • the sterol or sterol 205 derivative of the composition may be selected from the group consisting of: ⁇ -sterols having a tail on the 17 position and having no polar groups for example cholesterol, sitosterol, stigmasterol, ergosterol, as well as, C 10 -C 30 cholesterol/lanosterol esters, cholecalciferol, cholesteryl hydroxystearate, cholesteryl isostearate, cholesteryl stearate, 7-dehydrocholesterol, dihydrocholesterol, dihydrocholesteryl octyldecanoate, 210 dihydrolanosterol, dihydrolanosteryl octyldecanoate, ergocalciferol, tall oil sterol, soy sterol acetate, lanasterol, soy sterol, avocado sterols, cholesterol esters, sterol esters, and the like, as well as mixtures thereof.
  • the natural fat or oil of the composition may be selected from the group consisting 215 of: avocado oil, apricot oil, babassu oil, borage oil, camellia oil, canola oil, castor oil, coconut oil, corn oil, cottonseed oil, evening primrose oil, hydrogenated cottonseed oil, hydrogenated palm kernal oil, maleated soybean oil, meadowfoam oil, palm kernal oil, phospholipids, rapeseed oil, palmitic acid, rose hip oil, sunflower oil, soybean oil, derivatives of natural fats or oils (such as stearic acid, linoleic acid, stearyl alcohol, lauryl 220 alcohol, myristyl alcohol, benenyl alcohol, and the like), and the like, as well as mixtures thereof.
  • avocado oil apricot oil, babassu oil, borage oil, camellia oil, canola oil, castor oil, coconut oil, corn oil, cottonseed oil, evening primrose oil, hydrogenated cottonseed
  • the amount of the hydrophilic solvent used in the composition may be from about 5 to about 90 weight percent, and more specifically from about 25 to about 75 percent.
  • the amount of said high molecular weight polyethylene glycol used in the composition may be is from about 5 to about 95 weight percent, and more specifically from about 15 to about 50 weight percent.
  • the amount of said fatty alcohol used in the composition may be from about 1 to 230 about 30 percent.
  • the amount of said surfactant used in the composition may be from about 1 to about 20 percent.
  • the sterol or sterol derivative used in the composition may be from about 0.1 to about 10 percent.
  • the amount of said natural fat or oil used in the composition may be from about 0.1 to about 30 percent.
  • composition comprises about 48.2 weight percent propylene glycol, about 20 weight percent polyethylene glycol 8,000, about 20 weight percent stearyl alcohol about 5 weight percent glycerin, about 3 weight percent glyceryl stearate SE, about 0.8 weight percent soy sterol, and about 3 weight percent borage oil.
  • composition comprises about 34 weight percent propylene glycol, about 20 weight percent polyethylene glycol 8,000, about 10 weight percent stearyl alcohol, about 10 weight percent behenyl alcohol about 15 weight percent glycerin, about 5 weight percent propylene glycol oleate SE, about 1 weight percent cholesterol, and about 5 weight percent sunflower oil.
  • composition comprises about 42.2 weight percent propylene glycol, about 20 weight percent polyethylene glycol 8,000, about 20 weight percent stearyl alcohol, about 5 weight percent glycerin, about 2 weight percent glyceryl stearate SE, about 0.8 weight percent soy sterol, and about 10 weight percent borage oil.
  • compositions comprises about 42.2 weight percent propylene glycol, about 20 weight percent polyethylene glycol 8,000, about 20 weight percent stearyl alcohol, about 5 weight percent glycerin, about 2 weight percent glyceryl stearate SE, about 0.8 weight percent soy sterol, and about 10 weight percent avocado 255 oil.
  • compositions comprises about 42.2 weight percent propylene glycol, about 20 weight percent polyethylene glycol 8,000, about 20 weight percent stearyl alcohol, about 5 weight percent glycerin, about 2 weight percent glyceryl 260 stearate SE, about 0.8 weight percent soy sterol, and about 10 weight percent lanolin oil.
  • compositions comprises about 42.2 weight percent propylene glycol, about 20 weight percent polyethylene glycol 10,000, about 20 weight percent behenyl alcohol, about 5 weight percent glycerin, about 2 weight percent glyceryl 265 stearate SE, about 0.8 weight percent avocadin, and about 10 weight percent sunflower oil.
  • compositions comprises about 32.2 weight percent polyethylene 200, about 20 weight percent polyethylene glycol 1 ,000, about 30 weight 270 percent behenyl alcohol, about 5 weight percent hydrogenated starch hydrolysate, about 2 weight percent glyceryl stearate SE, about 0.8 weight percent avocadin, and about 10 weight percent avocado oil.
  • compositions comprises about 32.2 weight percent 275 polyethylene 200, about 20 weight percent polyethylene glycol 1 ,000, about 30 weight percent behenyl alcohol, about 5 weight percent hydrogenated starch hydrolysate, about 2 weight percent glyceryl stearate SE, about 0.8 weight percent avocadin, and about 10 weight percent sunflower oil.
  • composition comprises about 37 weight percent polyethylene 200, about 20 weight percent polyethylene glycol 8,000, about 10 weight percent behenyl alcohol, about 10 weight percent stearyl alcohol, about 5 weight percent hydrogenated starch hydrolysate, about 5 weight percent glycol stearate SE, about 3 weight percent avocado sterols, and about 0 weight percent borage oil.
  • compositions comprises about 20 weight percent polyethylene glycol 200, about 20 weight percent propylene glycol, about 20 weight percent polyethylene glycol 8,000, about 10 weight percent behenyl alcohol, about 10 weight percent stearyl alcohol, about 5 weight percent sodium PCA, about 5 weight 290 percent glycol stearate SE, about 2 weight percent cholesterol, and about 8 weight percent borage oil.
  • compositions comprises about 42 weight percent polyethylene 200 about 20 weight percent polyethylene glycol 8000, about 10 weight 295 percent behenyl alcohol, about 10 weight percent stearyl alcohol, about 5 weight percent glycerin, about 5 weight percent glycol stearate SE, about 3 weight percent soy sterol, and about 5 weight percent evening primrose oil.
  • Another embodiment of the present invention is a method for 300 enhancing/restoring/maintaining the skin barrier function of a user.
  • the method comprises the steps of: a) contacting a tissue or towel product on the skin of said user wherein said material comprises a skin barrier enhancing/restoring/maintaining composition that provides a skin barrier enhancing/restoring/maintaining
  • 305 benefit upon transfer of the composition to the user's skin; b) transferring at least a portion of the composition during use of the tissue or towel product; c) repeating steps a) and b) with one or more additional tissue or towel product with sufficient frequency to enhance/restore/maintain the skin
  • the skin barrier enhancing/restoring/maintaining composition of the method comprises from about 5 to about 90 weight percent hydrophilic solvent, from about 5 to about 95 315 weight percent high molecular weight polyethylene glycol having a molecular weight of about 720 or greater, from about 1 to about 25 weight percent of a C 14 to C 30 or greater fatty alcohol, from about 0.5 to about 10 weight percent of humectant, from about 1 to about 20 weight percent of oil-in-water emulsifying surfactant having an HLB range greater than 7, from about 0.1 to about 10 weight percent of sterol and sterol derivative.
  • the composition may have a melting point from about 30 °C. to about 100 °C.
  • the resolidified composition may have a process viscosity greater than about 50 centipoise.
  • the resolidified composition may have a penetration hardness of from about 5 to about 360 millimeters.
  • the method may further comprise using a tissue or towel
  • the method may further comprise using a tissue or towel material which does not comprise a skin-barrier enhancing/restoring/maintaining composition by the user intermittently.
  • the method may further comprise using the tissue or towel material comprising a skin-barrier enhancing/restoring/maintaining composition by a user
  • the amount of hydrophilic solvent, including water if present, in the hydrophilic composition can be from about 10 to about 95 weight percent, more specifically from about 25 to about 75 weight percent, more specifically from about 30 to about 60 weight
  • suitable hydrophilic solvents include, but are not limited to, the following materials: propylene glycol, low molecular weight polyethylene glycols (molecular weights of less than 720 and liquid at room temperature), methoxyisopropanol, PPG-2 propyl ether, PPG-2 butyl ether, PPG-2 methyl ether, PPG-3 methyl ether, dipropylene glycol propyl ether, dipropylene glycol butyl ether, dipropylene glycol, methyl
  • the amount of high molecular weight polyethylene glycol in the hydrophilic 345 composition can be from about 5 to about 95 weight percent, more specifically from about 10 to about 50 weight percent, and still more specifically from about 15 to about 25 weight percent.
  • the high molecular weight polyethylene glycol in the hydrophilic lotion compositions of the present invention primarily functions as an immobilizing agent for the hydrophilic solvent and any active ingredient. In addition to immobilizing the solvent, and 350 reducing its tendency to migrate, the high molecular weight polyethylene glycol in the hydrophilic lotion composition provides a tackiness to the hydrophilic lotion composition which improves the transfer to the skin of the user.
  • suitable high molecular weight polyethylene glycols include, but are not limited to, the following materials: polyethylene glycols having an average molecular weight of 720 daltons or 355 greater, and the like, as well as mixtures thereof. These materials are not liquid at room temperature. Particularly suitable high molecular weight polyethylene glycols can have an average molecular weight of from 720 to about 1 ,840,000 daltons, more specifically from about 1 ,400 to about 440,000 daltons, and still more specifically from about 1 ,760 to about 10,570 daltons. 360
  • the amount of fatty alcohol in the hydrophilic composition can be from about 1 to about 30 weight percent, more specifically from about 10 to about 25 weight percent, and still more specifically from about 15 to about 20 weight percent.
  • suitable fatty alcohols include, but not limited to, the following materials: alcohols having a carbon 365 chain length of C 14 -C 30 or greater, including cetyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol, and the like, as well as mixtures thereof.
  • the amount of humectant in the hydrophilic composition can be from about 0.5 to about 30 weight percent, more specifically from about 1 to about 20 weight percent, and
  • Humectants are typically cosmetic ingredients used to increase the water content of the top layers of the skin. This group of materials includes primarily hydroscopic ingredients. As used herein, suitable humectants include, but are not limited to, the following materials: Acetamide MEA, Aloe Vera Gel, Arginine PCA, Chitosan PCA, Copper PCA, Corn Glycerides, Dimethyl
  • the amount of oil-in-water emulsifying surfactant having an HLB range greater 385 than 7 in the hydrophilic composition can be from about 1 to about 20 weight percent, more specifically from about 2 to about 15 weight percent, and still more specifically from about 3 to about 10 weight percent.
  • Emulsifying surfactants are employed typically in cosmetic preparations to form emulsions of various components.
  • the immiscible phase, such as an oil, is dispersed as droplets in the continuous phase, such as water.
  • the preferred surfactants include, but not limited to Emulsifying Wax NF, Glyceryl Stearate, Glyceryl Stearate SE, Glycol Stearate, Glycol Stearate SE, Glycereth-20 Stearate, Glyceryl Behenate, Glyceryl Hydroxystearate, Glyceryl Laurate SE, Glyceryl Oleate, Glyceryl Oleate SE, Propylene Glycol Oleate, Propylene Glycol Oleate SE, 395 Propylene Glycol Stearate, Propylene Glycol Stearate SE, Sorbitan Stearate, Sorbitan Trioleate, and the like, as well as mixtures thereof.
  • the amount of a sterol or sterol derivative or mixture of sterols or sterol derivatives in the hydrophilic composition can be from about 0.1 to about 10 weight
  • suitable ⁇ -sterols include, but are not limited to, the following materials: sterols having a tail on the 17 position and having no polar groups, for example cholesterol, sitosterol, stigmasterol, and ergosterol, as well as, lanasterol, soy sterol, avocado sterols, sterol esters, and the like,
  • the amount of a natural fat or oil or a mixture of natural fats or oils in the hydrophilic composition can be from about 0.1 to about 30 weight percent, more
  • natural fats or oils is understood to include fats, oils, essential oils, fatty acids, fatty alcohols, phopholipids, and mixtures thereof.
  • suitable natural fats or oils include, but are not limited to, the following materials:
  • Fats and Oils Apricot Kernel Oil, Avocado Oil, Babassu Oil, Borage Seed Oil, Butter, C12-18 Acid Triglyceride, Camellia Oil, Canola Oil, Caprylic/Capric/Lauric Triglyceride, Caprylic/Capric/Linoleic Triglyceride, Caprylic/Capric/Stearic Triglyceride, Caprylic/Capric Triglyceride, Carrot Oil, Cashew Nut Oil, Castor Oil, Cherry Pit Oil, Chia Oil, Cocoa Butter,
  • Triglyceride Lesquerella Oil, Linseed Oil, Macadamia Nut Oil, Maleated Soybean Oil, Meadowfoam Seed Oil, Menhaden Oil, Mink Oil, Moringa Oil, Mortierella Oil, Neatsfoot Oil, Oleic/ ⁇ noleic Triglyceride, Oleic/Palmitic/Lauric/Myristic/Linoleic Triglyceride, Oleostearine, Olive Husk Oil, Olive Oil, Omental Lipids, Orange Roughy Oil, Palm Kernel Oil, Palm Oil, Peach Kernel Oil, Peanut Oil, Pengawar Djambi Oil, Pentadesma Butter,
  • Phospholipids Pistachio Nut Oil, Placental Lipids, Rapeseed Oil, Rice Bran Oil, Safflower Oil, Sesame Oil, Shark Liver Oil, Shea Butter, Soybean Oil, Sphingolipids, Sunflower Seed Oil, Sweet Almond Oil, Tall Oil, Tallow, Tribehenin, Tricaprin, Tricaprylin, Triheptanoin, Trihydroxymethoxystearin, Trihydroxystearin, Triisononanoin, Triisostearin, Trilaurin, Trilinolein, Trilinolenin, Trimyristin, Trioctanoin, Triolein, Tripalmitin, Trisebacin,
  • Tristearin Triundecanoin, Vegetable Oil, Walnut Oil, Wheat Bran Lipids, Wheat Germ Oil, Zadoary Oil, and the like, as well as mixtures thereof.
  • Fatty Acids Arachidic Acid, Arachidonic Acid, Behenic Acid, Capric Acid, Caproic Acid, Caprylic Acid, coconut Acid, Corn Acid, Cottonseed Acid, Hydrogenated Coconut Acid,
  • Isostearic Acid Wayne Acid, Linoleic Acid, Linolenic Acid, Linseed Acid, Myristic Acid, Oleic Acid, Palmitic Acid, Palm Kernel Acid, Pelargonic Acid, Ricinoleic Acid, Soy Acid, Stearic Acid, Tall Oil Acid, Tallow Acid, Undecanoic Acid, Undecylenic Acid, Wheat Germ Acid, and the like, as well as mixtures thereof.
  • Fatty Alcohols Behenyl Alcohol, Alcohols, C 12 -C 13 Alcohols, C 12 -C 15 Alcohols, C 12 - C 16 Alcohols, C 14 -C 15 Alcohols, Caprylic Alcohol, Cetearyl Alcohol, Cetyl Alcohol, coconut Alcohol, Decyl Alcohol, Hydrogenated Tallow Alcohol, Lauryl Alcohol, Myristyl Alcohol, Oleyl Alcohol, Palm Alcohol, Palm Kernel Alcohol, Stearyl Alcohol, Tallow Alcohol,
  • Essential Oils Anise Oil, Balm Mint Oil, Basil Oil, Bee Balm Oil, Bergamot Oil, Birch Oil, Bitter Almond Oil, Bitter Orange Oil, Calendula Oil, California Nutmeg Oil, Caraway Oil, Cardamom Oil, Chamomile Oil, Cinnamon Oil, Clary Oil, Cloveleaf Oil, Clove Oil, 460 Coriander Oil, Cypress Oil, Eucalyptus Oil, Fennel Oil, Gardenia Oil, Geranium Oil, Ginger Oil, Grapefruit Oil, Hops Oil, Hyptis Oil, Indigo Bush Oil, Jasmine Oil, Juniper Oil, Kiwi Oil, Laurel Oil, Lavender Oil, Lemongrass Oil, Lemon Oil, Linden Oil, Lovage Oil, Mandarin Orange Oil, Matricaria Oil, Musk Rose Oil, Nutmeg Oil, Olibanum, Orange Flower Oil, Orange Oil, Patchouli Oil, Pennyroyal Oil, Peppermint Oil, Pine Oil, Pine Tar Oil, Rose 465 Hips Oil, Rosemary Oil, Rose Oil, Rue Oil
  • Sassafras Oil Silver Fir Oil, Spearmint Oil, Sweet Marjoram Oil, Sweet Violet Oil, Tar Oil, Tea Tree Oil, Thyme Oil, Wild Mint Oil, Yarrow Oil, Ylang Ylang Oil, and the like, as well as mixtures thereof.
  • the preferred natural oils include but are not limited to: Avocado Oil, Apricot Oil,
  • the hydrophilic composition may contain petrolatum or mineral oil.
  • the amount of petrolatum or mineral oil in the 480 composition can be from about 0 to about 30 weight percent, more specifically from about 0 to about 20 weight percent, and still more specifically from about 0 to about 10 weight percent.
  • Resolidification of the melted composition can occur almost instantaneously, 485 without the need for external cooling means such as chill rolls, if the composition is heated to a temperature only slightly above or at the melting point of the composition.
  • external means such as chill rolls, either before or after the application of melt, can be used if desired to accelerate resolidification.
  • Such instantaneous resolidification tends to impede penetration of the composition into the tissue and retain it on the surface of the 490 tissue, which is advantageous.
  • the temperature of the melted composition can advantageously be above the melting point about 10°C. or less, more specifically about 5°C. or less and still more specifically about 2°C. or less.
  • melting point is the temperature at which the majority of the melting occurs, it being recognized that melting actually occurs over a range of temperatures.
  • the melting point of the compositions of this invention can be from about 500 30 °C. to about 100 °O, more specifically from about 40 °C. to about 70 °C, and still more specifically from about 50 °C. to about 60 °C.
  • penetration hardness is the needle penetration in millimeters according to ASTM D 1321, “Needle Penetration of Petroleum Waxes.
  • the penetration hardness of the compositions of this invention can be from about 5 to 360 millimeters, more specifically from about 5 to about 200 millimeters, more specifically from about 5 to about 150 millimeters, and still more specifically from about 5 to about 100 millimeters. (Formulations having a needle penetration hardness greater than 360
  • the hardness of the formulations of this invention is important for two reasons. First, the softer the formulation the more mobile the formulation will be, making the formulation more likely to migrate to the inward facing surfaces and inner plies of the
  • formulations having a needle penetration hardness of from about 200 to 360 millimeters feel creamy to slightly greasy with less smoothness (depending on additives).
  • Formulations that have needle penetration hardness values of from about 5 to about 200 millimeters feel silky to creamy
  • melt point viscosity and/or the process temperature viscosity of the formulations or compositions of this invention is important for two reasons: First, the higher the melt point viscosity or the process temperature viscosity as it is applied to the
  • the formulation is less likely to penetrate through to the inward facing surfaces and inner plies of the tissue or towel product.
  • formulation the less likely the formulation will migrate at typical or adverse storage conditions.
  • additional ingredients can be used.
  • the classes of ingredients and their corresponding benefits include, without
  • antiacne actives a drug product used to reduce the number of acne blemishes, acne pimples, blackheads, and whiteheads
  • antifoaming agents reduce the tendency of foaming during processing
  • antimicrobial actives antifungal actives
  • antiseptic actives antioxidants
  • product integrity to prevent oxidation of the natural ingredients or other formulation components
  • astringents - cosmetic induce a tightening or tingling sensation
  • astringent - drug a drug product which checks oozing, discharge, or bleeding when applied to skin or mucous membrane and works by coagulating protein
  • biological additives enhance the performance or consumer appeal of the product, including vitamins); colorants (impart color to the product); deodorants (reduce or eliminate unpleasant odor and protect against the formation of malodor on body surfaces);
  • emollients help to maintain the soft, smooth, and pliable appearance of the skin by their ability to remain on the skin surface or in the stratum corneum to act as lubricants, to reduce flaking, and to improve the skin's appearance
  • external analgesics a topically applied drug that has a topical analgesic, anesthetic, or antipruritic effect by depressing cutaneous sensory receptors, of that has a topical counterirritant effect by stimulating
  • cutaneous sensory receptors 550 cutaneous sensory receptors); film formers (to hold active ingredients on the skin by producing a continuous film on skin upon drying); fragrances (consumer appeal); humectants (increase the water content of the top layers of the skin); natural moisturizing agents (NMF) and other skin moisturizing ingredients known in the art; opacifiers (reduce the clarity or transparent appearance of the product); skin conditioning agents; skin
  • 555 exfoliating agents including alpha hydroxy acids and beta hydroxyacids
  • skin protectants a drug product which protects injured or exposed skin or mucous membrane surface from harmful or annoying stimuli
  • solvents liquids employed to dissolve components found useful in the cosmetics or drugs
  • sunscreens including sunscreens that absorb at least 85 percent of the light in the UV
  • 560 range at wavelengths from 290 to 420 manometers, but transmit UV light at wavelengths longer than 420 manometers); and, surfactants (as solubilizing agents and suspending agents).
  • oil soluble/dispersible or lipophilic materials can be easily emulsified into the formulation using anionic, amphoteric, cationic, nonionic and/or zwitterionic surfactants.
  • Lipophilic materials without limitation include: silicones/organomodified silicones (protection, delayed wetting, lubricity, tissue tactile softness); oils (mineral, vegetable, and animal); fatty esters and, the like. Powders to enhance lubricity, oil adsorption, 570 provide skin protection, astringency, opacity, etc. and microencapsulated ingredients can also be dispersed into the formulation.
  • the total tissue add-on of the composition can be from about 0.5 to about 40 weight percent, more specifically from about 5 to about 30 weight percent, and more
  • 575 specifically from about 10 to about 15 weight percent, based on the weight of the tissue.
  • the add-on amount will depend upon the desired effect of the composition on the product attributes and the specific composition.
  • a preferred method to uniformly apply the heated composition to the surface of the tissue web is rotogravure printing, either direct or indirect (offset), because it is a more precise printing process and offers maximum control of the
  • composition distribution and transfer rate 580 composition distribution and transfer rate.
  • other printing methods but not limted to, flexographic printing, slot coating, or spraying such as WEKO, can be used.
  • compositions of the present invention may be applied to the entire outer surface(s) of the tissue or towel product or portions thereof.
  • the compositions of the present invention may be applied non-uniformly to the outer surface of the tissue or towel 590 product.
  • non-uniformly refers to the amount, pattern of distribution, thickness of the application, areas of non-coverage, or the like, for which the composition can be varied over the outer surface(s) of the tissue or towel product.
  • tissue product can be a facial tissue, bath tissue, paper 595 towel, dinner napkin or the like.
  • the tissue products of this invention can be one-ply, two- ply, three- ply or more.
  • the composition is applied to one or both outer surfaces of the product after the product has been dried.
  • the composition can be applied after the plies are brought together or prior to bringing the plies together.
  • the individual plies can be layered or blended (homogeneous) creped or uncreped, throughdried or wet- 600 pressed. Examples
  • PROLIPID is commercially available from International Specialty Products located in Wayne, New Jersey. PROLIPID is generally described in U.S. Patent No. 5,849,315 to Rerek et al. which issued December 15, 1998; which is herein incorporated by reference to the extent it is consistent herewith.
  • Lipid-enriched absorbent tissue formulations promote barrier repair as measured by 675 Transepidermal water loss (TEWL).
  • TEWL Transepidermal water loss
  • lipid-enriched absorbent tissue formulations repaired the skin barrier compared to the untreated site at 1 ,2 and 4 hours after application of the formulas as measured by TEWL.
  • Formula 4 and 5 repaired the skin barrier compared to the untreated site as measured by TEWL.
  • Formula 5 repaired the barrier significantly better than Formula 4.
  • Formula 4 contains Lipomicron NSLE.a Sederma (Le Perray-en-Yvelines, France) product at the recommended use level that is marketed as a product for protection of the cutaneous barrier.
  • Lipid-enriched absorbent tissue formulations enhance skin moisturization as measured bv conductance.
  • Formula 5 significantly enhanced skin moisturization at 1 , 2 and 4 hours post 740 application of the formulas compared to the untreated site.
  • Formula 4 failed to enhance skin moisturization at any of the times tested.
  • Formula 4 contains Lipomicron NSLE.a Sederma (Le Perray-en-Yvelines, France) product at the recommended use level that is marketed as a product for protection of the cutaneous barrier.
  • the hydrophilic composition of 770 the present invention may provide absorbent tissue products having improved softness as well as providing improved protection of the skin barrier function. Accordingly, the different aspects of the present invention can advantageously provide absorbent tissue products which, when compared to conventional tissue products, are softer and have improved protection of skin barrier function.
  • Such absorbent tissue products can 775 advantageously be used for absorbent tissue products, such as facial tissue, bath tissue, paper towels, and the like.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)
  • Medicinal Preparation (AREA)

Abstract

Produit sous forme de tissu de qualité supérieure améliorant la barrière cutanée, tel qu'un mouchoir ou une serviette en papier, qu'on peut fabriquer par application sur la ou les surfaces de ce tissu d'une composition hydrophile fondue enrichie en lipides, qui contient un solvant hydrophile, un polyéthylène glycol à poids moléculaire élevé, un alcool gras (égal ou supérieur à C14-C30), un humectant, un tensioactif émulsifiant huile-dans-eau dont le niveau HLB est supérieur à 7, un β-stérol, ainsi qu'une graisse ou une huile naturelles, puis par resolidification de cette composition afin d'obtenir une répartition de composition solide sur la ou les surfaces du tissu.
PCT/US2000/011142 1999-04-23 2000-04-20 Tissus absorbants ameliorant la qualite de la barriere cutanee WO2000064409A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1020017013438A KR20010108523A (ko) 1999-04-23 2000-04-20 피부 차단성 강화 흡수성 티슈
AU44914/00A AU4491400A (en) 1999-04-23 2000-04-20 Skin barrier enhancing absorbent tissues
BR0009979-1A BR0009979A (pt) 1999-04-23 2000-04-20 Produto de lenço de papel ou toalha possuindo duas superfìcies externas, processo para fabricação do mesmo, e composição melhoradora de barreira da pele
DE10084499T DE10084499T1 (de) 1999-04-23 2000-04-20 Absorptionsfähige Gewebe zur Verbesserung der Hautschutzschicht
GB0126110A GB2367490A (en) 1999-04-23 2000-04-20 Skin barrier enhancing absorbent tissues

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13077999P 1999-04-23 1999-04-23
US60/130,779 1999-04-23
US37992999A 1999-08-24 1999-08-24
US09/379,929 1999-08-24

Publications (1)

Publication Number Publication Date
WO2000064409A1 true WO2000064409A1 (fr) 2000-11-02

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PCT/US2000/011142 WO2000064409A1 (fr) 1999-04-23 2000-04-20 Tissus absorbants ameliorant la qualite de la barriere cutanee

Country Status (8)

Country Link
KR (1) KR20010108523A (fr)
AR (1) AR023935A1 (fr)
AU (1) AU4491400A (fr)
BR (1) BR0009979A (fr)
CO (1) CO5160301A1 (fr)
DE (1) DE10084499T1 (fr)
GB (1) GB2367490A (fr)
WO (1) WO2000064409A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041869A2 (fr) * 2000-11-21 2002-05-30 Kimberly-Clark Worldwide, Inc. Produits papier traites avec des emulsions a face continue aqueuse
US6475197B1 (en) 1999-08-24 2002-11-05 Kimberly-Clark Worldwide, Inc. Absorbent articles having skin health benefits
US6534074B2 (en) 1999-08-24 2003-03-18 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
WO2004022116A1 (fr) * 2002-09-09 2004-03-18 Kimberly-Clark Worldwide, Inc. Composition d'hydratation et de lubrification de tampon interlabial
WO2005034905A1 (fr) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Produits en papier-linge comprenant une composition hydratante et lubrifiante
WO2005035013A1 (fr) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Produits absorbants contenant des compositions d'hydratation et de lubrification
WO2005035011A1 (fr) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Compositions d'humidification et de lubrification
WO2007134649A1 (fr) * 2006-05-18 2007-11-29 Fhw Feucht-Hygiene-Werk Gmbh Lingette nettoyante imprégnée de crème
WO2010135131A2 (fr) * 2009-05-22 2010-11-25 Wyeth Llc Bande jetable à usage unique pour application de compositions topiques
CN114059381A (zh) * 2020-08-07 2022-02-18 山东德泰纸业有限公司 一种具有抑菌效果的生活用纸及其制造方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
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KR100790014B1 (ko) * 2006-06-27 2008-01-02 주식회사 워터비스 해양 심층수를 포함하는 물티슈용 조성물 및 이를 함유하는물티슈
KR101233935B1 (ko) * 2011-03-28 2013-02-15 주식회사 엘지생활건강 기능성 물질을 포함하는 다색 다기능 티슈

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FR2331980A1 (fr) * 1975-11-24 1977-06-17 Chen Teng Mo Serviettes pour le rasage constituees de solutions ou d'emulsions cosmetiques de rasage et de matieres impregnees, telles que du papier
US4690821A (en) * 1984-02-10 1987-09-01 Creative Products Resource Associates, Ltd. Towel for skin moisturizing and drying
WO1999012519A1 (fr) * 1997-09-05 1999-03-18 The Procter & Gamble Company Produits de nettoyage et de conditionnement pour la peau et les cheveux ayant de meilleures qualites d'application des ingredients de conditionnement
WO1999013861A1 (fr) * 1997-09-12 1999-03-25 The Procter & Gamble Company Article nettoyant et revitalisant pour la peau ou les cheveux

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2331980A1 (fr) * 1975-11-24 1977-06-17 Chen Teng Mo Serviettes pour le rasage constituees de solutions ou d'emulsions cosmetiques de rasage et de matieres impregnees, telles que du papier
US4690821A (en) * 1984-02-10 1987-09-01 Creative Products Resource Associates, Ltd. Towel for skin moisturizing and drying
WO1999012519A1 (fr) * 1997-09-05 1999-03-18 The Procter & Gamble Company Produits de nettoyage et de conditionnement pour la peau et les cheveux ayant de meilleures qualites d'application des ingredients de conditionnement
WO1999013861A1 (fr) * 1997-09-12 1999-03-25 The Procter & Gamble Company Article nettoyant et revitalisant pour la peau ou les cheveux

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534074B2 (en) 1999-08-24 2003-03-18 Kimberly-Clark Worldwide, Inc. Absorbent articles providing skin health benefits
US6475197B1 (en) 1999-08-24 2002-11-05 Kimberly-Clark Worldwide, Inc. Absorbent articles having skin health benefits
KR100801828B1 (ko) * 2000-11-21 2008-02-11 킴벌리-클라크 월드와이드, 인크. 수중유 에멀젼으로 처리된 종이 제품
WO2002041869A3 (fr) * 2000-11-21 2003-05-01 Kimberly Clark Co Produits papier traites avec des emulsions a face continue aqueuse
WO2002041869A2 (fr) * 2000-11-21 2002-05-30 Kimberly-Clark Worldwide, Inc. Produits papier traites avec des emulsions a face continue aqueuse
WO2004022116A1 (fr) * 2002-09-09 2004-03-18 Kimberly-Clark Worldwide, Inc. Composition d'hydratation et de lubrification de tampon interlabial
WO2005034905A1 (fr) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Produits en papier-linge comprenant une composition hydratante et lubrifiante
WO2005035013A1 (fr) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Produits absorbants contenant des compositions d'hydratation et de lubrification
WO2005035011A1 (fr) * 2003-09-11 2005-04-21 Kimberly-Clark Worldwide, Inc. Compositions d'humidification et de lubrification
WO2007134649A1 (fr) * 2006-05-18 2007-11-29 Fhw Feucht-Hygiene-Werk Gmbh Lingette nettoyante imprégnée de crème
WO2010135131A2 (fr) * 2009-05-22 2010-11-25 Wyeth Llc Bande jetable à usage unique pour application de compositions topiques
WO2010135131A3 (fr) * 2009-05-22 2011-03-03 Wyeth Llc Bande jetable à usage unique pour application de compositions topiques
CN114059381A (zh) * 2020-08-07 2022-02-18 山东德泰纸业有限公司 一种具有抑菌效果的生活用纸及其制造方法

Also Published As

Publication number Publication date
KR20010108523A (ko) 2001-12-07
BR0009979A (pt) 2002-01-08
DE10084499T1 (de) 2002-07-25
AR023935A1 (es) 2002-09-04
CO5160301A1 (es) 2002-05-30
GB2367490A (en) 2002-04-10
AU4491400A (en) 2000-11-10
GB0126110D0 (en) 2002-01-02

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