WO2000063202A3 - BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS - Google Patents

BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS Download PDF

Info

Publication number
WO2000063202A3
WO2000063202A3 PCT/IB2000/000563 IB0000563W WO0063202A3 WO 2000063202 A3 WO2000063202 A3 WO 2000063202A3 IB 0000563 W IB0000563 W IB 0000563W WO 0063202 A3 WO0063202 A3 WO 0063202A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
benzo
antineoplastic agents
alkyl
dioxide derivatives
Prior art date
Application number
PCT/IB2000/000563
Other languages
French (fr)
Other versions
WO2000063202A2 (en
WO2000063202A8 (en
Inventor
Merino Victor Martinez
Iodate Maria Jose Gil
Martinez Ignacio Encio
Vazquez Marco Migliaccio
Martin Carmen Arteaga
Original Assignee
Univ Navarra Publica
Merino Victor Martinez
Iodate Maria Jose Gil
Martinez Ignacio Encio
Vazquez Marco Migliaccio
Martin Carmen Arteaga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Navarra Publica, Merino Victor Martinez, Iodate Maria Jose Gil, Martinez Ignacio Encio, Vazquez Marco Migliaccio, Martin Carmen Arteaga filed Critical Univ Navarra Publica
Priority to AU41370/00A priority Critical patent/AU4137000A/en
Publication of WO2000063202A2 publication Critical patent/WO2000063202A2/en
Publication of WO2000063202A3 publication Critical patent/WO2000063202A3/en
Publication of WO2000063202A8 publication Critical patent/WO2000063202A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Compounds of formula (I) or (II) wherein: n is 1 or 2; R4 and R5 each represents hydrogen or C1-C3 alkyl; and each R may be in position 4, 5, 6, or 7 of the benzothiophene ring and independently represents hydrogen; a halogen; C1-C3 alkyl; or a group -SO2Y, in whch Y represents a group -NR1R2, a group -NHCOOR3, -NHCONH2 or a group -NHCONHR3 in which R1 and R2 are independently hydrogen, C1-C3 alkyl or aryl, and R3 is C1-C3 alkyl or aryl; with the proviso that one and only one R represents a group -SO2Y; are useful in the treatment of cancerous tumours.
PCT/IB2000/000563 1999-04-19 2000-04-14 BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS WO2000063202A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41370/00A AU4137000A (en) 1999-04-19 2000-04-14 Benzo((b)) thiophene sulfonamide-1, 1-dioxide derivatives and their use as antineoplastic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009900883A ES2156550B1 (en) 1999-04-19 1999-04-19 BENZO DERIVATIVES (B) THIOPHENOSULPHONAMIDE-1,1-DIOXIDE AND ITS USE AS ANTHINEOPLASTIC AGENTS.
ESP9900883 1999-04-19

Publications (3)

Publication Number Publication Date
WO2000063202A2 WO2000063202A2 (en) 2000-10-26
WO2000063202A3 true WO2000063202A3 (en) 2001-03-08
WO2000063202A8 WO2000063202A8 (en) 2001-08-16

Family

ID=8308188

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/000563 WO2000063202A2 (en) 1999-04-19 2000-04-14 BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS

Country Status (3)

Country Link
AU (1) AU4137000A (en)
ES (1) ES2156550B1 (en)
WO (1) WO2000063202A2 (en)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1585930A (en) * 1968-06-27 1970-02-06
FR7782M (en) * 1968-09-18 1970-03-23
EP0212779A2 (en) * 1985-05-14 1987-03-04 E.I. Du Pont De Nemours And Company Herbicidal sulfonamides
EP0222475A1 (en) * 1985-09-23 1987-05-20 Eli Lilly And Company Sulfonyl ureas with anti-tumour activity
EP0241254A2 (en) * 1986-04-07 1987-10-14 E.I. Du Pont De Nemours And Company Herbicidal sulfonamides
EP0291269A2 (en) * 1987-05-12 1988-11-17 Eli Lilly And Company Anti-tumour sulfonyl urea derivatives
US4802908A (en) * 1987-01-22 1989-02-07 E. I. Du Pont De Nemours And Company Herbicidal 2-(1H)-pyrazinones
US4844727A (en) * 1987-11-16 1989-07-04 E. I. Du Pont De Nemours And Company Herbicidal sulfonamides
WO1990006308A1 (en) * 1987-08-19 1990-06-14 E.I. Du Pont De Nemours And Company Process for preparing sulfonylurea salts
EP0560554A2 (en) * 1992-03-13 1993-09-15 Eli Lilly And Company Antitumor compositions and methods of treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0724879A2 (en) * 1995-02-06 1996-08-07 Eli Lilly And Company 2-Phenyl-3-azoylbenzothiopenes for inhibiting effects of IL-6
US5731342A (en) * 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1585930A (en) * 1968-06-27 1970-02-06
FR7782M (en) * 1968-09-18 1970-03-23
EP0212779A2 (en) * 1985-05-14 1987-03-04 E.I. Du Pont De Nemours And Company Herbicidal sulfonamides
EP0222475A1 (en) * 1985-09-23 1987-05-20 Eli Lilly And Company Sulfonyl ureas with anti-tumour activity
EP0241254A2 (en) * 1986-04-07 1987-10-14 E.I. Du Pont De Nemours And Company Herbicidal sulfonamides
US4802908A (en) * 1987-01-22 1989-02-07 E. I. Du Pont De Nemours And Company Herbicidal 2-(1H)-pyrazinones
EP0291269A2 (en) * 1987-05-12 1988-11-17 Eli Lilly And Company Anti-tumour sulfonyl urea derivatives
WO1990006308A1 (en) * 1987-08-19 1990-06-14 E.I. Du Pont De Nemours And Company Process for preparing sulfonylurea salts
US4844727A (en) * 1987-11-16 1989-07-04 E. I. Du Pont De Nemours And Company Herbicidal sulfonamides
EP0560554A2 (en) * 1992-03-13 1993-09-15 Eli Lilly And Company Antitumor compositions and methods of treatment

Also Published As

Publication number Publication date
ES2156550A1 (en) 2001-06-16
WO2000063202A2 (en) 2000-10-26
WO2000063202A8 (en) 2001-08-16
AU4137000A (en) 2000-11-02
ES2156550B1 (en) 2002-02-01

Similar Documents

Publication Publication Date Title
PT1159279E (en) 4-OXO-4,7-DIHYDROTIENE-2,3-B | PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS
NZ514873A (en) 4,5,6,7-tetrahydroindazole derivatives as antitumor agents
MXPA02000973A (en) Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists.
BR0311771A (en) Nonane and azabicyclooctane derivatives with ddp-iv inhibitory activity
MXPA05007296A (en) (2-carboxamido) (3-amino) thiophene compounds.
MY125359A (en) Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods.
NZ510097A (en) Pyrroloindoles, pyridoindoles and azepinoindoles useful as 5-HT2C agonists
MY137156A (en) Dual nk1/nk3 derivatives
WO2004087056A3 (en) BI-CYCLIC PYRIMIDINE INHIBITORS OF TGFβ
AU2001293233A1 (en) Aza heterocyclic derivatives and their therapeutic use
WO2004108715A8 (en) 3-aryloxy and 3-heteroaryloxy substituted benzo(b) thiophenes as therapeutic agents with pi3k activity
WO2001094345A3 (en) Derivatives of 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
GB9923077D0 (en) Sapogenin derivatives and their use
SI1042319T1 (en) Dihydrobenzofurans
MXPA05013210A (en) Cycloalkylsulfanyl substituted benzo[b]thiophenes as therapeutic agents.
PL356541A1 (en) 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity
MXPA05012953A (en) 3-arylsulfanyl and 3-heteroarylsulfanyl substituted benzo[b]thiophenes as therapeutic agents.
ATE259813T1 (en) TRIAZOLOPYRIMIDE DERIVATIVES
NZ314570A (en) Treatment of emesis using tetrahydrobenz[cd]indole-6-carboxamides
WO2000063202A3 (en) BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS
MXPA03003971A (en) Indole derivatives as pde5-inhibitors.
GB9907055D0 (en) Antibacterial agents
AU2001261707A1 (en) Pirazino '1$m(1)2$m(1) :1, 6! pyrido '3,4-b! indole derivatives
AP2002002595A0 (en) Heterocyclic amide derivatives.
MY138845A (en) (2-carboxamido)(3-amino) thiophene compounds

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 43/2000 UNDER (81) ADD "KR, KZ, LC, LK"

AK Designated states

Kind code of ref document: B8

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: B8

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP