WO2000063182A3 - 2,4-diamino-pyrimidine derivatives and their use as microbicides and herbicides - Google Patents

2,4-diamino-pyrimidine derivatives and their use as microbicides and herbicides Download PDF

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Publication number
WO2000063182A3
WO2000063182A3 PCT/EP2000/003158 EP0003158W WO0063182A3 WO 2000063182 A3 WO2000063182 A3 WO 2000063182A3 EP 0003158 W EP0003158 W EP 0003158W WO 0063182 A3 WO0063182 A3 WO 0063182A3
Authority
WO
WIPO (PCT)
Prior art keywords
microbicides
herbicides
diamino
pyrimidine derivatives
novel
Prior art date
Application number
PCT/EP2000/003158
Other languages
German (de)
French (fr)
Other versions
WO2000063182A2 (en
Inventor
Stefan Lehr
Hans-Jochem Riebel
Astrid Mauler-Machnik
Karl-Heinz Kuck
Mark Wilhelm Drewes
Ingo Wetcholowsky
Original Assignee
Bayer Ag
Stefan Lehr
Riebel Hans Jochem
Mauler Machnik Astrid
Kuck Karl Heinz
Mark Wilhelm Drewes
Ingo Wetcholowsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Stefan Lehr, Riebel Hans Jochem, Mauler Machnik Astrid, Kuck Karl Heinz, Mark Wilhelm Drewes, Ingo Wetcholowsky filed Critical Bayer Ag
Priority to AU38192/00A priority Critical patent/AU3819200A/en
Publication of WO2000063182A2 publication Critical patent/WO2000063182A2/en
Publication of WO2000063182A3 publication Critical patent/WO2000063182A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Abstract

The invention relates to novel 2,4-diamino-pyrimidine derivatives of the formula (I), in which R?1, R2, R3, R4, R5 and R6¿ have the meanings defined in the description. The invention also relates to their acid addition salts and metal salt complexes and to several methods for producing said novel substances and to their use as microbicides and herbicides. Also disclosed are novel intermediates of the formulae (IIa) and (IIb), wherein R?1, R5, R6¿, X and Z have the meanings defined in the description, and to methods for producing them.
PCT/EP2000/003158 1999-04-20 2000-04-10 2,4-diamino-pyrimidine derivatives and their use as microbicides and herbicides WO2000063182A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU38192/00A AU3819200A (en) 1999-04-20 2000-04-10 2,4-diamino-pyrimidine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1999117785 DE19917785A1 (en) 1999-04-20 1999-04-20 New 2,4-diamino-pyrimidine derivatives useful as microbicides in protection of plants and materials and as herbicides
DE19917785.6 1999-04-20

Publications (2)

Publication Number Publication Date
WO2000063182A2 WO2000063182A2 (en) 2000-10-26
WO2000063182A3 true WO2000063182A3 (en) 2001-10-11

Family

ID=7905181

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/003158 WO2000063182A2 (en) 1999-04-20 2000-04-10 2,4-diamino-pyrimidine derivatives and their use as microbicides and herbicides

Country Status (3)

Country Link
AU (1) AU3819200A (en)
DE (1) DE19917785A1 (en)
WO (1) WO2000063182A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835430B2 (en) 2002-02-01 2014-09-16 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses

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SE0104140D0 (en) 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
IL166241A0 (en) 2002-07-29 2006-01-15 Rigel Pharmaceuticals Inc Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
DK1656372T3 (en) 2003-07-30 2013-07-01 Rigel Pharmaceuticals Inc 2,4-PYRIMIDINE DIAMINE COMPOUNDS FOR USING TREATMENT OR PREVENTION OF AUTO-IMMUNE DISEASES
JP2007510626A (en) 2003-10-17 2007-04-26 アストラゼネカ アクチボラグ 4- (Pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer
ES2380550T3 (en) 2004-11-24 2012-05-16 Rigel Pharmaceuticals, Inc. Spiro-2,4-pyrimidinediamine compounds and their uses
US8211929B2 (en) 2004-12-30 2012-07-03 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
US7449458B2 (en) 2005-01-19 2008-11-11 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
CN101155800B (en) 2005-02-04 2012-05-23 阿斯利康(瑞典)有限公司 Pyrazolylaminopyridine derivatives useful as kinase inhibitors
DK1853588T3 (en) 2005-02-16 2008-09-15 Astrazeneca Ab Chemical compounds
BRPI0610184A2 (en) 2005-05-16 2012-09-25 Astrazeneca Ab compound, pharmaceutically acceptable salt of a compound, process for preparing a compound or a pharmaceutically acceptable salt thereof, use of a compound or a pharmaceutically acceptable salt thereof, methods for inhibiting trk activity, for cancer treatment or prophylaxis and for producing an antiproliferative effect on a warm-blooded animal, and, pharmaceutical composition
CA2626375A1 (en) 2005-10-28 2007-05-03 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
US8222256B2 (en) 2006-07-05 2012-07-17 Exelixis, Inc. Methods of using IGFIR and ABL kinase modulators
UA99459C2 (en) 2007-05-04 2012-08-27 Астразенека Аб 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer
US10981899B2 (en) 2016-04-28 2021-04-20 Cornell University Inhibitors of soluble adenylyl cyclase
MA54864A (en) * 2019-02-01 2021-12-22 Fmc Corp PYRIDINES AND DIAMINO-SUBSTITUTED PYRIMIDINES AS HERBICIDES

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835430B2 (en) 2002-02-01 2014-09-16 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US9018204B1 (en) 2002-02-01 2015-04-28 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US9346765B2 (en) 2002-02-01 2016-05-24 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US9416112B2 (en) 2002-02-01 2016-08-16 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses
US9913842B2 (en) 2002-02-01 2018-03-13 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds and their uses

Also Published As

Publication number Publication date
WO2000063182A2 (en) 2000-10-26
AU3819200A (en) 2000-11-02
DE19917785A1 (en) 2000-10-26

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