WO2000061729A3 - Regulation of the expression of transcriptional repressor genes using nucleic acid molecules - Google Patents

Regulation of the expression of transcriptional repressor genes using nucleic acid molecules Download PDF

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Publication number
WO2000061729A3
WO2000061729A3 PCT/US2000/009721 US0009721W WO0061729A3 WO 2000061729 A3 WO2000061729 A3 WO 2000061729A3 US 0009721 W US0009721 W US 0009721W WO 0061729 A3 WO0061729 A3 WO 0061729A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
expression
regulation
transcriptional repressor
Prior art date
Application number
PCT/US2000/009721
Other languages
French (fr)
Other versions
WO2000061729A2 (en
Inventor
Lawrence Blatt
Michael Zwick
Pamela Pavco
James Mcswiggen
Original Assignee
Ribozyme Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribozyme Pharm Inc filed Critical Ribozyme Pharm Inc
Priority to EP00922089A priority Critical patent/EP1165758A2/en
Priority to AU42327/00A priority patent/AU4232700A/en
Priority to JP2000611654A priority patent/JP2002541795A/en
Priority to CA002364577A priority patent/CA2364577A1/en
Publication of WO2000061729A2 publication Critical patent/WO2000061729A2/en
Publication of WO2000061729A3 publication Critical patent/WO2000061729A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Nucleic acid molecules which inhibit the expression of repressor genes are described. Also described are methods for preparing and using such nucleic acid molecules.
PCT/US2000/009721 1999-04-12 2000-04-11 Regulation of the expression of transcriptional repressor genes using nucleic acid molecules WO2000061729A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00922089A EP1165758A2 (en) 1999-04-12 2000-04-11 Regulation of the expression of transcriptional repressor genes using nucleic acid molecules
AU42327/00A AU4232700A (en) 1999-04-12 2000-04-11 Regulation of repressor genes using nucleic acid molecules
JP2000611654A JP2002541795A (en) 1999-04-12 2000-04-11 Regulation of repressor genes using nucleic acid molecules
CA002364577A CA2364577A1 (en) 1999-04-12 2000-04-11 Regulation of repressor genes using nucleic acid molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12939099P 1999-04-12 1999-04-12
US60/129,390 1999-04-12

Publications (2)

Publication Number Publication Date
WO2000061729A2 WO2000061729A2 (en) 2000-10-19
WO2000061729A3 true WO2000061729A3 (en) 2001-08-09

Family

ID=22439716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/009721 WO2000061729A2 (en) 1999-04-12 2000-04-11 Regulation of the expression of transcriptional repressor genes using nucleic acid molecules

Country Status (5)

Country Link
EP (1) EP1165758A2 (en)
JP (1) JP2002541795A (en)
AU (1) AU4232700A (en)
CA (1) CA2364577A1 (en)
WO (1) WO2000061729A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395546B1 (en) 2000-02-01 2002-05-28 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
DE10049549A1 (en) * 2000-10-06 2002-05-02 Markus Hecker Inhibitor of the transcription factor IFR-1, useful for treating e.g. transplant rejection and autoimmune disease, reduces expression of CD40
GB0123401D0 (en) * 2001-09-28 2001-11-21 Novartis Forschungsstiftung Methods of inducing gene expression
CN101018868A (en) 2004-02-13 2007-08-15 马泰克生物科学公司 SCHIZOCHYTRIUM fatty acid synthase (FAS) and products and methods related thereto
GB2424886A (en) 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
CN112574343B (en) * 2020-11-19 2021-10-15 浙江大学 Cationic polymer with hypoxia response and preparation method and application thereof
CN115927038B (en) * 2022-07-06 2024-04-30 西北农林科技大学 Streptomyces strain and application thereof in plant pathogenic fungi control

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035170A2 (en) * 1998-01-05 1999-07-15 Genentech, Inc. Compositions and methods for the treatment of tumor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035170A2 (en) * 1998-01-05 1999-07-15 Genentech, Inc. Compositions and methods for the treatment of tumor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHANG C ET AL: "MOLECULAR CLONING OF NEW HUMAN TR2 RECEPTORS A CLASS OF STEROID RECEPTOR WITH MULTIPLE LIGAND-BINDING DOMAINS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 165, no. 2, 1989, pages 735 - 741, XP000960959, ISSN: 0006-291X *
CHRISTOFFERSEN R E ET AL: "RIBOZYMES AS HUMAN THERAPEUTIC AGENTS", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 38, no. 12, 9 June 1995 (1995-06-09), pages 2023 - 2037, XP002062054, ISSN: 0022-2623 *
IMAGAWA SHIGEHIKO ET AL: "Negative regulation of the erythropoietin gene expression by the GATA transcription factors.", BLOOD, vol. 89, no. 4, 1997, pages 1430 - 1439, XP000965159, ISSN: 0006-4971 *
LEE HAN-JUNG ET AL: "Suppression of the human erythropoietin gene expression by the TR2 orphan receptor, a member of the steroid receptor superfamily.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 17, 1996, pages 10405 - 10412, XP000960962, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2364577A1 (en) 2000-10-19
AU4232700A (en) 2000-11-14
WO2000061729A2 (en) 2000-10-19
JP2002541795A (en) 2002-12-10
EP1165758A2 (en) 2002-01-02

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