WO2000061574A3 - Method for producing thiophenyl-amidines - Google Patents

Method for producing thiophenyl-amidines Download PDF

Info

Publication number
WO2000061574A3
WO2000061574A3 PCT/EP2000/003018 EP0003018W WO0061574A3 WO 2000061574 A3 WO2000061574 A3 WO 2000061574A3 EP 0003018 W EP0003018 W EP 0003018W WO 0061574 A3 WO0061574 A3 WO 0061574A3
Authority
WO
WIPO (PCT)
Prior art keywords
amidines
producing
thiophenyl
amidoximes
reacted
Prior art date
Application number
PCT/EP2000/003018
Other languages
German (de)
French (fr)
Other versions
WO2000061574A2 (en
Inventor
Thomas Zierke
Helmut Mack
Original Assignee
Basf Ag
Thomas Zierke
Helmut Mack
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Thomas Zierke, Helmut Mack filed Critical Basf Ag
Priority to AU35590/00A priority Critical patent/AU3559000A/en
Priority to EP00914182A priority patent/EP1169315A2/en
Priority to CA002369267A priority patent/CA2369267A1/en
Priority to JP2000610848A priority patent/JP2002541252A/en
Publication of WO2000061574A2 publication Critical patent/WO2000061574A2/en
Publication of WO2000061574A3 publication Critical patent/WO2000061574A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to a method for producing amidines that are not substituted on the nitrogen atom and salts thereof with inorganic or organic acids. According to said method, the corresponding carboxylic acid amidoximes are reacted with Zn in the presence of carboxylic acids.
PCT/EP2000/003018 1999-04-09 2000-04-05 Method for producing thiophenyl-amidines WO2000061574A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU35590/00A AU3559000A (en) 1999-04-09 2000-04-05 Method for producing amidines
EP00914182A EP1169315A2 (en) 1999-04-09 2000-04-05 Method for producing amidines
CA002369267A CA2369267A1 (en) 1999-04-09 2000-04-05 Method for producing amidines
JP2000610848A JP2002541252A (en) 1999-04-09 2000-04-05 Amidine production

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19915930.0 1999-04-09
DE19915930 1999-04-09
DE19933873 1999-07-23
DE19933873.6 1999-07-23

Publications (2)

Publication Number Publication Date
WO2000061574A2 WO2000061574A2 (en) 2000-10-19
WO2000061574A3 true WO2000061574A3 (en) 2001-04-26

Family

ID=26052817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/003018 WO2000061574A2 (en) 1999-04-09 2000-04-05 Method for producing thiophenyl-amidines

Country Status (5)

Country Link
EP (1) EP1169315A2 (en)
JP (1) JP2002541252A (en)
AU (1) AU3559000A (en)
CA (1) CA2369267A1 (en)
WO (1) WO2000061574A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1489575A (en) * 2001-01-29 2004-04-14 ������������ʽ���� Benzamidine derivatives and process for producing same
WO2006101860A1 (en) * 2005-03-16 2006-09-28 Janssen Pharmaceutica N.V. Novel thiophene sulfoximines for treating complement-mediated diseases and conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2375611A (en) * 1941-08-19 1945-05-08 May & Baker Ltd Production of amidines
US2851490A (en) * 1955-04-20 1958-09-09 Monsanto Chemicals Guanyl aliphatic mono-carboxylic acids
WO1998006741A1 (en) * 1996-08-14 1998-02-19 Basf Aktiengesellschaft Thrombin inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2375611A (en) * 1941-08-19 1945-05-08 May & Baker Ltd Production of amidines
US2851490A (en) * 1955-04-20 1958-09-09 Monsanto Chemicals Guanyl aliphatic mono-carboxylic acids
WO1998006741A1 (en) * 1996-08-14 1998-02-19 Basf Aktiengesellschaft Thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
F. ELOY ET AL.: "THE CHEMISTRY OF AMIDOXIMES AND RELATED COMPOUNDS", CHEMICAL REVIEWS., vol. 62, 1962, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 155 - 183, XP002151891, ISSN: 0009-2665 *

Also Published As

Publication number Publication date
WO2000061574A2 (en) 2000-10-19
CA2369267A1 (en) 2000-10-19
EP1169315A2 (en) 2002-01-09
JP2002541252A (en) 2002-12-03
AU3559000A (en) 2000-11-14

Similar Documents

Publication Publication Date Title
WO2001075315A3 (en) Self adjusting screw system
EP0608838A3 (en) Method for producing an unsaturated carboxylic acid.
EP1409116A4 (en) Electrodialysis of multivalent metal salts
ZA9986B (en) Anhydrous carbonylation process for the production of acetic acid.
EP1277792A3 (en) Biodegradable plastic composition and method for control of biodegradation rate of biodegradable plastic
WO2001079305A3 (en) High-molecular, cross-linked polyvinyl butyrals, method for the production thereof and their use
AU5779400A (en) Process for the preparation of 3,3-dimethylbutanal
AU2001271085A1 (en) Organic acid producing microorganism and process for preparing organic acids employing the same
ZA200108917B (en) Process for the preparation of carboxylic acid salts from primary alcohols.
AU2003278114A1 (en) Flexible method for the joint production of (i) formic acid, (ii) a carboxylic acid comprising at least two carbon atoms and/or the derivatives thereof, and (iii) a carboxylic acid anhydride
AU6077798A (en) A condensed piperidine compound
WO2000061574A3 (en) Method for producing thiophenyl-amidines
MXPA03004479A (en) Method for the carbonylation of pentenoic acid and derivatives thereof.
ZA200202834B (en) Plants having altered amino acid contents and method for the production thereof.
WO2001035368A3 (en) Universal remote controller
EP1359180A3 (en) Method of producing polyamide resin wherein carboxylic acid-activator and/or inorganic salt is present in reaction system therefor
ZA975954B (en) Multifunctional acid modifiers for acid-containing polymer systems.
ZA200201779B (en) Intermediates for the production of quinolone carboxylic acid derivatives.
MXPA03001149A (en) Process for preparing alkylidene substituted succinic acid esters.
PL348526A1 (en) Method for producing glyoxylic acid esters or the hydrates thereof
EP1174413A3 (en) Process for production of carboxylic acid aryl esters
HK1042703A1 (en) Crystal modification a f 8-cyano-1-cyclopropyl-7-(1S,6S-2, 8-diazabicycloÄ4.3.0Ünonan-8-yl)-6-fluoro-1, 4-dihydro-4-oxo-3- quinoline carboxylic acid.
EP1013662A4 (en) Reaction products between carboxylic acid and amino acid or amino acid condensate and process for producing the same
CA2292618A1 (en) Improved precipitation process of 7-aminocephalosporanic acid (7-aca)
WO2002066666A3 (en) Method for producing d-pantothenic acid and/or salts thereof as an additive for animal feed

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2369267

Country of ref document: CA

Ref country code: CA

Ref document number: 2369267

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 610848

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09958352

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2000914182

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000914182

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2000914182

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642