WO2000061122A3 - Use of 6-methylmercaptopurine riboside in ophthalmologic compositions - Google Patents

Use of 6-methylmercaptopurine riboside in ophthalmologic compositions Download PDF

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Publication number
WO2000061122A3
WO2000061122A3 PCT/EP2000/002717 EP0002717W WO0061122A3 WO 2000061122 A3 WO2000061122 A3 WO 2000061122A3 EP 0002717 W EP0002717 W EP 0002717W WO 0061122 A3 WO0061122 A3 WO 0061122A3
Authority
WO
WIPO (PCT)
Prior art keywords
outcomes
methylmercaptopurine riboside
compositions
cornea
corneal
Prior art date
Application number
PCT/EP2000/002717
Other languages
French (fr)
Other versions
WO2000061122A2 (en
Inventor
Giorgio Zoppetti
Pasqua Oreste
Marco Presta
Original Assignee
Giorgio Zoppetti
Pasqua Oreste
Marco Presta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giorgio Zoppetti, Pasqua Oreste, Marco Presta filed Critical Giorgio Zoppetti
Priority to EP00912652A priority Critical patent/EP1171138A2/en
Priority to AU34323/00A priority patent/AU3432300A/en
Publication of WO2000061122A2 publication Critical patent/WO2000061122A2/en
Publication of WO2000061122A3 publication Critical patent/WO2000061122A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Use of 6-methylmercaptopurine riboside for the preparation of compositions in the form of ointment, suitable for the treatment of angiogenesis-dependent pathologies of the cornea, including ulcerative an not ulcerative keratites, pterygium, outcomes of corneal traumas, wounds and cauterizations, outcomes of corneal transplant operations, rejection of the cornea flap after transplant, outcomes of refractive surgery oeprations, kerato-uveites, trachoma and allergic conjunctivites.
PCT/EP2000/002717 1999-04-12 2000-03-28 Use of 6-methylmercaptopurine riboside in ophthalmologic compositions WO2000061122A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00912652A EP1171138A2 (en) 1999-04-12 2000-03-28 Use of 6-methylmercaptopurine riboside in ophthalmologic compositions
AU34323/00A AU3432300A (en) 1999-04-12 2000-03-28 Use of 6-methylmercaptopurine riboside in ophthalmologic compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000738A IT1311913B1 (en) 1999-04-12 1999-04-12 USE OF 6-METHYLMERCAPTOPURIN RIBOSIDE IN OPHTHALMOLOGICAL COMPOSITIONS.
ITMI99A000738 1999-04-12

Publications (2)

Publication Number Publication Date
WO2000061122A2 WO2000061122A2 (en) 2000-10-19
WO2000061122A3 true WO2000061122A3 (en) 2001-02-22

Family

ID=11382660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/002717 WO2000061122A2 (en) 1999-04-12 2000-03-28 Use of 6-methylmercaptopurine riboside in ophthalmologic compositions

Country Status (4)

Country Link
EP (1) EP1171138A2 (en)
AU (1) AU3432300A (en)
IT (1) IT1311913B1 (en)
WO (1) WO2000061122A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9023309B1 (en) * 2014-05-13 2015-05-05 Mahin Rameshni Process of conversion sulfur compounds to elemental sulfur by using direct reduction and oxidation catalysts in Claus units

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088756A (en) * 1973-01-16 1978-05-09 The Regents Of The University Of Michigan Pharmaceutical composition and process of treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4088756A (en) * 1973-01-16 1978-05-09 The Regents Of The University Of Michigan Pharmaceutical composition and process of treatment

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LESLIE, S. W. ET AL: "Adenosine analogs. Structure-activity relations in vascular and intestinal smoothe muscle", J. PHARM. SCI. (1973), 62(9), 1449-52, XP000946576 *
PRESTA, MARCO ET AL: "Purine analog 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process", CANCER RES. (1999), 59(10), 2417-2424, XP000946571 *

Also Published As

Publication number Publication date
WO2000061122A2 (en) 2000-10-19
AU3432300A (en) 2000-11-14
ITMI990738A1 (en) 2000-10-12
IT1311913B1 (en) 2002-03-20
EP1171138A2 (en) 2002-01-16

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