WO2000060092A3 - Dsp-3 dual-specificity phosphatase - Google Patents

Dsp-3 dual-specificity phosphatase Download PDF

Info

Publication number
WO2000060092A3
WO2000060092A3 PCT/US2000/009185 US0009185W WO0060092A3 WO 2000060092 A3 WO2000060092 A3 WO 2000060092A3 US 0009185 W US0009185 W US 0009185W WO 0060092 A3 WO0060092 A3 WO 0060092A3
Authority
WO
WIPO (PCT)
Prior art keywords
dsp
dual
specificity phosphatase
cell
polypeptides
Prior art date
Application number
PCT/US2000/009185
Other languages
French (fr)
Other versions
WO2000060092A9 (en
WO2000060092A2 (en
Inventor
Ralf M Luche
Bo Wei
Original Assignee
Ceptyr Inc
Ralf M Luche
Bo Wei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceptyr Inc, Ralf M Luche, Bo Wei filed Critical Ceptyr Inc
Priority to AU42067/00A priority Critical patent/AU4206700A/en
Priority to AU43676/00A priority patent/AU4367600A/en
Priority to PCT/US2000/010868 priority patent/WO2001002581A1/en
Priority to PCT/US2000/018207 priority patent/WO2001002582A1/en
Priority to CA002377670A priority patent/CA2377670A1/en
Priority to DK00943359T priority patent/DK1196598T3/en
Priority to AU57838/00A priority patent/AU5783800A/en
Publication of WO2000060092A2 publication Critical patent/WO2000060092A2/en
Publication of WO2000060092A3 publication Critical patent/WO2000060092A3/en
Publication of WO2000060092A9 publication Critical patent/WO2000060092A9/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-3, and polypeptide variants thereof that stimulate dephosphorylation of DSP-3 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-3 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation and survival.
PCT/US2000/009185 1999-04-07 2000-04-07 Dsp-3 dual-specificity phosphatase WO2000060092A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU42067/00A AU4206700A (en) 1999-04-07 2000-04-07 Dsp-3 dual-specificity phosphatase
AU43676/00A AU4367600A (en) 1999-07-02 2000-04-20 Dsp-3 dual-specificity phosphatase
PCT/US2000/010868 WO2001002581A1 (en) 1999-07-02 2000-04-20 Dsp-3 dual-specificity phosphatase
PCT/US2000/018207 WO2001002582A1 (en) 1999-07-02 2000-06-29 Dsp-3 dual-specificity phosphatase
CA002377670A CA2377670A1 (en) 1999-07-02 2000-06-29 Dsp-3 dual-specificity phosphatase
DK00943359T DK1196598T3 (en) 1999-07-02 2000-06-29 Double specificity DSP-3 phosphatase
AU57838/00A AU5783800A (en) 1999-07-02 2000-06-29 Dsp-3 dual-specificity phosphatase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12822599P 1999-04-07 1999-04-07
US60/128,225 1999-04-07
US14233899P 1999-07-02 1999-07-02
US60/142,338 1999-07-02

Publications (3)

Publication Number Publication Date
WO2000060092A2 WO2000060092A2 (en) 2000-10-12
WO2000060092A3 true WO2000060092A3 (en) 2001-01-04
WO2000060092A9 WO2000060092A9 (en) 2002-08-29

Family

ID=26826403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/009185 WO2000060092A2 (en) 1999-04-07 2000-04-07 Dsp-3 dual-specificity phosphatase

Country Status (2)

Country Link
AU (1) AU4206700A (en)
WO (1) WO2000060092A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4367600A (en) * 1999-07-02 2001-01-22 Ceptyr, Inc. Dsp-3 dual-specificity phosphatase
US7202024B2 (en) * 2001-09-17 2007-04-10 Immunogen Inc. bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter
US20040009946A1 (en) 2002-05-23 2004-01-15 Ceptyr, Inc. Modulation of PTP1B expression and signal transduction by RNA interference

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002704A2 (en) * 1997-07-08 1999-01-21 Cold Spring Harbor Laboratory Dual specifically phosphatase and methods of use
WO2000006728A2 (en) * 1998-07-28 2000-02-10 Incyte Pharmaceuticals, Inc. Phosphorylation effectors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002704A2 (en) * 1997-07-08 1999-01-21 Cold Spring Harbor Laboratory Dual specifically phosphatase and methods of use
WO2000006728A2 (en) * 1998-07-28 2000-02-10 Incyte Pharmaceuticals, Inc. Phosphorylation effectors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE SEQUENCE 3 October 1996 (1996-10-03), "88.9% identity with SEQ ID NO:1 from nt.78 to nt.330", XP002147546 *
DATABASE EMBL NUCLEOTIDE SEQUENCE 4 May 1997 (1997-05-04), "100% identity with SEQ ID NO:1 from nt.143 to nt.371. Similarity with a Dual Specificity Phosphatase", XP002147544 *
DATABASE EMBL NUCLEOTIDE SEQUENCE 5 May 1997 (1997-05-05), "99.3% identity with SEQ ID NO:1 from nt.354 to nt.800", XP002147545 *
KEYSE S.M.: "An emerging family of Dual Specificity MAP Kinase Phosphatases", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1265, 1995, pages 152 - 160, XP000196716, ISSN: 0167-4889 *

Also Published As

Publication number Publication date
AU4206700A (en) 2000-10-23
WO2000060092A9 (en) 2002-08-29
WO2000060092A2 (en) 2000-10-12

Similar Documents

Publication Publication Date Title
UA74325C2 (en) HETEROCYCLIC INHIBITORS р38, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND A METHOD FOR TREATMENT WITH THEIR USE
AU8377698A (en) Inhibitors of p38
GEP20033092B (en) Purine Inhibitors of Cyclin Dependent Kinase 2 and Ik-Aa
WO2003029418A3 (en) Proliferation and differentiation of stem cells using extracellular matrix and other molecules
DE69837393D1 (en) STIMULATION OF HEMATOPOIETIC CELLS IN THE VITRO
EP0919622A3 (en) Surface expression of enzyme in gene directed prodrug therapy
WO2003010291A3 (en) Treatment of immune disorders and b cell disorders
AU632846B2 (en) Substituted n-(quinolin-2-yl-methoxy)benzyl-sulphonyl-ureas
HK1037722A1 (en) Modulating multiple lineage kinase proteins.
WO2000015246A3 (en) Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto
WO2001034641A8 (en) Antimicrobial activity of the first cationic cluster of human lactoferrin
MXPA04001720A (en) Bv8 NUCLEIC ACIDS AND POLYPEPTIDES WITH MITOGENIC ACTIVITY.
AU4367600A (en) Dsp-3 dual-specificity phosphatase
WO2000060092A3 (en) Dsp-3 dual-specificity phosphatase
WO2002024740A3 (en) Dsp-15 dual-specificity phosphatase
WO2001083723A3 (en) Dsp-14 dual-specificity phosphatase
WO2002026997A3 (en) Dsp-16 dual-specificity phosphatase
AU5168099A (en) Use of novel agents inducing cell death in synergy with interferons
WO2001057221A3 (en) Dsp-12 and dsp-13 dual-specificity phosphatases
WO2000053636A3 (en) Dsp-1 dual-specificity map kinase phosphatase
WO2003025196A3 (en) Dsp-18 dual-specificity phosphatase
MY127675A (en) Substituted 3-pyridyl-4-arylpyrroles, and related therapeutic and prophylactic methods
WO2004016739A3 (en) Cell modulation using a cytoskeletal protein
WO2001028574A3 (en) Methods for inducing in vivo proliferation and migration of transplanted progenitor cells in the brain
WO2002014536A3 (en) Odulating multiple lineage kinase proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WPC Withdrawal of priority claims after completion of the technical preparations for international publication
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
AK Designated states

Kind code of ref document: C2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 1/4-4/4, DRAWINGS, REPLACED BY NEW PAGES 1/4-4/4; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

NENP Non-entry into the national phase

Ref country code: JP