WO2000057893A1 - Compositions containing boswellia extracts - Google Patents

Compositions containing boswellia extracts Download PDF

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Publication number
WO2000057893A1
WO2000057893A1 PCT/GB2000/001114 GB0001114W WO0057893A1 WO 2000057893 A1 WO2000057893 A1 WO 2000057893A1 GB 0001114 W GB0001114 W GB 0001114W WO 0057893 A1 WO0057893 A1 WO 0057893A1
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WIPO (PCT)
Prior art keywords
acid
carbon atoms
branched fatty
branched
composition according
Prior art date
Application number
PCT/GB2000/001114
Other languages
French (fr)
Inventor
Heather Eyre
Maxine Jayne Hills
Stephen David Watkins
Original Assignee
Quest International B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest International B.V. filed Critical Quest International B.V.
Priority to BRPI0009340-8B1A priority Critical patent/BR0009340B1/en
Priority to AT00912785T priority patent/ATE243524T1/en
Priority to US09/913,952 priority patent/US6589516B1/en
Priority to AU34432/00A priority patent/AU3443200A/en
Priority to EP00912785A priority patent/EP1165107B1/en
Priority to DE60003537T priority patent/DE60003537T2/en
Publication of WO2000057893A1 publication Critical patent/WO2000057893A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q9/00—Preparations for removing hair or for aiding hair removal
    • A61Q9/04—Depilatories

Definitions

  • the invention relates to compositions comprising at least one Boswellia extract, or at least one boswellic acid or derivative thereof.
  • the compositions are suitable for application to the skin or hair.
  • Boswellia family of plants including Boswellia Serrata can produce a soothing effect to irritated skin and that this activity is due to the terpenoid compounds grouped under the general name 'boswellic acids' .
  • the different boswellic acids share the same basic pentacyclic triterpene (steroid-like) structure but differ in their side groupings.
  • EP-A-755,940 relates to a novel fraction and a process for the isolation of said fraction comprising a mixture of specified boswellic acids from the gum resin of Boswellia Serrata.
  • the fraction is stated to exhibit anti-inflammatory, anti-arthritic and antiulcerogenic activity.
  • Typical extracts of Boswellia plants are solids or powders with a wide melting range - normally above 80° C.
  • an extract of Boswellia containing the boswellic acids, or boswellic acids or derivatives thereof themselves, need to be dissolved or dispersed in a suitable carrier. Although they can be dissolved in solvents such as methanol, ethyl acetate, acetone, and the like, these solvents are not suitable for use in typical skin and hair care formulations because of their aggressive solvent action on the skin and hair, and/or because of their high volatility and/or strong odour.
  • Ingredients which are commonly used in skin care or hair care formulations such as glycerine, sorbitol, mineral oil, cyclomethicone, dimethicone and petrolatum are not suitable solvents or carriers for Boswellia extracts or boswellic acids or derivatives thereof as they are either too polar or not sufficiently polar.
  • Alkalies can produce aqueous solutions of boswellic acids by forming the respective salts.
  • alkaline products e.g. with a pH greater than 8.5
  • prolonged skin or hair contact by alkaline products is not recommended, especially for sensitive skin or scalp, or for damaged hair.
  • a specified group of fatty alcohols or fatty acids, or derivatives, or mixtures thereof are suitable carriers for dissolving and/or dispersing at least one Boswellia extract, or at least one boswellic acid or derivative thereof. Further, the carrier aids the incorporation of the extract, or acid, into compositions suitable for use on the skin or hair and improves the stability of said compositions containing the extract, or acid.
  • composition suitable for use on the skin or hair comprising;
  • a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof.
  • a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof
  • a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof,
  • compositions suitable for application to the skin or hair are suitable for preparing compositions suitable for application to the skin or hair.
  • compositions of the invention comprise at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof.
  • the compositions of the present invention suitably comprise a safe and effective amount, preferably from 0.005 % to 50% by weight of the composition and more preferably from 0.05% to 25% by weight of the composition of at least one Boswellia extract, or at least one boswellic acid or derivative thereof.
  • Suitable extracts for use herein may be derived from the following Boswellia plants including Boswellia Carterii, Boswellia Frereana, Boswellia Bhau-dajaina, Boswellia Serrata and Boswellia Thurifera.
  • the preferred plants from which extracts are derived are Boswellia Serrata.
  • the extracts derived from Boswellia plants can comprise gums, oleo-gums, resins, essential oils and residues, or mixtures thereof.
  • Preferred extracts for use herein are gums.
  • Boswellia gum extract useful herein comprises a mixmre of active triterpenoid compounds more commonly known as boswellic acids. All boswellic acids have a pentacyclic structure based on 12-ursen-24-oic acid with differing substituents. Many individual boswellic acid compounds have been isolated from the Boswellia extract including - and ⁇ -boswellic acids and derivatives thereof. Of these, ⁇ -boswellic acid and derivatives thereof are thought to be the active components.
  • a typical extract comprising Boswellia Serrata gum resin will comprise greater than 50% by weight boswellic acids and often more than 60% by weight boswellic acids.
  • a typical extract of a Boswellia plant suitable for use herein comprises a mixture of boswellic acids comprising at least one of 3a-hydroxyurs-12-ene-24-oic acid, 3a- acetoxyurs-12-ene-24-oic acid, 3a-hydroxyurs-12-ene-l l-keto-24-oic acid and 3a- hydroxyurs-9.12-dien-24-oic acid.
  • Boswellia extracts suitable for use herein are commercially available for example from Quest International, Kent, UK.
  • the compositions of the invention also comprise a carrier for the at least one extract of a Boswellia plant, or the at least one boswellic acid or derivative thereof.
  • suitable carriers for this purpose are selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof.
  • compositions of the present invention typically comprise from 50% to 99.995% , preferably from 75% to 99.95% , and even more preferably from 80% to 95% of a carrier by weight of the composition.
  • the preferred carriers for use herein are selected from branched fatty alcohols or branched fatty acids containing 8 to 32 carbon atoms, or mixtures thereof, which are liquids at room temperature.
  • the branched fatty alcohols and fatty acids are saturated. Saturated compounds generally have good stability against oxidation. More preferred, are saturated, branched fatty alcohols or fatty acids containing from 8 to 20 carbon atoms.
  • Particularly useful branched fatty alcohols and fatty acids herein include isostearyl alcohol, isostearic acid, isocetyl alcohol, isopalmitic acid, octyldodecanol, octyldecanol, hexyldecanol, butyloctanol and ethylhexanol.
  • Unsaturated fatty alcohols and unsaturated fatty acids containing 12 to 24 carbon atoms which are liquid at room temperature are also good carriers for Boswellia extracts. However, their presence may be disadvantageous in compositions requiring long term storage because as they are unsaturated, they have the potential to become oxidised and rancid over time.
  • Preferred for use herein are unsaturated fatty alcohols or unsaturated fatty acids containing from 16 to 20 carbon atoms. Particularly useful unsaturated alcohols and unsaturated acids herein include oleyl alcohol, oleic acid, linoleic acid and linolenic acid.
  • Ethoxylated derivatives that are liquid at room temperature.
  • Useful ethoxylated derivatives herein include derivatives of branched fatty alcohols or acids and derivatives of unsaturated fatty alcohols or acids.
  • the number of ethylene oxide units per mole of fatty acid or fatty alcohol is in the range 1 to 15 and more preferably is in the range 1 to 10. It is also preferred that the derivative has a calculated HLB (hydrophilic / lipophilic balance) of less than 15 and preferably in the range 2 to 9.
  • esters of the abovementioned branched, or unsaturated fatty acids the esters being liquid at room temperature.
  • the fatty acids may be esterified with a wide variety of alcohols, including branched or linear, saturated or unsaturated alcohols.
  • the fatty acid is esterified with an alcohol containing from 2 to 18 carbon atoms.
  • Preferred esters for use herein are branched or unsaturated fatty acids esterified with a hexitol anhydride.
  • the esters of hexitol anhydrides can be mono-, di- or tri-esters but are preferably mono-esters (i.e. the ratio of acid to hexitol anhydride is 1 : 1).
  • a particularly preferred hexitol anhydride from which to prepare an ester is sorbitan.
  • Other preferred esters are monoesters of glycerol and a branched fatty acid (monoglycerides of branched fatty acids).
  • Monoglyceride compositions herein contain at least 80 per cent by weight of a monoglyceride of a single acid.
  • Yet other preferred esters are monoesters of propylene glycol, butylene glycol, hexylene glycol or dipropylene glycol and a branched or an unsaturated fatty acid.
  • esters of the branched fatty alcohols or unsaturated fatty alcohols the esters being liquid at room temperature.
  • the fatty alcohols may be reacted with a wide variety of acids, including branched or linear, samrated or unsaturated acids and hydroxy acids such as ⁇ - hydroxy acids or ⁇ -hydroxy acids.
  • the acid contains from 2 to 18 carbon atoms .
  • (e) Ethoxylated derivatives of monoglycerides as defined in (b) above.
  • the degree of ethoxylation is preferably from 1 to 15 ethylene oxide units per mole of monoglyceride and the ethoxylated monoglyceride is liquid at room temperature.
  • the carriers used in the compositions of the invention are liquid at room temperature. However, it is not essential that the carrier should be completely free from solid matter. Since many available fatty alcohols and fatty acids comprise mixtures of alcohols or acids, certain isomers can be present as solid matter in the mixture. The presence of such solid matter is not detrimental to the use of a particular carrier, provided that the carrier is fluid at room temperature. For the purposes of assessing fluidity in relation to this invention a temperature of 23° C is assumed for "room temperature" .
  • the carriers used in the compositions of the invention are capable of dispersing or dissolving the Boswellia extracts or boswellic acids or derivatives thereof. It is not essential that the extract or acid be completely soluble in the carrier, provided that the mixture of extract or acid and carrier can be incorporated into skin care or hair care products to produce a stable composition.
  • the carrier of the present invention may also include other exicipients conventionally added to compositions suitable for application to the skin or hair such as, silicones, solvents such as water, emollients, or emulsifiers for example.
  • exicipients conventionally added to compositions suitable for application to the skin or hair
  • solvents such as water, emollients, or emulsifiers for example.
  • compositions herein may comprise conventional ingredients normally present in compositions for application to the skin or hair.
  • ingredients include alkanolamide surfactants, alkyl polyglucose derivatives, alkyl ether sulphate surfactants, allantoin, aloe barbadensis mil (aloe vera linne), ⁇ -hydroxycarboxylic acids, aluminium chlorhydrate and its derivatives, aluminium salts, amide derivatives, amino acids, amphoteric surfactants, ascorbic acid and its salts, bentonite and hectorite, benzyl alcohol, bisabolol, butane propellants, carboxy vinyl polymer water soluble salts, carboxy methylcellulose, carrageenan, cetrimonium salts, cholesterol, cocamidopropyl betaine, depilatories, dihydroxyacetone, dimethyl ether, ethanol, fatty acids, fatty acid citrate esters, fatty alcohols, fragrance ingredients, glucose esters of higher
  • oil matter oligosaccharide(s), organic acids, pantothe ⁇ ic acid and its derivatives, petroleum jelly, phospholipid, polysaccharides eg locust bean gum, polyvinyl alcohol, polypeptides, proteins, piroctone olamine, quaternised silicone derivatives, raffinose, saponins, sodium chloride, sodium cocoyl isethionate, sodium hyaluronate, sources of linoleic acid, sterols, sterol esters, sucrose, sugar esters of higher fatty acids, sunscreens, surfactants, talc, tea tree oil (Melaleuca spp.), thioglycolic acid and its derivatives, titanium dioxide, tocopherol and esters thereof, triclosan, mono- or di- or triglycerides, vegetable oils, vitamins and analogues, volatile silicone fluids, water, water soluble moisture-retaining agents, water soluble polymers, waxes, zinc oxide, zinc pyri
  • compositions of the present invention may be used in a wide range of products suitable for use on, or application to, the skin or hair particularly, but not exclusively, cosmetic compositions.
  • Such products may be formulated in various product forms such as lotions, creams, gels, sticks, solutions, aerosols, solid soaps or liquid cleansers.
  • the present invention provides a product for application to the skin or hair comprising a composition in accordance with the invention.
  • 'skin' as used herein, means any outer surface of the body including the nails.
  • composition of the invention can be separately prepared and added to the other ingredients of the desired product, or the compositions of the invention can be formed during the manufacture of the product.
  • compositions according to the invention were prepared by mixing ingredients in the amounts listed below.
  • Composition 1 Boswellia Serrata Gum Resin Extract 10% w/w Isostearyl Alcohol 90% w/w
  • Composition 2 Boswellia Serrata Gum Resin Extract 15% w/w Isostearic Acid 85 % w/w
  • composition 3 Boswellia Serrata Gum Resin Extract 5% w/w Oleic Acid 95% w/w
  • composition 5 Boswellia Serrata Gum Resin Extract 5 % w/w Polyoxyethylene (3) isostearic acid 95% w/w Composition 6) Boswellia Serrata Gum Resin Extract 10% w/w Sorbitan monolaurate 90% w/w
  • composition 7 Boswellia Serrata Gum Resin Extract 20% w/w
  • Composition 8 Boswellia Serrata Gum Resin Extract 5% w/w Isopropyl isostearate 95 % w/w
  • An Aftersun Cream Gelee was prepared according to the following formulation.
  • Isostearyl alcohol Isostearyl Alcohol 1.35
  • Phase B Deionised water (A) and hydroxypropylcellulose were combined and mixed under very high shear for 1 hour. Carbomer was added and left to wet out. Phase B was prepared by combining the ingredients with heating to 65° C and was then added to A with minimal shearing so as to avoid breaking down the structure. Phase C was prepared by combining the ingredients and added to the mixture of Phases A and B and the combined mixmre was stirred gently for 15 minutes.
  • Boswellia Serrata extract helps to reduce redness and irritation and produces an even skin tone.
  • An Acne Minimising Night Cream was prepared to the following formulation.
  • Emcol E 607S Steapyrium chloride 3.50
  • Phase B was prepared by combining the ingredients.
  • Phase C was prepared by combining the ingredients and was added to Phase B using high shear.
  • Phase A was prepared by combining the ingredients and this mixmre and Phase A were heated to 75 °C.
  • Phase A was added to the mixmre using shear, and then cooled with stirring to 40 °C, when Phase D was added and stirred in thoroughly.
  • An After Hair Removal Cream was prepared according to the following formulation.
  • Phase C Triethanolamine 0.20 Phenonip Phenoxyethanol, methylparaben 0.50 Ethylparaben, propylparaben, butylparaben
  • Phase A and Phase B were separately prepared by combining the ingredients and heated to 75 °C when Phase B was added to Phase A, and the triethanolamine was added. The emulsion was stirred until it was homogeneous and cooled. When the temperature reached 40°C, the preservative (Phenonip) and apricot extract and perfume were added and stirred in thoroughly.
  • this cream prevents the appearance of red dots which usually appear after shaving as well as waxing or other ways of removing hair.
  • a shampoo suitable for cleansing a baby's hair and scalp was prepared according to the following formulation:
  • Isostearic acid Isostearic Acid 0.50
  • Phase A was prepared by firstly dissolving with stirring the disodium EDTA and benzophenone-4 in water. The remaining ingredients of Phase A were then combined with this solution, stirring the mixmre between each addition.
  • Phase B was prepared by combining the ingredients with heating to 65 °C. This mixture was then combined with Phase A. Perfume was then added to the mixmre of Phases A and B and the combined mixmre thickened upon the addition of sodium chloride.
  • a hair shampoo suitable for frequent use was prepared according to the following formulation:
  • Isostearic acid Isostearic Acid 0.40
  • Phase A was prepared by dissolving the disodium EDTA in water with stirring. The remaining ingredients of Phase A were then combined with this solution, stirring the mixture between each addition.
  • Phase B was prepared by combining the ingredients with heating to 65 °C. This mixmre was then combined with Phase A. Perfume was then added to the mixmre of Phases A and B and the combined mixture thickened upon the addition of sodium chloride.
  • Boswellia Serrata extract helps to prevent and calm irritation caused by surfactants.
  • a depilatory cream was prepared according to the following formulation.
  • Isostearyl Alcohol Isostearyl Alcohol 1.80
  • Phase B was prepared by combining the carbomer and dipropylene glycol with water and allowing the carbomer to wet out. Potassium thioglycolate (40%) was then carefully added to the hydrated polymer aqueous mixmre, followed by potassium hydroxide. Phase B was then heated to 65 °C.
  • Phase A was separately prepared by combining all of the ingredients and heating to 65 °C. Phase A was then added to phase B using high shear mixing. The emulsion was stirred until it was homogeneous and cooled to room temperature. The pH of the resulting emulsion was then adjusted to 12.5 with the addition of a 20% solution of potassium hydroxide.
  • this cream alleviates the appearance of red dots or rashes appearing on the skin following depilation with the alkaline cream.

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Abstract

A composition suitable for use on the skin or hair comprising: a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof. The extract, or boswellic acid or derivative thereof, is useful in preparing skin care or hair care compositions with the ability to provide a soothing effect to irritated skin.

Description

Title: Compositions Containing Boswellia Extracts
Field of Invention
The invention relates to compositions comprising at least one Boswellia extract, or at least one boswellic acid or derivative thereof. The compositions are suitable for application to the skin or hair.
Background of Invention
It has long been known that extracts of the Boswellia family of plants including Boswellia Serrata can produce a soothing effect to irritated skin and that this activity is due to the terpenoid compounds grouped under the general name 'boswellic acids' . The different boswellic acids share the same basic pentacyclic triterpene (steroid-like) structure but differ in their side groupings.
EP-A-755,940 relates to a novel fraction and a process for the isolation of said fraction comprising a mixture of specified boswellic acids from the gum resin of Boswellia Serrata. The fraction is stated to exhibit anti-inflammatory, anti-arthritic and antiulcerogenic activity.
Typical extracts of Boswellia plants are solids or powders with a wide melting range - normally above 80° C. To allow for easy incorporation into compositions which are suitable for use on the skin or hair, an extract of Boswellia, containing the boswellic acids, or boswellic acids or derivatives thereof themselves, need to be dissolved or dispersed in a suitable carrier. Although they can be dissolved in solvents such as methanol, ethyl acetate, acetone, and the like, these solvents are not suitable for use in typical skin and hair care formulations because of their aggressive solvent action on the skin and hair, and/or because of their high volatility and/or strong odour. Ingredients which are commonly used in skin care or hair care formulations, such as glycerine, sorbitol, mineral oil, cyclomethicone, dimethicone and petrolatum are not suitable solvents or carriers for Boswellia extracts or boswellic acids or derivatives thereof as they are either too polar or not sufficiently polar.
Alkalies can produce aqueous solutions of boswellic acids by forming the respective salts. However, prolonged skin or hair contact by alkaline products (e.g. with a pH greater than 8.5) is not recommended, especially for sensitive skin or scalp, or for damaged hair.
We have now surprisingly found that a specified group of fatty alcohols or fatty acids, or derivatives, or mixtures thereof, are suitable carriers for dissolving and/or dispersing at least one Boswellia extract, or at least one boswellic acid or derivative thereof. Further, the carrier aids the incorporation of the extract, or acid, into compositions suitable for use on the skin or hair and improves the stability of said compositions containing the extract, or acid.
Summary of the Invention
According to a first aspect of the invention, there is provided a composition suitable for use on the skin or hair comprising;
a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and
b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof. According to a second aspect of the present invention, there is provided a method of preparing a composition suitable for application to the skin or hair comprising mixing a composition comprising;
a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and
b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof
with at least one cosmetically or pharmaceutically acceptable ingredient.
According to a third aspect of the present invention, there is provided a use of a composition comprising;
a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and
b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof,
for preparing compositions suitable for application to the skin or hair.
The compositions of the invention comprise at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof. The compositions of the present invention suitably comprise a safe and effective amount, preferably from 0.005 % to 50% by weight of the composition and more preferably from 0.05% to 25% by weight of the composition of at least one Boswellia extract, or at least one boswellic acid or derivative thereof.
Suitable extracts for use herein may be derived from the following Boswellia plants including Boswellia Carterii, Boswellia Frereana, Boswellia Bhau-dajaina, Boswellia Serrata and Boswellia Thurifera. The preferred plants from which extracts are derived are Boswellia Serrata.
The extracts derived from Boswellia plants can comprise gums, oleo-gums, resins, essential oils and residues, or mixtures thereof. Preferred extracts for use herein are gums.
The Boswellia gum extract useful herein comprises a mixmre of active triterpenoid compounds more commonly known as boswellic acids. All boswellic acids have a pentacyclic structure based on 12-ursen-24-oic acid with differing substituents. Many individual boswellic acid compounds have been isolated from the Boswellia extract including - and β-boswellic acids and derivatives thereof. Of these, β-boswellic acid and derivatives thereof are thought to be the active components.
A typical extract comprising Boswellia Serrata gum resin will comprise greater than 50% by weight boswellic acids and often more than 60% by weight boswellic acids.
A typical extract of a Boswellia plant suitable for use herein comprises a mixture of boswellic acids comprising at least one of 3a-hydroxyurs-12-ene-24-oic acid, 3a- acetoxyurs-12-ene-24-oic acid, 3a-hydroxyurs-12-ene-l l-keto-24-oic acid and 3a- hydroxyurs-9.12-dien-24-oic acid.
Boswellia extracts suitable for use herein are commercially available for example from Quest International, Kent, UK. The compositions of the invention also comprise a carrier for the at least one extract of a Boswellia plant, or the at least one boswellic acid or derivative thereof.
In accordance with the invention, suitable carriers for this purpose are selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsaturated fatty acids containing 12 to 24 carbon atoms, and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsaturated fatty acids, or mixtures thereof.
The compositions of the present invention typically comprise from 50% to 99.995% , preferably from 75% to 99.95% , and even more preferably from 80% to 95% of a carrier by weight of the composition.
The preferred carriers for use herein are selected from branched fatty alcohols or branched fatty acids containing 8 to 32 carbon atoms, or mixtures thereof, which are liquids at room temperature. Preferably, the branched fatty alcohols and fatty acids are saturated. Saturated compounds generally have good stability against oxidation. More preferred, are saturated, branched fatty alcohols or fatty acids containing from 8 to 20 carbon atoms. Particularly useful branched fatty alcohols and fatty acids herein include isostearyl alcohol, isostearic acid, isocetyl alcohol, isopalmitic acid, octyldodecanol, octyldecanol, hexyldecanol, butyloctanol and ethylhexanol.
Unsaturated fatty alcohols and unsaturated fatty acids, containing 12 to 24 carbon atoms which are liquid at room temperature are also good carriers for Boswellia extracts. However, their presence may be disadvantageous in compositions requiring long term storage because as they are unsaturated, they have the potential to become oxidised and rancid over time. Preferred for use herein are unsaturated fatty alcohols or unsaturated fatty acids containing from 16 to 20 carbon atoms. Particularly useful unsaturated alcohols and unsaturated acids herein include oleyl alcohol, oleic acid, linoleic acid and linolenic acid.
Derivatives of the above described branched, or unsaturated fatty acids and alcohols are also good carriers for the Boswellia extract. Useful derivatives include the following:
(a) Ethoxylated derivatives that are liquid at room temperature. Useful ethoxylated derivatives herein include derivatives of branched fatty alcohols or acids and derivatives of unsaturated fatty alcohols or acids. Preferably, the number of ethylene oxide units per mole of fatty acid or fatty alcohol is in the range 1 to 15 and more preferably is in the range 1 to 10. It is also preferred that the derivative has a calculated HLB (hydrophilic / lipophilic balance) of less than 15 and preferably in the range 2 to 9.
(b) Esters of the abovementioned branched, or unsaturated fatty acids, the esters being liquid at room temperature. The fatty acids may be esterified with a wide variety of alcohols, including branched or linear, saturated or unsaturated alcohols. Preferably, the fatty acid is esterified with an alcohol containing from 2 to 18 carbon atoms. Preferred esters for use herein are branched or unsaturated fatty acids esterified with a hexitol anhydride. The esters of hexitol anhydrides can be mono-, di- or tri-esters but are preferably mono-esters (i.e. the ratio of acid to hexitol anhydride is 1 : 1). A particularly preferred hexitol anhydride from which to prepare an ester is sorbitan. Other preferred esters are monoesters of glycerol and a branched fatty acid (monoglycerides of branched fatty acids). Monoglyceride compositions herein contain at least 80 per cent by weight of a monoglyceride of a single acid. Yet other preferred esters are monoesters of propylene glycol, butylene glycol, hexylene glycol or dipropylene glycol and a branched or an unsaturated fatty acid.
(c) Esters of the branched fatty alcohols or unsaturated fatty alcohols, the esters being liquid at room temperature. The fatty alcohols may be reacted with a wide variety of acids, including branched or linear, samrated or unsaturated acids and hydroxy acids such as α- hydroxy acids or β-hydroxy acids. Preferably, the acid contains from 2 to 18 carbon atoms .
(d) Ethoxylated derivatives of hexitol anhydride esters as defined in (b) above. The degree of ethoxylation is preferably from 1 to 15 ethylene oxide units per mole of hexitol anhydride ester and the ethoxylated ester is liquid at room temperature.
(e) Ethoxylated derivatives of monoglycerides as defined in (b) above. The degree of ethoxylation is preferably from 1 to 15 ethylene oxide units per mole of monoglyceride and the ethoxylated monoglyceride is liquid at room temperature.
Generally, the carriers used in the compositions of the invention are liquid at room temperature. However, it is not essential that the carrier should be completely free from solid matter. Since many available fatty alcohols and fatty acids comprise mixtures of alcohols or acids, certain isomers can be present as solid matter in the mixture. The presence of such solid matter is not detrimental to the use of a particular carrier, provided that the carrier is fluid at room temperature. For the purposes of assessing fluidity in relation to this invention a temperature of 23° C is assumed for "room temperature" .
The carriers used in the compositions of the invention are capable of dispersing or dissolving the Boswellia extracts or boswellic acids or derivatives thereof. It is not essential that the extract or acid be completely soluble in the carrier, provided that the mixture of extract or acid and carrier can be incorporated into skin care or hair care products to produce a stable composition.
The carrier of the present invention may also include other exicipients conventionally added to compositions suitable for application to the skin or hair such as, silicones, solvents such as water, emollients, or emulsifiers for example.
Optionally, the compositions herein may comprise conventional ingredients normally present in compositions for application to the skin or hair. Non-limiting examples of such ingredients include alkanolamide surfactants, alkyl polyglucose derivatives, alkyl ether sulphate surfactants, allantoin, aloe barbadensis mil (aloe vera linne), α-hydroxycarboxylic acids, aluminium chlorhydrate and its derivatives, aluminium salts, amide derivatives, amino acids, amphoteric surfactants, ascorbic acid and its salts, bentonite and hectorite, benzyl alcohol, bisabolol, butane propellants, carboxy vinyl polymer water soluble salts, carboxy methylcellulose, carrageenan, cetrimonium salts, cholesterol, cocamidopropyl betaine, depilatories, dihydroxyacetone, dimethyl ether, ethanol, fatty acids, fatty acid citrate esters, fatty alcohols, fragrance ingredients, glucose esters of higher fatty acids, glycerin, glyceryl stearates, glycols, guar gum, gum arabic, hyaluronic acid, hydroxybenzoic acids, hydroquinone, isopropyl alcohol, kojic acid, lanolin, lauryl betaine, lipids extracted from the biomass of microorganisms, yeasts, moulds and bacteria, liposomes, liquorice (glycyrrhiza glabra) and its components (glycyrrhetinic acid, glycyrrhizic acid, etc.), low molecular weight acidic mucopolysaccharides & their salts, low molecular weight humectant components, magnesium aluminium silicate, methacrylate polymers, mineral oils, mineral powders, namral or synthetic amino acid with protein or peptide bond, namral moisturing factor ingredients eg lactic acid, non- volatile silicones, oil agent(s). oil matter, oligosaccharide(s), organic acids, pantotheπic acid and its derivatives, petroleum jelly, phospholipid, polysaccharides eg locust bean gum, polyvinyl alcohol, polypeptides, proteins, piroctone olamine, quaternised silicone derivatives, raffinose, saponins, sodium chloride, sodium cocoyl isethionate, sodium hyaluronate, sources of linoleic acid, sterols, sterol esters, sucrose, sugar esters of higher fatty acids, sunscreens, surfactants, talc, tea tree oil (Melaleuca spp.), thioglycolic acid and its derivatives, titanium dioxide, tocopherol and esters thereof, triclosan, mono- or di- or triglycerides, vegetable oils, vitamins and analogues, volatile silicone fluids, water, water soluble moisture-retaining agents, water soluble polymers, waxes, zinc oxide, zinc pyrithione.
The compositions of the present invention may be used in a wide range of products suitable for use on, or application to, the skin or hair particularly, but not exclusively, cosmetic compositions. Such products may be formulated in various product forms such as lotions, creams, gels, sticks, solutions, aerosols, solid soaps or liquid cleansers. Thus, in a further aspect, the present invention provides a product for application to the skin or hair comprising a composition in accordance with the invention. The term 'skin' as used herein, means any outer surface of the body including the nails.
When products comprising a composition in accordance with the invention are prepared, the composition of the invention can be separately prepared and added to the other ingredients of the desired product, or the compositions of the invention can be formed during the manufacture of the product.
The invention is illustrated by the following non-limiting examples.
EXAMPLE 1
Carrier/Boswellia Serrata Extract Blends
Compositions according to the invention were prepared by mixing ingredients in the amounts listed below.
Composition 1) Boswellia Serrata Gum Resin Extract 10% w/w Isostearyl Alcohol 90% w/w
Composition 2) Boswellia Serrata Gum Resin Extract 15% w/w Isostearic Acid 85 % w/w
Composition 3) Boswellia Serrata Gum Resin Extract 5% w/w Oleic Acid 95% w/w
Composition 4) Boswellia Serrata Gum Resin Extract 15 % w/w Polyoxyethylene (2) oleyl alcohol 85% w/w
Composition 5) Boswellia Serrata Gum Resin Extract 5 % w/w Polyoxyethylene (3) isostearic acid 95% w/w Composition 6) Boswellia Serrata Gum Resin Extract 10% w/w Sorbitan monolaurate 90% w/w
Composition 7) Boswellia Serrata Gum Resin Extract 20% w/w
Polyoxyethylene (20) sorbitan monolaurate 80% w/w
Composition 8) Boswellia Serrata Gum Resin Extract 5% w/w Isopropyl isostearate 95 % w/w
EXAMPLE 2
An Aftersun Cream Gelee was prepared according to the following formulation.
INGREDIENT INCI NAME w/w%
Phase A:
Deionised Water (A) to 100%
Klucel-99-H Hydroxypropylcellulose 0.20
Carbopol ultrez 10 Carbomer 0.80
Pha«e B:
Boswellia Serrata Gum Boswellia Serrata 0.15
Extract
Isostearyl alcohol Isostearyl Alcohol 1.35
Euxyl K400 Methyldibromoglutaronitrile and 0.10 phenoxyethanol
Cremaphor RH 40 PEG-40 hydro. castor oil 0.30
Flamingo pearl blue 100 0.50
Phase C:
Netrol TE Tetrahydroxypropyl ethylenedia -mine 0.20 Deionised Water 4.40
Quest perfume 0.50
(Klucel-99-H, Carbopol, Euxyl K400, Cremaphor RH40 and Netrol TE are all Trade Marks.)
Deionised water (A) and hydroxypropylcellulose were combined and mixed under very high shear for 1 hour. Carbomer was added and left to wet out. Phase B was prepared by combining the ingredients with heating to 65° C and was then added to A with minimal shearing so as to avoid breaking down the structure. Phase C was prepared by combining the ingredients and added to the mixture of Phases A and B and the combined mixmre was stirred gently for 15 minutes.
The presence of Boswellia Serrata extract helps to reduce redness and irritation and produces an even skin tone.
EXAMPLE 3
An Acne Minimising Night Cream was prepared to the following formulation.
INGREDIENT INCI NAME w/w%
Phase A:
Oleyl alcohol 4.00
Crodamol OP 2-Ethylhexyl palmitate 8.00
Dow Corning 200/350 Dimethicone 0.50
Emcol E 607S Steapyrium chloride 3.50
Dry Flo PC Aluminium starch octenyl 4.00 succinate
Boswellia Serrata Gum Boswellia Serrata 0.50 Extract Phase B:
Deionised water to 100.00 Lactic acid 2.50 Sodium lactate 2.00
Phase C:
Xanthan XP Xanthan gum 0.40 Glycerine 1.50
Phase D:
Euxyl K400 Methyldibromoglutaronitrile and 0.10 Phenoxyethanol
Quest perfume 0.50
(Crodamol OP, Dow Corning 200/300, Emcol E 6075, Dry Flo PC, Xanthan XP and Euxyl K400 are all Trade Marks.)
Phase B was prepared by combining the ingredients. Phase C was prepared by combining the ingredients and was added to Phase B using high shear. Phase A was prepared by combining the ingredients and this mixmre and Phase A were heated to 75 °C. Phase A was added to the mixmre using shear, and then cooled with stirring to 40 °C, when Phase D was added and stirred in thoroughly.
The Boswellia Serrata Extract produced calming benefits in this cream which are especially good for problematic and sensitive skin. EXAMPLE 4
An After Hair Removal Cream was prepared according to the following formulation.
INGREDIENT INCI NAME w/w%
Phase A:
Deionised water to 100.00
Propylene glycol 1.80
Dipropylene glycol 0.50
Carbopol ultrez Carbomer 0.20
Glycerine 0.25
Sepigel 305 Polyacrylamide, C13-14 i isoparaffin 0.30
Lubrajel TW Polyglycerylmethacrylate and 0.50 Propylene glycol
Algisium C Methylsilanol mannuronate 0.20
Phase B:
Finsolv TN C12-C15 alkyl benzoate 2.00
Dow Corning 344 Cyclomethicone 4.50
Polysynlane Hydrogenated polyisobutene 1.60
Wickenol 153 Isotridecyl isononanoate 2.00
Isostearyl alcohol 4.50
Dow Corning 200/350 Dimethicone 0.20
Questamide H Bishydroxyethyl Biscetyl Malonamide 0.80
Boswellia Serrata Boswellia Serrata 0.10
Gum Extract
Myristic acid 0.40
Cetearyl alcohol 4.00
Ceraphyl 375 Isostearyl neopentanoate 0.50
Phase C: Triethanolamine 0.20 Phenonip Phenoxyethanol, methylparaben 0.50 Ethylparaben, propylparaben, butylparaben
Apricot extract 0.30 Quest perfume 0.50
(Carbopol, Sepigel 305, Lubragel TW, Algisium C, Finsolv TN, Dow Corning 344, Polysynlane, Wickenol 153, Dow Corning 200/300, Questamide H, Ceraphyl 375 and Phenonip are all Trade Marks.)
Phase A and Phase B were separately prepared by combining the ingredients and heated to 75 °C when Phase B was added to Phase A, and the triethanolamine was added. The emulsion was stirred until it was homogeneous and cooled. When the temperature reached 40°C, the preservative (Phenonip) and apricot extract and perfume were added and stirred in thoroughly.
Due to the calming benefits of the Boswellia extract this cream prevents the appearance of red dots which usually appear after shaving as well as waxing or other ways of removing hair.
EXAMPLE 5
A shampoo suitable for cleansing a baby's hair and scalp was prepared according to the following formulation:
INGREDIENT INCI NAME w/ % Phase A:
Deionised water to 100.00 Tween 20 Polysorbate 20 25.00 Empicol TL40/T TEA-Lauryl Sulfate 20.00 Plantacare 1200 Decyl Polyglucose 7.50
Tego Betain F50 Cocamidopropyl Betaine 2.50
Germaben-II Diazolidinyl Urea & Methylparaben & 0.40 Propylparaben & Propylene Glycol
Nervanaid BA2 Disodium EDTA 0.10
Uvinul MS40 Benzophenone-4 0.03
Cetiol HE PEG-7 Glyceryl Cocoate 0.60
Phase B:
Boswellia Serrata Gum Boswellia Serrata 0.10
Extract
Dipropylene Glycol Dipropylene Glycol 1.00
Isostearic acid Isostearic Acid 0.50
Perfume 0.50 Sodium chloride 2.50
(Tween 20, Empicol TL40/T, Plantacare 1200, Tego Betain F50, Germaben-II, Nervanaid BA2, Uvinul MS40 and Cetiol HE are all Trade Marks.)
Phase A was prepared by firstly dissolving with stirring the disodium EDTA and benzophenone-4 in water. The remaining ingredients of Phase A were then combined with this solution, stirring the mixmre between each addition.
Phase B was prepared by combining the ingredients with heating to 65 °C. This mixture was then combined with Phase A. Perfume was then added to the mixmre of Phases A and B and the combined mixmre thickened upon the addition of sodium chloride.
The presence of Boswellia Serrata extract helps to calm and prevent irritation caused by surfactants. EXAMPLE 6
A hair shampoo suitable for frequent use was prepared according to the following formulation:
INGREDIENT INCI NAME w/w%
Phase A:
Deionised water to 100.00
Empicol ESB3 Sodium Laureth Sulfate (28%) 20.00
Texapon ALS Ammonium Sulfate 20.00
Plantacare 818 Coco Glucoside 7.50
Tego Betain F50 Cocamidopropyl Betaine 2.50
Nervanaid BA2 Disodium EDTA 0.10
Cetiol HE PEG-7 Glyceryl Cocoate 0.60
Germaben-II Diazolidinyl Urea & Methylparaben & 0.40
Propylparaben & Propylene Glycol
Phase B:
Boswellia Serrata Gum Boswellia Serrata 0.20
Extract
Dipropylene Glycol Dipropylene Glycol 1.00
Isostearic acid Isostearic Acid 0.40
Propylene Glycol Propylene Glycol 0.60
Perfume 0.50 Sodium chloride 2.50
(Empicol ESB3, Texapon ALS, Plantacare 818, Tego Betain F50, Nervanaid BA2, Cetiol HE, and Germaben-II are all Trade Marks.) Phase A was prepared by dissolving the disodium EDTA in water with stirring. The remaining ingredients of Phase A were then combined with this solution, stirring the mixture between each addition.
Phase B was prepared by combining the ingredients with heating to 65 °C. This mixmre was then combined with Phase A. Perfume was then added to the mixmre of Phases A and B and the combined mixture thickened upon the addition of sodium chloride.
The presence of Boswellia Serrata extract helps to prevent and calm irritation caused by surfactants.
EXAMPLE 7
A depilatory cream was prepared according to the following formulation.
INGREDIENT INCI NAME w/w%
Phase A:
Cetyl Alcohol 5.00
Eumulgin B3 Ceteareth-30 2.00
Mineral Oil 7.00
Boswellia Serrata Gum Boswellia Serrata 0.20
Extract
Isostearyl Alcohol Isostearyl Alcohol 1.80
Phase B:
Water to 100.00
Carbopol Ultrez Carbomer 1.50 Dipropylene Glycol 2.00 Potassium 10.00
Thioglycolate (40%) Potassium Hydroxide 2.50 (Eumulgin B3 and Carbopol are Trade Marks.)
Phase B was prepared by combining the carbomer and dipropylene glycol with water and allowing the carbomer to wet out. Potassium thioglycolate (40%) was then carefully added to the hydrated polymer aqueous mixmre, followed by potassium hydroxide. Phase B was then heated to 65 °C.
Phase A was separately prepared by combining all of the ingredients and heating to 65 °C. Phase A was then added to phase B using high shear mixing. The emulsion was stirred until it was homogeneous and cooled to room temperature. The pH of the resulting emulsion was then adjusted to 12.5 with the addition of a 20% solution of potassium hydroxide.
Due to the calming benefits of Boswellia extract, this cream alleviates the appearance of red dots or rashes appearing on the skin following depilation with the alkaline cream.

Claims

1. A composition suitable for use on the skin or hair comprising;
a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and
b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsamrated fatty acids containing 12 to 24 carbon atoms and derivatives of said branched fatty alcohols, said branched fatty acids, said unsamrated fatty alcohols and said unsamrated fatty acids, or mixtures thereof.
2. A composition according to claim 1 , wherein the extract comprises a Boswellia Serrata gum resin.
3. A composition according to claim 1 or 2, wherein said at least one extract of a Boswellia plant comprises a mixmre of boswellic acids comprising at least one of 3a- hydroxyurs-12-ene-24-oic acid, 3a-acetoxyurs-12-ene-24-oic acid. 3a-hydroxyurs-12-ene- 1 l-keto-24-oic acid and 3a-hydroxyurs-9, 12-dien-24-oic acid.
4. A composition according to any one of the preceding claims, wherein the carrier is a samrated branched fatty alcohol or a samrated branched fatty acid and is liquid at room temper ature.
5. A composition according to claim 4, wherein the samrated branched fatty alcohol or the saturated branched fatty acid contains from 8 to 20 carbon atoms.
6. A composition according to claims 1, 2 or 3, wherein the carrier is an unsamrated fatty alcohol or an unsaturated fatty acid containing from 16 to 20 carbon atoms.
7. A composition according to claims 1 , 2, or 3, wherein the carrier is an ethoxylated derivative of a branched fatty alcohol, a branched fatty acid, an unsaturated fatty alcohol or an unsaturated fatty acid.
8. A composition according to claim 7, wherein the ethoxylated derivative has from 1 to 15 ethylene oxide units per mole of fatty alcohol or per mole of fatty acid.
9. A composition according to claims 1, 2 or 3, wherein the carrier is a branched or unsamrated fatty acid ester, esterified with a hexitol anhydride.
10. A composition according to claims 1, 2 or 3, wherein the carrier is a monoester of glycerol and a branched fatty acid.
11. A composition according to claims 1,2 or 3, wherein the carrier is a monoester of propylene glycol, butylene glycol, hexylene glycol or dipropylene glycol and a branched fatty acid or an unsamrated fatty acid.
12. A composition according to claims 1 , 2 or 3, wherein the carrier is an ester of a branched fatty alcohol or an unsaturated fatty alcohol with an acid.
13. A composition according to claim 1, 2 or 3, wherein the carrier is an ethoxylated derivative of an ester of a hexitol anhydride and a branched fatty acid or an unsaturated fatty acid.
14. A composition according to claims 1 , 2 or 3, wherein the carrier is an ethoxylated derivative of a monoglyceride of a branched fatty acid.
15. A composition according to any one of the preceding claims, wherein the composition comprises from 0.005 % to 50% , preferably from 0.05 % to 25% by weight of at least one Boswellia extract, or at least one boswellic acid or derivative thereof.
16. A composition according to any one of the preceding claims, wherein the extract of a Boswellia plant is Boswellia Serrata gum resin extract which contains greater than 50% by weight boswellic acids.
1.7. A product for application to the skin or hair, comprising a composition in accordance with anyone of the preceding claims.
18. A method of preparing a composition suitable for application to the skin or hair comprising mixing a composition comprising;
a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and
b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsaturated fatty alcohols containing 12 to 24 carbon atoms, unsamrated fatty acids containing 12 to 24 carbon atoms and derivatives of said branched fatty alcohols, said branched fatty acids, said unsamrated fatty alcohols and said unsamrated fatty acids, or mixmres thereof
with at least one cosmetically or pharmaceutically acceptable ingredient.
19. The use of a composition comprising;
a) at least one extract of a Boswellia plant, or at least one boswellic acid or derivative thereof; and
b) a carrier selected from the group consisting of branched fatty alcohols containing 8 to 32 carbon atoms, branched fatty acids containing 8 to 32 carbon atoms, unsamrated fatty alcohols containing 12 to 24 carbon atoms, unsamrated fatty acids containing 12 to 24 carbon atoms and derivatives of said branched fatty alcohols, said branched fatty acids, said unsaturated fatty alcohols and said unsamrated fatty acids, or mixtures thereof 11
for preparing compositions suitable for application to the skin or hair.
PCT/GB2000/001114 1999-03-26 2000-03-23 Compositions containing boswellia extracts WO2000057893A1 (en)

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AT00912785T ATE243524T1 (en) 1999-03-26 2000-03-23 COMPOSITIONS CONTAINING BOSWELLIA EXTRACTS
US09/913,952 US6589516B1 (en) 1999-03-26 2000-03-23 Compositions containing Boswellia extracts
AU34432/00A AU3443200A (en) 1999-03-26 2000-03-23 Compositions containing boswellia extracts
EP00912785A EP1165107B1 (en) 1999-03-26 2000-03-23 Compositions containing boswellia extracts
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WO2004082643A2 (en) * 2003-03-20 2004-09-30 Shiseido International France Cosmetic composition
WO2004082643A3 (en) * 2003-03-20 2007-06-14 Shiseido Int France Cosmetic composition
US8192768B2 (en) 2007-04-03 2012-06-05 Laila Impex Synergistic anti-inflammatory and antioxidant dietary supplement compositions
US8420132B2 (en) 2007-04-03 2013-04-16 Laila Impex Synergistic anti-inflammatory and antioxidant dietary supplement compositions
NL1033954C2 (en) * 2007-06-08 2008-12-09 Otc Pharma Internat B V Composition for shaving.
WO2008150155A2 (en) * 2007-06-08 2008-12-11 Otc Pharma International B.V. Composition for shaving
WO2008150155A3 (en) * 2007-06-08 2010-03-04 Otc Pharma International B.V. Composition for shaving
ES2333639A1 (en) * 2009-10-27 2010-02-24 Cosmetica Cosbar S.L. Protective composition of hair and scalp leather (Machine-translation by Google Translate, not legally binding)
WO2020174093A1 (en) * 2019-02-28 2020-09-03 Bic -Violex S.A. Skin engaging member for razor cartridge comprising skin active ingredient

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AU3443200A (en) 2000-10-16
GB9906914D0 (en) 1999-05-19
DE60003537D1 (en) 2003-07-31
ATE243524T1 (en) 2003-07-15
BR0009340B1 (en) 2013-08-27
EP1165107B1 (en) 2003-06-25
US6589516B1 (en) 2003-07-08
EP1165107A1 (en) 2002-01-02
DE60003537T2 (en) 2003-12-24
BR0009340A (en) 2002-04-23

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