WO2000054785A3 - Stabilized bicyclo[3.3.1]nonenes and methods of use - Google Patents

Stabilized bicyclo[3.3.1]nonenes and methods of use Download PDF

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Publication number
WO2000054785A3
WO2000054785A3 PCT/US2000/006380 US0006380W WO0054785A3 WO 2000054785 A3 WO2000054785 A3 WO 2000054785A3 US 0006380 W US0006380 W US 0006380W WO 0054785 A3 WO0054785 A3 WO 0054785A3
Authority
WO
WIPO (PCT)
Prior art keywords
nonenes
bicyclo
pharmaceutical compositions
methods
dietary supplements
Prior art date
Application number
PCT/US2000/006380
Other languages
French (fr)
Other versions
WO2000054785A9 (en
WO2000054785A2 (en
Inventor
Diana M Fort
Robert L Arslanian
Wayne D Inman
Original Assignee
Shaman Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shaman Pharmaceuticals Inc filed Critical Shaman Pharmaceuticals Inc
Priority to AU37387/00A priority Critical patent/AU3738700A/en
Publication of WO2000054785A2 publication Critical patent/WO2000054785A2/en
Publication of WO2000054785A3 publication Critical patent/WO2000054785A3/en
Publication of WO2000054785A9 publication Critical patent/WO2000054785A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Bicyclo[3.3.1]nonenes extracted from hypericum spp. That are subsequently redcued at the level of unsatuated prenyl side chains, are described that are useful as dietary supplements, enriched extracts and pharmaceutical compositions. Methods for the use of the dietary supplements, enriched extracts and pharmaceutical compositions are also described. The bicyclo[3.3.1]nonenes are useful as dietary supplements and pharmaceutical compositions for a lower blood glucose levels, lowering serum triglyceride levels, treating hyperglycemia, treating diabetes and treating hyperlipidemia.
PCT/US2000/006380 1999-03-15 2000-03-14 Stabilized bicyclo[3.3.1]nonenes and methods of use WO2000054785A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37387/00A AU3738700A (en) 1999-03-15 2000-03-14 Stabilized bicyclo(3.3.1)nonenes and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27030599A 1999-03-15 1999-03-15
US09/270,305 1999-03-15

Publications (3)

Publication Number Publication Date
WO2000054785A2 WO2000054785A2 (en) 2000-09-21
WO2000054785A3 true WO2000054785A3 (en) 2001-05-03
WO2000054785A9 WO2000054785A9 (en) 2001-12-27

Family

ID=23030776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006380 WO2000054785A2 (en) 1999-03-15 2000-03-14 Stabilized bicyclo[3.3.1]nonenes and methods of use

Country Status (2)

Country Link
AU (1) AU3738700A (en)
WO (1) WO2000054785A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031098A1 (en) * 2003-05-30 2004-11-30 Indena Spa USEFUL COMPOUNDS IN ALZHEIMER DISEASE THERAPY AND FORMULATIONS CONTAINING THEM
EP2714638A4 (en) * 2011-06-03 2015-09-23 Harvard College Hyperforin analogs, methods of synthesis, and uses thereof
CN111149761B (en) * 2020-02-26 2022-01-07 中国水产科学研究院黄海水产研究所 Method for reducing stress in transportation process of oplegnathus punctatus

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524884A (en) * 1966-11-28 1970-08-18 Procter & Gamble Intramolecular cyclization of cis-4-cyclooctene-1-carboxylic acid chloride to form bicyclo(3.3.1)nonyl compounds
CH536603A (en) * 1970-04-17 1973-05-15 Firmenich & Cie Unsaturated cycloaliphatic ketones
JPH09227545A (en) * 1996-02-26 1997-09-02 Mitsubishi Chem Corp Phloroglucin derivative
DE19714450A1 (en) * 1997-04-08 1998-10-15 Schwabe Willmar Gmbh & Co Stable extract of Hypericum perforatum L., process for its preparation and pharmaceutical preparation
US5972357A (en) * 1996-12-19 1999-10-26 Kikkoman Corporation Healthy foods and cosmetics
JP2000044468A (en) * 1998-07-29 2000-02-15 Kikkoman Corp Lipase inhibitor and antiobestic medicine or hyperlipidemia inhibitor
DE19903570A1 (en) * 1998-11-04 2000-05-11 Schwabe Willmar Gmbh & Co Stable preparations with hyperforin
WO2000054760A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3524884A (en) * 1966-11-28 1970-08-18 Procter & Gamble Intramolecular cyclization of cis-4-cyclooctene-1-carboxylic acid chloride to form bicyclo(3.3.1)nonyl compounds
CH536603A (en) * 1970-04-17 1973-05-15 Firmenich & Cie Unsaturated cycloaliphatic ketones
JPH09227545A (en) * 1996-02-26 1997-09-02 Mitsubishi Chem Corp Phloroglucin derivative
US5972357A (en) * 1996-12-19 1999-10-26 Kikkoman Corporation Healthy foods and cosmetics
DE19714450A1 (en) * 1997-04-08 1998-10-15 Schwabe Willmar Gmbh & Co Stable extract of Hypericum perforatum L., process for its preparation and pharmaceutical preparation
JP2000044468A (en) * 1998-07-29 2000-02-15 Kikkoman Corp Lipase inhibitor and antiobestic medicine or hyperlipidemia inhibitor
DE19903570A1 (en) * 1998-11-04 2000-05-11 Schwabe Willmar Gmbh & Co Stable preparations with hyperforin
WO2000054760A2 (en) * 1999-03-15 2000-09-21 Shaman Pharmaceuticals, Inc. Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200019, Derwent World Patents Index; Class B05, AN 2000-217924, XP002155247 *
DECOSTERD L A ET AL: "55. NEW HYPERFORIN DERIVATIVES FROM HYPERICUM REVOLUTUM VAHL WITH GROWTH-INHIBITORY ACTIVITY AGAINST A HUMAN COLON CARCINOMA CELL LINE", HELVETICA CHIMICA ACTA,CH,VERLAG HELVETICA CHIMICA ACTA. BASEL, vol. 72, no. 3, 1989, pages 464 - 471, XP000907328, ISSN: 0018-019X *
FUKUYAMA, YOSHIYASU ET AL: "Chemical constituents of Garcinia subelliptica and their biological activities", TENNEN YUKI KAGOBUTSU TORONKAI KOEN YOSHISHU (1997), 39TH, 577-582, XP000964789 *
FUKUYAMA, YOSHIYASU ET AL: "Garsubellin A, a novel polyprenylated phloroglucin derivative, increasing choline acetyltransferase (ChAT) activity in postnatal rat septal neuron cultures", CHEM. PHARM. BULL. (1997), 45(5), 947-949, XP000960639 *
KRISHNAMURTHY, N. ET AL: "On the structure of garcinol, isogarcinol, and camboginol", TETRAHEDRON LETT. (1981), 22(8), 793-6, XP000960626 *
MAISENBACHER P ET AL: "ADHYPERFORIN A HOMOLOGUE OF HYPERFORIN FROM HYPERICUM-PERFORATUM", PLANTA MEDICA, vol. 58, no. 3, 1992, pages 291 - 293, XP000964798, ISSN: 0032-0943 *
MAISENBACHER P ET AL: "ANALYSIS AND STABILITY OF HYPERICI OLEUM", PLANTA MEDICA, vol. 58, no. 4, 1992, pages 351 - 354, XP000964768, ISSN: 0032-0943 *
ORTH H C J ET AL: "Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L.", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 51, no. 2, February 1999 (1999-02-01), pages 193 - 200, XP000964765, ISSN: 0022-3573 *
TRIFUNOVIC, SNEZANA ET AL: "Oxidation products of hyperforin from Hypericum perforatum", PHYTOCHEMISTRY (1998), 49(5), 1305-1310, XP000964861 *

Also Published As

Publication number Publication date
AU3738700A (en) 2000-10-04
WO2000054785A9 (en) 2001-12-27
WO2000054785A2 (en) 2000-09-21

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