WO2000053759A8 - Expression of human alpha-fetoprotein in mammalian cells - Google Patents

Expression of human alpha-fetoprotein in mammalian cells

Info

Publication number
WO2000053759A8
WO2000053759A8 PCT/US2000/006038 US0006038W WO0053759A8 WO 2000053759 A8 WO2000053759 A8 WO 2000053759A8 US 0006038 W US0006038 W US 0006038W WO 0053759 A8 WO0053759 A8 WO 0053759A8
Authority
WO
WIPO (PCT)
Prior art keywords
fetoprotein
mammalian cells
human alpha
expression
cells
Prior art date
Application number
PCT/US2000/006038
Other languages
French (fr)
Other versions
WO2000053759A1 (en
Inventor
Stace Lindsay
Robert Mulroy
Daniel Semeniuk
Original Assignee
Atlantic Biopharmaceuticals In
Stace Lindsay
Robert Mulroy
Daniel Semeniuk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atlantic Biopharmaceuticals In, Stace Lindsay, Robert Mulroy, Daniel Semeniuk filed Critical Atlantic Biopharmaceuticals In
Priority to EP00917794A priority Critical patent/EP1161533A1/en
Priority to CA002365843A priority patent/CA2365843A1/en
Priority to JP2000603380A priority patent/JP2002537838A/en
Priority to IL14505600A priority patent/IL145056A0/en
Priority to AU38712/00A priority patent/AU3871200A/en
Publication of WO2000053759A1 publication Critical patent/WO2000053759A1/en
Publication of WO2000053759A8 publication Critical patent/WO2000053759A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention features a nucleic acid, vector, cells, and processes for expressing recombinant human alpha-fetoprotein (rHuAFP) in cultured mammalian cells.
PCT/US2000/006038 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells WO2000053759A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP00917794A EP1161533A1 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells
CA002365843A CA2365843A1 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells
JP2000603380A JP2002537838A (en) 1999-03-09 2000-03-08 Expression of human α-fetoprotein in mammalian cells
IL14505600A IL145056A0 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells
AU38712/00A AU3871200A (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12366699P 1999-03-09 1999-03-09
US60/123,666 1999-03-09

Publications (2)

Publication Number Publication Date
WO2000053759A1 WO2000053759A1 (en) 2000-09-14
WO2000053759A8 true WO2000053759A8 (en) 2000-11-09

Family

ID=22410086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006038 WO2000053759A1 (en) 1999-03-09 2000-03-08 Expression of human alpha-fetoprotein in mammalian cells

Country Status (6)

Country Link
EP (1) EP1161533A1 (en)
JP (1) JP2002537838A (en)
AU (1) AU3871200A (en)
CA (1) CA2365843A1 (en)
IL (1) IL145056A0 (en)
WO (1) WO2000053759A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208576B2 (en) * 1999-01-06 2007-04-24 Merrimack Pharmaceuticals, Inc. Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof
US7022892B1 (en) 1999-07-12 2006-04-04 Universite Libre De Bruxelles Non-human genetically modified mammal lacking the alpha-fetoprotein
DE60041189D1 (en) * 1999-07-12 2009-02-05 Univ Bruxelles GENETICALLY MODIFIED NICHTHUMAN ANIMAL WITH LACK IN ALPHA-FETOPROTEIN
EA011606B1 (en) * 2004-07-14 2009-04-28 Эдуард Борисович Татулов Methods of producing recombinant alpha-fetoprotein and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3906314B2 (en) * 1994-04-25 2007-04-18 ジェネンテク・インコーポレイテッド Cardiotrophin and its use

Also Published As

Publication number Publication date
CA2365843A1 (en) 2000-09-14
EP1161533A1 (en) 2001-12-12
IL145056A0 (en) 2002-06-30
AU3871200A (en) 2000-09-28
JP2002537838A (en) 2002-11-12
WO2000053759A1 (en) 2000-09-14

Similar Documents

Publication Publication Date Title
CA2323086A1 (en) Regulation of endogenous gene expression in cells using zinc finger proteins
AU4095999A (en) Cell cycle genes, proteins and uses thereof
NZ509633A (en) A recombinant chimeric PEG-uricase with a long circulatory life and reduced immunogenicity
AU3462899A (en) Sequence and method for genetic engineering of proteins with cell membrane translocating activity
AU5488501A (en) Modified es cells and es cell-specific gene
WO2001049728A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
WO1997020933A3 (en) Mutational variants of mammalian ob gene proteins
ZA986051B (en) Isolated mammalian membrane protein genes related reagents
CA2306449A1 (en) Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins
WO2000069884A3 (en) Compositions isolated from skin cells and methods for their use
WO2000029448A3 (en) Human proteins having hydrophobic domains and dnas encoding these proteins
WO2002036627A3 (en) Interferons, uses and compositions related thereto
WO2001049721A3 (en) Bacterial genes and proteins that are essential for cell viability and their uses
WO2000029551A3 (en) Cells, culture methods, and their use in autologous transplantation therapy
WO2001002563A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
AU6458400A (en) Nucleic acid, polypeptides, assays, therapeutic methods and means
WO2000066731A3 (en) Recombinant laminin 5
WO2000053759A8 (en) Expression of human alpha-fetoprotein in mammalian cells
AU1814995A (en) Galanin receptor, nucleic acids, transformed cells and uses thereof
AU2002303277A1 (en) Artificial chromosomes that can shuttle between bacteria, yeast, and mammalian cells
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor
WO1999022005A3 (en) Heparan sulfate d-glucosaminyl 3-o-sulfotransferases, an uses therefor
AU3063699A (en) Isolated mammalian membrane protein genes and related reagents
WO2001072773A3 (en) Genes isolated from dendritic cells, gene products and methods employing the same
AU2002309989A1 (en) Directed evolution of protein in mammalian cells

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WR Later publication of a revised version of an international search report
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 145056

Country of ref document: IL

Ref document number: 38712/00

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2365843

Country of ref document: CA

Kind code of ref document: A

Ref document number: 2365843

ENP Entry into the national phase

Ref document number: 2000 603380

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2000917794

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000917794

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2000917794

Country of ref document: EP