WO2000053169A8 - Method of inhibiting a chaperone protein - Google Patents

Method of inhibiting a chaperone protein

Info

Publication number
WO2000053169A8
WO2000053169A8 PCT/US2000/006482 US0006482W WO0053169A8 WO 2000053169 A8 WO2000053169 A8 WO 2000053169A8 US 0006482 W US0006482 W US 0006482W WO 0053169 A8 WO0053169 A8 WO 0053169A8
Authority
WO
WIPO (PCT)
Prior art keywords
inhibiting
chaperone protein
chaperone
protein
Prior art date
Application number
PCT/US2000/006482
Other languages
French (fr)
Other versions
WO2000053169A2 (en
Inventor
Monica G Marcu
Leonard M Neckers
Theodor W Schulte
Original Assignee
Us Health
Monica G Marcu
Leonard M Neckers
Theodor W Schulte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Monica G Marcu, Leonard M Neckers, Theodor W Schulte filed Critical Us Health
Priority to EP00916277A priority Critical patent/EP1161231A2/en
Priority to AU37406/00A priority patent/AU776652B2/en
Priority to CA002367108A priority patent/CA2367108A1/en
Priority to JP2000603658A priority patent/JP2003523313A/en
Publication of WO2000053169A2 publication Critical patent/WO2000053169A2/en
Publication of WO2000053169A8 publication Critical patent/WO2000053169A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PCT/US2000/006482 1999-03-12 2000-03-10 Method of inhibiting a chaperone protein WO2000053169A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00916277A EP1161231A2 (en) 1999-03-12 2000-03-10 Method of inhibiting a chaperone protein
AU37406/00A AU776652B2 (en) 1999-03-12 2000-03-10 Method of inhibiting a chaperone protein
CA002367108A CA2367108A1 (en) 1999-03-12 2000-03-10 Method of inhibiting a chaperone protein
JP2000603658A JP2003523313A (en) 1999-03-12 2000-03-10 Methods for inhibiting chaperone proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12413599P 1999-03-12 1999-03-12
US60/124,135 1999-03-12

Publications (2)

Publication Number Publication Date
WO2000053169A2 WO2000053169A2 (en) 2000-09-14
WO2000053169A8 true WO2000053169A8 (en) 2001-01-11

Family

ID=22412989

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006482 WO2000053169A2 (en) 1999-03-12 2000-03-10 Method of inhibiting a chaperone protein

Country Status (5)

Country Link
EP (1) EP1161231A2 (en)
JP (1) JP2003523313A (en)
AU (1) AU776652B2 (en)
CA (1) CA2367108A1 (en)
WO (1) WO2000053169A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858331B2 (en) 2000-11-03 2010-12-28 Dana Farber Cancer Institute, Inc. Compositions and methods for the treatment of cancer
US20040235813A1 (en) * 2001-05-03 2004-11-25 Erich Wanker Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation
US7959915B2 (en) 2003-03-12 2011-06-14 Tufts University Inhibitors of extracellular Hsp90
EP1457499A1 (en) * 2003-03-12 2004-09-15 Tufts University School Of Medicine Inhibitors of extracellular Hsp90
EP1642880B1 (en) * 2003-06-27 2013-09-04 Kyowa Hakko Kirin Co., Ltd. Hsp90 family protein inhibitors
DE102004039280A1 (en) 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-diphenyl-pyrazoles
DE102004049078A1 (en) 2004-10-08 2006-04-13 Merck Patent Gmbh phenylpyrazoles
WO2006050501A2 (en) * 2004-11-03 2006-05-11 University Of Kansas Novobiocin analogues as anticancer agents
US8212012B2 (en) 2004-11-03 2012-07-03 University Of Kansas Novobiocin analogues having modified sugar moieties
DE102005009440A1 (en) 2005-03-02 2006-09-07 Merck Patent Gmbh thienopyridine derivatives
DE102007002715A1 (en) 2007-01-18 2008-07-24 Merck Patent Gmbh triazole
DE102007028521A1 (en) 2007-06-21 2008-12-24 Merck Patent Gmbh Indazolamidderivate
DE102007032739A1 (en) 2007-07-13 2009-01-15 Merck Patent Gmbh Chinazolinamidderivate
DE102007041116A1 (en) 2007-08-30 2009-03-05 Merck Patent Gmbh 1,3-dihydro-isoindole derivatives
US8546320B2 (en) 2008-11-14 2013-10-01 Kyoto University Hsp9O-targeted anti-cancer chimeric peptide
DE102008061214A1 (en) 2008-12-09 2010-06-10 Merck Patent Gmbh Chinazolinamidderivate
CN101942017B (en) 2009-07-07 2013-08-14 清华大学 Tumor marker
DE102009054302A1 (en) 2009-11-23 2011-05-26 Merck Patent Gmbh quinazoline derivatives
DE102010046837A1 (en) 2010-09-29 2012-03-29 Merck Patent Gmbh Phenylchinazolinderivate
WO2012162054A1 (en) * 2011-05-20 2012-11-29 The University Of Kansas Dynamic inhibitors of heat shock protein 90

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216014A (en) * 1991-09-10 1993-06-01 Sphinx Pharmaceuticals Corporation Furo-coumarinsulfonamides as protein kinase C inhibitors

Also Published As

Publication number Publication date
CA2367108A1 (en) 2000-09-14
JP2003523313A (en) 2003-08-05
AU776652B2 (en) 2004-09-16
WO2000053169A2 (en) 2000-09-14
EP1161231A2 (en) 2001-12-12
AU3740600A (en) 2000-09-28

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