WO2000044703A3 - A novel synthetic route for obtaining 1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one - Google Patents

A novel synthetic route for obtaining 1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one Download PDF

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Publication number
WO2000044703A3
WO2000044703A3 PCT/IL2000/000063 IL0000063W WO0044703A3 WO 2000044703 A3 WO2000044703 A3 WO 2000044703A3 IL 0000063 W IL0000063 W IL 0000063W WO 0044703 A3 WO0044703 A3 WO 0044703A3
Authority
WO
WIPO (PCT)
Prior art keywords
dimethyl
chlorophenyl
pentane
obtaining
synthetic route
Prior art date
Application number
PCT/IL2000/000063
Other languages
French (fr)
Other versions
WO2000044703A2 (en
Inventor
Yoel Sasson
David Ovadia
Raya Sturkovich
Original Assignee
Makhteshim Chem Works Ltd
Yoel Sasson
David Ovadia
Raya Sturkovich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Makhteshim Chem Works Ltd, Yoel Sasson, David Ovadia, Raya Sturkovich filed Critical Makhteshim Chem Works Ltd
Priority to AU23170/00A priority Critical patent/AU2317000A/en
Publication of WO2000044703A2 publication Critical patent/WO2000044703A2/en
Publication of WO2000044703A3 publication Critical patent/WO2000044703A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Abstract

1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one of formula (I) is prepared by the alkylation of pinacolone (3,3-dimethyl-2-butanone) with p-chlorobenzylchloride where the pinacolone is used both as a reagent and the solvent. The alkylation is done under either Phase Transfer Catalysis conditions in the presence of a base or in the presence of a strong base.
PCT/IL2000/000063 1999-01-31 2000-01-30 A novel synthetic route for obtaining 1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one WO2000044703A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23170/00A AU2317000A (en) 1999-01-31 2000-01-30 A novel synthetic route for obtaining 1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12829099A IL128290A0 (en) 1999-01-31 1999-01-31 A novel synthetic route for obtaining 1-(4-chlorophenyl)-4,4-dimethyl - pentane-3-one
IL128290 1999-01-31

Publications (2)

Publication Number Publication Date
WO2000044703A2 WO2000044703A2 (en) 2000-08-03
WO2000044703A3 true WO2000044703A3 (en) 2000-11-23

Family

ID=11072435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2000/000063 WO2000044703A2 (en) 1999-01-31 2000-01-30 A novel synthetic route for obtaining 1-(4-chlorophenyl)-4,4-dimethyl-pentane-3-one

Country Status (3)

Country Link
AU (1) AU2317000A (en)
IL (1) IL128290A0 (en)
WO (1) WO2000044703A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3668255A (en) * 1967-10-31 1972-06-06 Rhodia Process for alkylation of aliphatic ketones and product
DE2737489A1 (en) * 1976-08-19 1978-02-23 Ici Ltd TRIAZOLE AND IMIDAZOLE COMPOUNDS
EP0089592A2 (en) * 1982-03-24 1983-09-28 Bayer Ag Process for the preparation of methyl ketones
EP0355350A1 (en) * 1988-07-20 1990-02-28 Bayer Ag Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)-pentan-3-one

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3668255A (en) * 1967-10-31 1972-06-06 Rhodia Process for alkylation of aliphatic ketones and product
DE2737489A1 (en) * 1976-08-19 1978-02-23 Ici Ltd TRIAZOLE AND IMIDAZOLE COMPOUNDS
EP0089592A2 (en) * 1982-03-24 1983-09-28 Bayer Ag Process for the preparation of methyl ketones
EP0355350A1 (en) * 1988-07-20 1990-02-28 Bayer Ag Process for the preparation of 4,4-dimethyl-1-(p-chlorophenyl)-pentan-3-one

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 116, no. 19, 11 May 1992, Columbus, Ohio, US; abstract no. 194214e, IMAI T ET AL: "Synthesis and antifungal activity of imidazole-1-carboxylates" page 718; column 2; XP002901048 *
MONTIGNOUL C ET AL: "Synthèse de tertiobutylcétones alpha-azotées de type >N-C(R1)(R2)-CO-C(CH3)3", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 21, no. 4, July 1984 (1984-07-01) - August 1984 (1984-08-01), pages 1509 - 1519, XP002901047 *
PESTIC. SCI., vol. 34, no. 2, 1992, pages 119 - 125 *

Also Published As

Publication number Publication date
AU2317000A (en) 2000-08-18
IL128290A0 (en) 1999-11-30
WO2000044703A2 (en) 2000-08-03

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