WO2000044424A1 - Access system and methods having reversible cannulas - Google Patents
Access system and methods having reversible cannulas Download PDFInfo
- Publication number
- WO2000044424A1 WO2000044424A1 PCT/US2000/002359 US0002359W WO0044424A1 WO 2000044424 A1 WO2000044424 A1 WO 2000044424A1 US 0002359 W US0002359 W US 0002359W WO 0044424 A1 WO0044424 A1 WO 0044424A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cannula
- cannulas
- port
- cut
- ports
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0208—Subcutaneous access sites for injecting or removing fluids
Definitions
- Implantable ports are entirely subcutaneous and connected to a vein or an artery by a subcutaneous “connecting" cannula. Access to the port is achieved by percutaneous placement of a needle or other connecting tube. Such ports typically comprise a needle-penetrable septum to permit percutaneous penetration of the needle. Recently, several valved-port designs have been proposed, where percutaneous introduction of a needle or other access tube into the port opens the valve to permit flow to or from the cannula which connects to the blood vessel.
- the implanted ends of the draw and return cannulas may differ, e.g., the blood draw cannula may have a distal end with a plurality of side holes (flow diffusers) over a portion thereof in order to reduce possible blockage resulting from a "fibrin sheath" which forms over the catheter in some patients.
- the return catheter is at less risk of such fibrin sheath blockage and may therefore have fewer or no side holes or other means for flow diffusion.
- the need to provide separate draw cannulas and return cannulas makes maintaining an inventory of these cannulas more difficult.
- the improved systems and methods will permit inventory reduction and/or simplification while still allowing the treating physician to choose from different cannula designs for implantation in a blood vessel or other body lumen.
- U.S. Patent No. 5,718,692 describes a double catheter assembly where each catheter has side holes at its distal end.
- U.S. Patent Nos. 5,562,617 and 5,041,098 are exemplary of implantable systems employing cannulas extending between a port and a blood vessel for providing extraco ⁇ oreal circulation.
- U.S. Patent Nos. 5,417,656 and 5,281 , 199 show implantable ports which are connected to vascular cannulas via a transition region (Fig. 1 A) and to a multiple branch cannula (Fig. 21).
- U.S. Patent No. 4,892,518 shows an implanted port with a transition region extending to a cannula.
- the present invention provides improved systems, methods, and kits for connecting an implantable port to a connecting cannula to establish access to a patient's body lumen or other target location. While the present invention is particularly suited for establishing access to a patient's vasculature for performing extraco ⁇ oreal treatment on circulating blood, it might also find use in other procedures, such as drug delivery, peritoneal dialysis, cerebral shunting, bladder cannulation, and the like. Exemplary extraco ⁇ oreal treatment procedures include hemodialysis, hemofiltration, plasmapheresis, apheresis, and the like.
- the present invention is most advantageous with access systems comprising a pair of connecting cannulas having tubular bodies, where one of the cannulas will have a modified end and the other of the cannulas will be intended for use with an unmodified or differently modified end.
- one of the connecting cannulas will be intended as a "draw" cannula for removing blood from the patient's vasculature while the other of the cannulas will be intended as a "return” cannula for returning treated blood to the patient.
- the "modified end" will be modified to have flow diffusers formed integrally as side holes or otherwise formed in or attached to the cannula at or near the end.
- the present invention will cover any other functional and/or structural modifications of one end of the cannula where a user has the option of implanting either end of the cannula depending on selection criteria.
- the draw catheter will be provided with flow diffusers, typically with side holes, over a portion of one end, while the return catheter will have a plain (unmodified) tubular end intended for placement in the vasculature.
- access systems employing such connecting cannulas have usually included one plain tubular cannula free from side holes or other modifications and a second cannula having the desired side holes at one end thereof. The need to maintain systems having two different types of catheters is inconvenient. It would be advantageous to provide for access systems which utilize only a single common catheter for both the draw and return functions.
- the implanted cannulas may then be connected to implantable ports, be placed transcutaneously, be connected to other cannulas (which may optionally have different sizes, characteristics, etc.), or be otherwise used to establish flow and return access to the vasculature.
- the present invention will also find use with single cannula systems where, under different circumstances, it may be desirable to allow the treating physician to select between implanting one end of a cannula which is modified in some manner or an opposite end which is unmodified or modified in a second manner.
- the proximal end of the cannula i.e., the end which is not implanted
- the tubular body will be adapted to be cut at a point spaced inwardly from either end in order to produce the cut end which is able to mate with the connector on either of the implantable ports.
- the modified end of a first of the connecting cannulas can be implanted in a blood vessel
- the unmodified end of a second of the cannulas can be implanted in the same or different blood vessel.
- the proximal ends of each of the cannulas may then be cut to length and connected to the implantable ports, either before or after implantation.
- the outlet connectors on each of the ports will comprise male fittings so that the cut ends of the tubular bodies may simply be placed over the fittings.
- the tubular bodies of the connecting cannulas will comprise elastomeric materials, such as latex, silicone rubber, polyurethane, or the like.
- the cannulas will usually (but not necessarily) have a uniform inside diameter along their entire length, typically being the range from 1 mm to 15 mm, usually being in the range from 2 mm to 5 mm.
- the lengths of the connecting cannulas will usually, but not necessarily, be identical, typically being the in range from 15 cm to 100 cm, preferably being in the range from 20 cm to 40 cm.
- the connecting cannulas may differ in certain respects, e.g., length.
- the connecting cannulas would normally cut to length, the system and methods of the present invention will work equally well even if one of the cannulas has a different initial length than the other (so long as each of the cannulas is sufficiently long for the intended use). Either or both of the cannulas may then be trimmed to length during implantation.
- Both ends of each connecting cannula should also be adapted in all respects for implantation within the blood vessel or other target body lumen or location.
- the ends of each of the connecting cannulas be chamfered or beveled in order to reduce the risk of trauma when implanted within a blood vessel. In this way, both ends of each cannula are ready for implantation within a blood vessel without modification or other preparations.
- the method according to the present invention comprises providing an implantable port as described above and a connecting cannula, also as described above.
- the connecting cannula will have one modified end, typically including flow diffusers such as side holes, and another unmodified or differently modified end.
- the connecting catheter is cut to length at one end to remove at least one of the modifications, e.g., side holes.
- the cut end is then connected to an outlet connector on the port.
- the method may further comprise implanting the port into the cannula subcutaneously in the patient.
- the implantation step may occur either before or after the connecting cannula is attached to the port.
- the modified end of the connecting cannula will be implanted within a blood vessel, more usually within a vein where the modified end comprises side holes or other flow diffusers and the port is intended for drawing blood. While this method will normally be employed with a pair of connecting cannulas and implanted the ports, it may also find use in circumstances where only a single connecting cannula and port will be desired.
- the method for establishing access to a patient's vasculature for establishing extraco ⁇ oreal circulation comprises providing two identical connecting cannulas and two implantable ports, generally as described above.
- a first of the two identical cannulas is then implanted with its flow diffuser and within a blood vessel, typically a vein.
- a second of the identical cannulas is then implanted with its plain or unmodified end within the same or a different blood vessel.
- the proximal ends of the two connecting cannulas may then be connected to ports, other cannulas, or be left transcutaneously in order to establish the desired extraco ⁇ oreal access.
- the connecting cannulas may be cut to length before or after implantation.
- kits having different configurations In a first configuration, the kit comprises the system of at least one (usually two) implantable ports and at least one (usually two) cannulas as generally described above. The system components will then be packaged in a conventional and usually sterile package, such as a pouch, tray, tube, box, or the like. In a second configuration, the kit comprises at least one implantable port and one connecting cannula, generally as described above, in combination with instructions for use according to any of the methods described above. Optionally, the port, connecting cannula, and instructions may be packaged in the conventional medical device package.
- FIG. 1 is an isometric view of an access system constructed in accords with the principles of the present invention which comprises a pair of implantable ports and a pair of identical connecting cannulas.
- Figs. 2A-2C illustrate an exemplary connecting catheter having flow diffusers in the form of side holes constructed in accordance with the principles of the present invention.
- Fig. 3 illustrates a connecting cannula attached to an implantable port, where the modified end having flow diffusing side holes has been cut off prior to attachment.
- Fig. 4 illustrates an implantable port attached to a connecting cannula, where the portion of the unmodified end of the connecting cannula has been cut prior to attachment to the implantable port.
- Fig. 5 illustrates patient vasculature to which the implantable access systems of the present invention can be attached.
- Fig. 6 illustrates an initial step in implantation of the pair of connecting cannulas in accordance with the principles of the present invention.
- Fig. 7 illustrates connection of the connecting cannulas of Fig. 6 to implantable ports according to the methods of the present inventions.
- Fig. 9 illustrates a kit according to the present invention comprising a pair of implantable ports, a pair of connecting cannulas, instructions for use, and a package for holding all kit components.
- the present invention provides methods and apparatus for facilitating percutaneous and transcutaneous access to a body lumen or other target site of a patient.
- body lumens include blood vessels, the peritoneal cavity, and the like.
- the methods are particularly useful for accessing blood vessels, and most particularly for accessing venous blood vessels. While the remaining description is directed particularly at accessing veins, it will be appreciated that the invention applies to all body lumens and cavities where selective percutaneous access might be desired.
- the ports 12 are subcutaneously implantable and provide for percutaneous access by means of a needle or other access tube which is introduced through the patient's skin into an inlet aperture 16 on the top of the port.
- the port will also include an outlet connector 18 typically a male fitting, which is intended to attachably receive a cut end of the connecting cannula 14, as described in more detail below.
- the illustrated ports 12 include internal valves which open and close in response to insertion of the access tube through the aperture 16, as described in detail in co-pending Application Serial No. 08/942,990, the full disclosure of which is inco ⁇ orated herein by reference, the present invention may also utilize a wide variety of ports having other valve structures, membrane-access structures, and other means for permitting an access tube to connect to a flow path defined by the outlet connector.
- the connecting cannulas will comprise tubular bodies, typically fabricated by extruding biocompatible polymeric materials, such as silicone rubber, latex, polyurethane, PTFE, and the like.
- the cannulas will have lengths, lumen diameters, and other dimensions as generally set forth above, and will have at least one end modified to include features other than a plain tubular body.
- the modification comprises flow diffusers, more particularly comprising side holes 20 which extend over one end portion of the tubular body of the cannula as best observed in Figs. 2A-2C.
- side holes 20 extend in a spiral pattern over a length of the catheter in the range from 1 cm to 60 cm, usually from 2 cm to 40 cm.
- each of the two or more cannulas 14 will be identical in construction and dimensions. More preferably, each of the cannulas 14 will comprise tubular bodies having a uniform luminal diameter, more preferably a uniform luminal and outside diameter over the entire length so that connection may be made to the male fitting 18 regardless of where the catheter is cut along its length. Also preferably, both ends of the catheter will be chamfered, rounded, or radiused so that either end may be placed into a blood vessel with reduced risk of trauma. The chamfer is typically at 45° relative to the axial direction, but could vary between 10° and 80°, usually 25° and 75°.
- each cannula 14 may be plain or have a simple chamfer or radiused end, as shown in Fig. 1.
- the other end may be differently modified, e.g., having an angled end optionally including one or more side holes 22, as shown in Figs. 2A-2C. This second type of end is presently preferred as the return cannula.
- the cannula 14 when intended for returning blood to a blood vessel, the cannula 14 may be cut to a preselected length, with the end including side holes 20 being removed. The cut end may then be attached to the male fitting 18 (Fig. 1) as shown in Fig. 3. The distal end 26 of the cut cannula 14' which is intended for implantation will thus be free from side holes 20 or other modifications.
- the cannula 14 when intended for blood return, the cannula 14 may be cut on the modified end, and the cut end attached to implantable port 12.
- the distal end 28 of the cut cannula 14" which is intended for implantation will thus have the side holes 20 intended for flow diffusion for the draw cannula.
- the access systems described above are particularly suitable for establishing percutaneous and transcutaneous access to single or multiple locations in the patient's vasculature, including both the arterial and venous vasculature.
- the arterial and venous vasculature of patient P in the region immediately surrounding the heart H includes the jugular vein JN, the subclavian vein SN, the subclavian artery SA, and the aorta A.
- the connecting cannulas 14 may be implanted by either a cut-down procedure or by the Seldinger technique. For simplicity, only the cut-down procedure will be described.
- a small venotomy is performed at the desired site in the jugular vein JN, typically from 5 cm to 10 cm above the junction of the superior vena cava SVC and the right atrium of the heart H.
- first connecting cannula 14 The distal tip of a first connecting cannula 14 is then inserted through the incision in the vascular wall with the end having side holes 20 therein positioned within the venous lumen.
- a second connecting cannula 14, which is usually identical to the first, is then inserted into the venous lumen through the same incision so that it's non-modified tip (i.e., free from side holes 20) is located approximately 4 cm above the distal tip of the first cannula.
- the positioning of the distal tips of the access cannulas 14 may be verified by X-ray.
- the cannulas 14 may be prepared for transcutaneous use, i.e., where the proximal ends remain outside the patient's body available for connection to the desired extraco ⁇ oreal recirculation system.
- the proximal end of the cannula 14 having the exposed side holes 20 will be cut off to desired length, with at least the portion having the side holes being removed.
- the other cannula will also be cut to a desired length. Both cannulas may then be connected to suitable external connectors for interconnection to the extraco ⁇ oreal recirculation system.
- the connectors 14, as shown in Fig. 6, will then be cut for attachment to implantable ports 12, as shown in Fig. 7.
- Placement of each of the ports 12 may be selected based on a number of criteria.
- the infraclavicular fossa is generally satisfactory, but the actual site may vary depending on the patient characteristics.
- the implantable ports 12 should be located in an anatomic area that provides for good stability, does not interfere with patient mobility, create pressure points, or interfere with clothing. Placement should allow for a proper amount of overlying cutaneous tissue, with an optimum tissue thickness in the range from 5 mm to 15 mm. Sufficient space should be available for placement of two implantable catheters when blood circulation through a single venous location is to be effected.
- a subcutaneous pocket is formed by a cut-down procedure using blunt dissection.
- the pocket should be sufficiently large to accommodate the ports 12 and allow positioning of the ports away from the incision.
- a tunnel is created between the pocket and the venous entry site using a tunneling tool.
- the distal ends of the connecting cannulas 14 are then cut to length so that the so that they terminate at the venous entry site with sufficient slack for body movement and subcutaneous connection.
- the cut distal ends of each connector cannula is then placed over the connector 18, and secured with a suture or other biocompatible filament.
- the implanted cannulas 14, as shown in Fig. 6, may be attached using intermediate connectors 30 to additional connecting tubes 30 and 34.
- the connecting tubes 32 and 34 may themselves be identical, e.g., be of the same diameter as the cannulas 14, but will often be different in dimensions and other characteristics than the connecting cannulas 14.
- the connecting tubes 32 may be positioned transcutaneously, but will more usually be connected to implantable ports, as illustrated.
- the use of internal connectors is described in detail in co-pending Application Serial No. 08/856,641, the full disclosure which is inco ⁇ orated herein by reference.
- FIG. 8A A third general approach for connecting the cannulas 14 of Fig. 6 is illustrated in Fig. 8A.
- Transcutaneous catheters such as Tesio catheters available from Med Comp, Harleysville, Pennsylvania, may be connected to the remote ends, i.e., the ends not placed in the jugular vein, in a conventional manner.
- the transcutaneous catheters are then implanted, also in a conventional manner.
- the present invention provides, as in all previously described instances, the ability to maintain a single or reduced number of cannula types where both ends of each cannula have different characteristics allowing the physician to choose which end should be implanted in a particular patient or in a particular circumstance.
- kits according to the present invention will include at least one port 12 and cannula 14, as generally described above, usually including at least a pair of ports 12 and a pair of cannulas 14. Kits will also comprise instructions for use 40 setting forth any of the methods described above for connection and/or implantation of the cannulas 14 and ports 12.
- the instructions for use 40 will usually be printed on a separate sheet of paper (package insert), but may also be printed in whole or in part on other kit packaging.
- the kit components will usually be packaged in a conventional medical device package, such as a pouch 50, tray, tube, box, or the like. Kits may comprise different combination of kit components.
- kits will comprise at least two ports 12, two cannulas 14, and a package, such as a pouch 50.
- the kits will comprise at least one port 12, one cannula 14, and instructions for use 40.
- the kits may comprise all of the components illustrated in Fig. 9.
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00905863A EP1154814A4 (en) | 1999-01-27 | 2000-01-27 | Access system and methods having reversible cannulas |
JP2000595725A JP2002535096A (en) | 1999-01-27 | 2000-01-27 | Access system and method with reversible cannula |
AU27479/00A AU2747900A (en) | 1999-01-27 | 2000-01-27 | Access system and methods having reversible cannulas |
CA002361039A CA2361039A1 (en) | 1999-01-27 | 2000-01-27 | Access system and methods having reversible cannulas |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23852399A | 1999-01-27 | 1999-01-27 | |
US09/238,523 | 1999-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000044424A1 true WO2000044424A1 (en) | 2000-08-03 |
Family
ID=22898280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/002359 WO2000044424A1 (en) | 1999-01-27 | 2000-01-27 | Access system and methods having reversible cannulas |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1154814A4 (en) |
JP (1) | JP2002535096A (en) |
AU (1) | AU2747900A (en) |
CA (1) | CA2361039A1 (en) |
WO (1) | WO2000044424A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3427692A1 (en) * | 2017-07-12 | 2019-01-16 | Defymed | Locking kit for implantable artificial organ |
US10463845B2 (en) | 2013-01-23 | 2019-11-05 | C.R. Bard, Inc. | Low-profile access port |
USD870264S1 (en) | 2017-09-06 | 2019-12-17 | C. R. Bard, Inc. | Implantable apheresis port |
US11420033B2 (en) | 2013-01-23 | 2022-08-23 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
US11464960B2 (en) | 2013-01-23 | 2022-10-11 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
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US4490137A (en) * | 1982-09-30 | 1984-12-25 | Moukheibir Nabil W | Surgically implantable peritoneal dialysis apparatus |
US4892518A (en) | 1987-12-04 | 1990-01-09 | Biocontrol Technology, Inc. | Hemodialysis |
US5041098A (en) | 1989-05-19 | 1991-08-20 | Strato Medical Corporation | Vascular access system for extracorporeal treatment of blood |
US5215530A (en) | 1991-07-11 | 1993-06-01 | City Of Hope | Sleeved extension and anchoring system for percutaneous catheters |
US5234406A (en) | 1992-04-06 | 1993-08-10 | The Regents Of The University Of California | Method and system for continuous spinal delivery of anesthetics |
US5281199A (en) | 1990-03-01 | 1994-01-25 | Michigan Transtech Corporation | Implantable access devices |
US5417656A (en) | 1990-03-01 | 1995-05-23 | Michigan Transtech Corporation | Implantable access devices |
US5562617A (en) | 1994-01-18 | 1996-10-08 | Finch, Jr.; Charles D. | Implantable vascular device |
US5718692A (en) | 1995-06-06 | 1998-02-17 | Twineath, L.L.C. | Self-retaining single insertion double catheter assembly and method for making double catheter systems |
US5931829A (en) * | 1997-01-21 | 1999-08-03 | Vasca, Inc. | Methods and systems for establishing vascular access |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11514248A (en) * | 1995-03-21 | 1999-12-07 | セレックス・リミテッド・パートナーシップ | Vascular access device |
US5792104A (en) * | 1996-12-10 | 1998-08-11 | Medtronic, Inc. | Dual-reservoir vascular access port |
WO1998031272A2 (en) * | 1997-01-21 | 1998-07-23 | Vasca, Inc. | Methods and systems for establishing vascular access |
US5848989A (en) * | 1997-06-05 | 1998-12-15 | Davinci Biomedical Research Products, Inc. | Implantable port with low profile housing for delivery/collection of fluids and implantation method |
-
2000
- 2000-01-27 JP JP2000595725A patent/JP2002535096A/en not_active Withdrawn
- 2000-01-27 EP EP00905863A patent/EP1154814A4/en not_active Ceased
- 2000-01-27 AU AU27479/00A patent/AU2747900A/en not_active Abandoned
- 2000-01-27 CA CA002361039A patent/CA2361039A1/en not_active Abandoned
- 2000-01-27 WO PCT/US2000/002359 patent/WO2000044424A1/en not_active Application Discontinuation
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490137A (en) * | 1982-09-30 | 1984-12-25 | Moukheibir Nabil W | Surgically implantable peritoneal dialysis apparatus |
US4892518A (en) | 1987-12-04 | 1990-01-09 | Biocontrol Technology, Inc. | Hemodialysis |
US5041098A (en) | 1989-05-19 | 1991-08-20 | Strato Medical Corporation | Vascular access system for extracorporeal treatment of blood |
US5281199A (en) | 1990-03-01 | 1994-01-25 | Michigan Transtech Corporation | Implantable access devices |
US5417656A (en) | 1990-03-01 | 1995-05-23 | Michigan Transtech Corporation | Implantable access devices |
US5215530A (en) | 1991-07-11 | 1993-06-01 | City Of Hope | Sleeved extension and anchoring system for percutaneous catheters |
US5234406A (en) | 1992-04-06 | 1993-08-10 | The Regents Of The University Of California | Method and system for continuous spinal delivery of anesthetics |
US5562617A (en) | 1994-01-18 | 1996-10-08 | Finch, Jr.; Charles D. | Implantable vascular device |
US5718692A (en) | 1995-06-06 | 1998-02-17 | Twineath, L.L.C. | Self-retaining single insertion double catheter assembly and method for making double catheter systems |
US5931829A (en) * | 1997-01-21 | 1999-08-03 | Vasca, Inc. | Methods and systems for establishing vascular access |
Non-Patent Citations (1)
Title |
---|
See also references of EP1154814A4 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10463845B2 (en) | 2013-01-23 | 2019-11-05 | C.R. Bard, Inc. | Low-profile access port |
US11420033B2 (en) | 2013-01-23 | 2022-08-23 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
US11464960B2 (en) | 2013-01-23 | 2022-10-11 | C. R. Bard, Inc. | Low-profile single and dual vascular access device |
EP3427692A1 (en) * | 2017-07-12 | 2019-01-16 | Defymed | Locking kit for implantable artificial organ |
WO2019011943A1 (en) | 2017-07-12 | 2019-01-17 | Defymed | Locking kit for implantable artificial organ |
US11707352B2 (en) | 2017-07-12 | 2023-07-25 | Defymed | Locking kit for implantable artificial organ |
USD870264S1 (en) | 2017-09-06 | 2019-12-17 | C. R. Bard, Inc. | Implantable apheresis port |
USD885557S1 (en) | 2017-09-06 | 2020-05-26 | C. R. Bard, Inc. | Implantable apheresis port |
Also Published As
Publication number | Publication date |
---|---|
EP1154814A1 (en) | 2001-11-21 |
CA2361039A1 (en) | 2000-08-03 |
EP1154814A4 (en) | 2002-03-20 |
AU2747900A (en) | 2000-08-18 |
JP2002535096A (en) | 2002-10-22 |
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