WO2000043546A3 - Detection of drug resistant organisms - Google Patents

Detection of drug resistant organisms Download PDF

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Publication number
WO2000043546A3
WO2000043546A3 PCT/US1999/030377 US9930377W WO0043546A3 WO 2000043546 A3 WO2000043546 A3 WO 2000043546A3 US 9930377 W US9930377 W US 9930377W WO 0043546 A3 WO0043546 A3 WO 0043546A3
Authority
WO
WIPO (PCT)
Prior art keywords
organism
mutation
complex
strain
gene
Prior art date
Application number
PCT/US1999/030377
Other languages
French (fr)
Other versions
WO2000043546A9 (en
WO2000043546A2 (en
Inventor
Yen Ping Liu
Nurith Kurn
Original Assignee
Dade Behring Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Inc filed Critical Dade Behring Inc
Publication of WO2000043546A2 publication Critical patent/WO2000043546A2/en
Publication of WO2000043546A3 publication Critical patent/WO2000043546A3/en
Publication of WO2000043546A9 publication Critical patent/WO2000043546A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays

Abstract

A method is disclosed for detecting drug resistance in a strain of an organism. In the method the presence of at least one mutation in a predetermined region within the gene of the strain is detected. The predetermined region has a multiplicity of mutations among strains of the organism that differ from a corresponding region of the wild type strain of the organism. To detect the mutation, a complex is formed comprising the predetermined region of the gene of the organism and the corresponding region of the gene of the wild type organism in double stranded form. Each member of at least one pair of non-complementary strands within the complex has a label. The association of the labels within the complex is detected wherein the association of the labels in the complex is related to the presence of the mutation. The presence of the mutation is related to the drug resistance of the strain.
PCT/US1999/030377 1999-01-19 1999-12-20 Detection of drug resistant organisms WO2000043546A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23399699A 1999-01-19 1999-01-19
US09/233,996 1999-01-19

Publications (3)

Publication Number Publication Date
WO2000043546A2 WO2000043546A2 (en) 2000-07-27
WO2000043546A3 true WO2000043546A3 (en) 2000-11-02
WO2000043546A9 WO2000043546A9 (en) 2000-12-14

Family

ID=22879459

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030377 WO2000043546A2 (en) 1999-01-19 1999-12-20 Detection of drug resistant organisms

Country Status (1)

Country Link
WO (1) WO2000043546A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232104B1 (en) * 1999-08-17 2001-05-15 Dade Behring Inc. Detection of differences in nucleic acids by inhibition of spontaneous DNA branch migration
CN110923298B (en) * 2019-12-27 2023-09-22 领航基因科技（杭州）有限公司 Primer probe system, kit and method for simultaneously detecting multiple drug-resistant genes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033074A1 (en) * 1994-05-26 1995-12-07 Mayo Foundation For Medical Education And Research Detection of a genetic locus encoding resistance to rifampin
WO1997023646A1 (en) * 1995-12-22 1997-07-03 Behringwerke Aktiengesellschaft Detection of differences in nucleic acids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033074A1 (en) * 1994-05-26 1995-12-07 Mayo Foundation For Medical Education And Research Detection of a genetic locus encoding resistance to rifampin
WO1997023646A1 (en) * 1995-12-22 1997-07-03 Behringwerke Aktiengesellschaft Detection of differences in nucleic acids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
COLE S T ET AL: "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 393, 11 June 1998 (1998-06-11), pages 537 - 544, XP002087941, ISSN: 0028-0836 *
PANYUTIN I G ET AL: "FORMATION OF A SINGLE BASE MISMATCH IMPEDES SPONTANEOUS DNA BRANCH MIGRATION", JOURNAL OF MOLECULAR BIOLOGY,GB,LONDON, vol. 230, no. 2, 20 March 1993 (1993-03-20), pages 413 - 424, XP000673372, ISSN: 0022-2836 *

Also Published As

Publication number Publication date
WO2000043546A9 (en) 2000-12-14
WO2000043546A2 (en) 2000-07-27

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