WO2000043514A3 - Human acid sensing ion channel and uses thereof - Google Patents

Human acid sensing ion channel and uses thereof Download PDF

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Publication number
WO2000043514A3
WO2000043514A3 PCT/US2000/001601 US0001601W WO0043514A3 WO 2000043514 A3 WO2000043514 A3 WO 2000043514A3 US 0001601 W US0001601 W US 0001601W WO 0043514 A3 WO0043514 A3 WO 0043514A3
Authority
WO
WIPO (PCT)
Prior art keywords
asic4
nucleic acid
acid molecules
ion channel
expression vectors
Prior art date
Application number
PCT/US2000/001601
Other languages
French (fr)
Other versions
WO2000043514A9 (en
WO2000043514A2 (en
Inventor
Rory A J Curtis
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Priority to AU33485/00A priority Critical patent/AU3348500A/en
Publication of WO2000043514A2 publication Critical patent/WO2000043514A2/en
Publication of WO2000043514A3 publication Critical patent/WO2000043514A3/en
Publication of WO2000043514A9 publication Critical patent/WO2000043514A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The invention provides isolated nucleic acids molecules, designated ASIC4 nucleic acid molecules, which encode novel ASIC family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ASIC4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ASIC4 gene has been introduced or disrupted. The invention still further provides isolated ASIC4 proteins, fusion proteins, antigenic peptides and anti-ASIC4 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
PCT/US2000/001601 1999-01-22 2000-01-21 Human acid sensing ion channel and uses thereof WO2000043514A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33485/00A AU3348500A (en) 1999-01-22 2000-01-21 A novel acid sensing ion channel and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23569899A 1999-01-22 1999-01-22
US09/235,698 1999-01-22

Publications (3)

Publication Number Publication Date
WO2000043514A2 WO2000043514A2 (en) 2000-07-27
WO2000043514A3 true WO2000043514A3 (en) 2000-11-02
WO2000043514A9 WO2000043514A9 (en) 2001-08-02

Family

ID=22886577

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/001601 WO2000043514A2 (en) 1999-01-22 2000-01-21 Human acid sensing ion channel and uses thereof

Country Status (2)

Country Link
AU (1) AU3348500A (en)
WO (1) WO2000043514A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE420636T1 (en) 1999-05-19 2009-01-15 Painceptor Pharma Corp PROTON DEPENDENT CATION CHANNEL INHIBITORS AND THEIR USE IN THE TREATMENT OF ISCHEMIA-RELATED DISEASES
CA3179456A1 (en) * 2020-05-19 2021-11-25 Henricus J. DUCKERS Detection and treatment of conditions characterized by perfusion shortage

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0875570A2 (en) * 1997-05-01 1998-11-04 Smithkline Beecham Plc Neurodegenerative polypeptides HHPDZ65
WO1999063081A2 (en) * 1998-06-03 1999-12-09 University College London Ion channels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0875570A2 (en) * 1997-05-01 1998-11-04 Smithkline Beecham Plc Neurodegenerative polypeptides HHPDZ65
WO1999063081A2 (en) * 1998-06-03 1999-12-09 University College London Ion channels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEN, C.C. ET AL.: "A sensory neuron-specific, proton-gated ion channel", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 95, no. 17, 18 August 1998 (1998-08-18), pages 10240 - 10245, XP002086506 *
WALDMANN, R. & LAZDUNSKI, M.: "H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels", CURRENT OPINION IN NEUROBIOLOGY, vol. 8, no. 3, June 1998 (1998-06-01), pages 418 - 424, XP000864723 *

Also Published As

Publication number Publication date
WO2000043514A9 (en) 2001-08-02
AU3348500A (en) 2000-08-07
WO2000043514A2 (en) 2000-07-27

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