WO2000038664A3 - Amine condensation polymer bile acid sequestrants - Google Patents

Amine condensation polymer bile acid sequestrants Download PDF

Info

Publication number
WO2000038664A3
WO2000038664A3 PCT/US1999/030469 US9930469W WO0038664A3 WO 2000038664 A3 WO2000038664 A3 WO 2000038664A3 US 9930469 W US9930469 W US 9930469W WO 0038664 A3 WO0038664 A3 WO 0038664A3
Authority
WO
WIPO (PCT)
Prior art keywords
bile acid
condensation polymer
acid sequestrants
amine condensation
mammal
Prior art date
Application number
PCT/US1999/030469
Other languages
French (fr)
Other versions
WO2000038664A2 (en
Inventor
Chad C Huval
Stephen Randall Holmes-Farley
George M Whitesides
Original Assignee
Geltex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geltex Pharma Inc filed Critical Geltex Pharma Inc
Priority to AU23748/00A priority Critical patent/AU2374800A/en
Publication of WO2000038664A2 publication Critical patent/WO2000038664A2/en
Publication of WO2000038664A3 publication Critical patent/WO2000038664A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A method for binding bile salts in a mammal, comprising the step of administering to the mammal a therapeutically effective amount of one or more amine polymers prepared by the process comprising the step of reacting a substituted or unsubstituted aliphatic, aromatic or aralkyl bifunctional electrophile with at least one monomer comprising a substituted or unsubstituted hydrophobic moiety and a single nucleophilic substituent which is multireactive.
PCT/US1999/030469 1998-12-23 1999-12-20 Amine condensation polymer bile acid sequestrants WO2000038664A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU23748/00A AU2374800A (en) 1998-12-23 1999-12-20 Amine condensation polymer bile acid sequestrants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21955898A 1998-12-23 1998-12-23
US09/219,558 1998-12-23

Publications (2)

Publication Number Publication Date
WO2000038664A2 WO2000038664A2 (en) 2000-07-06
WO2000038664A3 true WO2000038664A3 (en) 2001-07-26

Family

ID=22819761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030469 WO2000038664A2 (en) 1998-12-23 1999-12-20 Amine condensation polymer bile acid sequestrants

Country Status (2)

Country Link
AU (1) AU2374800A (en)
WO (1) WO2000038664A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT411463B (en) 2002-09-03 2004-01-26 Dsm Fine Chem Austria Gmbh High yield production of alkylated nitrogen containing crosslinked polymer gels, e.g. epichlorohydrin crosslinked poly allylamine hydrochloride, comprises washing with methanol, sodium chloride and water
AT412473B (en) 2003-01-15 2005-03-25 Dsm Fine Chem Austria Gmbh METHOD FOR THE CONTINUOUS DRYING OF N- BZW. AMINO, AMMONIUM OR SPIROBICYCLIC AMMONIUM GROUPS OF POLYMERS
EP2539389B1 (en) 2010-02-24 2017-12-20 Relypsa, Inc. Amine polymers for use as bile acid sequestrants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004596A1 (en) * 1992-08-20 1994-03-03 E.I. Du Pont De Nemours And Company Crosslinked polymeric ammonium salts
WO1995019384A1 (en) * 1994-01-18 1995-07-20 E.I. Du Pont De Nemours And Company Crosslinked polymeric ammonium salts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004596A1 (en) * 1992-08-20 1994-03-03 E.I. Du Pont De Nemours And Company Crosslinked polymeric ammonium salts
WO1995019384A1 (en) * 1994-01-18 1995-07-20 E.I. Du Pont De Nemours And Company Crosslinked polymeric ammonium salts

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHARLES E. DAY: "Control of low density lipoproteins and atherosclerosis with the bile acid sequestrants colestipol, cholestyramine and polidexide", LOW DENSITY LIPOPROTEINS, 1976, pages 421 - 438, XP000971182 *
PARKINSON, T.M. ET AL: "Effects of colestipol (U-26,597A), a new bile acid sequestrant, on serum lipids in experimental animals and man", ATHEROSCLEROSIS, vol. 11, no. 3, 1970, pages 531 - 537, XP000974394 *

Also Published As

Publication number Publication date
WO2000038664A2 (en) 2000-07-06
AU2374800A (en) 2000-07-31

Similar Documents

Publication Publication Date Title
WO1998029107A3 (en) Poly(diallylamine)-based bile acid sequestrants
WO1999022721A3 (en) Unsubstituted polydiallylamine for treating hypercholesterolemia
EP0878488A3 (en) Method for production of hydrophilic resin
EP0829766A3 (en) Novel polymers and photoresist compositions
WO1997049736A3 (en) Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
EP0923924A3 (en) Dental adhesive kit
WO1996022338A3 (en) Fast hardening aqueous coating composition and paint
RU95101024A (en) Production of cross-linked anion-exchange particles
AU5643998A (en) Fluorescent cationic monomers useful for tagging water soluble polymers
NO20002041D0 (en) End-functionalized polymers by controlled free radical polymerization process and polymers prepared therefrom
EP0922715A3 (en) Stimuli-responsive polymer utilizing keto-enol tautomerization
FI935496A0 (en) Sequestration means Foer gallsyror
EP0379932A3 (en) Water-soluble adhesive compounds and their use in preparing permanently temperature-resistant splittable films adhering to damp substrates
WO2000038664A3 (en) Amine condensation polymer bile acid sequestrants
AU4918997A (en) Water-soluble polymers for the reduction of dietary phosphate or oxalate absorption
AU7419196A (en) Tea extract preparation
ATE390447T1 (en) CONJUGATION REACTIONS
EP0805169A3 (en) Process for preparing in-basic-medium soluble copolymers based on (meth)acrylates
AU1139188A (en) Photopolymerisable composition
ATE74940T1 (en) BINDING AGENT FOR NON-STICKY, NON-STAINING, ELASTIC COATINGS.
DE3462286D1 (en) Use of polyblends based on cellulose esters in optical contact lenses, and contact and scleroid lenses made from these polyblends
EP1347014A3 (en) Infrared-photosensitive composition
EP0331052A3 (en) Process for the preparation of imidized acrylic polymers
CA2287157A1 (en) Introducing functional groups to a polymer
BG101235A (en) Method for the preparation of granules from acryl-based polymers

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase